Speaker: Dane B. Cook, Ph.D. Assistant Professor Department of Kinesiology University of Wisconsin - Madison Title: Psychophysiological Aspects of Muscle Pain and Exercise in Health and Disease Chronic musculoskeletal pain affects nearly 20% of adults and is considered the most frequent cause of disability throughout the world. At the extreme end of the chronic pain continuum, fibromyalgia (FM) affects nearly 5% of the U.S. population (women 10:1) and is quickly becoming a public health crisis. Exercise is one of the few efficacious treatments for chronic musculoskeletal pain conditions, including FM. However, the psychobiological mechanisms that underlie acute and chronic muscle pain, including how exercise affects these mechanisms, are poorly understood. Moreover, a better understanding of the causes and consequences of muscle pain could potentially contribute to a host of topics relevant to physical activity including sport performance, adoption and maintenance of physically active lifestyles, exercise-induced analgesia and chronic pain maintenance. Thus, this seminar will focus on the psychobiological aspects of muscle pain and exertion in both healthy individuals and those with chronic pain and fatigue. Several studies will be described demonstrating the usefulness of exercise for understanding both the physiological and perceptual aspects of muscle pain. Studies will be presented characterizing pain intensity during exercise, investigating the effects of pharmacological manipulations on muscle pain perception and determining the influence of disease on pain and effort.