Approximate schedule. Readings are posted on courseweb site by topic.
Date
January 17, 2011
January 24 2011
Topics
No Class – Martin Luther King Holiday
Review syllabus
Organ systems approach to course content
Reading and evaluating nutrition research
January 31 2011
Bart de Jonghe, PhD
Gastrointestinal health, function, common clinical diseases
February 7, 2011
Bone health
Key nutrients: calcium, phosphorus, magnesium, vitamins D &K
Disorders: Osteoporosis
Review 2 papers on gastrointestinal health
 Diagnosing celiac disease: Erica Shandell
 Diet and celiac disease: Debbie Schub
February 14, 2011
Compher
Bruce Kinosian, MD
February 21, 2011
February 28, 2011
Blood health
Key nutrients: protein, vitamin B12, folate, vitamin K, iron, copper
Disorders: Blood clotting, nutritional anemias
Review 4 papers on bone health:
 Heaney dairy & bone health: Brielle Franklin
 Maternal vitamin D for BF infants: Naomi Yager
 Nutrition & bone food patterns: Sarah Downs
 Vitamin K & bone: Danielle Greenberg
Cardiovascular health
Key nutrients: lipoproteins, antioxidant vitamins
Disorders: hyperlipidemia, atherosclerosis, hypertension, congestive heart
failure
Review 4 papers on blood health:
 Common nutr def in children: Line Stensland
 Nutr def in children on restricted diets: Marlene Rossman
 Nutritional anemias in elderly: Tracie Husted
 B12 in older adults: Anna Dusenbery
Glucose homeostasis
Hormonal regulation, metabolic pathways to come later
Disorders: diabetes, insulin resistance
Review 3 papers on cardiovascular health
 Biomedical effects of grapes: Louise Xue
 Dairy & BP: Angela Champion
 Vitamin E & stroke: Alana Ferrari
March 7, 2011
March 14, 2011
Babette Zemel, PhD
March 21, 2011
March 28, 2011
April 4, 2011
April 11, 2011
Papers Due:
Xue
Ferrari
Payne
Merrill
Greenberg
Shandell
Downs
Bilan
Hullings
April 18, 2011
Papers Due:
Husted
Rossman
No Class – Spring Break
Body composition, energy expenditure, bone mass measures
Tour of CHOP metabolic laboratory
Review 4 papers on body composition, energy expenditure:
 Adiosity rebound: Jasmine Santos
 Annu Rev Nutr 17.1 (DEXA, body comp, REE children):
 Compher best pract RMR:
 Protein vs bone & muscle in elderly: Octavia Payne
Antioxidant health
Key nutrients: vitamins A, C, E, selenium
Disorders: Cancer, Keshan’s disease
Review 3 papers on glucose homeostasis
 Dairy & Insulin resistance: Christy Hullings
 Fruit phenols & disease: Jacinda Li
 Omega 3 FA & T2DM: Yulia Bilan
Neurological health
Key nutrients: vitamin B12, E, folate, copper, choline, thiamine, pyridoxine
Disorders: Wernicke-Korsakoff syndrome, neuropathies, neural tube
defects
Review 4 papers on antioxidant health
 Diet & cancer epidemiology:
 Mg, inflammation, oxidative stress: Ross Merrill
 Vit D antimicrobial response: Ian Penkala
 Vit D in aging: Lan Dinh
Midterm exam
Carbohydrate metabolism
Key micronutrients:Thiamine/riboflavin/niacin
Metabolic pathways: glycolysis, glycogenesis, TCA cycle, Cori cycle
Fasting, fed, starvation, overfed states
Measuring metabolism
Review 3 papers on neurological health:
 B vitamins aging brain:
 Choline review:
 Copper def neuropathy: Laura Rupprecht
Lipid metabolism
Key micronutrients:
Metabolic pathways: fatty acid oxidation & synthesis, ketones
Fasting, fed, starvation, overfed states
Dusenbery
Rupprecht
Santos
Dinh
Franklin
Xue
Penkala
Yager
April 25, 2011
Papers Due:
Schub
Champion
Xia
Li
Rossman
Husted
Stensland
Protein metabolism
Key micronutrients: pyridoxine
Metabolic pathways: protein synthesis, metabolism, protein flux,
gluconeogenesis, inborn error of metabolism - PKU
Fasting, fed, starvation, overfed states
Nitrogen balance