12/02/16
Prognostic consequences of borderline dysnatremia: Pay attention to
minimal serum sodium change
Michael DARMON et al.
Additional File 1.
1
Se
ve
rn
a
a
a
mi
mi
tre
tr e
er
na
pe
hy
yp
mi
a
tre
na
er
mi
a
tre
t io
n
tra
ia
mi
a
mi
a
re
m
en
nc
at
tre
er
na
yp
co
hy
p
eh
re
er
at
od
M
ild
eh
rlin
M
rd
e
ium
od
yp
on
eh
rlin
po
na
hy
re
ia
re
m
at
on
at
on
yp
hy
p
eh
re
M
ild
rd
e
rm
al
s
Bo
No
Bo
ve
er
at
od
M
Se
12/02/16
Additional file 1, Figure S1. Frequency of dysnatremia for each of the evaluated
subgroups
2
12/02/16
Additional file 1, Figure S2. Cumulative incidence (Y) for mortality according to serum
sodium concentration at ICU admission in patients with hyponatremia (S2a) and
hypernatremia (S2b)
S2a-
0.30
Cumulative incidence : Hyponatremia
0.15
0.10
0.05
0.00
Probability
0.20
0.25
Borderline hyponatremia, [135;138[
Mild hyponatremia, [130;135[
Moderate hyponatremia, [125;130[
Severe hyponatremia, <125
No dysnatremia, [138;142]
0
5
10
15
20
25
Days
3
12/02/16
S2b-
0.6
Cumulative incidence : Hypernatremia
0.3
0.2
0.1
0.0
Probability
0.4
0.5
Borderline hypernatremia, ]142;145]
Mild hypernatremia, ]145;150]
Moderate hypernatremia, ]150;155]
Severe hypernatremia, >155
No dysnatremia, [138;142]
0
5
10
15
20
25
Days
4
3
12/02/16
Additional file 1, Figure S3. Relationship between hospital admission serum sodium concentrations and Day-30 mortality. Grey lines
represent the 95% confidence interval. Influence of natremia on day-30 mortality is reported as subdistribution hazard ratio.
Subdistribution
hazard ratio
Hazard Ratio
11
10
9
8
7
6
5
4
3
2
1
0
90
100
110
120
130
140
Serum sodium concentration
150
160
170
180
5
12/02/16
APPENDIX: Member of the Outcomerea Study Group
Scientific committee
Jean-François Timsit (Hôpital Albert Michallon and Grenoble 1 university U823, Grenoble, France), Pierre
Moine (Surgical ICU, Denver, Colo), Elie Azoulay (Medical ICU, Hôpital Saint Louis, Paris, France), Yves Cohen
(ICU, Hôpital Avicenne, Bobigny, France), Michael Darmon (Medical-Surgical ICU, Hopital Nord, Saint-Etienne
University Hospital, France), Maïté Garrouste-Orgeas (ICU Hôpital Saint- Joseph, Paris, France), Lilia Soufir
(ICU, Hôpital Saint-Joseph, Paris, France), Jean-Ralph Zahar (Department of Microbiology, Hôpital Necker,
Paris, France), Christophe Adrie (Department of Physiology,Hôpital Cochin,
France), Adel Benali (Microbiology and Infectious Diseases, Hôpital Saint-Joseph, Paris, France), Christophe
Clec'h (ICU, Hôpital Avicenne, Bobigny, France), and Jean Carlet (ICU, Hôpital Saint-Joseph, Paris, France).
Biostatistical and informatics expertise
Jean-Francois Timsit (Epidemiology of Cancer and Severe Illnesses, Grenoble 1 university U823, Grenoble,
France), Sylvie Chevret (Medical Computer Sciences and Biostatistics Department, Hôpital Saint-Louis, Paris,
France), Corinne Alberti (Medical Computer Sciences and Biostatistics Department, Robert Debré, Paris,
France), Adrien Français (Epidemiology of Cancer and Severe Illnesses, Grenoble 1 university U823, Grenoble,
France), Aurélien Vésin (Epidemiology of Cancer and Severe Illnesses, Grenoble 1 university U823, Grenoble,
France), Sylvain Anselme (Epidemiology of Cancer and Severe Illnesses, Grenoble 1 university, Grenoble,
France), Muriel Tafflet (Outcomerea, France), Frederik Lecorre (Supelec, France), and Didier Nakache
(Conservatoire National des Arts et Métiers, Paris, France).
Investigators of the Outcomerea database
Christophe Adrie (Department of Physiology, Hôpital Cochin, France),Bernard Allaouchiche (Surgical ICU,
Hôpital Edouard Herriot, Lyon), Claire Ara-Somohano (University hospital A Michallon, Grenoble,
France ), Agnès Bonadona (University hospital A Michallon, Grenoble, France ), Caroline Bornstain (ICU,
Hôpital de Montfermeil, France), Alexandre Boyer (ICU, Hôpital Pellegrin, Bordeaux, France), Antoine Caubel
(ICU, Hôpital Saint-Joseph, Paris, France), Anh-Tuan Dinh-Xuan (Department of Physiology, Hôpital Cochin,
France), Christine Cheval (SICU, Hôpital Saint-Joseph, Paris, France), Jean-Pierre Colin (ICU, Hôpital de
Dourdan, Dourdan, France), Michael Darmon (Medical-Surgical ICU, Hopital Nord, Saint-Etienne University
Hospital, France), Anne-Sylvie Dumenil (Hôpital Antoine Béclère, Clamart France), Adrien Descorps-Declere
(Hôpital Antoine Béclère, Clamart France), Jean-Philippe Fosse (ICU, Hôpital Avicenne, Bobigny, France),
Rebecca Hamidfar-Roy (University hospital A Michallon, Grenoble, France ), Samir Jamali (ICU, Hôpital de
Dourdan, Dourdan, France), Christian Laplace (ICU, Hôpital Kremlin-Bicêtre, Bicêtre, France), Thierry Lazard
(ICU, Hôpital de la Croix Saint-Simon, Paris, France), Eric Le Miere (ICU, Hôpital Louis Mourier, Colombes,
France), Laurent Montesino (ICU, Hôpital Bichat, Paris, France), Bruno Mourvillier (ICU, Hôpital Bichat,
France), Benoît Misset (ICU, Hôpital Saint-Joseph, Paris, France), Delphine Moreau (ICU, Hôpital Saint-Louis,
Paris, France), Roman Mounier (ICU, Hôpital Louis Mourier, Colombes, France), Etienne
Pigné (ICU, Hôpital Louis Mourier, Colombes, France), Carole Schwebel (University hospital A Michallon,
Grenoble, France), Jean-Francois Timsit (University hospital A Michallon, Grenoble, France ), Gilles Troché
(Hôpital Antoine Béclère, Clamart France), Marie Thuong (Agence de Biomédicine, Saint Denis, France), Dany
Golgran-Toledano (CH Gonesse, France), and François Vincent (ICU, Hôpital Avicenne, Bobigny, France).
Clinical research assistants Caroline Tournegros (Hôpital Albert Michallon), Silvia Calvino (Hôpital Albert
Michallon), Loic Ferrand (Hôpital Albert Michallon), Samir Bekhouche (Hôpital Saint Louis), and Kaoutar
Mellouk (Hôpital Saint-Joseph, Paris, France).
6