Student Research Poster Session Abstract
(Submit as Word document)
E-mail this completed abstract along with your application to Posters@ASDAnet.org by
11:59 p.m. CST on Sept. 17, 2012.
Author(s): Vahdati Seyed Aliakbar, Hassani Hanieh, Sadr-Eshkevari Pooyan, Sharifi Davood,
Masoumi Poopak, Rashad Ashkan
School: UCLA School of Dentistry
Poster title: Biphasic Calcium Phosphate Ceramic vs. Bovine Bone: Self controlled
Histomorphometric Rabbit Calvarium Study of Bone Regeneration
Hypothesis:
Although the use of autogenous bone graft is considered as the gold standard in bone
regeneration, their application is facing some limitations. Synthetic bone substitutes are
introduced to overcome these limitations. The present study aimed to compare osteogenic
properties of biphasic calcium phosphate ceramic (Osteon) and bovine bone mineral (Bio-Oss).
Summarize your research project in 250 words or less. You must include the identified problem,
methods and processes of conducted study, results and conclusion.
Materials and Methods: Four round defects of 6.5 mm in diameter were prepared on the
calvarium of twelve rabbits (48 defects). Three sites were filled with 1) Bio-Oss, 2) small (SOsteon) and 3) large (L-Osteon) particle Osteon, and the fourth was 4) left empty as control.
After 4 and 8 weeks, rabbits were sacrificed and histological and histomorphometrical
examinations were performed and the data were analyzed by Friedman, Wilcoxon, and Multiple
Comparison Mann-Whitney U tests.
Results: Inflammation: significant differences were found between control and Bio-Oss (p =
0.008), control and S-Osteon (p = 0.013), control and L-Osteon (p = 0.011), and Bio-Oss
compared to S-Osteon (p = 0.029) and L-Osteon (p = 0.023) after 8 weeeks, respectively. Foreign
body reaction (p < 0.05): L-Osteon and Bio-Oss respectively showed the most and the least
foreign body reaction in our study. L-Osteon showed more inflammation and foreign body
reaction than the other groups.
There were no statistically significant differences in bone fill between the four groups (p > 0.05).
The scored bone regeneration was the only variable which showed to be significantly higher
after 8 weeks compared to those of after 4 weeks regarding Bio-Oss group (p = 0.038).
Conclusion: Although it may be concluded that biphasic calcium phosphate ceramic and bovine
bone mineral have similar osteogenic potentials, further studies seem necessary.
Please indicate one of the following categories for your abstract research:
____ Endodontics
____ Periodontics
____ Prosthodontics
____ Orthodontics
____ Pediatric dentistry
__x__ Oral and maxillofacial surgery
____ Oral and maxillofacial radiology
____ Oral pathology
__x__ Dental materials
____ Basic science
____ Operative/restorative dentistry
____ Public health dentistry