Posters –
Devices and Imaging
NAME OF THE PROJECT
NAME OF THE MAIN CONTACT
ORGANISATION NAME
Technology
Customers / Target market
Industry and competitors
Financing need / Commercial
opportunity
IP – Patent situation
Future steps / Milestones
Canal BRET : Novel voltage-dependent ion channel fusion subunits
JEAN-LUC CHAGNAUD
AQUITAINE SCIENCE TRANSFERT
BRET is an innovative technology based on the use of biological probes, allowing highthroughput screening of new modulators of voltage-dependent ion channels. This
technology coupled to the energy transfer technique BRET is particularly suited to
development of new molecules by the pharmaceutical industry.
Oncology market
N/A
We are looking for a partner in capacity to co-develop with us the product
or Licensing out
"NOVEL VOLTAGE DEPENDENT ION CHANNEL FUSIONS AND METHOD OF USE THEREOF"
priority date 16 February 2015 N° EP15155202
TRL : technology validated in lab
BRET Canal is a technology for monitoring in high throughtput, the specific activation in
real time on any living cells of voltage-gated ion channels of interest. the proposed
sensors are designed for the BRET technique, simple to implement, accepted and used by
the industry Traditional screening methods (fluorescent dyes, radiometric flux, and
binding assays) are indirect measures of ion channel activity. Electrophysiological
techniques combined with pharmacology provide the most detailed and direct way to
study ion channel function; however, conventional electrophysiological techniques do not
meet the throughput demands of large compound library screening.
Further reading
New technologies, including automated electrophysiology and planar patch-clamp
techniques, have also been tried and tested. However these methods are not yet
performing at the high throughput speeds desired.
A major limitation of the patch clamp technique is its low throughput. Furthermore the
technique is not easily amenable to automation, and produces complex results that
require extensive analysis.
FRET is the non-radiative transfer of energy from an excited state donor molecule to a
ground state acceptor molecule. The main disadvantages of FRET, as opposed to BRET,
are the consequences of the required excitation of the donor with an external light
source.
Contact person
Jean-Luc CHAGNAUD, Healthcare Business Development Manager, AQUITAINE SCIENCE
TRANSFERT
jl.chagnaud@ast-innovations.com