PRESS RELEASE To Editor (Business / Finance / China / Medical / Supplement) The First Chinese Herbal Medicine to Relieve AIDS Symptoms Succeeds in Gaining PRC SFDA Approval Golden Meditech (8180) Plans to Acquire 51% Equity Stake in HIV / AIDS Treatment Company [Hong Kong - 10 June 2004] On April 8th of this year, PRC’s State Food and Drug Administration (SFDA) issued the first ever approval for a Chinese herbal medicine, Tang Cao Pian, to be used in the treatment of AIDS symptoms. This medicine brings fresh hope to PRC’s over 840,000 AIDS patients and HIV carriers. Tang Cao Pian is the world’s first all-natural Chinese medicine to be certified as effective in the alleviation of AIDS symptoms. This herbal medicine is the result of years of intensive research performed by Beijing Qi Jie Yuan Medicine Technology Limited (“Beijing QJY”). Clinical trials have proven that the herb can effectively increase the number of CD4 lymph cells (also called T4 cells) in AIDS patients and HIV carriers, strengthening their immune systems. Furthermore, the herb has shown to reduce fatigue, hair loss, lack of appetite, diarrhoea and other symptoms of the virus, allowing AIDS patients and HIV carriers to resume normal activity and greatly improving their quality of life. Golden Meditech Company Limited (“Golden Meditech”) (Stock Code: 8180) has always held its mission to be the guardian of people’s well-being and quality of life. Consequently, it plans to acquire a 51% equity stake in Beijing QJY. This will allow Golden Meditech to provide HIV carriers and AIDS patients with the high quality, reasonably priced Tang Cao Pian treatment, helping the PRC government resolve this social problem. Mr. Yuen KAM, Chairman of Golden Meditech, said, “AIDS, the epidemic of the century, has brought to the world and particularly developing countries a tremendous burden. The treatments currently in use are extremely expensive and have strong side effects, creating both physiological and financial strains that are difficult for those infected by the virus to bear. We are very proud of the 1 development of Tang Cao Pian; this breakthrough is truly great news for the medical community. “We are very happy to become shareholders in Beijing QJY, which will expand our business into new territory. Golden Meditech will use our corporate resources effectively to bring the benefits of Tang Cao Pian to more patients and carriers. At the same time, the herb can also help us to repay the society by implementing our mission of improving people’s well-being and enhancing their quality of life. Golden Meditech hopes that Tang Cao Pian will also be able to help AIDS patients and HIV carriers in Hong Kong. Golden Meditech will do its best to comply with the HKSAR government and complete the registration of Tang Cao Pian, bringing the benefits of the herbal medicine to more people in need of aid.” Recently, the PRC government has initiated a series of measures curbing the AIDS virus from spreading, including free testing and consultation, providing free medication for AIDS patients, issuing preventative regulations, building a caring centre for AIDS, and educating the public to fight the disease, etc. Golden Meditech will acquire Beijing QJY for HK$452 million, of which HK$136 million will be paid in cash, HK$226 million in convertible bonds will be paid when the acquisition is complete, and the remaining HK$90.4 million will be paid within one year of the acquisition. Mr. Kam went on to say, “Golden Meditech has been looking for pharmaceutical companies with strong growth potential as long term investments, in order to diversify the group’s portfolio. The medical community has shown increasing interest in the use of natural herbs to cure disease, and the number of doctors who recommend a combination of eastern- and western-style treatments continues to grow. China has a long history and deep knowledge in herbal treatments. We strongly believe that herbal treatments will play a more significant role in the future of pharmaceutical business, especially on treating those diseases which cannot be cured by conventional western medicines. Therefore, the Group’s acquisition of Beijing QJY is a major advancement for its development in herbal medicine treatment business while at the same time, it helps strengthen its position in the medical sector in the PRC and provide another source of income for shareholders.” 2 About Tang Cao Pian In recent years, clinical trials for Tang Cao Pian have taken place at China’s Beijing Youan Hospital, Beijing Ditan Hospital, People’s Liberation Army Hospital No. 302 (『解放 軍 302 醫院』), Peking Union Medical College Hospital, and Third People’s Hospital of Kunming. The clinical trials were set up as randomized, double-blind, placebo-controlled parallel-group multicenter studies to gauge the efficacy and safety of Tang Cao Pian. The results clearly showed that Tang Cao Pian visibly increased patients’ CD4 cell count and ameliorated their clinical condition, allowing them to gain weight and also increasing their CD4/CD8 cell count ratio. There is also a possibility that the herb can delay the replication of the HIV virus. No obvious adverse side effects were found in the course of the clinical trials. Early AIDS patients taking Tang Cao Pian can suppress or reverse the development of the disease. Mid-term patients using it can prevent further damage to the immune system as well as regain and strengthen their autoimmunity. Advanced stage virus patients can use it to control the onset of complications. Tang Cao Pian comes in tablet form and should be taken orally, 3 doses a day, 8 tablets per dose. continuously. It should be taken Production of Tang Cao Pian will begin at the end of the year at the very earliest. Tang Cao Pian ARVs Treatments (Antiretroviral Therapies) Increases CD4 cells number Delays the replication of HIV virus - Improves patients’ conditions such as diarrhoea, weariness, loss of hair, appetite etc When to initiate Both HIV carriers and AIDS the treatment patients can take the medicine Effectiveness - Side-effects Very few side effects Duration of treatment Patients can take the medicine continuously Cost per Estimated RMB3,000 per treatment treatment Sales Channels - By Prescription; - Over the Counter 3 - Reduce HIV virus Stop HIV virus from further infecting uninfected CD4 cells; no effect on those infected with the virus ARVs treatments recommended for advanced HIV carriers or/and AIDS patients Associated with lose of muscle, anemia, skin rash, lop, mouth and tongue sores, abnormal bruising or bleeding headaches etc. Need to be changed occasionally for either treatment failure or toxicity Range from RMB 3,000 to RMB 10,000 per treatment By Prescription only About Golden Meditech Company Limited Golden Meditech is a leading hi-tech integrated medical corporation in the People’s Republic of China. The Group operates three main businesses: medical devices, tumour treatment and stem cell storage. Its main product, Autologous Blood Recovery Systems, is the first product of its kind to receive approval from the State Food and Drug Administration in the PRC to develop, manufacture and sell in the PRC. The Group is also one of the only two holders of Umbilical Cord Stem Cells Storage permits issued by the PRC Ministry of Health. To broaden and diversify its business, it has signed agreements to be engaged in the distribution of both domestic and overseas medical devices in the PRC, and the research and development of herbal medicine. Through research and development, manufacture, expansion of distribution networks and investment in mergers and acquisitions, the Group aspires to and is striving to become one of the world’s leading hi-tech integrated medical corporations. ### Issued by A-World Consulting Ltd on behalf of Golden Meditech. For further information and inquiries, please contact: Ms Viki Li Account Executive A-World Consulting Tel: (852) 2864 4882 Fax: (852) 2157 0505 Email: viki.li@a-world.com.hk Mrs Fanny Lui Project Director A-World Consulting Tel: (852) 2114 4974 Fax: (852) 2157 0505 E-mail: fanny.lui@a-world.com.hk 4