THE 9th Middle East Best of San Antonio Breast Cancer Symposium 10-11 January 2015 DAY 1 TIME TOPICS SPEAKER Dr. Omalkhair Abulkhair 8:30 – 8:35 Opening Remarks 8:35 – 10:05 Breast Cancer Predisposition: Gremlins and Risk 8:35 – 9:05 Characterizing Cancer Risks for the Carrier of Mutations BRCA1, BRCA2, PALB2 and RAD51C Genes Dr. Antonis C. Antoniou 9:05 - 9:35 Risk Management of Hereditary Breast Cancer Dr. Banu Arun 9:35 - 9:50 16 Year Old Long- Term Follow-up of the IBIS-I Breast Cancer Prevention Trial Dr. Omalkhair Abulkhair 9:50-10:05 Coffee Break 10:05- 11:30 Hormonal Therapy Update 10:05- 10:30 Biomarkers for Clinical Management and Research ER+ Dr. Susan Fuqua 10:30- 11:00 Adjuvant Endocrine Therapy in 2015 Including Soft Trail Dr. Olivia Pagani 11:00 – 11:15 Fulvestrant 500mg Versus Anastrozole as First Line Treatment for Advanced Breast Cancer: Overall Survival from the Phase II ‘ First Study’ Dr. Ahmed Saadeddin MODERATOR Dr. Ezeldeen Ibrahim Dr. Banu Arun Dr. Heba El Zawahry Dr. Huda Abdulkareem Prof. Jean-Marc Nabholtz 11:15- 11:30 The FERGI Phase II Study of the PI3K Inhibitor Pictilisib ( GDC- 0941) plus Fulvestrant plus Placebo in Patients with ER+, Aromatase Inhibitor (AI) – Resistant Advanced or Metastatic bBreast Cancer – Part I Results Dr. Mohammed Jaloudi 11:30-12:40 Triple Negative Breast Cancer Updates 11:30-11:45 The Clinical Significance of Heterogeneity in Triple Negative Breast Cancer Dr. Hamdy Azim 11:45-12:00 S3-01 The TNT trial: A Randomized Phase III Trial of Carboplatin (C) Compared with Docetaxel (D) for Patients with Metastatic or Recurrent Locally Advanced Triple Negative or BRCA1/2 Breast Cancer (CRUK/07/012) Dr. Sana Al Sukhun 12:00-12:15 S4-05 . Impact of Intrinsic Subtype by PAM50 and Other Gene Signatures on Pathologic Complete Response (pCR) Rates in Triple-Negative Breast Cancer (TNBC) after Neoadjuvant Chemotherapy (NACT)+/Carboplatin (Cb) or Bevacizumab (Bev): CALGB 40603/150709 (Alliance) Dr. Shaheena Dawood 12:15-12:40 Recent Management of HER2-Triple Negative Breast Cancer Dr. Chris Twelves 12:40-1:40 Lunch 1:40-2:55 Update on HER2 the Breast Cancer Dr. Shafiqah Al Awadhi Dr. Hassan Idrisi Dr. Jamal Al Zekeri Dr. Nadia Mokhtar Dr. Saleha Bajasoum 1:40 – 2:10 HER2 Positive Breast Cancer: Insights from the Lab and Clinic Dr. Taher Al Twigiri 2:10 -2:25 Phase 3, Randomized, Double-Blind, PlaceboControlled Multicenter Trial of Daily Everolimus plus Weekly Trastuzumab and Paclitaxel as First-Line Therapy in Women with HER2+ Advanced Breast Cancer: BOLERO-1 Dr. Meteb Al Foheidi 2:25- 2:40 TBCRC023: A Randomized Multicenter Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab , with Endocrine Therapy and Without Chemotherapy, for 12 vs. 24 Weeks in Patients with HER2 Overexpressing Breast Cancer. Dr. Nagi Al Saghir 2:40 - 2:55 Detrimental Effects of Sequential Compared to Dr. Hassan Jaafar Concurrent Treatment of Pertuzumab plus T- DM1 in HER2+ Breast Cancer Cell Lines 2:55-3:30 Middle East Abstract 3:30-3:45 Break 3:45-4:30 Case for Discussion - Dr. Omalkhair Abulkhair - Naghy Al Sagir - Dr. Amin Eltigani Dr. Jean-Mark Nabholtz Panelist - Dr. Banu Arun - Prof. Jean-Mark Nabholtz - Dr. Mohammed AL Belwi - Dr. Olivia Pagani - Dr. Ezzelddin Ibrahim - Dr. Sanaa Al Sukhun Dr. Ahmed Saadeddin - Dr. Hamdi Azim Dr. Shafiqah Al Awadhi DAY 2 8:30-10:30 Chemotherapy Update 8:30- 8:45 9:30-10:10 S2-07. A Randomized Phase III Trial Comparing Neoadjuvant Chemotherapy with Weekly Nanoparticle-Based Paclitaxel with Solvent-Based Paclitaxel Followed by Anthracyline/ Cyclophosphamide for Patients with Early Breast Cancer (GeparSepto);GBG69 S3-02. NSABP B-36: A Randomized Phase III Trial Comparing Six Cycle of 5-Fluorouracil (5-FU), Epirubicin, and Cyclophosphamide (FEC) to Four Cycle of Adriamycin and Cyclophoshamid (AC) in Patients (pts) with Node-Negative Breast Cancer S3-03. Ten Year Update of E119:phase III Study of Doxorubicin-Cyclophosphamide Followed by Paclitaxel or Docetaxel Given Every 3 weeks or Weekly in Patients with Axillary Node-Positive or High-Risk Node-Negative Breast Cancer S3-04. The phase III ICE study: Adjuvant Ibandronate with or without Capecitabine in Elderly Patients with Moderate or High Risk Early Breast Cancer Update on Transitional Research 10:10- 10:20 Coffee Break 10:20-11:10 Radiation Update 8:45-9:00 9:00- 9:15 9:15- 9:30 Dr. Sami Al Khatib Dr. Mahmoud Shahin Dr. Ahmed Al Shehri Dr. Khalid Al Saleh Dr. Alaa Kandil Dr. Medhat Faris Dr. Ahmed Awada Dr. Mohamed Shabana Dr. Abdulrahman Al Hadab 10:20- 10:35 S5-03.Accelerated Partial Breast Irradiation Using Intensity Modulated Radiotherapy versus Whole Breast Irradiation : 5 –Year Survival Results of a Phase 3 Randomized Trial Dr. Belal El Hawarri 10:35 – 11:10 New Insights in Beast Radiation Dr. Fady Geara 11:10- 12:20 Surgical Update 11:10 – 11:25 S5-04. A Large Prospectively-Designed Study of the DCIS Score: Predicting Recurrence Risk after Local Excision for Ductal Carcinoma in Situ Patients with and without Irradiation Posters on Sential Node Dr. Abdulaziz Al Saif Delayed and Immediate Partial Breast Reconstruction after Breast Conserving Surgery Reconstruction for the High Risk Patient: Challenges of Chemotherapy, Radiation Therapy and Selection Dr. Jean-Yves Petit 11:25-11:40 11:40-12:00 12:00-12:20 Dr. Osama Al Malik Dr. Manal Al Zaid Dr. Khalid Al Hajri Dr. Mahmoud Mohammed Al Masri Dr. Mehra Golshan 12:30-1:30 Lunch Break 1:30-2:00 Supportive 1:30-1:45 S5-07. A Randomized, Open-Label, Multicenter, Phase Dr. Lobna Sedky Khalil 3 Study of Epoetin Alfa (EPO) Plus Standard Supportive Care versus Standard Supportive Care in Anemic Patients with Metastatic Breast Cancer (MBC) Receiving Standard Chemotherapy S5-08. Final Survival Analysis from the Randomized Dr. Bassim Al Bahrani Women’s Intervention Nutrition Study (WINS) Evaluating Dietary Intervention as Adjuvant Breast Cancer Therapy 1:45-2:00 Dr. Hesham El Ghazaly Dr. Osama Al Hemsi 2:00-3:00 Case Discussion 3:00- 4:00 Closing Ceremony Panelists: - Dr. Alaa Kandil - Dr. Ahmed Awada - Dr. Heba El Zawahry - Dr. Anees Hassan Dr. Ahmed Faraj