Scientific Program
International Congress of Liver Flukes and Cholangiocarcinoma:
Towards control and elimination
Orchid Ballroom 1, Pullman Raja Orchid Hotel
Khon Kaen, Thailand
11-12 May 2015
Monday 11May 2015
8.00-9.00
9.00-9.30
Registration
Opening ceremony
Report: Chairman, Organizing Committee
Banchob Sripa
Welcome Address:
- Director, Liver Fluke and Cholangiocarcinoma Research Center,
Khon Kaen University, Thailand
Narong Khuntikeo
- Dean, Faculty of Medicine, Khon Kaen University, Thailand
Chanchai Panthongviriyakul
- President, Parasitology and Tropical Medicine Society of Thailand
Jitra Waikagul
Opening Address:
- Director General, Department of Disease Control, MOPH, Thailand
Sopon Mekthon
* VDO Presentation-100 Years of human opisthorchiasis*
9.30-10.00
Centenary presentation: Opisthorchiasis and control in Thailand
Chairperson: Kumnuan UngChusak (Senior Expert in Prevention Medicine,
MOPH, Thailand)
Combating liver fluke and cholangiocarcinoma: a national agenda
Sopon Mekthon (Director General, MOPH, Thailand)
Current status of liver fluke and other helminthiases in Thailand
Rungrueng Kitphati (Director, Bureau of General Communicable
Disease, MOPH)
10.00-10.15
Coffee break (and press conference)
10.15-12.00
Plenary session
Chairperson: Puangrat Yongvanit (Khon Kaen University)
Genomics of worms, with an emphasis on liver fluke - major opportunities for
discovery and biomedical outcomes (30 min)
Robin B. Gasser (University of Melbourne, Australia)
Recent advances in the pathogenesis of liver fluke-induced cancer (20 min)
Banchob Sripa (Khon Kaen University)
Genomic lanscape of cholangiocarcinoma (30 min)
Teh Bin Tean (Duke-NUS, Singapore)
New perspective of cholangiocarcinoma control (20 min)
Narong Khuntikeo (Khon Kaen University)
12.00-13.30
Lunch and Poster presentation
13.30-15.00
Epidemiology I: Epidemiology of human liver flukes and CCA
Chairpersons: Paiboon Sithithaworn (KKU)
Advance in diagnosis of opisthorchiasis: essential tools for control and
eliminate the liver fluke
Paiboon Sithithaworn (KKU)
From Recognition to Practice: The 140th Anniversary in Discovery of
Clonorchiasis
Qian Men-Bao (National Institute of Parasitic Diseases, China)
Opisthorchiasis and cholangiocarcinoma in the Russian federation: a review of
medical statistics data
Olga S. Fedorova (Tomsk Medical University, Russia)
The Development of Behavior Modification Model on Liver Fluke Prevention
of Ordinary People in North-East Region Community, Thailand
Manasanun Limpawittayakul (Department of Disease Control, MOPH,
Thailand)
Human, Snail, Fish, and Waterscape Interactions: Geographic Investigations
of Liver Fluke Infections in Thailand
Yi-Chen Wang (NUS, Singapore)
Assessing Opisthorchis viverrini transmission dynamics: experimental and
modeling investigations of miracidium infectiousness and survival over time
and across a temperature gradient
Pierre Echaubard (TDR-KKU) and Tomas Leon (UC, Berkeley, USA)
15.00-15.30
Coffee break
15.30-17.00
Epidemiology II: Epidemiology of human liver flukes and CCA
Chairpersons: Thanh Hoa Le
Opisthorchiasis/Clonorchiasis in Vietnam: endemicity/geographical
distribution and genetic diversification
Thanh Hoa Le (Institute of Biotechnology, Vietnam)
Epidemiology of Opisthorchis viverrini in Lao People Democratic Republic
Somphou Sayasone (NIOPH, Lao PDR)
Risk factors for Opisthorchis viverrini infection in high risk area Thailand
Kesorn Thaewnongiew (DPC 6, Khon Kaen, Thailand)
Seasonal and spatial environmental influence on Opisthorchis viverrini
intermediate host abundance and distribution: insights on sustainable disease
control and prevention
Christina S. Kim (TDR-KKU)
Trends of Opisthorchis viverrini in the catchment area of Kwae Noi dam,
Thailand: an evaluation of health impact assessment
Thitima Wongsaroj (Department of Disease Control, MOPH, Thailand)
Effectiveness of a community-directed intervention against liver fluke and
soil-transmitted helminths in southern Lao PDR
Khampheng Phongluxa (NIOPH, Lao PDR)
17.00-18.00
Evening talk: Lessons learned on liver fluke control in endemic sites
Chairpersons: Wachara Eamratsameekool (Thailand)
Jitra Waikagul (Mahidol, Thailand)
Somphou Sayasone (NIOPH, Lao PDR)
Muth Sinuon (CNM, Cambodia)
Tuesday 12May 2015
8.45-10.00
Biology of liver flukes: Molecular biology, functional/systems biology
Chairpersons: Paul J. Brindley
Two groups of glucose transporters work together in Clonorchis sinensis
Fuhong Dai and Sung-Jong Hong (Chung-Ang University, Korea)
Apoptosis of cholangiocytes modulated by thioredoxin of
Opisthorchis viverrini
Paul J. Brindley (Gorge Washington University, USA)
Carcinogenic potential of liver fluke Opisthorchis felineus
Viatcheslav Mordvinov (Siberian RAS, Russia)
Identification and characterization of protein 14-3-3 in carcinogenic liver fluke
Opisthorchis viverrini
Alok Kafle (Mahidol, Thailand)
Dynamics of thiol-based redox switches in the parasitic flatworm Fasciola
gigantica
TimirTripathi (North-Eastern Hill University, Shillong, India)
10.00-10.30
Coffee Break
10.30-12.00
Opisthorchiasis&cholangiocarcinoma I: Tumor biology, pathogenesis and
carcinogenesis
Chairpersons: Sopit Wongkham (Khon Kaen University)
Formation of carcinogenic oxysterols and their roles in liver fluke-induced
cholangiocarcinogenesis
Puangrat Yongvanit (Khon Kaen University)
Schistosoma haematobium and liver fluke associated cancers: a possible role
for derived cathecol-estrogens and oxysterols
José Manuel Costa,(INSA-National Health Institute, Porto, Portugal)
Diabetes mellitus-a missing jigsaw of cholangiocarcinoma
Sopit Wongkham (Khon Kaen University)
The liver fluke Opisthorchis viverrini: a reservoir for Helicobacter spp.
Raksawan Deenonpoe (Thammasart University, Thailand)
Roles of microRNAs in Opisthorchis viverrini -associated
cholangiocarcinoma
Nisana Namwat (Khon Kaen University)
Epigenetic changes of early B cell factor 1 (ebf1) in relation to oxidative stress
and poor prognosis in cholangiocarcinoma
Raynoo Thanan (Khon Kaen University)
12.00-13.00
13.00-15.00
Lunch and Poster presentation
Opisthorchiasis & cholangiocarcinoma II: Diagnosis and treatment
Chairpersons: Peter Odermatt
Treatment of Opisthorchis viverrini with Tribendimidine
Peter Odermatt (Swiss TPH, Switzerland)
Serial bile duct changes in opisthorchiasis detected by 1H-MRS and
MRI:Animal model.
Eimorn Mairiang (Khon Kaen University)
Imaging diagnosis of cholangiocarcinoma
Nitaya Chamadol (Khon Kaen University)
Current management in cholangiocarcinoma
Attapon Titapun (Khon Kaen University)
Increased Eph receptors and its ligands predicts cholangiocarcinoma
metastasis
Watcharin Loilome (Khon Kaen University)
The identification of antigens which could be applied to develop
serodiagnostics for clonorchiasis
Jung-Won Ju (NIH, Korea)
Humanized Engineered Antibodies: Alternative Agents for Opisthorchiasis
immunotherapy
Salma Teimoori (Mahidol University, Thailand)
Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors
(saha and tsa) on cholangiocarcinoma cell lines
Md. Ali Asgar (Khon Kaen University)
15.00-15.15
Coffee Break
15.15-16.30
Control and elimination of OV-CCA
Chairpersons: Banchob Sripa
Liver fluke and cholangiocarcinoma in a social-ecological systems context:
disease control implications for northeast Thailand
Bruce Wilcox (Tufts, USA)
Lawa model: an integrate liver fluke control using EcoHealth approach
Banchob Sripa (Khon Kaen University)
Misunderstanding, misrepresentation and miscommunication in liver fluke
education: the double-edged sword of Northeast Thailand’s healthcare system
Yee Ting Lee and Carl Grundy-Warr (NUS, Singapore)
CASCAP: Cholangiocarcinoma Screening and Care Program
Bandit Thinkhamrop (Khon Kaen University)
16.30-16.45
Closing ceremony