BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Helen Hathaway
Associate Professor
eRA COMMONS USER NAME
Hhathaway
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
University of Delaware, Newark, DE
Rutgers University, Piscataway, NJ
University of Texas, M.D. Anderson Cancer
Center, Houston, TX
DEGREE
(if applicable)
MM/YY
B.S.Ag.
Ph.D.
01/77-05/79
09/81-09/86
Plant Science
Biology
N/A
10/86-07/91
Cell & Devel. Biology
FIELD OF STUDY
A. Personal Statement
The goal of the proposed research is to provide state-of-the-art animal modeling and imaging capabilities. The
Keck-UNM small animal models and imaging resource delivers value to members of the UNM Cancer Center
by providing a comprehensive service in the development and use of animal models for basic and pre-clinical
cancer research. It was established in July 2006 as a developing resource with both internal CC funds and a
contribution from the developmental funds from the UNM P30 award. The resource offers a wide range of
services, including consultation, protocol development and guidance through the compliance process, animal
housing (provided through the Animal Resource Facility, husbandry, handling, treatment, monitoring, surgery,
and dissection/ necropsy. In addition, the resource has state-of-the-art capabilities in small animal
radioimaging through the Keck-UNM Small Animal Imaging Resource, (made possible by a grant from the
Keck Foundation. MRI and other magnetic-based imaging modalities are also available, and many
investigators are actively involved in imaging technology research and development. The Core is continually
developing and offering new techniques to enhance researchers’ cancer research programs. I have the
necessary expertise, skills, and leadership to contribute to the successful completion of the Keck-UNM Small
Animal Models and Imaging Resource. I am an expert in animal models of reproductive biology, mammary
gland development, and female cancers. I have extensive experience in mouse colony husbandry, breeding,
and management, as well as genetically modified mouse models and rodent cancer progression models. I also
served on the UNM HSC Institutional Animal Care and Use Committee for 9 years (1999 – 2008). I assist
investigators with experimental design, animal protocol development, and compliance issues, I interact
extensively with Co-Director Norenberg.
B. Positions and Honors
Positions and Employment
1991 – 1996
Research Associate, University of Texas, M.D. Anderson Cancer Center
1996 - 1998
Research Assistant Professor, Emory University School of Medicine
1998 – 2004
Assistant Professor, University of New Mexico School of Medicine (UNM SOM), Dept. of
Cell Biology & Physiology
2004 – present Associate Professor, UNM SOM, Dept. of Cell Biology & Physiology
2006 – present Co-Director, Animal Models & Imaging Core, Cancer Research & Treatment Ctr., UNM SOM
2008 – present Director, UNM SOM, Biomedical Sciences Graduate Program
Other Experience and Professional Memberships
1990 – present
1998 – present
2002 – present
American Society for Cell Biology
American Association for the Advancement of Science
UNM Cancer Center Member
Honors
Keynote speaker and guest speaker, American Cancer Society “Making Strides for Breast Cancer” breakfast,
“Relay for Life” events in Albuquerque, Santa Fe, and Clovis, NM; M.D. Anderson, Genes and Development
Program Poster Award, First Place, 1994; M. D. Anderson Basic Science Paper Competition, 1991; NIH
Training Grant (HD 07325) Postdoctoral Fellowship, 1986-1989; Busch Predoctoral Fellowship, 1985-1986;
Rutgers University, Steinetz Award, 1983-1985.
C. Selected Peer-Reviewed Publications (selected from 25 peer-reviewed publications)
Most relevant to the current application (in chronological order)
1. De La Cruz, L., Steffgen, K., McGee, C., Martin, A., and Hathaway, H. J. (2004) Apoptosis and involution
in the mammary gland are altered in mice lacking a novel receptor, 1,4-galactosyltransferase I. Devel.
Biol., 272:286-309.
2. Nayak, T., Hathaway, H. J., Ramesh, C., Arterburn, J. A., Dai, D., Sklar, L. A., Norenberg, J. P., and
Prossnitz, E. P. (2008) Pre-clinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)
estradiol pyridine-2-yl hydrazine derivative for imaging of breast and endometrial cancers. J. Nucl. Med.,
49:978-986. PMCID: PMC2435083.
3. Dennis, M. K., Burai, R., Ramesh, C., Petrie, W. K., Alcon, S. N., Nayak, T. K., Bologa, C. G., Leitao, A.,
Brailoiu, E., Deliu, E., Dun, N. J., Sklar, L. A., Hathaway, H. J., Arterburn, J. B., Oprea, T. I., and Prossnitz,
E. R. (2009) In vivo effects of a GPR30 antagonist. Nature Chem. Biol., 5:421-427. PMCID: PMC2864230.
4. Nayak, T. K., Dennis, M. K., Ramesh, C., Burai, R., Atcher, R. W., Sklar, L. A., Norenberg, J. P.,
Hathaway, H. J., Arterburn, J. B., and Prossnitz, E. R. (2010) Influence of charge on cell permeability and
tumor imaging of GPR30-targeted 111In-labeled non-steroidal imaging agents. ACS Chem. Biol., 5:681-690.
PMCID: PMC2912446.
5. Guo, H., Hathaway, H. J., Royce, M. E., Prossnitz, E. R., and Miao, Y. (2011) Synthesis and evaluation of
novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjugate Chem., 22:1682-1689.
6. Hathaway, H. J., Butler, K. S., Adolphi, N. L., Lovato, D. M., Belfon, R., Fegan, D., Monson, T. C., Trujillo,
J. E., Tessier, T. E., Bryant, H. C., Huber, D. L., Larson, R. S., and, Flynn, E. R. (2011) Detection of breast
cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors. Breast
Cancer Res., 13:R108 doi:10.1186/bcr3050.
7. Butler, K. S., Lovato, D. M., Adolphi, N. L., Belfon, R., Fegan, D. L., Monson, T. C., Hathaway, H. J., Huber,
D. L., Tessier, T. E., Bryant, H. C., Flynn, E. R., and Larson, R. S. (2012) Development of antibody-tagged
nanoparticles for detection of transplant rejection using biomagnetic sensors. Cell Transplant., PMID:
23069078.
8. Williamson, E. A., Damiani, L., Leitao, A., Hu, C., Hathaway, H., Oprea, T., Sklar, L., Shaheen, M.,
Bauman, J., Wang, W., Nickoloff, J. A., Lee, S.-H., and Hromas, R. (2012) Targeting the transposase
domain of the DNA repair component metnase to enhance chemotherapy. Cancer Res., 72:6200-6208.
Additional recent publications of importance to the field (in chronological order)
1. Jaetao, J.S., Butler, K.S., Adolphi, N.L., Lovato, D.M., Bryant, H.C., Rabinowitz, I., Winter, S.S., Tessier,
T.E., Hathaway, H.J., Bergemann, C., Flynn, E.R., and Larson, R.S. (2009) Development and
characterization of a magnetic bone marrow needle and CD34-conjugated nanoparticles for isolation and
identification of acute leukemia cells. Cancer Res., 69:8310–8316. PMCID: PMC2783727.
2. Ramesh, C., Nayak, T. K., Burai, R., Dennis, M. K., Hathaway, H. J., Sklar, L. A., Prossnitz, E. R., and
Arterburn, J. B. (2009) Synthesis and characterization of iodinated tetrahydroquinolines targeting the G
protein-coupled estrogen receptor GPR30. J. Med. Chem., 53:1004-1014. PMCID: PMC2818973.
3. Adolphi, N. L., Huber, D. L., Jaetao, J. E., Bryant, H. C., Lovato, D. M., Fegan, D. L., Venturini, E. L.,
Monson, T. C., Tessier, T. E., Hathaway, H. J., Bergemann, C., Larson, R. S., and Flynn, E. R. (2009)
Characterization of Magnetite Nanoparticles for SQUID-relaxometry and Magnetic Needle Biopsy. J. Magn.
Magn. Mater., 321:1459-1464. PMCID: PMC2734090.
4. Wu, Y., Guo, X., Brandt, Y., Hathaway, H.J., and Hartley, R. S. (2010) Three-dimensional collagen
represses cyclin E1 via beta one integrin in breast cancer cells. Breast Cancer Res. & Treat., DOI
10.1007/s10549-010-1013-x. PMCID: in process.
5. Adolphi, N. L., Huber, D. L., Bryant, H. C., Monson, T. C., Fegan, D. L., Lim, J., Trujillo, J. E., Tessier, T. E.,
Lovato, D. M., Butler, K. S., Provencio, P. P., Hathaway, H. J., Majetich, S. A., Larson, R. S., and Flynn, E.
R. (2010) Characterization of Single-core Magnetite Nanoparticles for Magnetic Imaging by SQUIDrelaxometry. Phys. Med. Biol., 55:5985–6003. PMCID: in process.
6. Dennis, M. K., Field, A. S., Burai, R., Ramesh, C., Petrie, W. K., Bologa, C. G., Oprea, T. I., Yamaguchi, Y.,
Hayashi, S., Sklar, L. A., Hathaway, H. J., Arterburn, J. B., and Prossnitz, E. R. (2011) Identification of a
GPER/GPR30 Antagonist with Improved Estrogen Receptor Counterselectivity. J. Ster. Biochem. Mol. Biol.,
in press.
7. Adolphi, N. L., Butler, K. S., Lovato, D. M., Tessier, T. E., Trujillo, J. E., Hathaway, H. J., Fegan, D. L.,
Monson, T. C., Stevens, T. E., Huber, D. L., Ramu, J., Milne, Ph.D., M. L., Altobelli, S. A., Bryant, H. C.,
Larson, R. L., and Flynn, E. R. (2011) Detection and imaging of Her2-targeted magnetic nanoparticles:
Direct comparison of SQUID-detected magnetic relaxometry and magnetic resonance. Contrast Media Mol.
Imaging, in press.
D. Research Support
Ongoing Research Support
R01 CA163890
Co-Investigator
08/01/12-07/31/17
NIH/NCI
Title: G protein-coupled estrogen receptor GPER and breast carcinogenesis/metastasis
The goal of this project is to explore the function of GPER in breast cancer progression using in vitro and
animal models, as well as patient samples.
R01 CA127731
Co-Investigator
08/05/08-05/31/13
NIH/NCI
MPI (Prossnitz, Arterburn, Oprea)
Title: Development of GPR30-specific ligands
The goal of this project is to identify novel GPR30-specific agonists and antagonists.
UNM HSC RAC
Principal Investigator
03/01/11 – 02/28/12
Title: Estrogen regulation of mitotic spindle orientation
The goal of this project is to elucidate the function of estrogen receptors in orienting the mitotic spindle
apparatus during cell division.
W81XWH-11-1-0189
Co-Investigator (Adolphi-PI)
06/01/11 – 05/31/12
DOD/BCRP
(in no-cost extension)
Title: Novel Synergistic Therapy for Metastatic Breast Cancer: Magnetic Nanoparticle Hyperthermia on the
Neovasculature Enhanced by a Vascular Disruption Agent
The goal of this project is to test the therapeutic efficacy of localized, vascular-targeted hyperthermia combined
with vascular disrupting agents, for breast cancer.
2 P30 CA118100-06 Animal Models and Imaging Resource Co-Director (Willman-PI) 9/1/10-8/31/15
NIH/NCI
Title: University of New Mexico Cancer Center Support Grant
This renewal provides NCI support for administration, programs, shared resources, clinical trials support, and
developmental funds for the University of New Mexico NCI-Designated Cancer Center.
The goals of this sub-project are to promote the research of investigators at the UNM Cancer Center by
providing outstanding services in cancer research using animal models.
Completed Research (Last Three Years)
R44CA105742
Co-Investigator (Flynn-PI)
08/12/03-03/31/11
NIH/NCI
Title: Improving biopsies using magnetic nanoparticles
The goals of this proposal are to specifically label leukemia cells with magnetic nanoparticles, followed by
collection of labeled cells on a magnetic needle in order to sensitively detect minimal residual disease.
R44 CA123785
Co-Investigator (Flynn-PI)
06/01/08 – 05/31/11
NIH/NCI
Title: Fast-Track:Biomagnetic In-vivo Imaging of Ovarian Cancer
The goals of this proposal are to apply a novel magnetic nanoparticle-based imaging system to the early
detection, localization and potential treatment of ovarian cancer.
R01 CA118743
Co-Investigator (Prossnitz-PI)
08/23/07-05/31/10
NIH/NCI
Title: The role of GPR30 in advanced endometrial cancer
The goal of this project is to examine the role of GPR30 in endometrial cells and endometrial cancer.
R01 CA116662
Co-Investigator (Prossnitz-PI)
04/01/06-03/31/11
NIH/NCI
Title: A novel intracellular 7TM estrogen receptor in breast
The goal of this project is to examine the role of GPR30 in breast development and mammary cell function.
R44A1066765
Co-Investigator (Flynn-PI)
08/01/08-07/31/10
NIH/NIAID
Title: Biomagnetic determination of transplant rejection
The goals of this proposal are to use magnetic nanoparticles targeted to T cells and SQUID sensors to
determine if a transplant is being rejected early in the process
R44 CA096154
Co-Investigator (Flynn-PI)
09/01/06 – 08/31/09
NIH/NCI
Title: A Biomagnetic Sensor for Detecting Breast Cancer
The goals of this proposal are to establish a new methodology for the early detection of abnormal lesions in
breast imaging using superconducting quantum interference devices.