MOLECULAR
PHARMACOLOGY
October 2002
Volume 62
Number 4
http://molpharm.aspetjournals.org
ISSN 0026-895X
ACCELERATED COMMUNICATIONS
Inhibition of Bcl-XL Phosphorylation by Tea Polyphenols or Epigallocatechin-3-Gallate Is Associated
with Prostate Cancer Cell Apoptosis
Aslamuzzaman Kazi, David M. Smith, Qing Zhong, and Q. Ping Dou
765
Resveratrol Suppresses Angiotensin II-Induced Akt/Protein Kinase B and p70 S6 Kinase
Phosphorylation and Subsequent Hypertrophy in Rat Aortic Smooth Muscle Cells
Ursula G. B. Haider, Dan Sorescu, Kathy K. Griendling, Angelika M. Vollmar, and
Verena M. Dirsch
772
ARTICLES
Conformation of Ligands Bound to the Muscarinic Acetylcholine Receptor
Hiroyasu Furukawa, Toshiyuki Hamada, Mariko K. Hayashi, Tatsuya Haga, Yutaka Muto,
Hiroshi Hirota, Shigeyuki Yokoyama, Kazuo Nagasawa, and Masaji Ishiguro
778
Structurally and Functionally Important Amino Acids of the Agonistic Conformation of the Human
Vitamin D Receptor
Sami Vdisdnen, Sanna Ryhdnen, Janne T. A. Saarela, Mikael Perdkyld, Teemu Andersin, and
Pekka H. Mdenpdd
788
Kinetics and Crystal Structure of Catechol-O-Methyltransferase Complex with Co-Substrate and a
Novel Inhibitor with Potential Therapeutic Application
Maria Jodo Bonifacio, Margarida Archer, Maria L. Rodrigues, Pedro M. Matias,
David A. Learmonth, Maria Armenia Carrondo, and Patricio Soares-da-Silva
795
Ligand-Dependent and Independent Modulation of Aryl Hydrocarbon Receptor Localization,
Degradation, and Gene Regulation
Zhijuan Song and Richard S. Pollenz
806
Desensitization of Homomeric al Glycine Receptor Increases with Receptor Density
Pascal Legendre, Emilie Midler, Carmen lonela Badiu, Jochen Meier, Christian Vannier, and
Antoine Triller
817
DNA Microarray Analysis of Cannabinoid Signaling in Mouse Brain in V ivo
Sophie Parmentier-Batteur, Kunlin Jin, Lin Xie, Xiao Ou Mao, and David A. Greenberg
828
Molecular Basis of Pimarane Compounds as Novel Activators of Large-Conductance Ca2+-Activated K+
Channel a-Subunit
Yuji Imaizumi, Kazuho Sakamoto, Aki Yamada, Aya Hotta, Susumu Ohya, Katsuhiko Muraki,
Masanobu Uchiyama, and Tomohiko Ohwada
836
Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate -1 Phosphorylation by
Inhibitor of 90-kDa Heat-Shock Protein Family: Endoplasmic Reticulum Retention of Monomeric
Insulin Receptor Precursor with Calnexin in Adrenal Chromaffin Cells
Tomokazu Saitoh, Toshihiko Yanagita, Seiji Shiraishi, Hiroki Yokoo, Hideyuki Kobayashi,
Shin-ichi Minami, Toshio Onitsuka, and Akihiko Wada
847
Tranilast Inhibits Cytokine-Induced Nuclear Factor K B Activation in Vascular Endothelial Cells
Martin Spiecker, Ioana Lorenz, Nikolaus Marx, and Harold Darius
856
Translocation of Liposomes into Cancer Cells by Cell-Penetrating Peptides Penetratin and Tat: A
Kinetic and Efficacy Study
Yun-Long Tseng, Jun-Jen Liu, and Ruey-Long Hong
864
Inhibition of DNA Topoisomerases II and/or I by Pyrazolotl,5-alindole Derivatives and Their Growth
Inhibitory Activities
Ken Umemura, Tomoko Mizushima, Hajime Katayama, Yoshimitsu Kiryu, Takao Yamori , and
Toshiwo Andoh
873
Regulation of Mouse K Opioid Receptor Gene Expression by Different 3'-Untranslated Regions and the
Effect of Retinoic Acid
Xinli Hu, Jing Bi, Horace H. Loh, and Li-Na Wei
881
Unexpected Anthracycline-Mediated Alterations in Iron-Regulatory Protein-RNA-Binding Activity: The
Iron and Copper Complexes of Anthracyclines Decrease RNA-Binding Activity
Juliana C. Kwok and Des R. Richardson
888
Regulation of the Neuronal Glutamate Transporter Excitatory Amino Acid Carrier -1 (EAAC1) by
Different Protein Kinase C Subtypes
Marco I. Gonzalez, Marcelo G. Kazanietz, and Michael B. Robinson
901
Selective Estrogen Receptor (ER) Modulators Differentially Regulate Phospholipase D Catalytic
Activity in ER-Negative Breast Cancer Cells
Susanne F. Eisen and H. Alex Brown
911
Identification of a Mechanism by Which the Methylmercury Antidotes JV-Acetylcysteine and
Dimercaptopropanesulfonate Enhance Urinary Metal Excretion: Transport by the Renal Organic
Anion Transporter-1
Albert S. Koh, Tracey A. Simmons-Willis, John B. Pritchard, Steven M. Grassl, and
Nazzareno Ballatori
921
Activation of the Mitogen Activated Protein Kinase Extracellular Signal -Regulated Kinase 1 and 2 by the
Nitric Oxide-cGMP-cGMP-Dependent Protein Kinase Axis Regulates the Expression of Matrix
Metalloproteinase 13 in Vascular Endothelial Cells
Carlos Zaragoza, Estrella Soria, Esther Lopez, Darren Browning, Milagros Balbin,
Carlos Lopez-Otin, and Santiago Lamas
927
Revisiting an Old Antimicrobial Drug: Amphotericin B Induces Interleukin -1-Converting Enzyme as
the Main Factor for Inducible Nitric-Oxide Synthase Expression in Activated Endothelia
Christoph Viktor Suschek, Eckhard Bonmann, Anna Kapsokefalou, Karsten Hemmrich,
Hartmut Kleinert, Ulrich Forstermann, Klaus-Dietrich Kroncke, Csaba Mahotka, and
Victoria Kolb-Bachofen
936
High Affinity Antagonists of the Vanilloid Receptor
Yun Wang, Tamas Szabo, Jacqueline D. Welter, Attila Toth, Richard Tran, Jiyoun Lee,
Sang Uk Kang, Young-Ger Suh, Peter M. Blumberg, and Jeewoo Lee
947
Sensitization by Extracellular Ca2+ of Rat P2X5 Receptor and Its Pharmacological Properties
Compared with Rat P2X1.
Scott S. Wildman, Sean G. Brown, Mary Rahman, Carole A, Noel, Linda Churchill,
Geoffrey Burnstock, Robert J. Unwin, and Brian F. King
, 957
Correction to "Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for
m2 nmscarinic receptor-stimulated G"
967
Correction to "Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor
agonists"
968