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Featured article: Are clinical drug trials more marketing
than science?
Analysis of trial documentation has revealed that some industry-funded trials may be done more
for marketing purposes than scientific endeavour. Confidential internal company documents
have revealed drug trials designed, or heavily influenced by, the marketing departments of
pharmaceutical companies.
In this study, Barbour et al. examined reports of randomised controlled trials of drugs published
published in 2011 in the top six general medical journals, based on Impact Factor, revealing that
a fifth of drug trials had features that were suggestive of being designed for marketing purposes
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1. Study protocol
Impact of the radiographic examination on diagnosis and treatment
decision of caries lesions in primary teeth – the Caries Detection in
Children (CARDEC-01) trial: study protocol for a randomized controlled
trial
Fausto Medeiros Mendes, Laura Regina Antunes Pontes, Thais Gimenez, Juan Sebastian
Lara, Lucila Basto de Camargo, Edgard Michel-Crosato, Claudio Mendes Pannuti,
Daniela Prócida Raggio, Mariana Minatel Braga and Tatiane Fernandes Novaes
Published on: 9 February 2016
2. Study protocol
Assessment of chiropractic treatment for active duty, U.S. military
personnel with low back pain: study protocol for a randomized controlled
trial
Christine M. Goertz, Cynthia R. Long, Robert D. Vining, Katherine A. Pohlman, Bridget
Kane, Lance Corber, Joan Walter and Ian Coulter
Published on: 9 February 2016
3. Study protocol
Evaluation of short message service and peer navigation to improve
engagement in HIV care in South Africa: study protocol for a three-arm
cluster randomized controlled trial
Sheri A. Lippman, Starley B. Shade, Jeri Sumitani, Julia DeKadt, Jennifer M. Gilvydis,
Mary Jane Ratlhagana, Jessica Grignon, John Tumbo, Hailey Gilmore, Emily Agnew,
Parya Saberi, Scott Barnhart and Wayne T. Steward
Published on: 6 February 2016
4. Study protocol
National Safety Associates nutritional supplementation trial of fruit and
vegetable extracts and vascular function (NNTV): study protocol for a
randomised controlled trial
Marietta Sayegh, Melina Tsiountsioura, Polly Page, Dan Del Rio and Sumantra Ray
Published on: 4 February 2016
5. Study protocol
Community occupational therapy for people with dementia and family
carers (COTiD-UK) versus treatment as usual (Valuing Active Life in
Dementia [VALID] programme): study protocol for a randomised
controlled trial
Jennifer Wenborn, Sinéad Hynes, Esme Moniz-Cook, Gail Mountain, Fiona Poland,
Michael King, Rumana Omar, Steven Morris, Myrra Vernooij-Dassen, David Challis,
Susan Michie, Ian Russell, Catherine Sackley, Maud Graff, Aidan O’Keeffe, Nadia
Crellin…
Published on: 3 February 2016
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1. Review
Through the looking glass: understanding non-inferiority
Jennifer Schumi and Janet T Wittes
Published on: 3 May 2011
2. Review
Managing clinical trials
Barbara Farrell, Sara Kenyon and Haleema Shakur
Published on: 13 July 2010
3. Study protocol
Efficacy and safety of acupuncture for chronic dizziness: study protocol
for a randomized controlled trial
Zhe Xue, Cun-Zhi Liu, Guang-Xia Shi, Yan Liu, Zhao-Xin Li, Zhen-Hua Zhang and LinPeng Wang
Published on: 13 December 2013
4. Study protocol
Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on
aromatase inhibitor-associated musculoskeletal symptoms: a study
protocol for a multicenter, randomized, controlled clinical trial
Nan Peng, Yi Zhang, Cong Ma, Ming-Wei Yu, Guo-Wang Yang, Qi Fu, Wei-Ru Xu and
Xiao-Min Wang
Published on: 15 May 2014
5. Review
Reporting bias in medical research - a narrative review
Natalie McGauran, Beate Wieseler, Julia Kreis, Yvonne-Beatrice Schüler, Heike Kölsch
and Thomas Kaiser
Published on: 13 April 2010
View all articles
Aims and scope
Trials is an open access, peer-reviewed journal that encompasses all aspects of the performance
and findings of randomized controlled trials in health. Trials encourages full and transparent
reporting of all research. We publish articles on general trial methodology as well as protocols,
commentaries and traditional results papers - regardless of outcome or significance of findings.
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About the Editors
Doug Altman graduated in statistics from the University of Bath and has worked for the Medical
Research Council as a statistical consultant in a wide variety of medical areas. In 1988 he
became head of the newly formed Medical Statistics Laboratory (now Medical Statistics Group)
at ICRF (now Cancer Research UK), and in 1995 also became founding director of the Centre
for Statistics in Medicine in Oxford. In 1997, Professor Altman received the Bradford Hill Medal
for his contributions to medical statistics and a DSc from the University of London, and in 1998
was made Professor of Statistics in Medicine by the University of Oxford. His varied research
interests include the use and abuse of statistics in medical research, studies of prognosis,
regression modelling, systematic reviews and meta-analysis, randomised trials, and studies of
medical measurement.
Jeremy Grimshaw is the Director of the Clinical Epidemiology Program at the Ottawa Health
Research Institute and the Director of the Center for Best Practice at the University of Ottawa.
He holds a Tier 1 Canadian Research Chair in health knowledge transfer and uptake and was
made a Professor of Medicine by the University of Ottawa. Prior to this, he held a Personal Chair
in health services research at the University of Aberdeen and was the Program Director of the
Effective Professional Program within health services research, one of the largest
implementation research programs within the UK. Professor Grimshaw’s research interests are in
knowledge translation,quality improvement,complex interventions. systematic reviews, cluster
randomized trials, quasi experimental studies and behavioural theories (and their application to
professional behaviour).
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