7th BIANNUAL WORKSHOP IN ANTIGEN PRESENTATION
April 24-27, 2012
Amsterdam, The Netherlands
~SESSION 1 – Wednesday, April 25~
Antigen Presenting Cells – Presentation by Class II MHC Molecules
Paul Roche – Session Chair
8:45 am
Welcome and Introductory Statements
9:00 – 9:30 am
Jose Villadangos - Cell Biology of Pathogen
Detection, Processing and Presentation by
Dendritic Cells
9:30 – 10:00 am
Yvette van Kooyk - Glycan Based DC Targeting
Strategies that Enhance Cross-Presentation for
Improved Vaccination
10:00 – 10:30 am
Lawrence Stern - Crystal Structure of the Peptideexchange Inhibitor HLA-DO Bound to HLA-DM and
Insight into the Mechanism of DM-facilitated
Peptide Exchange
10:30 – 11:00 am
Coffee break
11:00 - 11:30 am
Petra Paul – A Multi-dimensional RNAi Screen
Reveals Pathways Controlling MHC Class II
Antigen Presentation
11:30 – 12:00 pm
Sebastian Amigorena - Autonomous Antigen
Degradation and Presentation in Dendritic Cell
Phagosomes
12:00 – 1:00 pm
Lunch break
~SESSION 2- Wednesday, April 25~
Presentation by Class II MHC Molecules
Elizabeth Mellins – Session Chair
1:00 – 1:30 pm
Paul Allen - Endogenous p/MHC: Their Role in Positive
Selection of T Cells and Peripheral Function
1:30 – 2:00 pm
Laurence Eisenlohr - Relative Contribution of Endogenous
Epitopes to the H-2b-restricted Anti-influenza CD4+ T Cell
Response
2:00 – 2:30 pm
James Mohan - Register Shifting of an Insulin Peptide-MHC
Complex Allows Diabetogenic T Cells to Escape Thymic Deletion
2:30 – 3:00 pm
Coffee break
3:00 – 3:30 pm
Philippe Pierre - Microbial Detection Controls Defective
Ribosomal Proteins Degradation by Autophagy and Subsequent
Endogenous MHC II-restricted Presentation in Dendritic Cells
3:30 – 4:00 pm
Ana-Maria Lennon-Duménil – Opposite Effects of Short-tail and
Long-tail Class I Myosins on Antigen Processing and Presentation
4:00 – 5:00 pm
Poster Sessions 1 & 2
5:00 – 6:00 pm
Poster Sessions 3 & 4
6:00 – 7:00 pm
Open Disussion #1 – Can Our Understanding of Antigen
Presentation be Translated into the Clinic and New
Therapeutics? Leader – Cornelis Melief – TBA
~SESSION 3 – Thursday, April 26~
Presentation by Class I MHC Molecules
Tim Elliott – Session Chair
9:00 – 9:30 am
Jonathan Yewdell - Will Wonders Never Cease? Unraveling the
Intricacies of the Class I Processing Pathway
9:30 – 10:00 am
Alex Theodossis - Shedding Light on MHC Class I Antigen
Loading: A UV-labile Peptide Ligand Approach
10:00 – 10:30 am
Elke Krüger - Oxidant-damage of Viral Proteins by NADPHoxidase Nox4-induced Radical Production Drives MHC Class I
Antigen Processing
10:30 – 11:00 am
Coffee break
11:00 – 11:30 am
Paul Lehner - Identifying Novel Ubiquitin E3 Ligases in the MHC
Class I Antigen Presentation Pathway
11:30 – 12:00 pm
Eva Huber - Constitutive and Immunoproteasome Crystal
Structures Reveal Differences in Substrate and Inhibitor
Specificity
12:00 – 1:00 pm
Lunch break
~SESSION 4 – Thursday, April 26~
Presentation by Class I MHC Molecules
Margarita del Val – Session Chair
1:00 – 1:30 pm
Nilabh Shastri - A Novel Transfer RNA Shapes the Cryptic
Peptide Repertoire Presented by MHC Class I Molecules
1:30 – 2:00 pm
Cornelis Melief - Mechanism of Superior Cross Presentation of
Synthetic Long Peptides in Comparison with Protein for
Therapeutic Cancer Vaccination
2:00 – 2:30 pm
José Lòpez de Castro– The influence of natural ERAP1
Polymorphism on the HLA-B27 Peptidome In Vivo
2:30 – 3:00 pm
Coffee break
3:00 – 3:30 pm
David Margulies - The Peptide-receptive Transition State of
MHC-I Molecules: Insights from Structure and Molecular
Dynamics
3:30 – 4:00 pm
Thorbald Van Hall - Non-classical Antigen Presentation of Tumor
Antigens Enables CTL Immunity to Tumor Escape Variants
4:00 – 5:00 pm
Poster Session 5 & 6
5:00 – 6:00 pm
Poster Session 7 & 8
6:30 – 7:30 pm
Open Discussion #2 – Are there more different modes of
processing presentation and cross presentation? Leader –
Hidde Ploegh, TBA
~SESSION 5 – Friday, April 27~
Biology of Class I MHC Presentation
Oddmund Bakke – Session Chair
9:00 – 9:30 am
Peter van Endert - IRAP is Required for Normal Phagosome and
Endosome Maturation in Dendritic Cells
9:30 – 10:00 am
Peter Cresswell - Structural and Mechanistic Aspects of the
Peptide Loading Complex
10:00 – 10:30 am
Jeff Colbert/Kenneth Rock - Substrate-induced Protein
Stabilization Reveals a Predominant Contribution from Mature
Protein to Peptides Presented on MHC Class I
10:30 – 11:00 am
Coffee break
11:00 – 11:30 am
Louise Boyle - The Tapasin-related Protein TAPBPR Modulates
the ER Export Rate of MHC Class I
11:30 – 12:00 pm
Jim Kaufman – Chicken TAP Genes are Polymorphic and Coevolve with the Dominantly-expressed Class I Gene
12:00 – 1:00 pm
Lunch break
~SESSION 6 – FRIDAY, APRIL 27~
Presentation by Non-classical MHC Molecules
Sebastian Springer – Session Chair
1:00 – 1:30 pm
Erin Adams - Antigen Presentation by CD1 Molecules
1:30 – 2:00 pm
Enzo Cerundolo - title to be announced
2:00 – 2:30 pm
Luc Teyton - Extracellular Processing of Lipid Antigens
2:30 – 3:00 pm
James McCluskey – A Structural Basis for Selection of the
Mucosal Associated Invariant T Cell Receptor in MR1-restricted
Antigen Recognition
3:00 – 5:00 pm
Selected Oral-poster Presentation
5:00 – 6:00 pm
Open Discussion #3 – Headed by junior colleagues in the
field, to be selected.
What did I learn from the old boys, and what can the old boys
learn from me?