Topic: Her-2/neu gene amplification, FISH Date: 1/1/05

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Technical Laboratory Bulletin
Topic: Her-2/neu gene amplification, FISH
Test Name:
Test Code:
Method:
Specimen:
Test Schedule:
Date: 1/1/05
Her-2/neu gene amplification, FISH
FH2N
Fluorescent in-situ Hybridization, FISH
2 H&E stained slides, 3 unstained slides
Every Monday
Indications:
 Used as a prognostic factor in stage II, node-positive breast cancer patients.

An aid to predict disease-free and overall survival of the above patients when treated with
cyclophosphamide, doxorubicin and 5-fluorouracil.

Breast cancer patients with a 2+ IHC Her-2/neu stain who are candidates for Herceptin treatment.
Result Reporting:
Non-Amplified or Amplified with the ratio of control to Her-2/neu genes present.
References:
http://www.vysis.com/BreastCancer_27.asp
Additional Information:
Contact Dr. Gene R. Putz, Ph.D., Laboratory Director, NorDx, (207) 885-7809 or Email at putzg@mmc.org.
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