Listing Conditions – Scientific Research Based Company Checklist Name of Company Nature of Transaction Name of Sponsor Date submitted Listing Rule Requirement 3.2.1(1) Duly incorporated 3.2.1(2) Operating in conformity with constitution 3.2.2(1) Conforms with law of place of constitution 3.2.2(2) Duly authorised 3.2.2(3) Statutory and other consents 3.2.3 Admitted on RIE 3.2.4(1) Freely transferable 3.2.4(2) Fully paid 3.2.7(1) Minimum market capitalisation 3.2.9(1) Whole class to be listed 3.2.10(2)(a) Prospectus approved by FSA and published 3.2.10(1)(b) Other EEA home member state documentation 3.2.12(1) Convertible into listed securities 3.2.12(2) Convertible into recognised market securities 3.2.14 Warrants or options to subscribe 1 of 3 Submit completed form to equity@ise.ie in PDF form Page Proof number Comment (where applicable) Irish Stock Exchange – Listing Conditions – Scientific Research Based Company Checklist Listing Rule Requirement 3.3.3(1)(b) Six month rule 3.3.3(1)(c) Accounts consolidated 3.3.3(1)(d) EEA State accounting standards or equivalent 3.3.3(1)(e) Audited without modification 3.3.3(2)(a) Independent auditors 3.3.3(2)(b) Auditors confirmation 3.3.12(1) Demonstrate ability to attract funds from sophisticated investors 3.3.12(2) Raising at least £10m 3.3.12(3) Market cap before fundraising of £20m 3.3.12(4) Use finance to bring identified product to revenue generating stage 3.3.12(5) Demonstrate that it has three year record of operations in laboratory research and development including: (a) details of patents granted or details of progress of patent applications; and (b) successful completion of, or the successful progression of, significant testing of the effectiveness of its products 3.3.16 Working capital 3.3.19 Shares in public hands 3.3.22 Warrants limited to 20% 3.3.23 Eligible for electronic settlement 2 of 3 Submit completed form to equity@ise.ie in PDF form Page Proof number Comment (where applicable) Irish Stock Exchange – Listing Conditions – Scientific Research Based Company Checklist Listing Rule Requirement Page Proof number Comment (where applicable) If a scientific research based company seeks a listing on the Irish Stock Exchange only (and not a dual primary listing), the following additional conditions apply: 3.4.3 Appropriate expertise and experience of directors 3.4.4 Directors free of conflicts between duties to the company and private interests or other duties 3.4.5 Controlling shareholder Non-applicability Confirmation We inform you that items marked ‘N/A’ in the Page column of the above checklist are considered not applicable and no equivalent information is available. Signed by on behalf of 3 of 3 Submit completed form to equity@ise.ie in PDF form