Biomolecules and synthetic
nanostructures in cells and
model systems: experimental
and theoretical studies
Workshop, Kyiv, 15-18 November 2013
Photo: Oleg Zharii, www.zharii.kiev.ua
The Workshop is sponsored by the Alexander von Humboldt Foundation, a nonprofit organization established by the Federal Republic of Germany for promotion
of scientific collaboration. It is the second event of this kind (the first one was held
in Kyiv, 5-7 May 2008), organized jointly by German and Ukrainian scientists
working under collaborative Research Group Linkage Program, ongoing currently
between Leibniz-Institut für Molekulare Pharmakologie (Berlin, Germany) and
Taras Shevchenko National University (Kyiv, Ukraine). The idea of the workshops
is to promote exchanging of ideas relevant to chemical, biophysical and
theoretical research of peptides and other biomolecules. It is anticipated that
bringing together the experts in related, but different fields of science will promote
generation of innovative ideas and technologies.
Preliminary work program of the Workshop:
15-17 November, 2013
Arrival of guests to Kyiv, accommodation, hotel “Rus”
Welcome dinner
Saturday, 16 November
(Conference Hall of the hotel “Rus”)
900-915 Welcome words by Prof. Igor V. Komarov and members of the
Humboldt-Club Ukraine
915-1000 "Protein translation with proline analogs" (Prof. Dr. Nediljko
Budisa, Technische Universität Berlin, Institut für Chemie, Berlin, Germany)
1000-1045 “Overview of the structure and function of membrane-bound
peptides” (Prof. Dr. Anne Ulrich, Karlsruhe Institute of Technology,
Karlsruhe, Germany)
1045-1100 Coffee break
1100-1145 “Synthesis and structure of fluorinated -amino acids as basic
skeletons for the construction of medicinally relevant molecules” (Prof. Dr.
Günter Haufe, Organisch-Chemisches Institut, Universität Münster,
Germany)
1145-1230 “Fluorine-containing amino phosphonates. A family of bioactive
molecules” (Prof. Dr. Valery P. Kukhar, Member of NAS of Ukraine,
Institute of Bioorganic Chemistry and Petrochemistry, National Academy of
Sciences, Kyiv, Ukraine)
1230-1400 Lunch at the hotel, discussions, free time
1400-1430 “19F-NMR with CF3-labels to measure peptide orientation and
conformation in membranes” (Dr. Sergii Afonin, Karlsruhe Institute of
Technology, Karlsruhe, Germany)
1430-1500 „Structure and dynamics of membrane-active peptides from solidstate 19F-NMR distance and relaxation measurements“ (Dr. Stephan L.
Grage, Karlsruhe Institute of Technology, Karlsruhe, Germany)
1500-1530 „Expanding the toolbox of the 19F-NMR labels for peptide structural
studies“ (Dr. Pavel Mykhailiuk, Taras Shevchenko National University of
Kyiv, Ukraine)
1530-1545 Coffee break
1545-1615 „Synthesis of enantiopure Tfm-amino acids and their incorporation
into relevant peptides” (Prof. Thierry Brigaud, Universite de CergyPontoise, Laboratoire SOSCO, Cergy-Pontoise, France)
1615-1645 “Difluorocyclopropanated cyclic amines: molecules under the
sword of Damocles” (Dr. Vladimir Kubyshkin, Taras Shevchenko National
University of Kyiv, Ukraine)
1645-1715 „Exploiting molecular rigidity in design of unnatural amino acids“
(Dr. Dmytro Radchenko, Taras Shevchenko National University of Kyiv,
Ukraine)
1715-1745 „The world beyond the -amino acids“ (Dr. Oleksandr
Grygorenko, Taras Shevchenko National University of Kyiv, Ukraine)
1800 Dinner at the hotel and discussions
Sunday, 17 November
(Conference Hall of the hotel “Rus”)
900-945 “Membrane binding interactions of cyclotides” (Prof. David Craik,
Institute for Molecular Bioscience, University of Queensland, St. Lucia,
Australia)
945-1030 „Dual-Fluorescence L-Amino Acid for Registration of Environment of
Peptide Segment and Peptide Orientation in Model and Natural Cellular
Membranes“ (Prof. Vasyl Pivovarenko, Taras Shevchenko National
University of Kyiv, Ukraine)
1030-1045 Coffee break
1045-1130 „Switching peptidomimetic antimicrobial activity by light“ (Oleg
Babii, Karlsruhe Institute of Technology, Germany)
1130-1215 “Evaluating fluorine’s impact on amyloid formation – a systematic
study using a coiled coil-based model peptide” (Dr. Ulla Gerling, Institut für
Chemie und Biochemie - Organische Chemie, Freie Universität Berlin,
Germany)
1215-1245 “A Vicious Cycle or How to Elucidate the Mode of Action of a Small
Cyclic Peptide” (Dr. Kathi Scheinpflug, Leibniz Institute of Molecular
Pharmacology, Berlin, Germany)
1245 – 1400 Lunch at the hotel
1500-1700 – (optional) Excursion to Lavra
1700-1800 – Free time
1800- Vine tasting and dinner (vine museum of Massandra)
Monday, 18 November
(Conference Hall of the hotel “Rus”)
900-930 “Molecular dynamics simulations of human tyrosyl-tRNA synthetase
and its mutant forms using MOLDYNGRID virtual lab space” (Prof.
Oleksandr I. Kornelyuk, corresponding member of NAS of Ukraine,
Institute of molecular biology and genetics, National academy of sciences,
Kyiv, Ukraine)
930-1000 “Peptide-modified Nanoparticles: Their Targeting and Cellular
Uptake Mediating Potential” (Dr. Margitta Dathe, Leibniz Institute of
Molecular Pharmacology, Berlin, Germany)
1000-1030 Shuttling SiC-based Nanoparticles into Live Cells by CellPenetrating Peptides” (Prof. Dr. Igor V. Komarov, Taras Shevchenko
National University of Kyiv, Ukraine)
round-table, discussions
1200-1300 Lunch at the hotel
Departure of guests