Appendix S3. Summary of case series (CS) and controlled clinical trials (CCT).
Authors, Year
Study Design, Sample
(T/C), Age, Miller Class,
Follow-up
Treatment
CRC
Site Level
CRC
Patient/area
Level
PRC
RecRed
(mm)
KT gain
(mm)
CAF + CTG
80%
NR
96 %
3.0 ± 0.8*
1.2 ± 0.4
CAF + CTG
NR
71%
96.05 ± 6.50%*
3.70 ± 1.51*
2.16 ± 2.10*
T: CAF + CTG + EMD;
C: CAF + CTG
T: 69.4 % (24 m)
C: 83.7 % (24 m)
NR
T: 92.1 ± 13.2 %
C: 94.3 ±13.9 %
T: 4.0 ± 1.4*
C: 3.0 ± 1.2*
T: 2.6 ± 1.3*
C: 1.8 ± 3.1*
3.12 ± 0.88*
2.48 ± 0.84*
CAF + CTG
Cetiner et al. 2006
Chambrone et al.
2006
Gunay et al. 2008
CS; 10 p; 33.7 ± 7.12 y; I, II;
12 m
CS; 28 p; 36.1 ± 9.5 y; I, II; 6
m
CCT, parallel groups; 20
(10/10) p; 32.2 ± 11.2
I, II; 24 m
MCAF
91.2% ± 4.1%
De Sanctis et al. 2011
CS; 10 p; 28-35 y; I, II; 12 m
MCAF + CTG
50%
10%
Pini Prato et al. 2010
CCT, split-mouth; 13 p; 31.4
y; I, II, III; 60 m
T: CAF + CTG
C: MCAF
T: 34% (6 m)
52% (60 m)
C: 57% (6 m)
35% (60 m)
NR
NR
T: 3.2 ± 1.3
C: 2.2 ± 1.2
NR
Zucchelli & de Sanctis
2005
CS; 22 p; 18-34 y; I, II; 60 m;
MCAF
85%
73% (12 m)
68% (60 m)
97% (12 m)
94% (60 m)
2.56 ± 1.26
0.56 ± 1.14
CS; 10 p; 28.7 y; I, II; 6 m
MCAF + CTG
93.1 %
90%
96.7 %
2.03 ± 0.78
CS; 18 p; 32.0 ± 9.7 y; I, II;
12 m
MCAT + CTG
Class I 79.2 %;
Class II 72.2 %
NR
Class I 99.1 %,
Class II 98.9 %
Class I 2.9*;
Class II 2.8*
Carvalho et al. 2006
1.31 ± 1.23
MCAT
Dembowska &
Drozdzik 2007
Class I 1.5*,
Class II 2.8*
*reviewers calculation; p, patients; y, years; m, months; NR, not reported; T, test group; C, control group; CRC, complete root coverage; PRC, percentage of root
coverage; RecRed, recession reduction; KT, keratinised tissue.
CTG, connective tissue graft; MCAF, modified coronally advanced flap; MCAT, modified coronally advanced tunnel; EMD, enamel matrix derivatives.
References.
Carvalho, P.F.M., da Silva, R.C., Cury, P.R. & Joly, J.C. (2006) Modified coronally advanced flap associated
with a subepithelial connective tissue graft for the treatment of adjacent multiple gingival recessions.
Journal of Periodontology 77, 1901–6.
Cetiner, D., Bodur, A. & Uraz, A. (2004) Expanded mesh connective tissue graft for the treatment of
multiple gingival recessions. Journal of Periodontology 75, 1167–72.
Chambrone, L.A. & Chambrone, L. (2006) Subepithelial connective tissue grafts in the treatment of multiple
recession-type defects. Journal of Periodontology 77, 909–16.
Dembowska, E. & Drozdzik, A. (2007) Subepithelial connective tissue graft in the treatment of multiple
gingival recession. Oral surgery, Oral medicine, Oral pathology, Oral radiology, and Endodontics 104,
e1–7.
De Sanctis, M., Baldini, N., Goracci, C. & Zucchelli, G. (2011) Coronally advanced flap associated with a
connective tissue graft for the treatment of multiple recession defects in mandibular posterior teeth.
The International Journal of periodontics & Restorative Dentistry 31, 623–630.
Gunay, H., Dogan, S. & Geurtsen, W. (2008) Harvesting technique using a mucotome and modified surgical
procedure for root coverage with enamel matrix derivatives with and without a connective tissue
graft. The International Journal of periodontics & Restorative Dentistry 28, 497–507.
Pini-Prato, G.P., Cairo, F., Nieri, M., Franceschi, D., Rotundo, R. & Cortellini, P. (2010) Coronally advanced
flap versus connective tissue graft in the treatment of multiple gingival recessions: a split-mouth study
with a 5-year follow-up. Journal of Clinical Periodontology 37, 644–650.
Zucchelli, G. & De Sanctis, M. (2005) Long-term outcome following treatment of multiple Miller class I and II
recession defects in esthetic areas of the mouth. Journal of Periodontology 76, 2286–92.