Table 2  Supplementary Data.
Endpoint definitions of included trials
Trial
Death
Myocardial infarction
EXCELLENT6
PRODIGY5
REAL/ZEST-LATE4
RESET22
All-cause of death
All-cause of death
All-cause of death
All-cause of death
<48 hours after PCI:
Increase of cardiac enzyme
(CK-MB fraction or
Troponin T/Troponin I) 3
times above the ULN in
stable patients; in patients
with elevated baseline
levels of cardiac enzyme,
as a subsequent increase of
>2-fold from baseline
values.
>48 hours after PCI:
Presence of clinical signs
combined with a CK-MB
fraction or Troponin
T/Troponin I increase
>ULN
Stent thrombosis
Definite or probable (ARC)
<48 hours after PCI:
<48 hours after PCI:
CK-MB ≥3 times the ULN, CK-MB ≥3 times the ULN,
whether or not
whether or not
accompanied by chest pain accompanied by chest pain
and/or ECG changes, or
and/or ECG changes, or
new pathologic Q waves
new pathologic Q waves
(≥0.04 second in duration
(≥0.04 second in duration
in ≥2 contiguous leads) in
in ≥2 contiguous leads) in
stable patients; in patients
stable patients; in patients
with baseline CK-MB
with baseline CK-MB
elevation as a ≥25%
elevation as a ≥25%
decrease in CK-MB from a decrease in CK-MB from a
prior peak level, followed
prior peak level, followed
by a new increase of ≥50% by a new increase of ≥50%
above the preceding valley above the preceding valley
and ≥3 times ULN.
and ≥3 times ULN.
n/r
>48 hours after PCI:
>48 hours after PCI:
New pathologic Q waves or New pathologic Q waves or
CK-MB or Troponin I/T
CK-MB or Troponin I/T
elevation >ULN,
elevation >ULN,
accompanied by ischemic
accompanied by ischemic
symptoms and/or ECG
symptoms and/or ECG
changes
changes
Definite or probable (ARC)
Definite (ARC)
Definite or probable (ARC)
Cerebrovascular accidents
Major bleeding
Stroke, as detected by the
occurrence of a new
neurological deficit, was
confirmed by a neurologist
and on imaging
Stroke, as detected by the
occurrence of a new
neurologic deficit, was
confirmed by a neurologist
and on imaging whereas
the occurrence of a
transient ischemic attack
required hospitalization and
clinical confirmation by a
neurologist
Stroke, as detected by the
occurrence of a new
neurologic deficit, was
confirmed by a neurologist
and on imaging
n/r
TIMI Classification
TIMI Classification
TIMI Classification
TIMI Classification
PCI: Percutaneous coronary intervention; CK-MB: Creatine Kinase-myocardial band; ULN: Upper level of normal; ARC: Academic Research
Consortium; TIMI: Thrombolysis in myocardial infarction.
Trial acronyms: EXCELLENT: Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting; PRODIGY: Prolonging Dual
antiplatelet treatment after Grading stent-induced Intimal hyperplasia study; REAL/ZEST-LATE: Correlation of Clopidogrel Therapy
Discontinuation in Real-World Patients Treated with Drug-Eluting Stent Implantation/ Evaluation of the Long-Term Safety after ZotarolimusEluting Stent, Sirolimus-Eluting Stent, or Paclitaxel-Eluting Stent Implantation for Coronary Lesions — Late Coronary Arterial Thrombotic Events;
RESET: Real Safety and Efficacy of a 3-month Dual Antiplatelet Therapy Following Zotarolimus-eluting Stents Implantation.