Bursic 2:00 R11 CLONING: A SCIENCE THAT’S BENEFITS CANNOT BE DUPLICATED Sarah Foran (saf79@pitt.edu) INTRODUCTION: WHAT IS CLONING AND WHY IS IT IMPORTANT? The application of reproductive, therapeutic, and DNA cloning can bring a vast amount of benefits to society as a whole in a variety of ways. The strict definition of cloning is the act of taking a single cell from an organism and growing a new duplicate organism from that cell, resulting in a clone of the original organism. [1] Each type of cloning, which is performed a little differently, brings about its own benefits, whether it be advances in healthcare, food production, conservation of species, etc. Despite the taboo that goes along with cloning, the breakthrough science provides much advancement that outweighs the risks. This topic of controversy is very interesting to me for a few reasons. I plan on majoring in the field of bioengineering, which is directly connected to genetic engineering and cloning. Cloning has great potential to help improve the quality of life for humans, whether it through increasing quality and quantity of food supply or by decreasing the amount of life altering diseases that affect much of humanity. These sorts of improvements are things I’ve always wanted to contribute to throughout my life and possibly can through my current major choice. Therefore, I firmly believe that the science of cloning should be more widely used for the sake of advancement. With advancement in any field comes controversy. To quell this controversy and/or set boundaries on the potential harm that the advancement could possibly bring, ethical codes of conduct and regulation are put in place. There are many moral and ethical concerns in regards to genetic engineering. Most are related to moral integrity along with human safety, such as the ethical concerns of destroying an embryo during stem cell research or the consumption of cloned animals. The regulatory codes keep engineers in check in their practices and provide a source of relief to those which these scientific studies bear on. Although such codes can at times slow the speed of advancement, they are necessary to reassure the public of the safety of such procedures and to make sure public safety and morality are concerns that are put first. Taking a position on a prevalent issue in engineering is a valuable experience altogether for anyone interested in the field I believe for the fact that it allows students to expand their horizons and explore current improvements being made to our world in a multitude of scientific manners. In addition to increasing scientific awareness, it teaches engineers how to effectively research University of Pittsburgh, Swanson School of Engineering 1 10/29/12 and piece this research together to form an official opinion on a certain subject. Such analytical skills are necessary to a budding engineer such as myself for the fact that these skills can translate to analytical approaches of thinking in the workplace and research lab in future vocations. For these reasons, I appreciate the knowledge that this position research paper has given me. REPRODUCTIVE CLONING The first type of cloning to be discussed is reproductive cloning. Reproductive cloning is the process of producing an animal using the DNA of another, creating a replicate. The creation of the cell is done by SCNT, or Somatic Cell Nuclear Transfer. Through this process, scientists take an egg, remove its genetic material, and put genetic material from the nucleus of another cell into it. This new cell is stimulated with an electric current so that it will divide, allowing it to grow. After some time, the embryo gets placed inside a surrogate mother until it’s fully grown [2]. Many uses come from this type of cloning. First of all, many types of endangered species could potentially be repopulated through cloning. This was attempted in 2000, when scientists attempted to clone a gaur, an endangered Asian ox. The trial was somewhat successful. The clone was born healthy enough to stand on its own. However, the calf died two days later of infection. Similar complications have arisen in other trials, where specimens were born with poor immune systems, enlarged organs, or were larger than average overall at birth [1]. However, this still gives hope to later recovering certain species. Some believe that if species can easily be regenerated, people will be less concerned with preserving the environment. This is a valid concern, but in general it’s important to try to bring back species that have already been negatively impacted by humans. Secondly, cloning animals could greatly increase the amount and quality of food products available to the ever increasing population. Cloning allows farmers to breed better traits into their livestock. These improvements would increase the quality and quantity of meats, decrease the price, and increase the resistance of the animals to diseases. In addition, the FDA found and stated in 2008 that “meat and milk from cattle, swine, and goat clones or their offspring are as safe to eat as food we eat from those species now.” Despite the reassurance, some people still don’t feel comfortable consuming meat or any other products that come from clones, whether it for moral reasons or Sarah Foran foundation of an organism affects the subject’s life processes, giving them insight into how much of a creature’s life is predetermined by genetics. It is also used to engineer plants that are more resistant to disease and/or are more nutritious in general. This is beneficial to the population for the obvious reason that it provides people with higher grade produce. DNA cloning has been widely used to combat genetic disorders by creating medicines and other products to help deal with diseases such as diabetes, anemia, and hemophilia [5]. This form of cloning has already been very helpful to society in the ways of improving food quality and quality of life for those who suffer from genetic ailments. DNA cloning is a worthwhile science that should continue to be used to its fullest potential. uncertainty of if the products are really safe. In a 2008 survey of 1000 U.S. adults, 45% did not think highly of cloning. However, 48% said that they would buy products of the offspring of cloned creatures. In general, the study showed that people are becoming more used to the idea of purchasing meat, eggs, and milk from the offspring of clones in comparison with the previous survey in 2005[3]. Cloning animals for food production can have a great impact on the food supply and quality. THERAPEUTIC CLONING Therapeutic cloning is the second prevalent type of cloning. It involves producing human embryos to gather stem cells for research. Stem cells are very useful for the fact that they can replace almost any specialized cell in the human body. This type of cloning is one of the more controversial because by extracting the stem cell, the embryo dies. This is seen as destroying a human life by a wide range of people and is hotly debated as to whether it is an ethical practice or not. Despite the controversy, these cells hold great potential to combat many diseases, such as cancer, Alzheimer’s, Parkinson’s, and heart disease [2]. An important advancement therapeutic cloning brings to the table is the possibility of cloning organs. This would be done by harvesting the stem cells of a patient in need of an organ, developing the cell so that it would produce that organ, and allowing it to grow until it’s suitable for transplant. This would get rid of the possibility of a patient’s body rejecting a donated organ. It would also eliminate the long wait there always is for a donated organ to become available. Another way to produce organs through therapeutic cloning would be by genetically altering pigs to carry organs that could be used by human patients. Currently, the technology available is not ready to create organs through either of these processes. However, with time and perfection of the science, this process could save an abundance of lives [4]. Looking at both sides of the debate, I do agree that by acquiring the stem cell, a potential life is lost. However, the stem cell retrieved provides a great potential to preserve the lives of those already born. THE WRITER’S VIEWPOINT I believe that the practice of cloning is a revolutionary and incredibly valuable resource for our society to take advantage of. It has the potential to provide our population with many advancements and improvements in numerous fields. As I stated in the introduction, improving the life quality and longevity of people is a goal that I’m very passionate about fulfilling. I feel very fortunate to have the life that I do. I have never had to go to bed hungry or worry about the quality of what I’m eating. But the fact that a large percentage of the world’s population doesn’t have that luxury pains me. The practice of cloning has the possibility of making food more readily available, safer in quality, and cheaper to those who need it most, not to mention makes far strides in fighting life altering diseases and potentially curing them. I hope that by attaining a degree in bioengineering that I can assist in these advancements to improve the quality of life for those less fortunate. ETHICS: A MORAL OBLIGATION There are a variety of codes that directly apply to genetic engineering and the three major types of cloning. All engineers are required to follow the National Society of Professional Engineers Code of Ethics and the numerous canons that go along with it. One of the major canons that directly applies to the topic of this paper is ‘Engineers shall hold paramount the safety, health, and welfare of the public [6].’ In other words, the wellbeing of society is most important and should be held as such. Cloning has great potential to help society in numerous ways, but there is always a possibility of something going awry that could negatively impact society as well. Reproductive cloning brings the possibility of cloning animals to increase food supply. However, this practice had to be thoroughly tested to determine the safety to humans of eating the meat or products of an animal that was cloned or the offspring of a DNA CLONING DNA cloning is the final type of cloning to be discussed. It is the act of moving a fragment of DNA from an organism to bacterial plasmid or some other type of selfreplicating genetic element, which is then put into a host cell. This practice has become common in labs and is used in making copies of the same gene [2]. The practice of cloning DNA is useful in many ways. It allows genetic engineers to see if the genetic 2 Sarah Foran clone because of the canon stated above. In addition, it is important to practice methods of cloning in a humane manner. Therapeutic cloning, which includes the practice of harvesting stem cells, is a subject that has been ethically debated over for years. Some find the whole practice unethical while others believe that it is a worthy practice that can greatly improve the quality of life to those living. Regardless of one’s personal opinion, the canon that states ‘Engineers shall at all times strive to serve the public interest’ exemplifies that the foremost obligation of engineers is to improve life in manners that the public sees fit [6]. Of course there will always be controversy over the subject of stem cell research, but as long as there are those who think that its benefits are worthy, it will continue to be looked into and researched, but respectively, due to the opinions of others who disagree with the practice. This is also shown through the one of the canons of the Biomedical Engineering Society Code of Ethics, which states ‘Biomedical engineers involved in research shall comply fully with legal, ethical, institutional, governmental, and other applicable research guidelines, respecting the rights of and exercising the responsibilities to colleagues, human and animal subjects, and the scientific and general public [7].’ In some ways, the codes slow progress due to the extreme precautions and testing that need to occur to ensure safety to the public and moral integrity, but in general they are a necessary hindrance because without these codes, scientific practices could easily endanger society. The concept of integrating ethical checks and balances is very important to me for various reasons. As much as I believe that cloning has more potential to be beneficial than harmful, I personally have an extremely high regard for the beliefs and thought processes of others. I believe that everyone is entitled to their own opinions and all have the right to express those opinions. In addition, as stated before, my main desire in life as a future engineer is to assist in improving the quality of life for others. To achieve this, the practices involved must be tested over and over to ensure the complete safety of humanity as a whole. beliefs on a scientific subject. I will have to constantly be learning and keeping up with these advancements for the rest of my working life as an engineer. This paper has assisted in that tremendously and I am satisfied with the benefits that it has brought to me. CONCLUSION: BENEFITS OUTWEIGH RISKS In conclusion, cloning has an enormous amount of benefits that greatly outweigh its risks. Through the three types of cloning, reproductive, therapeutic, and DNA, there are possibilities to improve the quality and increase the quantity of food readily available to the world’s population, bring an end to malicious diseases, increase life span, and get a better idea of how greatly our genes determine who we are. Writing this paper has been a very beneficial experience for me for the fact that I now have had the opportunity to gain significant knowledge on a subject in and to take a stance on it while expressing my opinions. With all great advancements in science comes great controversy. There are a multitude of ethical concerns about this topic and codes that must be followed to keep research ethically pure and safe to the population. However, society should open its eyes to the possibilities that lie ahead of it. It’s understandable to have reservations about something so extreme and groundbreaking, but don’t let those reservations hold society back from what it can achieve. REFERENCES [1] “Cloning Controversy.” (Online blog). http://www.riverdeep.net/current/2001/12/120301t_cloning.j html [2] “Cloning Fact Sheet.” (May 9, 2009) Human Genome Project Information. (Online Article). http://www.ornl.gov/sci/techresources/Human_Genome/elsi/ cloning.shtml [3] K. Brooks, J. Lusk. (October 2011) “U.S. Consumers’ Attitude Toward Farm Animal Cloning.” Sciverse. (Online Article). Vol. 57, Issue 2. pp. 483-492 http://www.sciencedirect.com/science/article/pii/S01956663 11005137 [4] “Organ Cloning” Organ Cloning. (Online Article). http://www.cloneorgans.com/ [5] S. Panse. “What is DNA Cloning?” WiseGEEK. (Online Article). http://www.wisegeek.com/what-is-dna-cloning.htm [6] “NSPE Code of Ethics For Engineers” NSPE. (Online Article). http://www.nspe.org/Ethics/CodeofEthics/index.html [7] “Biomedical Engineering Society Code of Ethics” (February 2004) BMES. (Online Article). http://www.bmes.org/aws/BMES/asset_manager/get_file/19 110?ver=3480 EDUCATION: THE BENEFITS RESEARCH BRINGS I believe that through writing this paper, I have gained much insight into the ethical side of engineering and the advancements and potential that cloning can and has brought. It has been shown that through researching and writing scientific papers, engineering students benefit by gaining critical thinking and literacy skills that will enhance their writing and thinking patterns [8]. I fully agree with this statement. My fellow engineers and I have had the opportunity to explore the ever growing advances in scientific improvement and discoveries. We have also gotten to take a stance on one of these issues and develop our 3 Sarah Foran [8] “Engineering Education Research” (2006) Purdue University. (Online Article). https://engineering.purdue.edu/ENE/Research/ResearchRepo rt ACKNOWLEDGMENTS I would first like to thank Professor Bursic for reminding us about the paper at least once a day to keep us on task. I would also like to thank the Writing Center Instructors for always explaining to the class in detail how to exceed expectations at writing our papers. Thank you to the library staff that helped me find one or two of my articles. Another thank you goes to Laura Rubino and Jen Brashayko for keeping me on task and making sure I took as little writing breaks as possible. Thank you to Tatiana Sunseri for clarifying the reference instructions for me. And finally, thank you Alana Monastra for showing me where the formatting template was located. 4