Acute Spontaneous Subdural Hematoma in a Middle-aged Adult: A Case Report and Review of the Literature Coombs JB, DO1; and Coombs BL2, BS; Chin E, MD1 (210-667-8082) 1 Department of Emergency Medicine: San Antonio Uniformed Service Health Education Consortium – San Antonio, Texas 2 Des Moines College of Osteopathic Medicine – Des Moines, Iowa Acute spontaneous subdural hematomas (ASSDHs) are rare entities reported in the literature. A thirty-seven year old male, with no history of trauma, presented to the emergency department (ED) with a headache, myalgias, and vomiting. Noncontrast computed tomography (CT) revealed a unilateral ASSDH with 9 mm midline shift and a normal neurological exam. Within twenty-four hours, the patient developed an abducen’s palsy and, interpreted as a sign of increasing intracranial pressure, was taken for an urgent hemicraniectomy. Pathological sampling revealed large atypical cells indicative of a possible hematopoietic neoplasm. There was no sign of cerebral tumor, vascular malformation, or arterial extravasation identified by various imaging modalities. A literature review of the etiology, incidence, and mortality rates of ASSDH is discussed as these nontraumatic cases are limited to case reports and a few case series—especially in nonelderly patients.