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Scientist for Downstream Process R&D
Oxford, Oxfordshire
Salary competitive
Permanent
Profile of Role
Oxford BioMedica’s Process R&D team is being rapidly expanded to support an increasing portfolio of cell and gene
therapies. The team is responsible for delivering robust GMP manufacturing process from early phase clinical trial
material to launch and the development of innovative technologies to enable step-change improvements to cell &
gene therapy manufacture and industrialisation of our platform process.
A highly motivated and independent individual is sought to work within this team. The successful candidate will be
expected to:
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Develop and scale-up scientific and technical projects to deliver new and improved manufacturing processes
using DoE that can be operated within a GMP environment.
Be responsible for executing the downstream process development, optimisation and scale-up activities for
the manufacture of gene-based medicines.
Maintain Oxford BioMedica process technologies at the fore-front of the industry.
Skills/Knowledge/Qualifications
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Min. BSc/B.Eng Degree in Life Sciences/Science/Biochemical Engineering
A good R&D technological background in protein purification/downstream processing
Practical industry experience in executing protein purification/downstream projects/activities
Good level of communication and presentation skills
Key Tasks
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Innovation and technology development of new downstream manufacturing processes.
Technology development to optimise and improve the current downstream manufacturing capabilities.
Development and implementation of new downstream manufacturing platforms
Working closely within the Process R&D team; executes the Manufacturing Development technical approach
to downstream process improvements for development and manufacture of our gene-based products and
those of our key partners.
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Competencies
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A background in downstream process development. A strong interest in manufacture of biopharmaceuticals
and/or experience of working with lentiviral vectors would be an advantage.
Good practical competence and technical understanding of bio therapeutic manufacturing.
Ability to execute routine chromatographic purification activities using ÄKTA systems (UNICORN control
software).
Demonstrated ability to work independently as well as in a team setting
Ability to execute complex projects to aggressive timelines with the ability to adapt to rapid changes in
project priorities
Ability to work collaboratively in a matrix and complex project environment
Good written and verbal communication skills
Be enthusiastic and motivated for working and solving very challenging projects
Effective communication skills to gain company support
Additional Experience which would be considered an advantage:
 Candidates with experience in cell based assays, FACS based assays, western blot analysis and qPCR
The successful candidate will report to the Group Lead, Ocular
Key Words: Process Development / GMP / Purification / ÄKTA systems / Downstream / Biotechnology / Life Science /
Bioprocessing
Please use the cover letter to highlight how you meet the competencies for the role and to state your salary
requirements and current salary. Your cover letter will be used along with your CV to assess your application.
With your application could you please quote job reference OXB04.