Program of the Regensburg Meeting, 17.9.

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International meeting of the DFG priority program 1170
and the GBM study group “Protein Engineering and Design”
Thursday, 17.09.09
14.00-14.15
Welcome addresses by N. Raffler (DFG) and R. Sterner
Chair: R. Sterner
14.15-15.00
D. Hilvert: Coupling computation and evolution for enzyme design
15.00-15.45
R. Armstrong: Evolution of catalytic diversity in the VOC superfamily
15.45-16.15
Coffee
16.15-17.00
M. Danson: Catalytic promiscuity in the hyperthermophilic Archaea: from metabolic
efficiency to engineering stereoselectivity
17.00-17.30
J. Reinstein: Tailoring molecular chaperones - in vivo and in vitro selection
approaches for improved folding assistance
17.30-18.00
J. Pleiss: Molecular dynamics simulation of protein hydration
18.00-19.30
Dinner in the restaurant “Kneitinger”
19.30-20.15
A. Plückthun: Designing, evolving and exploiting protein stability
Friday, 18.09.09
Chair: H. Kolmar
8.30-9.00
W. Wende: Generation of meganucleases of pre-defined specificity by rational and
combinatorial strategies
9.00-9.30
A. Jeltsch: Directed evolution of DNA methyltransferases
9.30-10.00
S. Brakmann: Directed evolution of polymerases with reduced fidelity
10.00-10.30
Coffee
10.30-11.15
L. Loeb: Involvement of mutator DNA polymerases in carcinogenesis
11.15-11.45
A. Marx: Translesion synthesis across non-instructive abasic DNA sites by DNA
polymerase
11.45-12.45
Lunch
12.45-13.30
S. Lutz: Making the lock fit the key - engineering kinases to phosphorylate nucleoside
analogs for antiviral and cancer therapy
13.30-14.15
P. Bryan: A minimal sequence code for switching protein structure and function
14:15-14:30
J. Podtetenieff: A new artificial metalloenzyme: Creation of a copper binding site in a
thermostable protein
14:30-15:00
Coffee
15.00-15.30
K. Müller: Evolutionary optimization of enzyme stability and of enzyme fragment
folding for complementation assays
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15.30-16.00
F. Schmid: Dimer formation of a stabilized G1 variant: A structural and energetic
analysis
Chair: F. Schmid
16.00-16.30
U. Bornscheuer: (Focused) directed evolution to understand relationships in α/β hydrolase-fold enzymes
16.30-17.00
H. Kolmar: Novel display strategies for high throughput screening of enzyme libraries
17.00-17.30
M. Stubbs: Directed evolution of the S1 subsite specificity of trypsin
17.30-19.00
Dinner in the restaurant “Kneitinger”
19.00-19.45
J. Gerlt: Predicting and discovering new reactions in the Enolase and RuBisCO
superfamilies
19.45-20.30
F. Raushel: Annotating orphan enzymes
Saturday, 19.09.09
Chair: A. Jeltsch
8.30-9.15
E. Westhof: Elementary modules of RNA architecture
9.15-10.00
J. Burke: GlmS ribozyme: Folding and catalysis
10.00-10.30
R. Hartmann: Insights into RNase P RNA structure and function by a "retro-evolution"
approach
10.30-11.00
Coffee
11.00-11.30
M. Mörl: In vitro evolution of nucleotidyltransferases
11.30-12.00
J. Müller: Structure and function of new oligomeric protein species of human PAPS
synthetases
12.00-12.30
A. Samland: Changing the substrate scope of transaldolase B towards nonphosphorylated compounds
12.30-13.30
Lunch
13.30-14.30
Meeting of SPP 1170 and Protein Engineering & Design study group members
14:30-16:30
Guided tour through the Old City of Regensburg
Chair: A. Marx
16.30-17.00
B. Höcker: Evolutionary relationships beyond fold boundaries
17.00-17.30
M. Wilmanns: Catalytic promiscuity in an ancestral isomerase from Mycobacterium
tuberculosis by active site metamorphosis
17.30-18.00
M. Bocola: Analysis and redesign of ()8-barrel stability and activity
18.00-18.30
R. Sterner: Activation of a thermostable enzyme by removal of Mg2+-inhibition and
acceleration of product release
18.30
Dinner in the restaurant “Fürstliches Brauhaus”
Sunday, 20.09.09
Departure after breakfast
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