Topics for Biol 130 Test 3 (helpful to do relevant Ch. problems for self-testing)
Mendelian Genetics Ch 14
understand concepts of standard dominance and recessivenes as well as variations
(incomplete dominance, codominance, epistasis, polygenic, pleiotropy etc.) know specific
examples of each
Pedigree analysis: how to determine probable genotype (mode of inheritance) of offspring given
pedigree phenotype
Familiarity with discussed human genetic disorders
karyotyping and fetal screening
Chromosome abnormalities and Sex-linkage Ch 15
how to determine probability of inheriting a sex-linked gene
What causes aneuploidy?
Various ways chromosomes can be rearranged
(we did not go over imprinting: not on test)
Molecular basis of Inheritance Ch 16
Science history: know seminal discoveries relating importance of DNA (genotype) to
phenotype and scientists who made discoveries (structure of DNA(Watson , Crick, Franklin),
transformation (Griffiths, Avery et al.); Hershey-Chase experiment
DNA synthesis: know Meselson and Stahl labeling experiment to determine mode of DNA
replication (semi-conservative)
Structure of nucleotides (deoxyribonucleotide and ribonucleotide) Ch 5
Mechanism of DNA replication: constituents, direction, products
Be able to fill in a replication bubble with the appropriate daughter strands
Examples of DNA proofreading and editing mechanisms
Function of telomerase and telomeres
where is telomerase activity found; how does it relate to cancer and longevity of cell's life
Gene expression Ch 17
Mechanism and components of transcription & translation
distinctions between between prokaryotes and eukaryotes (e.g. mRNA processing,
coupled transciption & translation)
How are secreted or membrane proteins synthesized: what role does SRP play
Ability to read codon table for translation purposes, effects of mutations in DNA on transcription
and translation products; memorize start and stop codons