Biology
Study Guide: DNA Replication
1. If the sequence of one single strand of DNA is C-A-A-G-T-A-G-G-C-T, what is the sequence of
the complementary strand?
2. Describe the origin of each strand of the new double helices created after DNA replication.
3. Why is DNA replication important to the growth and development of a multi-cellular organism?
4. Place the following terms in the correct order from smallest to largest: Histone form
Nucleosomes, supercoils, coils, chromosome, DNA double helix
5. List the 3 basic steps of DNA replication:
1
6. The model of DNA below is ready to be copied. Compared to the original
double helix, evaluate the copies made during three attempts of DNA
replication. List any errors with the replication if they occurred:
A
T
C
C
G
T
G
Replication #1
T
A
G
G
AND
C
A
C
Replication #2
A
T
T
A
C
G
C
G
G
C
T
A
G
C
AND
A
T
C
A
G
T
G
T
A
G
G
C
A
C
A
T
C
C
G
T
G
T
A
G
G
C
A
C
Original
A
T
C
C
G
T
G
List problems if any:
_______________________
_______________________
_______________________
_______________________
_______________________
_______________________
T
A
G
G
C
A
C
List problems if any:
_______________________
_______________________
_______________________
_______________________
_______________________
_______________________
7. Complete the diagram on the left. Then circle the areas in the diagram on the right that show
a genetic mutation (change in the DNA).
DNA Correctly Copied
DNA Incorrectly Copied
A
G
C
T
A
T
A
A
G
C
T
A
T
A
A
G
C
T
A
T
A
T
C
G
A
T
G
T
G
G
C
T
A
C
A
8. Explain how the mutations (changes in DNA) might have been caused in the diagram above.
2
T
C
G
A
T
A
T