2015
ATTACHMENT
E
HAZARDOUS AGENTS
Hazardous agents include radioisotopes, DNA/RNA vectors, infectious agents, transformed cell
lines, primary human tumors and hazardous chemicals such as carcinogens and neurotoxins.
The use of hazardous agents in animals requires approval from both the UCLA and the
University Safety Office. It is the investigator’s responsibility to ensure that the safety office
has approved the use of the hazardous agent.
What hazardous agent (s) will be used?
Is there a Material Safety Data Sheet (MSDS) for the hazardous agent?
NO
YES
If yes, please ensure that one copy is available in your lab, and another copy is provided to the
Director of the Animal Facility.
Have all personnel in your laboratory been advised of the potential hazards of these agents and
provided with the appropriate training? NO
YES
What dose of agent will be administered to each animal?
What is the route of administration?
Is the parent compound or any active metabolite excreted in urine and/or feces? What is the
duration of excretion?
When this agent is used in vivo are there any risks to other animals or to people handling the
animals? If yes, please describe and answer questions a-d below:
a) How would personnel become exposed, and how can they protect themselves from
exposure?
b) Are special precautions required for handling animals or for disposal of bedding and
other wastes? What are they?
c) If special husbandry procedures are required, who will provide daily care
for the animals?
d) How will the animals/cages be marked to identify the potential hazard?
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2015
Will RADIOISOTOPES be used (in vivo)? NO
YES
The investigator (permit holder) is responsible for the care of animals
injected with isotopes and is responsible for the proper disposal of wastes,
animals, etc. The details of care must be arranged with the Director of the Animal
Facility.
Permit Holder:
Dalhousie Permit Number:
Approved by Radiation Officer: NO
YES
Will INFECTIOUS AGENTS be used?
Is this agent infectious to animals?
Is this agent infectious to humans?
NO
NO
NO
YES
YES
YES
NO
YES
Permit Holder:
Permit Number:
Has the use of this agent been approved by the Biosafety Officer?
What is the Risk Group of the pathogen?
What level of containment is required?
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