Supplemental Digital Content 4: Side-effect assessment.
DEX +
Ropiv
1.16 (2.35)
Nausea (0-10)
Ropiv
P value
0.0799
2.47 (3.39)
Nausea frequency (number of
times nauseated)
0.548 (1.21) 1.4 (3.11)
Vomiting (% patients for each
score [0-10])
0
100
93.3
3
3.3
8
3.3
Vomiting frequency (number
of times vomited [%
patients])
0
100
93.3
1
3.3
15
3.3
Lack of appetite (0-10)
1.19 (2.23) 0.967 (2.14)
Constipation (% patients for
each score [0-10])
0
Urinary retention (0-10)
Difficulty Concentrating (010)
Drowsiness (0-10)
Confusion (0-10)
Fatigue (0-10)
Dizziness (0-10)
96.8
3.2
NA
0.0645
(0.359)
1.55 (1.98)
0.226
(0.884)
2.16 (2.24)
1.26 (1.91)
1
NA
0.8 (1.69)
1.33 (1.79)
0.267 (0.98)
2.37 (2.79)
1.2 (1.67)
Itchiness (% patients for each
score [0-10])
0
96.8
90
4
3.3
5
3.3
7
3.2
10
3.3
Dry Mouth (0-10)
2.58 (2.67) 1.53 (2.16)
0.156
0.234
0.234
0.685
0.242
NA
0.0178
0.657
0.864
0.75
0.9
0.224
0.0927
Headache (0-10)
0.323 (1.08) 0.967 (1.73)
0.08
On the first postoperative day, patients completed a structured self-report measure that assessed
for the symptoms listed. Patients were asked to rate each symptom on a 0-10 numeric rating
scale (0 = not bad; 10 = bad as you can imagine). In addition to the 0-10 scale, the frequency of
nausea and vomiting were assessed separately.
Data presented as percentages or as mean (standard deviation) for normally distributed data or as
the percentage (%) of patients in that particular category for non-normally distributed data.