Humane Genome Project Influence Bioinformatics and Computational Biology Informatics is the creation, development, and operation of databases and other computing tools to collect, organize, and interpret data. Continued investment in current and new databases and analytical tools is critical to the future usefulness of HGP data. Databases must adapt to the evolving needs of the scientific community and must allow queries to be answered easily. Planners suggest developing a human genome database, analogous to model organism databases, that will link to phenotypic information. Also needed are databases and analytical tools for studying the expanding body of gene-expression and functional data, for modeling complex biological networks and interactions, and for collecting and analyzing sequence-variation data. Some goals of this area related to the HGP are: Improve content and utility of databases. Develop better tools for data generation, capture, and annotation. Develop and improve tools and databases for comprehensive functional studies. Develop and improve tools for representing and analyzing sequence similarity and variation. Create mechanisms to support effective approaches for producing robust, exportable software that can be widely shared. Medicine The medical industry is building upon the knowledge, resources, and technologies emanating from the HGP to further understanding of genetic contributions to human health. As a result of this expansion of genomics into human health applications, the field of genomic medicine was born. Genetics is playing an increasingly important role in the diagnosis, monitoring, and treatment of diseases. Some specific areas of application are: Medical genetics, genetic counseling, genetic nursing Gene testing, gene therapy Organ transplantation, fertility, and reproduction Public health Pharmaceutical industry and suppliers Pharmacogenomics Chemical, vaccine, medicine development and production Database development. Communication, work with regulatory agencies Biotechnology Almost everyone will be affected by applications of information and technologies derived from the HGP era of the late 20th century. Entirely new approaches will be implemented in biological research and the practice of medicine and agriculture. Genetic data will provide the foundation for research in many biological subdisciplines, leading to an unprecedented understanding of the inner workings of whole biological systems. The benefits of genomic research are, or soon will be, realized in such areas as ecology and environmental science, toxicwaste cleanup, creation of new bioenergy sources and more efficient industrial processes, all these areas related with biotechnology. The biotechnology industry has more than tripled in size between 1992 and 2001, with revenue increasing from $8 billion to $27.6 billion. In 2001, there were 191,000 U.S. employees, and more opportunities are expected in healthcare, food production, and environmental cleanup Some specific areas of application are: Agriculture and Wildlife Genetic modification of foods and seeds Biopesticide and neutriceutical development Wildlife management: Identification, protection of endangered species Authentication of consumables such as wine, caviar. Engineering disciplines Bioprocessing chamber, vat design and production Toxic-waste cleanup Instrumentation development Creation of new energy sources via engineering, life science research Biomedical engineering Homework done by: Camilo Mancera Arias