Jordan University of Science and Technology
Faculty of Medicine
Department of Biochemistry and Molecular Biology
Molecular Genetics (M 211A);
Course Description and Objectives: Objectives of this course are designed to
understand the basic principles of molecular genetics. Emphasis will be given to those
principles that have application in medical practice. The structure of DNA and RNA
as genetic material, DNA organization and its replication, mutation and repair in both
prokaryotes and eukaryotes will be covered. Furthermore, gene expression will also
be discussed. Finally, the course will cover some aspects of cancer genetics,
cytogenetics and molecular biology techniques.
Text Book: Biochemistry with Clinical Correlation, Devlin "6th edition". And
department Handouts (HO)
Topic
Introduction
Nucleotides Structure & metabolism I
Nucleotides Structure & metabolism II
DNA I: Structure and Conformation
DNA II: Structure and Conformation
DNA: Replication I
DNA: Replication II
DNA: Replication III
Gene mutations, DNA repair , and Recombination I
Gene mutations, DNA repair and Recombination II
RNA: Structure, Transcription, and Processing I
RNA: Structure, Transcription, and Processing II
RNA: Structure, Transcription, and Processing III
Protein Synthesis: Translation and Posttranslational Modifications I
Protein Synthesis: Translation and Posttranslational Modifications II
Protein Synthesis: Translation and Posttranslational Modifications III
Regulation of Gene Expression I
Regulation of Gene Expression II
Chromosomal structure and organization in the human cell
Chromosomal numerical variations
Chromosomal structural variations
Principles of inheritance I (Mendelian inheritance I)
Principles of inheritance II (Mendelian inheritance II)
Non-Mendelian inheritance (Gene imprinting)
The molecular genetics of Cancer Cell I
The molecular genetics of Cancer Cell II
Molecular diagnosis of genetic diseases I
Molecular diagnosis of genetic diseases II
Chapter.
20
20
2
2
4
4
4
4
4
5
5
5
6
6
6
8
8
HO
HO
HO
HO
HO
HO
25
25
7
7
ASSESMNET
First exam
Second exam
Final exam
MCQ
MCQ
MCQ
%30
%30
%60
1