• Nutrition for Patients with Diabetes Mellitus Chapter 19 • Nutrition for Patients With Diabetes Mellitus • Glucose circulating in the blood is a source of ready fuel for body cells • The amount of carbohydrate consumed and, to a lesser extent, the type of carbohydrate eaten are the primary determinants of how quickly and how high blood glucose levels rise after eating • A rise in postprandial blood glucose levels stimulates the pancreas to secrete insulin • Fasting blood glucose levels over 126 mg/dL indicate diabetes • Diabetes • Diabetes is one of the most costly and burdensome chronic diseases of our time • Increasing in epidemic proportions • The estimated direct and indirect cost associated with diabetes in 2007 was $174 billion • The CDC estimates that one in three children born in the U.S. in 2000 will have diabetes in his or her lifetime; for Hispanics, the estimate is one out of two • Diabetes (cont’d) • Type 1 diabetes – Formerly known as insulin-dependent diabetes mellitus – Characterized by the absence of insulin – Risk factors for type 1 diabetes may be: o Autoimmune o Genetic o Environmental • Diabetes (cont’d) • Type 1 diabetes (cont’d) – No known way to prevent type 1 diabetes – All people with type 1 diabetes require exogenous insulin to control blood glucose levels – Most often detected in children, adolescents, and young adults – Classic symptoms of polyuria, polydipsia, and polyphagia • Diabetes (cont’d) • Type 2 diabetes – Occurs most often after the age of 45 – Accounts for 90% to 95% of diagnosed cases of diabetes – A slowly progressive disease that usually begins as a problem of insulin resistance – Type 2 diabetes is often asymptomatic • Diabetes (cont’d) • Type 2 diabetes (cont’d) – Insulin resistance is strongly linked to obesity – Risk factors for type 2 diabetes o Age 45 years or older o Overweight (BMI ≥25 kg/m2) o First-degree relative with diabetes o Physically inactive or exercises fewer than 3 times/week • Diabetes (cont’d) • Risk factors for type 2 diabetes (cont’d) – Member of high-risk ethnic group: African American, Latino, Native American, Asian American, Pacific Islander – Previously identified with prediabetes such as impaired fasting glucose or impaired glucose tolerance – History of gestational diabetes or giving birth to a baby weighing more than 9 pounds – Hypertensive – HDL <35 mg/dL and/or triglyceride level ≥250 mg/dL – Diabetes (cont’d) • Many of the risks for type 2 diabetes are characteristics of metabolic syndrome (MetS) – People with MetS are twice as likely to develop heart disease and five times as likely to develop diabetes compared to those without – Estimated that more than two thirds of people with type 2 diabetes have metabolic syndrome – Even modest weight loss can lessen the risks associated with metabolic syndrome • Diabetes (cont’d) • Modifiable risk factors for metabolic syndrome include excess body fat, a sedentary lifestyle, and a high–saturated-fat diet • Diabetes (cont’d) • Gestational diabetes – Hyperglycemia that develops during pregnancy – Risk factors: o A family history of gestational diabetes o Obesity, being a member of a certain ethnic population (Native Americans, Hispanic Americans, Mexican Americans, African Americans, Asian Americans, and Pacific Islanders) o A history of giving birth to an infant weighing more than 9 pounds • Diabetes (cont’d) • Gestational diabetes (cont’d) – All women are routinely screened between 24 and 28 weeks’ gestation – Immediately after pregnancy, 5% to 10% of women with gestational diabetes are diagnosed with diabetes, usually type 2 • Question • Type 1 diabetes, once referred to as insulin- dependent diabetes, is caused by what? a. Hyperinsulinemia b. Absence of insulin c. Sensitivity to insulin d. Metabolic syndrome • Answer b. Absence of insulin Rationale: Type 1 diabetes, formerly known as insulin-dependent diabetes mellitus, is characterized by the absence of insulin. • Acute Diabetes Complications • Untreated or poorly controlled diabetes can lead to acute life-threatening complications • Conversely, hypoglycemia caused by overuse of medication, too little food, or too much exercise, can also be life threatening • Acute Diabetes Complications (cont’d) • Diabetic ketoacidosis (DKA) – People with type 1 diabetes are susceptible to diabetic ketoacidosis (DKA) – Characterized by hyperglycemia (glucose levels >250 mg/dL) and ketonemia – Caused by a severe deficiency of insulin or from physiologic stress, such as illness or infection • Acute Diabetes Complications (cont’d) • Diabetic ketoacidosis (DKA) (cont’d) – Polyuria may lead to dehydration, electrolyte depletion, and hypotension – Hyperventilation occurs in an attempt to correct acidosis by increasing expiration of carbon dioxide – Fatigue, nausea, vomiting, and confusion develop – Diabetic coma and death are possible • Acute Diabetes Complications (cont’d) • Diabetic ketoacidosis (DKA) (cont’d) – DKA is sometimes the presenting symptom when type 1 diabetes is diagnosed – DKA rarely develops in people with type 2 diabetes – DKA is treated with electrolytes, fluid, and insulin • Acute Diabetes Complications (cont’d) • Hyperosmolar hyperglycemic nonketotic syndrome (HHNS) – Characterized by hyperglycemia (>600 mg/dL) without significant ketonemia – Occurs most commonly in people with type 2 diabetes – Dehydration and heat exposure increase the risk – Illness or infection is usually the precipitating factor • Acute Diabetes Complications (cont’d) • Hyperosmolar hyperglycemic nonketotic syndrome (HHNS) (cont’d) – Older people may be particularly vulnerable – Develops relatively slowly – Symptoms – Best protection against HHNS is regular glucose monitoring – Treatment includes insulin and fluid and electrolyte replacement • Acute Diabetes Complications (cont’d) • Hypoglycemia – Blood glucose level less than 70 mg/dL – Commonly referred to as “insulin reaction” – Occurs from taking too much insulin, inadequate food intake, delayed or skipped meals, extra physical activity, or consumption of alcohol without food – Symptoms • Acute Diabetes Complications (cont’d) • Hypoglycemia (cont’d) – Mild hypoglycemia is treated with 15 to 20 g of glucose o – Symptoms normally improve in 10 to 20 minutes Hypoglycemic unawareness o Consistent monitoring of blood glucose is especially important • Question • Is the following statement true or false? Diabetic ketoacidosis is characterized by glucose levels greater than 250 mg/dL. • Answer True. Rationale: People with type 1 diabetes are susceptible to diabetic ketoacidosis (DKA), characterized by hyperglycemia (glucose levels >250 mg/dL) and ketonemia. • Long-Term Complications • Retinopathy • Nephropathy • Neuropathy • Myocardial infarction • Stroke • Peripheral vascular disease • Long-Term Complications (cont’d) • Mild to severe forms of nervous system damage • Impaired wound healing • Periodontal disease • Pregnancy complications • Increased susceptibility to other illnesses • Diabetes Management • Type 1 diabetes – • Type 2 diabetes – • Managed by a coordinated regimen of nutrition therapy and insulin Diet and exercise Goals and interventions are specified for 3 levels of prevention: – Primary prevention of diabetes among people with prediabetes or at high risk of diabetes – Secondary prevention of managing existing diabetes – Tertiary prevention of slowing the rate of diabetes complications • Diabetes Management (cont’d) • Calories, overweight, and obesity – Weight loss has traditionally been the focus of nutrition intervention for overweight and obese people with prediabetes or type 2 diabetes o No one proven strategy that can be uniformly recommended to promote weight loss in all clients o Weight loss medications o Bariatric surgery • Diabetes Management (cont’d) • Preventing diabetes – Weight loss through a combination of healthy eating and exercise is the primary focus of diabetes prevention – Diabetes Prevention Program (DPP) – A low–saturated-fat intake may reduce the risk for diabetes by improving insulin resistance and promoting weight loss – Several studies show that an increased intake of whole grains and fiber lower the risk of diabetes • Diabetes Management (cont’d) • Secondary prevention: managing diabetes – Primary goal of diabetes management is to keep blood glucose levels as near normal as possible – Secondary goals o Attain and maintain control of blood lipid levels and blood pressure o Prevent or delay the development of complications • o Meet the individual’s cultural and personal needs o Maintain the pleasure of eating by not limiting any foods unless indicated by scientific evidence o Diabetes Management (cont’d) Secondary prevention: managing diabetes (cont’d) – Nutrition therapy is an essential component of diabetes management – Coronary heart disease (CHD) is the leading cause of death among people with diabetes – Total carbohydrates o RDA for carbohydrates is 130 g/day o Acceptable macronutrient distribution range (AMDR) is 45% to 65% of total calories • Diabetes Management (cont’d) • Secondary prevention: managing diabetes (cont’d) – – – • Total carbohydrates (cont’d) o Glycemic control depends on matching carbohydrate intake with the action of insulin or other medication o A low–glycemic-index diet may provide a modest benefit in controlling postprandial hyperglycemia Sweeteners o Sucrose and sucrose-containing foods are not restricted o Foods high in sugar are usually nutrient poor Diabetes Management (cont’d) Secondary prevention: managing diabetes (cont’d) – Sweeteners (cont’d) o Use of fructose as an added sweetener is not recommended May adversely affect serum lipid levels No reason for people with diabetes to avoid naturally occurring fructose in fruit and vegetables – • Diabetes Management (cont’d) Secondary prevention: managing diabetes (cont’d) – Sugar alcohols o Provide fewer calories and cause a smaller increase in glucose o Do not contribute to dental cavities o Nonnutritive sweeteners Saccharin, aspartame, acesulfame, sucralose, and neotame May safely be used by people with diabetes • Diabetes Management (cont’d) • Secondary prevention: managing diabetes (cont’d) – Fiber o Recommendations for fiber are the same as for the general population o Foods rich in fiber provide other benefits such as increasing satiety; providing vitamins, minerals and phytochemicals; and lowering serum cholesterol levels • Diabetes Management (cont’d) • Secondary prevention: managing diabetes (cont’d) – Fat o People with diabetes appear to have the same cardiovascular risk as people with preexisting cardiovascular disease o People with diabetes are advised to limit their intake of saturated fat to less than 7% of total calories, minimize their intake of trans fat, and consume less than 200 mg of cholesterol daily o Little difference from AHA recommendations • Diabetes Management (cont’d) • Secondary prevention: managing diabetes (cont’d) – Protein o – In the American diet, protein provides 15% of total calories Alcohol o Moderate use of alcohol (1 drink/day or less in women and 2 drinks/day or less in men) by people who have well-controlled diabetes minimally affects blood glucose and insulin levels • Diabetes Management (cont’d) • Secondary prevention: managing diabetes (cont’d) – Vitamins and minerals o Vitamin and mineral requirements of people with diabetes are no different from those of the general population o Uncontrolled diabetes is often associated with micronutrient deficiencies Treatment is a balanced diet that supplies natural sources of nutrients o Chromium • Diabetes Management (cont’d) • Tertiary prevention: controlling diabetes complications – • Progression of microvascular diabetes complications may be modified by improving glycemic control and lowering blood pressure Meal planning approaches – Monitoring carbohydrate intake is key to controlling blood glucose levels – Meal plan should reflect the individual’s lifestyle, preferences, and willingness/ability to make dietary changes • Diabetes Management (cont’d) • Meal planning approaches (cont’d) – Exchange lists for meal planning o Choose Your Foods: Exchange Lists for Meal Planning is a framework for choosing a healthy diet o Groups foods into lists that, per serving size given, are similar in carbohydrate, protein, fat, and calories, based on rounded averages o Three major categories are Carbohydrates; Meat and Meat Substitutes; and Fats • Diabetes Management (cont’d) • Exchange lists for meal planning (cont’d) • – Sample meal pattern is designed for clients based on their usual pattern of eating – Clients are encouraged to eat a variety of foods within each list and to make healthy choices – Food should be weighed or measured until portion sizes can be accurately estimated – Eliminates the need for daily calculations – Diabetes Management (cont’d) Exchange lists for meal planning (cont’d) – Some items on some lists are counted as more than just one choice or one exchange – Some items appear on more than 1 list and in different amounts – Best suited to people who want or need structured meal-planning guidance and are able to understand complex details o • Carbohydrate counting – Easier and more flexible alternative to using the exchange system – Clients are given an individualized meal pattern that specifies the number of carbohydrate “choices” for each meal and snack – Carbohydrate choice lists – Protein and fat cannot be disregarded o • Diabetes Management (cont’d) Diabetes Management (cont’d) Carbohydrate counting (cont’d) – Appropriate for people who understand the importance of consuming a consistent carbohydrate intake to match insulin or medication peaks – Feel more in control and benefit from improved glucose control – Keeping records of blood glucose tests and food intake helps • Diabetes Management (cont’d) • Changing behaviors – Diagnosis of diabetes often triggers anxiety and uncertainty – Before recommending dietary changes, it may be useful to ask the client: o What are your goals for nutrition counseling? o What behaviors do you want to change? o What changes can you make in your present lifestyle? • Diabetes Management (cont’d) • Changing behaviors (cont’d) – – • Before recommending dietary changes, it may be useful to ask (cont’d): o What obstacles may prevent you from making changes? o What changes are you willing to make right now? o What changes would be difficult for you to make? Diabetes Management (cont’d) Changing behaviors (cont’d) – Ideally, positive changes occur progressively – Patient actively involved in goal setting, self-monitoring, and recordkeeping – Periodic and ongoing follow-up improves compliance • Question • Is the following statement true or false? Sugar alcohols do not contribute to dental cavities. • True. Answer Rationale: Sugar alcohols do not contribute to dental cavities yet using them is not likely to produce weight loss or improve glycemic control. • Pharmacologic Management of Diabetes • People with type 1 diabetes rely on exogenous insulin for survival • Due to the progressive nature of the disease, most people with type 2 diabetes eventually require oral agents, insulin, or a combination of both to manage blood glucose levels • Pharmacologic Management of Diabetes (cont’d) • Insulin therapy for people with type 1 diabetes – Insulin preparations vary in how quickly they act, when their peak action occurs, and how long their effects last – Intermediate- or long-acting insulin is used to meet basal needs – Rapid- or short-acting insulin is used before each meal – Closely resembles how insulin is normally secreted – Nighttime hypoglycemia can be a problem with NPH peaking during the night • Pharmacologic Management of Diabetes (cont’d) • Intensive insulin therapy for people with type 1 diabetes (cont’d) – Popular and dynamic insulin regimen for type 1 diabetes – Algorithm gives formulas for clients to calculate the carbohydrate-to-insulin ratio for the anticipated carbohydrate content of a meal/snack – Requires more calculations at each meal but allows greater flexibility in when meals are eaten and how much carbohydrate is consumed • Pharmacologic Management of Diabetes (cont’d) • Insulin therapy for people with type 2 diabetes – Approximately 30% of people with type 2 diabetes eventually require insulin – Often begins with a single injection of intermediate- or long-acting insulin at bedtime – Another regimen uses a morning injection of rapid and intermediate-acting insulin with an intermediate- or long-acting insulin at dinner or before bedtime – Self-monitoring of blood glucose levels • Pharmacologic Management of Diabetes (cont’d) • Glucose lowering medications – Oral glucose lowering medications vary in their mechanism of action and food concerns – Considered adjunct to nutrition therapy and exercise, not a sole mode of therapy • Exercise • An important aspect of treatment for both types of diabetes • Unless it is contraindicated for other medical reasons, the client should exercise every day • Exercise (cont’d) • Exercise in insulin users – Has not been shown to improve glycemic control in type 1 diabetics – May worsen hyperglycemia – Should occur within 2 hours of eating – If exercise is unplanned, an additional 10 to 15 g of carbohydrate per hour of moderate activity is recommended • Exercise (cont’d) • Exercise in type 2 diabetes – Offers substantial benefits – Helps to maintain long-term weight reduction – Monitor blood glucose levels – Should occur within 2 hours after eating – Stop activity if signs and symptoms of hypoglycemia develop – Sick Day Management • Acute illnesses can significantly raise blood glucose levels • Maintain normal medication schedule, monitor blood glucose levels every 2 to 4 hours, and maintain an adequate fluid intake • A daily intake of 150 to 200 g of carbohydrates, approximately 45 to 50 g every 3 to 4 hours, is recommended • Life Cycle Considerations • Children and adolescents – Children with diabetes appear to have the same nutrient needs as their age-matched peers – Managing diabetes in children and adolescents is complicated by the impact of growth on nutrient needs, irregular eating patterns, and erratic activity levels – Failure to provide adequate calories and nutrients results in poor growth, as does poor glycemic control and inadequate insulin administration • Life Cycle Considerations (cont’d) • Children and adolescents (cont’d) – Individualized meal plans and intensive insulin regimens can provide flexibility for erratic eating, activity, and growth – Annually, 3,700 American youths are diagnosed with type 2 diabetes – Weight control is key to preventing type 2 diabetes in children • Life Cycle Considerations (cont’d) • Diabetes in later life – Unique considerations related to aging that affect glycemic control – Blood glucose levels rise with age for reasons that are unclear – Cognitive impairments may preclude self-management – Older adults may be at greater nutritional risk for a variety of reasons – A fasting target level of 120 to 150 mg/dL may be considered appropriate – Diabetic Diets in the Hospital • A consistent-carbohydrate diet • Appropriate modifications in fat intake are made • Consistent timing of meals and snacks is stressed • No one way to provide adequate nutrition for diabetics in the hospital