Eligibility for Listing – Premium Listing Scientific Research Based Company For issuers to be admitted on or after 16 May 2014 Name of Company: Nature of Transaction: New applicant Name of Sponsor Date Submitted: Rule Page Proof Comment (where applicable) Number LR 2 Required by LR6.1.2 Duly incorporated 2.2.1 (1) 2.2.1 (2) Operating in conformity with constitution 2.2.2 (1) Conforms with law of place of constitution 2.2.2 (2) Duly authorised 2.2.2 (3) Statutory and other consents 2.2.3 Admitted on RIE 2.2.4 (1) Freely transferable 2.2.4 (2) Fully paid 2.2.7 (1) Minimum market capitalisation 2.2.9 (1) Whole class to be listed 2.2.10 (2)(a) Prospectus approved by FCA and published 2.2.10 (2)(b) Other EEA home member state documentation LR 6 6.1.3 (1)(b) 6/9 month rule 6.1.3 (1)(c) Accounts consolidated 6.1.3 (1)(d) Reported on in accordance with standards acceptable under item 20.1 of Annex I of the PD regulation 6.1.3 (1)(e) Not subject to a modified report, except as set out in LR 6.1.3AG or LR 5.6.21R 6.1.3 (2)(a) Independent person providing the opinion 6.1.3 (2)(b) Confirmation from person providing the opinion 1 of 3 May 2014 Rule Page 6.1.3D (1) Where insufficient to meet 75% requirement: historical financial information related to acquired entities for 3 years prior to acquisition 6.1.3D (2) Consistent with accounting policies adopted Not subject to a modified report 6.1.3D (3) 6.1.3D (4) In aggregate, represents 75% of enlarged business 6.1.4 Independent business as main activity 6.1.4B(1) Written agreement with controlling shareholder 6.1.4B(2) Constitution that allows for election in accordance with LR 9.2.2ER and LR 9.2.2FR Agreement with appropriate number of controlling shareholders in light of understanding Agreement includes procurement provision 6.1.4C(1) 6.1.4C(2)(a) 6.1.4C(2)(b) Agreement includes names of nonsigning controlling shareholders 6.1.4D(1) Agreement includes undertaking regarding transactions 6.1.4D(2) Agreement includes undertaking regarding compliance with obligations Agreement includes undertaking regarding resolutions 6.1.4D(3) 6.1.11 (1) 6.1.12 (1) Published or filed historical financial information since inception Demonstrate ability to attract funds from sophisticated investors prior to marketing at time of listing 6.1.12 (2) Raising at least £10m 6.1.12 (3) Market cap before fundraising of £20m 6.1.12 (4) Use finance to bring identified product to revenue generating stage 6.1.12 (5) Demonstrate that it has 3 yr record of operations in laboratory research and development including: (a) details of patents granted or details of progress of patent applications; and (b) successful completion of, or the successful progression of, significant testing of the effectiveness of its products Working capital 6.1.16 6.1.19 (1) Proof Comment (where applicable) Number Shares in public hands in EEA states 2 of 3 May 2014 Rule Page 6.1.22 (1) Warrants limited to 20% 6.1.23 Compatible with electronic settlement Constitution provides at least equivalent rights Conferring such rights not incompatible with law of country of incorporation Discretion of board not limited or transferred, and capable board 6.1.25 (1) 6.1.25 (2) 6.1.26 Proof Comment (where applicable) Number Constitution allows compliance with LR 9.2.22R 6.1.28 Non-applicability Confirmation We inform you that items marked “N/A” in the Page column of the above checklist are considered not applicable and no equivalent information is available in relation to the enclosed document. Signed by: On behalf of1: 1 The signatory should be properly authorised to do so on behalf of the sponsor 3 of 3 May 2014