CURRICULUM TOOL: DNA AND RNA NYS Living Environment Core Curriculum Standard 4: Students will understand and apply scientific concepts, principles, and theories pertaining to the physical setting and living environment and recognize the historical development of ideas in science. Performance Indicator 2.1 Explain how the structure and replication of genetic material result in offspring that resemble their parents. In all organisms, the coded instructions for specifying the characteristics of the organism are carried in DNA, a large molecule formed from subunits arranged in a sequence with bases of four kinds (represented by A, G, C, and T). The chemical and structural properties of DNA are the basis for how the genetic information that underlies heredity is both encoded in genes (as a string of molecular “bases”) and replicated by means of a template. Cells store and use coded information. The genetic information stored in DNA is used to direct the synthesis of the thousands of proteins that each cell requires. Genes are segments of DNA molecules. Any alteration of the DNA sequence is a mutation. Usually, an altered gene will be passed on to every cell that develops from it. The work of the cell is carried out by the many different types of molecules it assembles, mostly proteins. Protein molecules are long, usually folded chains made from 20 different kinds of amino acids in a specific sequence. This sequence influences the shape of the protein. The shape of the protein, in turn, determines its function. Offspring resemble their parents because they inherit similar genes that code for the production of proteins that form similar structures and perform similar functions. Curriculum-Based Questions Describe the shape of the DNA double helix. Explain the steps of DNA replication. How does RNA differ from DNA? What happens during transcription? What are the main events of translation? How do mutations affect genes? Key Vocabulary: nucleotide, base pair, adenine, thymine, guanine, cytosine, uracil, protein, DNA, RNA, mRNA, double helix, amino acid, polymer, mutation, offspring, chromosomes, prokaryotes, eukaryotes, histones, clone, replication, cancer, tumor, apoptosis, growth, gametes, diploid, haploid Some Past Part A, B-1, B-2, C Questions: January 2013 ~32, 33, 54, 55, 83, 84, 85 August 2012 ~ 78, 79, 80 June 2012 ~ 69, 70, 71, 72, 82, 83, 84, 85 Released Regents Tests: http://www.nysedregents.org/livingenvironment/ High School of Language and Innovation 2012 CURRICULUM TOOL: DNA AND RNA Past Part A Regents Questions 1. A molecule of DNA is a polymer composed of (1) glucose (2) amino acids (3) fatty acids (4) nucleotides 3. Which nitrogenous bases makes up DNA nucleotides? (1) adenine, thymine, guanine, and cytosine (2) adenine, uracil, guanine, and cytosine (3) adenine, thymine, uracil, and cytosine (4) adenine, thymine, guanine, and uracil 2. The presence of DNA is important for cellular metabolic activities because DNA (1) directs the production of enzymes (2) is a structural component of cell walls (3) directly increases the solubility of nutrients (4) is a major component of cytoplasm 4. The DNA of a fly and the DNA of a gorilla are made up of subunits that are (1) arranged in the same order in both species (2) arranged in chains of the same length in both species (3) different bases in each of the two species (4) in different sequences in each of the two species Readings Prentice Hall Biology p.286-317 Holt Living Environment p. 290-315 Holt Living Environment Spanish p. 290-315 Miller & Levine Biology p. 336-389 Holt McDougal Biology p. 212-245 Websites http://www.brainpop.com/science/cellularlifeandgenetics/dna/ http://www.brainpop.com/health/geneticsgrowthanddevelopment/rna/preview.weml http://www.brainpop.com/health/geneticsgrowthanddevelopment/geneticmutations/ preview.weml http://www.untamedscience.com/biology/genetics https://www.khanacademy.org/science/biology/evolution-and-natural-selection/v/dna http://www.dnai.org/a/index.html http://www.dnaftb.org/15/index.html Videos In the womb Curriculum Tool Guide In the womb with multiples Worksheet station Activity stations In the womb with animals HIV/AIDS THE FOLLOWING IS REQUIRED INDEPENDENT WORK http://www.brainpop.com/science/cellularlifeandgenetics/dna/quiz/ graded quiz EMAIL TO: christinehunkele@yahoo.com or mcneilnakita@yahoo.com High School of Language and Innovation 2012 In-Class Activities Discovery Human Body Common Core Writing Prompt