BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
John DeWolfe MacKenzie, MD
Assistant Professor in Residence
eRA COMMONS USER NAME (credential, e.g., agency login)
MACKENZIE.JOHN
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training and
residency training if applicable.)
INSTITUTION AND LOCATION
Stanford University, Stanford, CA
Stanford University, Stanford, CA
Albert Einstein College of Medicine, Bronx, NY
Hospital of the Univ. of Pennsylvania, Philadelphia, PA
Brigham and Women’s Hospital, Boston, MA
Hospital of the U. of Pennsylvania, Philadelphia, PA
Children’s Hospital of Philadelphia, Philadelphia, PA
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
BS
1995
MS
MD
Internship
Residency
Fellowship
Fellowship
1995
2000
2001
2005
2006
2007
Computer Science &
Biology (with Honors)
Biology
Medicine
Internal Medicine
Radiology
Musculoskeletal Radiology
Pediatric Radiology
A. Personal Statement
The objective of this project is to obtain preliminary validation of the utility of MR diffusion tensor imaging
(MR-DTI) in the detection of renal allograft rejection in pediatric patients. Preliminary validation will allow
for larger scale assessment of this technique as a potential non-invasive alternative to renal transplant
biopsy. My role in this project will be to help with the overall project design and facilitate the data
collection, analysis and presentation of results. I will be a co-investigator and help Dr. Jesse Courtier, the
PI for the project. My primary research focuses on developing imaging techniques for the detection and
treatment monitoring of pediatric disease and the MR-DTI project is well suited within this focus. I study
imaging methods that may depict anatomic and molecular alterations in human diseases and am
engaged in several clinical and basic science research projects focused on advancing the imaging
detection and monitoring of pediatric disease. My clinical research ranges from the study of improved
MRI techniques for the detection and monitoring of inflammation to minimizing the amount of ionizing
radiation delivered during pediatric computed tomography. This work is performed in collaboration with
colleagues in radiology, pediatric clinical subspecialists and basic research scientists.
B. Positions and Honors
Positions and Employment
6/94–8/96
Research Assistant, Department of Genetics, Herzenberg Lab, Stanford University
7/00–6/01
Medicine Intern, Hospital of the University of Pennsylvania, Philadelphia
7/01–6/05
Radiology Resident (Holman Research Pathway), Brigham and Women’s Hospital,
Boston
7/05–6/06
Musculoskeletal Imaging Fellow, Hospital of the U. of Pennsylvania, Philadelphia
7/06–6/07
Pediatric Radiology Fellow, Children’s Hospital of Philadelphia
8/07–6/10
Assistant Professor of Radiology, Stanford University
8/07–6/10
Chief of Pediatric Musculoskeletal Imaging, Lucile Packard Children’s Hospital, Stanford
7/10–present Assistant Professor in Residence, University of California San Francisco
7/10–present Chief of Pediatric Radiology, UCSF Department of Radiology, San Francisco
Other Experience and Professional Memberships
2002–present Radiology Society of North America
2007–present Society of Pediatric Radiology
2010–present American Roentgen Ray Society
2013–
Member of Society of Pediatric Radiology Committee on Computed Tomography
Honors
1988
1993
1995
1997
2000
2000
2002
2002
2003–2005
2004
2004
2004
2004
2005
2005
2007
2010
2011
2012
2013
Boettcher Scholarship (Colorado)
Stanford University Award for Excellence in Teaching Biological Sciences
Stanford University Firestone Medal for Excellence in Biological Research
Harvard Medical School Summer Research Grant
Albert Einstein College of Medicine Research Scholarship
Alpha Omega Alpha
Resident Award for Teaching (Brigham and Women’s Hospital)
Radiology Society of North America Introduction to Research Program
American Board of Radiology B. Leonard Holman Pathway Research Resident
Resident Award for Radiology Research (Brigham and Women’s Hospital)
Int. Society of Magnetic Resonance in Medicine/Amersham Health MRI Fellowship
Siemens Medical Systems Research Resident
Radiology Society of North America Resident Research Trainee Prize
Resident Award for Radiology Research (Brigham and Women’s Hospital)
RSNA Roentgen Resident/Fellow Research Award (Brigham and Women’s Hospital)
Radiology Society of North America Fellow Research Trainee Prize
National Academies Keck Futures Initiative – Imaging Science Conference
Pacific Coast Pediatric Radiology Association Award for Best Conference Presentation –
13
C Imaging of Pediatric Inflammatory Diseases.
Best Scientific Poster UCSF Dept. Radiology Symposium: mentor to Linda Nguyen
Best Scientific Poster UCSF Dept. Radiology Symposium: mentor to Julia Nguyen
C. Selected Peer-Reviewed Publications
Most relevant to the current application
1. MacKenzie JD, Siddiqi F, Babb JS, Bagley LJ, Mannon LJ, Sinson GP, Grossman RI. Brain atrophy
in mild and moderate closed head injury: a longitudinal quantitative analysis. American Journal of
Neuroradiology. October 2002. 23:1509-1515. PMID: 12372740
2. Gu J, Nguyen L, Chaudari A, MacKenzie JD. Magnetic Resonance Molecular Imaging for
Rheumatoid Arthritis. Topics in MRI. Top Magn Reson Imaging. 2011 Apr;22(2):61-9. PMID:
22648081
3. MacKenzie JD, Yen Y, Mayer D, Tropp J, Hurd R, and Spielman DM. Detection of inflammatory
arthritis using hyperpolarized 13C-pyurvate with magnetic resonance imaging and spectroscopy.
Radiology. 2011. May;259(2):414-20. PMCID: PMC3079121
4. Courtier J, Perito E, Rhee S, Heyman M, Mackenzie JD. Targeted MRI contrast agents for pediatric
hepatobiliary disease. J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):454-62. PMID: 22193178
5. MacKenzie JD, Hernandez A, Pena A, Gonzalez L, Ruppert K, Khrichenko D, Jawad AF, Wells L,
Smith-Whitley K, Jaramillo D. Diffusion-Weighted Imaging in Early Avascular Necrosis Measurement of the Apparent Diffusion Coefficient in the Hips of Sickle Cell Patients with Early
Avascular Necrosis. Pediatric Radiology. 2012. Jun;42(6):706-13. PMID: 22200862
6. Courtier, J, Ohliger, M, Rhee SJ, Terreblanche O, Heyman, M, MacKenzie, JD. Shooting a Moving
Target: Use of Real-time Cine MRI in Assessment of the Small Bowel. Journal of Pediatric
Gastroenterology & Nutrition. In press May, 2013.
Additional recent publications of importance to the field (in chronological order)
1.
2.
3.
Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA and Herzenberg LA.
Recurrent identical rearrangement and repeated expression of identical heavy and light chains in
single anti-phosphatidylcholine B cells. Ann Annals of the New York Academy of Science. 1997.
815:484-8. PMID: 9186705
Seidl KJ, MacKenzie JD (co-first author), Wang D, Kantor AB, Kabat E and Herzenberg LA. Frequent
occurrence of identical heavy and light chain Ig rearrangements. International Immunology. 1997.
9(5):689-702. PMID: 9184914
Seidl KJ, Wilshire JA, MacKenzie JD, Kantor AB, Herzenberg LA and Herzenberg LA. Predominant
VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites.
4.
5.
6.
7.
8.
Proceedings of the National Academy of Sciences USA. March 1999. 96(5): 2262-7. PMCID:
PMC26771
Shu KM, MacKenzie JD, Smith JB, Blinder EM, Bourgeois LM, Ledbetter S, Castronovo FP, Judy
PF, FJ Rybicki. Lowering the thyroid dose in screening examinations of the cervical spine.
Emergency Radiology. 12(3): 133-6. 2006.
MacKenzie JD, Nazario-Larrieu J, Cai T, Ledbetter SM, Duran-Mendicuti MA, Vargas TM, Judy PF,
Rybicki FJ. Lower Dose Computed Tomography for the Detection of Acute Pulmonary Embolism.
American Journal of Roentgenology. 189(6):1371-9. 2007. PMID: 18029873
Patel A, Soares B, Courtier J, and MacKenzie JD. Strategies to reduce radiation dose during
pediatric musculoskeletal procedures. Pediatric Radiology. 2013. Oct;43(10):1303-8. PMID:
23624510
Lambert J, MacKenzie JD, Cody DD, Gould R. Safety in CT: Techniques and Tactics for Optimizing
Dose in Adults and Children: State-of-the-Art and Future Advances. Journal of the American College
of Radiology. in press Oct 2013.
Koc, G, Courtier, J, Phelps A, Marcovici PA, MacKenzie JD. Improved CT Depiction of Small
Pediatric Vessels with Model-Based Versus Adaptive Statistical Iterative Reconstruction. Pediatric
Radiology. 2014 Feb 16. [Epub ahead of print] PMID: 24531191.
D. Research Support
Active Research Support
1 K08 AR061412-01A1 (MacKenzie)
07/01/12-06/30/17
NIH: Molecular imaging for detection and treatment monitoring of arthritis
Role: PI
9.0 CM
2 (Majumdar)
General Electric Healthcare: MRI / PET Imaging for Pediatric Disease
Role: co-PI
07/01/14-06/30/16
0.24 CM
3 (Von Scheven, Nakamura, Mellins)
Arthritis Foundation: Northern California Arthritis Center of Excellence
Role: co-investigator
07/01/14-06/30/16
0 CM
Completed Research Support
(MacKenzie)
07/01/2011 – 06/30/2013
Nat Acad Keck Futures Initiative Imaging Science: Multiscale biomedical imaging for autoimmune disease
Role: Principal Investigator
(Vasanawala)
07/01/2008 – 06/30/2010
Lucile Packard Children's Hospital: Child Health Research Program – Pilot Early Career Grant.
Role: Co-PI
(MacKenzie)
07/01/2008 – 06/30/2010
Society of Pediatric Radiology REF: Molecular imaging strategies with 13C for pediatric arthritis.
Role: Co-PI