JYH-HORNG, WANG (王至弘)
by sharon, 2011-01-26 15:07, 人氣(246)
ASSISTANT PROFESSOR
As an orthopaedic surgeon specializing in sports
medicine, my clinical practice and research interest
are focused on the related studies concerning cruciate
ligament reconstruction. We have published papers
about ligament biology, biomedical materials and tissue
engineering in orthopaedics (J Biomed Mater Res 2007;
Biochem Biophys Res Commun 2007; Artificial organs
2009).
We evaluated the phenotypic responses of human ACL
(anterior cruciate ligament) cells on two biodegradable
materials: PCL(poly ε-caprolactone) and chitosan. And
we proposed that the different properties of materials
will cause cells to present different responses and
the character of chitosan to promote ECM synthesis
might be a ideal scaffold for successful ACL tissue
engineering.
Also, based on the different adhesion characteristics
of human ACL cells on chitosan and PCL, our further
study is concerned with the gene expression and ECM
production of ACL cells through cell shape changes on
blends of chitosan with PCL. It is possible to combine
the advantages of chitosan and PCL to create a new
blended material, which could maintain the viability
and stimulate the collagen synthesis of human ACL
cells simultaneously. The blended material might be a
potential candidate for ACL tissue engineering.
• Shao HJ, Chen CS, Lee YT, Wang JH, Young TH: The phenotypic
responses of human anterior cruciate ligament cells cultured on
poly(ε-caprolactone) and chitosan. Journal of Biomedical Materials
Research: Part A. 2010;93A:1297-1305.
• Shao HJ, Lee YT, Chen CS, Wang JH, Young TH: Modulation of gene
expression and collagen production of anterior cruciate ligament
cells through cell shape changes on polycaprolactone/chitosan
blends. Biomaterials 2010;31:4695-4705.