Located in Grenoble, in the heart of the French Alps, Resolution Spectra Systems (RSS) is a young
company commercializing a range of Fourier-Transform spectrometers based on a proprietary
integrated-photonics technology. In this project you will apply RSS's technology to Raman
spectroscopy of live cells. Your goal will be to establish a chemometric model of Total Cell Density
(TCD) and Viable Cell Density (VCD) based on Raman spectroscopy of cell cultures1,2. You will acquire
data using an existing Raman optical setup, and build your own imaging setup in order to correlate
the Raman measurements with optical images of the cells. You will use this data to build a predictive
model of TCD and VCD. You will be part of a small team of experts in optical instrumentation and
data modeling providing the necessary guidance.
Who you are:
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You are looking for an internship to complete your Master’s Degree in the field of Optics,
Physics, Biomedical Engineering, Electrical Engineering, Biotechnology, and related areas.
You have a sound understanding of optical instrumentation (imaging and non-imaging).
You are familiar with image-processing, machine-learning and/or statistical modeling, as well
as with the related computer tools. Ideally, you have completed a project in one of these
fields during your curriculum.
You have hands-on experience at the optical bench.
Most importantly, you enjoy multi-disciplinary projects, and biotechnology in particular.
What we offer:
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An opportunity to apply and complete your training on a multi-disciplinary project.
To work on a unique technology of Raman spectrometers.
To gain experience in the exciting and rapidly growing field of biomedical applications of
Raman spectroscopy.
A monthly allowance to cover your living expenses.
Aside from working on cutting-edge technology, you will be able to enjoy the very decent range of
outdoor activities easily reachable from Grenoble.
Interested candidates should send their application to Jean-Charles Baritaux (jeancharles.baritaux@resolutionspectra.com).
Website : www.resolutionspectra.com
References
1. Abu-Absi, N. R. et al. Real time monitoring of multiple parameters in mammalian cell culture
bioreactors using an in-line Raman spectroscopy probe. Biotechnol. Bioeng. 108, 1215–1221
(2011).
2. Whelan, J., Craven, S. & Glennon, B. In situ Raman spectroscopy for simultaneous monitoring of
multiple process parameters in mammalian cell culture bioreactors. Biotechnol. Prog. 28, 1355–
1362 (2012).