Curriculum Vitae (May 2014) Name : Anastasia Surname : Antoniadou Born : June 13th 1959 Nationality : Greek Married to : Konstantinos Kanavos (MD) Children : Fotios (1986) and Sofia (1990) Foreign languages : English Affiliation and official address : 4th Dpt of Internal Medicine, Athens University Medical School Attikon University General Hospital 1, Rimini str, Haidari 12462, Athens, Greece mobile : +306976 441762 e-mail : ananto@med.uoa.gr Education / Career / Employment 1984 : Medical Doctor, Athens University School of Medicine 1984 : State license of practice in Medicine 1984 – 1986 : Obligatory rural medical service (primary care physician in the Cretan village of Anogia ). 1986 – 1992 : Resident in Internal Medicine in the First Department of Propedeutic Medicine in Laiko General Hospital. During my residency I worked on empiric antimicrobial therapy in neutropenic hosts and on treatment of chronic viral hepatitis with interferon. 1992 : Internal Medicine Specialist (registered after State examinations). 1992 – 1996 : Infectious Diseases trainee in Laiko General Hospital, Infectious Diseases Lab of the 1st Dpt of Propedeutic Medicine. 1996 : Registered Infectious Diseases Specialist. 1997 – 1998 : Physician of the Hellenic Centre for Infectious Diseases Control (HCIDC), AIDS Unit, 1st Dpt of Propedeutic Medicine, Laiko General Hospital 1 1998-1999 : Physician of the Hellenic Centre for Infectious Diseases Control (HCIDC), AIDS Unit, 4th Dpt of Internal Medicine of Athens Medical School, Sismanoglion General Hospital 1998 : MD Thesis on “Amikacin plus ceftazidime or aztreonam in the febrile episodes of neutropenic patients”. Grade A (Excellent) 1999 - 2003 : Attending physician in the 4th Department of Internal Medicine (of Athens University Medical School), in Sismanoglion General Hospital, active member of the Hospital Infection Control Committee and member of the stuff of the hospital’s HIV Unit May-June 2001 : Fungus Testing Laboratory at University of Texas Health Science Center , San Antonio (USA), training in fungal identification and sensitivity testing June – September 2001: Infectious Diseases Dpt, MDΑnderson Cancer Center Houston Texas (USA).Observer in clinical mycology December 2003 – March 2009 : Lecturer in Internal Medicine and Infectious Diseases, Athens University Medical School, 4th Dpt of Internal Medicine, Attikon University General Hospital April 2009 – 2014 : Assistant Professor in Internal Medicine and Infectious Diseases, Athens University Medical School, 4th Dpt of Internal Medicine, University General Hospital ATTIKON April 2014 elected Associated Professor in Internal Medicine and Infectious Diseases, Athens University Medical School, 4th Dpt of Internal Medicine, University General Hospital ATTIKON Memberships : Hellenic Society of Infectious Diseases, Hellenic Society of Chemotherapy, Hellenic Society for Medical Studies, Hellenic AIDS Society, Hellenic Society for Medical Mycology, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America and HIV Medical Association, European AIDS Society, European Society for Intensive Care Medicine. Areas of special interest : Infections in immunocompromised patients, HIV Infection, fungal infections, Health-care associated (especially ICU) infections, antibiotic policies. Member of the Infection Control Committee of the University Hospital ATTIKON (2003-today) and coordinator of the antibiotic team (2013-today), member of the Intersectoral Committee for Antimicrobial Resistance (2009-2010), alternate member of the National Committee for Nosocomial Infections(2005-2010), member of the coordinating group for the surveillance of Health Care Associated Infections at ECDC (2009-2011), National focal point for the ESACNET(2010-13), Scientific responsibility of the HIV Unit at University General Hospital ATTIKON, Member of the steering committee of the Greek HIV cohort AMACS (participant in INSIGHT and COHERE).Currently member of the administrative board of the Hellenic Society of Medical Mycology 2 Abstracts in scientific meetings : 263 (143 in international meetings and 120 in Greek medical meetings) Invited speaker in scientific meetings : 225 Faculty in postgraduate cources : 47 Publications (peer review articles) in the English Literature : 103 [Citations 2118, h-index 23 (scopus)] Study group publications : 52 Chapters in English scientific books: 6 Publications 1. Helen Giamarellou, Maria Soulis, Anastasia Antoniadou andJohn Gogas. Periareolar nonpuerperal breast infection : Treatment of 38 cases. Clinical Infectious Diseases 1994; 18 :73 – 76 2. H. Giamarellou, A. Antoniadou, K. Kanavos, C. Papaioannou, S. Kanatakis, K. Papadaki. Yersinia enterocolitica endocarditis : Case report and literature review. Eur J Clin Microbiol Infect Dis 1995; 14 : 126 – 130. 3. Helen Giamarellou , Anastasia Antoniadou . Epidemiology, diagnosis and therapy of fungal infections in surgery. Infection Control and Hospital Epidemiology 1996; 17 : 558 – 564. 4. Helen Giamarellou and Anastasia Antoniadou. The effect of monitoring of antibiotic use on decreasing antibiotic resistance in the hospital. In Antibiotic Resistance : Origins, Evolution, Selection and Spread. Wiley, Chichester, Ciba Found Symp. 1997; 207 : 76 – 92. 5. H. Bassaris, G. Saroglou, G. Petrikkos, J. Starakis, A. Vassiloyiannakopoulos, A. Antoniadou, C. Tsagaraki, E. Skeparni, P. Goumas, J. Boutsikakis, M. Lazanas, O. Paniara and E. Platsouka. Once-daily high-dose netilmicin : A new short term treatment regimen for patients with moderate to severe Gram negative infections. Clin Drug Invest 1998; 15 (3) : 205 – 216 6. Choremi-Papadopoulou H, Panagiotou N, Samouilidou E, Kontopidou F, Viglis V, Antoniadou A, Kosmidis J, Kordossis T. CD28 costimulation and CD28 expression in T lymphocyte subsets in HIV-1 infection with and without progression to AIDS. Clin Exp Immunol 2000; 119(3) : 499 – 506 7. H. Giamarellou, H Bassaris, G. Petrikkos, W. Busch, M. Voulgarelis, A. Antoniadou, E. Grouzi and N. Zoumbos. Monotherapy with sequential high dose ciprofloxacin iv / po versus combination therapy with ceftazidime plus amikacin as initial empiric therapy in granulocytopenic patients with fever. Antimicrobial Agents and Chemotherapy , 2000 ; 44912): 3264-71 8. Η. Giamarellou, A. Antoniadou. Αntipseudomonal antibiotics. Medical Clinics of North America, 2001 ;85(1): 19 - 42 3 9. G. Touloumi, V. Paparizos, H. Sambatakou, O. Katsarou, G. Chrysos, T. Kordossis, A. Antoniadou, H. Hatzitheodorou, N. Stavrianeas, P.Gargalianos, A. Karafoulidou, M. Lazanas, H.Giamarellou, A. Hatzakis. Virological and immunological response to HAART therapy in a community based cohort of HIV-1 positive individuals. HIV Clin Trials 2001; 2(1): 6 - 16 10. Giamarellou H, Antoniadou A. Infectious complications of febrile leukopenia. Infect Dis Clin North Am 2001; 15(2): 457 - 82 11. Petrikkos G, Skiada A, Sabatakou H, Antoniadou A, Dosios T, Giamarellou H. Case report. Successful treatment of two cases of post-surgical sternal osteomyelitis, due to Candida krusei and Candida albicans, respectively, with high doses of triazoles(fluconazole, itraconazole). Mycoses, 2001; 44(9-10): 422-5 12. Magiorkinis E, Paraskevis D, Magiorkinis G, Chryssou S, Chini M, Lazanas M, Paparizos V, Saroglou G, Antoniadou A, Giamarellou H, Karafoulidou A, Hatzakis A. Mutations associated with phenotypic resistance to antiretroviral therapy in treatment naïve HIV–1 infected patients in Greece. Virus Res. 2002; 85(1): 109-15 13. Anastassopoulou k, Paraskevis D, Sypsa V, Chryssou S, Antoniadou A, Giamarellou H, Hatzakis A. genetic evolution of Human Immunodeficiency Virus Type 1 in two Spouses Who Are Successfully Responding To Higly-Active Antiretroviral Therapy (HAART)” AIDS Res Hum Retrov 2003; 19(1): 65-71 14. J Malamitsi, H. Gaiamarellou, K. Kanellakopoulou, E. Dounis, V. Grecka, J Christakopoulos, G. Koratzanis, A. Antoniadou, G. Panoutsopoulos, C. Batsakis, C. Proukakis. Infecton: A99m Tc – ciprofloxacin radiopharmaceutical for the detection of bone infection. Clin Microbiol Infect 2003; 9 (2): 101-109 15. Antoniadou A, Torres HA, Lewis RE, Thornby J, Raad II, Bodey GP, Rolston KVI, Han XY, Tarrand JJ, Kontoyiannis DP. Candidemia in a tertiary care cancer center: In vitro susceptibility and its correlation with outcome of antifungal therapy. Medicine 2003; 82 (5): 309-321 16. Antoniadou A, Kontoyiannis DP. Status of combination therapy for refractory mycoses. Curr Opin Infect Dis. 2003 16(6) : 539-45 17. Katsoulidou A, Papachristou E, Petrodaskalaki M, Sypsa V, Anastassopoulou CG, Gargalianos P, Karafoulidou A, Lazanas M, Kordossis T, And(t)oniadou A, Hatzakis A.Comparison of three current viral load assays for the quantitation of human immunodeficiency virus type 1 RNA in plasma. J Virol Methods. 2004;121(1):93-9 18. Kampougeris G, Antoniadou A, Kavouklis E, Chryssouli Z, Giamarellou H.Penetration of moxifloxacin into the human aqueous humour after oral administration.Br J Ophthalmol. 2005 ;89(5):628-31 19. Paraskevis D, Magiorkinis E, Katsoulidou A, Hatzitheodorou E, Antoniadou A, Papadopoulos A, Poulakou G, Paparizos V, Botsi C, Stavrianeas N, Lelekis M, Chini M, Gargalianos P, Magafas N, Lazanas M, Chryssos G, Petrikkos G, Panos G, Kordossis T, Theodoridou M, Sypsa V, Hatzakis A; Hellenic Multi-centre study on HIV-resistance.Prevalence of resistance-associated mutations in newly diagnosed HIV-1 patients in Greece. Virus Res. 2005;112 (1-2):115-22 20. A. Antoniadou, B. Dupont. Lipid formulations of amphotericin B: where are we today? J Mycol Med 2005; 15:230-8 21. Panagopoulos P, Tsiodras S, Antoniadou A, Katsarolis I, Papadopoulos A, Poulakou G, Giamarellou H. Efficacy and safety of an anti-retroviral combination regimen including either 4 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. efavirenz or lopinavir-ritonavir with a backbone of two nucleoside reverse transcriptase inhibitors. Clin Microbiol Infect. 2006 May;12(5):486-9 Souli M, Kontopidou FV, Koratzanis E, Antoniadou A, Giannitsioti E, Evangelopoulou P, Kannavaki S, Giamarellou H. In vitro activity of tigecycline against multiple-drug-resistant, including pan-resistant, gram-negative and gram-positive clinical isolates from Greek hospitals. Antimicrob Agents Chemother. 2006;50(9):3166-9 Katsoulidou A, Petrodaskalaki M, Sypsa V, Papachristou E, Anastassopoulou CG, Gargalianos P, Karafoulidou A, Lazanas M, Kordossis T, And(t)oniadou A, Hatzakis A.Evaluation of the clinical sensitivity for the quantification of human immunodeficiency virus type 1 RNA in plasma: Comparison of the new COBAS TaqMan HIV-1 with three current HIV-RNA assays-LCx HIV RNA quantitative, VERSANT HIV-1 RNA 3.0 (bDNA) and COBAS AMPLICOR HIV-1 Monitor v1.5. J Virol Methods. 2006;131(2):168-74 Antoniadou A, Kontopidou F, Poulakou G, Koratzanis E, Galani I, Papadomichelakis E, Kopterides P, Souli M, Armaganidis A, Giamarellou H. Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients: first report of a multiclonal cluster. J Antimicrob Chemother. 2007;59(4):786-90 Giannitsioti E, Skiadas I, Antoniadou A, Tsiodras S, Kanavos K, Triantafyllidi H, Giamarellou H; Hellenic Endocarditis Study Group. Nosocomial vs. community-acquired infective endocarditis in Greece: changing epidemiological profile and mortality risk. Clin Microbiol Infect. 2007;13(8):763-9 Kampougeris G, Antoniadou A. Vitreous and aqueous penetration of orally administered moxifloxacin in humans. Eye. 2007;21(9):1242-3; author reply 1243 Ntagiopoulos PG, Paramythiotou E, Antoniadou A, Giamarellou H, Karabinis A.Impact of an antibiotic restriction policy on the antibiotic resistance patterns of Gram-negative microorganisms in an Intensive Care Unit in Greece. Int J Antimicrob Agents. 2007; 30(4):360-5 Paraskevis D, Magiorkinis E, Magiorkinis G, Sypsa V, Paparizos V, Lazanas M, Gargalianos P, Antoniadou A, Panos G, Chrysos G, Sambatakou H, Karafoulidou A, Skoutelis A, Kordossis T, Koratzanis G, Theodoridou M, Daikos GL, Nikolopoulos G, Pybus OG, Hatzakis A; Multicentre Study on HIV Heterogeneity. Increasing prevalence of HIV-1 subtype A in Greece: estimating epidemic history and origin. J Infect Dis. 2007;196(8):1167-76 Sakka V, Tsiodras S, Galani L, Antoniadou A, Souli M, Galani I, Pantelaki M, Siafakas N, Zerva L, Giamarellou H. Risk-factors and predictors of mortality in patients colonised with vancomycin-resistant enterococci. Clin Microbiol Infect. 2008;14(1):14-21 30. Antoniadou A, Giamarellou H. Fever of unknown origin in febrile leukopenia. Infect Dis Clin North Am. 2007;21(4):1055-90 Lekakis J, Tsiodras S, Ikonomidis I, Palios J, Poulakou G, Rallidis L, Antoniadou A, Panagopoulos P, Papadopoulos A, Giamarellou H, Kremastinos DT. HIV positive patients treated with protease inhibitors have vascular changes resembling those observed in atherosclerotic cardiovascular disease. Clin Sci (Lond). 2008; 115: 189-96 Giamarellou H, Antoniadou A, Kanellakopoulou K. Acinetobacter baumannii: a universal threat to public health? Int J Antimicrob Agents. 2008;32:106-119) E. Papadomichelakis, F. Kontopidou, A. Antoniadou, G. Poulakou, E. Koratzanis, P. Kopterides, I. Mavrou, A. Armaganidis, H. Giamarellou . Screening for resistant gram-negative 5 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. microorganisms to guide empiric therapy of subsequent infection. Intensive Care Med 2008;34:2169-75 H.C. Maltezou, V. Tsagris, A. Antoniadou, L. Galani, C. Douros, I. Katsarolis, A. Maragos, V. Raftopoulos, P. Biskini, K. Kanellakopoulou, A. Fretzayas, T. Papadimitriou, P. Nikolaidou, H. Giamarellou. Evaluation of a rapid antigen detection test in the diagnosis of streptococcal pharyngitis in children and its impact on antibiotic prescription. J Antimicrob Chemother 2008;62:1407-12 Makris M, Spanoudaki N, Giannoula F, Chliva C, Antoniadou A, Kalogeromitros D. Acute generalized exanthematous pustulosis (AGEP) triggered by a spider bite. Allergol Int. 2009;58:301-3 Poulakou G, Kontopidou FV, Paramythiotou E, Kompoti M, Katsiari M, Mainas E, Nicolaou C, Yphantis D, Antoniadou A, Trikka-Graphakos E, Roussou Z, Clouva P, Maguina N, Kanellakopoulou K, Armaganidis A, Giamarellou H. 40.Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens. J Infect. 2009 ;58:273-84 Plachouras D, Karvanen M, Friberg LE, Papadomichelakis E, Antoniadou A, Tsangaris I, Karaiskos I, Poulakou G, Kontopidou F, Armaganidis A, Cars O, Giamarellou H. Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria. Antimicrob Agents Chemother 2009 ;53:3430-6 Lekakis J, Ikonomidis I, Palios J, Tsiodras S, Karatzis E, Poulakou G, Rallidis L, Antoniadou A, Panagopoulos P, Papadopoulos A, Triantafyllidi H, Giamarellou H, Kremastinos DT. Association of highly active antiretroviral therapy with increased arterial stiffness in patients infected with human immunodeficiency virus. Am J Hypertens. 2009;22:828-34) Panagopoulos P, Antoniadou A, Kanellakopoulou K, Tsiodras S, Katsarolis I, Papadopoulos A, Galani L, Giamarellou H. Fluoroquinolone treatment of chronic bacterial prostatitis: a prospective cohort study. J Chemother. 2009 ;21:317-21 Antoniadou A. Outbreaks of zygomycosis in hospitals. Clin Microbiol Infect. 2009;15 Suppl 5:55-9 E. Giannitsioti, S. Athanasia, A. Antoniadou, Helen Fytrou, K. Athanassiou, P. Bourvani, K. Kanellakopoulou, K. Kouvelas, A. Papadopoulos, D. Plachouras, H. Giamarellou. Does a bed-rail system of hand rub dispenser improve compliance of Health Care Workers (HCWs) with hand hygiene? Results from a pilot study. Am J Infect Control 2009;37:160-3 P. Panagopoulos, D. Paraskevis, A. Antoniadou, A. Papadopoulos, G. Poulakou, A. Hatzakis, H. Giamarellou. Successful virological outcome in an HIV-infected individual with a three-class resistant variant and an insertion in the protease genome with a tripranavir based regimen. Irish J Med Sci 2010;179:305-7 Souli M, Galani I, Antoniadou A, Papadomichelakis E, Poulakou G, Panagea T, Vourli S, Zerva L, Armaganidis A, Kanellakopoulou K, Giamarellou H. 33.An outbreak of infection due to betaLactamase Klebsiella pneumoniae Carbapenemase 2-producing K. pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes.Clin Infect Dis. 2010;50:364-73 Plachouras D, Kavatha D, Antoniadou A, Giannitsioti E, Poulakou G, Kanellakopoulou K, Giamarellou H. Dispensing of antibiotics without prescription in Greece, 2008: another link in the antibiotic resistance chain. Euro Surveill. 2010 ;15. doi:pii: 1948 6 45. Papadopoulos AI, Ferwerda B, Antoniadou A, Sakka V, Galani L, Kavatha D, Panagopoulos P, Poulakou G, Kanellakopoulou K, van der Meer JW, Giamarellos-Bourboulis EJ, Netea MG. Association of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms with increased infection risk in patients with advanced HIV-1 infection. Clin Infect Dis. 2010 ;51:242-7 46. Palios J, Ikonomidis I, Lekakis J, Tsiodras S, Poulakou G, Antoniadou A, Panagopoulos P, Papadopoulos A, Giamarellou H, Anastasiou-Nana M, Kremastinos D. 30. Microcirculatory vascular dysfunction in HIV-1 infected patients receiving highly active antiretroviral therapy. Microcirculation. 2010 May;17(4):303-10 47. Kopterides P, Papageorgiou C, Antoniadou A, Papadomichelakis E, Tsangaris I, Dimopoulou I, Armaganidis A. Failure of tigecycline to treat severe Clostridium difficile infection. Anaesth Intensive Care. 2010;38:755-8 48. Souli M, Sakka V, Galani I, Antoniadou A, Galani L, Siafakas N, Zerva L, Fytrou H, Tsiodras S, Giamarellou H. Colonisation with vancomycin- and linezolid-resistant Enterococcus faecium in a university hospital: molecular epidemiology and risk factor analysis. Int J Antimicrob Agents. 2009 ;33:137-42 49. Chatzigeorgiou KS, Ikonomopoulou C, Kalogeropoulou S, Siafakas N, Giannopoulos G, Antoniadou A, Tassios PT, Tarpatzi E, Giannitsioti E, Vlachakos D, Ikonomopoulos T, Petinaki E, Zerva L. Two successfully treated cases of Staphylococcus lugdunensis endocarditis. Diagn Microbiol Infect Dis. 2010;68:445-8 50. The Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE)(μέλος της 15μελούς συγγραφικής ομάδος εκ μέρους της COHERE). Is It Safe to Discontinue Primary Pneumocystis jiroveci Pneumonia Prophylaxis in Patients with Virologically Suppressed HIV Infection and a CD4 Cell Count !200 Cells/mL? Clin Infect Dis 2010; 51:611–619 51. Panagea T, Galani I, Souli M, Adamou P, Antoniadou A, Giamarellou H. Evaluation of CHROMagar™ KPC for the detection of carbapenemase-producing Enterobacteriaceae in rectal surveillance cultures. Int J Antimicrob Agents. 2011;37:124-8 52. Kontopidou F, Galani I, Panagea T, Antoniadou A, Souli M, Paramythiotou E, Koukos G, Karadani I, Armaganidis A, Giamarellou H. 21.Comparison of direct antimicrobial susceptibility testing methods for rapid analysis of bronchial secretion samples in ventilator-associated pneumonia. Int J Antimicrob Agents. 2011;38:130-4 53. Paraskevis D, Nikolopoulos G, Tsiara C, Paraskeva D, Antoniadou A, Lazanas M, Gargalianos P, Psychogiou M, Malliori M, Kremastinou J, Hatzakis A. HIV-1 outbreak among injecting drug users in Greece, 2011: a preliminary report. Euro Surveill. 2011 8;16(36) 54. Kontopidou F, Plachouras D, Papadomichelakis E, Koukos G, Galani I, Poulakou G, Dimopoulos G, Antoniadou A, Armaganidis A, Giamarellou H. 18.Colonization and infection by colistinresistant Gram-negative bacteria in a cohort of critically ill patients. Clin Microbiol Infect. 2011;17:E9-E11 55. Rosentul DC, Plantinga TS, Papadopoulos A, Joosten LA, Antoniadou A, Venselaar H, Kullberg BJ, van der Meer JW, Giamarellos-Bourboulis EJ, Netea MG. 17.Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients. Immunol Invest. 2011;40:735-50 56. Tsangaris I, Paramythiotou E, Tsaknis G, Argentos S, Antoniadou A, Kopterides P, Armaganidis A. Ovarian hyperstimulation syndrome complicated by severe community-acquired pneumonia 7 due to methicillin-resistant Staphylococcus aureus positive for Panton-Valentine leukocidin. J Obstet Gynaecol Res. 2012;38:476-8 57. Mohamed AF, Karaiskos I, Plachouras D, Karvanen M, Pontikis K, Jansson B, Papadomichelakis E, Antoniadou A, Giamarellou H, Armaganidis A, Cars O, Friberg LE. Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill. Antimicrob Agents Chemother. 2012;56:4241-9 58. Papadopoulos AI, Ferwerda B, Antoniadou A, Sakka V, Galani L, Kavatha D, Panagopoulos P, Poulakou G, Protopapas K, van der Meer JW, Netea MG, Giamarellos-Bourboulis EJ. Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection Cytokine. 2012 ;60:104-7 59. Paraskevis D, Touloumi G, Bakoyannis G, Paparizos V, Lazanas M, Gargalianos P, Chryssos G, Antoniadou A, Psichogiou M, Panos G, Katsarou O, Sambatakou H, Kordossis T, Hatzakis On Behalf Of Amacs A. Effect of HIV Type 1 Subtype on Virological and Immunological Response to Combination Antiretroviral Therapy: Evidence for a More Rapid Viral Suppression for Subtype A Than Subtype B-Infected Greek Individuals. AIDS Res Hum Retroviruses 2013; 29: 461-469 60. Antoniadou A, Kanellakopoulou K, Kanellopoulou M, Polemis M, Koratzanis G, Papademetriou E, Poulakou G, Giannitsioti E, Souli M, Vatopoulos A, Giamarellou H. Impact of a hospital-wide antibiotic restriction policy program on the resistance rates of nosocomial Gram-negative bacteria. Scand J Infect Dis. 2013; 45:438-445 61. Kontopidou FV, Antoniadou A*, Tsirigotis P, Venetis E, Polemis M, Patrinos S, Giamarellou H. The impact of an antimicrobial cycling strategy for febrile neutropenia in a haematology unit. J Chemother. 2013; 25:279-285 62. Bassetti M, Marchetti M, Chakrabarti A, Colizza S, Garnacho-Montero J, Kett DH, Munoz P, Cristini F, Andoniadou A, Viale P, Rocca GD, Roilides E, Sganga G,Walsh TJ, Tascini C, Tumbarello M, Menichetti F, Righi E, Eckmann C, Viscoli C, Shorr AF, Leroy O, Petrikos G, De Rosa FG. A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts. Intensive Care Med. 2013 Dec;39(12):2092-106 63. Panagopoulos P, Paraskevis D, Katsarolis I, Sypsa V, Detsika M, Protopapas K, Antoniadou A, Papadopoulos A, Petrikkos G, Hatzakis A. High prevalence of the UGT1A1*28 variant in HIV1 infected individuals in Greece. Int J STD AIDS. 2014 Feb 10. [Epub ahead of print] 64. Helena C. Maltezou, Efstratios Maltezos, Anastasia Antoniadou,Georgios-Michael Gourgoulis, Panos Katerelos, Georgios Adamis,George Petrikkos, Panagiotis Gargalianos. Prescription of antibiotics and knowledge about antibiotic costs among physicians working in tertiary-care hospitals. J Chemother. 2014 Jan 2:1973947813Y0000000160. [Epub ahead of print] 65. Diamantis Plachouras, Anastasia Antoniadou, Efthimia Giannitsioti, Lambrini Galani, Ioannis Katsarolis, Dimitra Kavatha, George Koukos, Periklis Panagopoulos, Antonios Papadopoulos, Garyfallia Poulakou, Vissaria Sakka, Maria Souli, Styliani Symbardi, Sotirios Tsiodras, Kyriaki Kanellakopoulou, Helen Giamarellou. Promoting prudent use of antibiotics: the experience from a multifaceted regional campaign in Greece. BMC Public Health 2014(in press) 66. Tsiodras, S., Daikos, G.L., Lee, A., Plachouras, D., Antoniadou, A, Ploiarchopoulou, F., Psichogiou, M., Petrikkos, G, Harbarth, S. Risk factors for community-associated methicillinresistant Staphylococcus aureus colonisation in a large metropolitan area in Greece: An 8 epidemiological study using two case definitions. Journal of Global Antimicrobial Resistance(in press) PUBLICATIONS AS COLLABORATOR AUTHORIN MULTICENTER STUDIES 67. Strategies for Management of Antiretroviral Therapy (SMART) Study Group, Emery S, Neuhaus JA, Phillips AN, Babiker A, Cohen CJ, Gatell JM, Girard PM, Grund B, Law M, Losso MH, Palfreeman A, Wood R.,Collaborators (750)(included A.Antoniadou) Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study. J Infect Dis. 2008 ;197(8):1133-44 68. Strategies for Management of Antiretroviral Therapy (SMART) Study Group, Lundgren JD, Babiker A, El-Sadr W, Emery S, Grund B, Neaton JD, Neuhaus J, Phillips AN, Collaborators (750)(included A.Antoniadou) Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ Cell counts and HIV RNA levels during follow-up. J Infect Dis. 2008 ;197(8):1145-55 69. SMART Study Group, El-Sadr WM, Grund B, Neuhaus J, Babiker A, Cohen CJ, Darbyshire J, Emery S, Lundgren JD, Phillips A, Neaton JD and Collaborators (651)(included A. Antoniadou). Risk for opportunistic disease and death after reinitiating continuous antiretroviral therapy in patients with HIV previously receiving episodic therapy: a randomized trial. Ann Intern Med. 2008;149:289-99 70. van de Sande-Bruinsma N, Grundmann H, Verloo D, Tiemersma E, Monen J, Goossens H, Ferech M; European Antimicrobial Resistance Surveillance System Group; European Surveillance of Antimicrobial Consumption Project Group.Collaborators (81) Mittermayer H, Metz S, Koller W, Hendrickx E, Goossens H, Markova B, Tambic-Andrasevic A, Francetic I, Kalenic S, Bagatzouni D, Dvorak P, Urbaskova P, Monnet D, Nielsen AA, Naaber P, Huovinen P, Paakkari P, Lyytikainen O, Nissinen A, Maugendre P, Guillemot D, Coignard B, Jarlier V, Kern W, Schroeder H, Witte W, Heckenbach K, Giamarellou H, Antoniadou A, Tsakris A, Vatopoulos A, Ternak G, Fuzi M, Kristinsson K, Smyth E, Cunney R, Igoe D, Murphy O, Raz R, Cornaglia G, Pantosti A, D'Ancona P, Berzina S, Balode A, Valenteliene R, Miciulevicience J, Hemmer R, Bruch M, Borg M, Zarb P, Janknegt R, Filius M, de Neeling H, Tiemermsa E, Degener J, Blix HS, Hoiby A, Simonsen G, Hryniewicz W, Grzesiowski P, Caldeira L, Canica M, Codita I, Foltan V, Tesar T, Langsadl L, Cizman M, Mueller-Premru M, Kolman J, Campos J, Baquero F, Cars O, Skoog G, Liljequist B, Kahlmeter G, Unal S, Gür D, Davey P, Johnson A, Hughes H, Coyne M. Antimicrobial drug use and resistance in Europe. Emerg Infect Dis. 2008 ;14(11):1722-30 71. Fox Z, Phillips A, Cohen C, Neuhaus J, Baxter J, Emery S, Hirschel B, Hullsiek KH, Stephan C, Lundgren J; SMART Study Group. Collaborators (746)(included A.Antoniadou). Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen. AIDS. 2008;22(17):2279-89 72. Mocroft A, Wyatt C, Szczech L, Neuhaus J, El-Sadr W, Tracy R, Kuller L, Shlipak M, Angus B, Klinker H, Ross M; INSIGHT SMART Study Group Collaborators (718)(included A.Antoniadou). Interruption of antiretroviral therapy is associated with increased plasma cystatin C. AIDS 2009 ;23:71-82 73. Earnshaw S, Monnet DL, Duncan B, O'Toole J, Ekdahl K, Goossens H; European Antibiotic Awareness Day Technical Advisory Committee; European Antibiotic Awareness Day Collaborative Group.European Antibiotic Awareness Day, 2008 - the first Europe-wide public information 9 74. 75. 76. 77. 78. 79. 80. 81. 82. campaign on prudent antibiotic use: methods and survey of activities in participating countries.Euro Surveill. 2009 Jul 30;14(30):19280 Rodger AJ, Fox Z, Lundgren JD, Kuller LH, Boesecke C, Gey D, Skoutelis A, Goetz MB, Phillips AN; INSIGHT Strategies for Management of Antiretroviral Therapy (SMART) Study Group .Collaborators (747)(included A. Antoniadou). Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection. J Infect Dis. 2009 ;200:973-83 Study Group on Death Rates at High CD4 Count in Antiretroviral Naive Patients, Lodwick RK, Sabin CA, Porter K, Ledergerber B, van Sighem A, Cozzi-Lepri A, Khaykin P, Mocroft A, Jacobson L, De Wit S, Obel N, Castagna A, Wasmuth JC, Gill J, Klein MB, Gange S, Riera M, Mussini C, Gutiérrez F, Touloumi G, Carrieri P, Guest JL, Brockmeyer NH, Phillips AN. Collaborators (353)(included A.Antoniadou) Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study. Lancet. 2010 ;376: 340-5. Epub 2010 Jul 15 Amadeo B, Zarb P, Muller A, Drapier N, Vankerckhoven V, Rogues AM, Davey P, Goossens H; ESAC III Hospital Care Subproject Group. Collaborators (30)(A.Antoniadou included) European Surveillance of Antibiotic Consumption (ESAC) point prevalence survey 2008: paediatric antimicrobial prescribing in 32 hospitals of 21 European countries. J Antimicrob Chemother. 2010 ;65:2247-52 Ansari F, Molana H, Goossens H, Davey P; ESAC II Hospital Care Study Group. Development of standardized methods for analysis of changes in antibacterial use in hospitals from 18 European countries: the European Surveillance of Antimicrobial Consumption (ESAC) longitudinal survey, 2000-06. J Antimicrob Chemother. 2010;65:2685-91 Zarb P, Amadeo B, Muller A, Drapier N, Vankerckhoven V, Davey P, Goossens H; ESAC-3 Hospital Care Subproject Group. Identification of targets for quality improvement in antimicrobial prescribing: the web-based ESAC Point Prevalence Survey 2009. J Antimicrob Chemother. 2011 Feb;66(2):443-9 Skiada A, Pagano L, Groll A, Zimmerli S, Dupont B, Lagrou K, Lass-Florl C, Bouza E, Klimko N, Gaustad P, Richardson M, Hamal P, Akova M, Meis JF, Rodriguez-Tudela JL, Roilides E, MitrousiaZiouva A, Petrikkos G; European Confederation of Medical Mycology Working Group on Zygomycosis. Collaborators (12)(A.Antoniadou included). Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007. Clin Microbiol Infect. 2011;17:1859-67 Dwyer DE; INSIGHT Influenza Study Group. 20.Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies.Collaborators (247)(A. Antoniadou included) Vaccine. 2011;29 Suppl 2:B56-62 Versporten A, Coenen S, Adriaenssens N, Muller A, Minalu G, Faes C, Vankerckhoven V, Aerts M, Hens N, Molenberghs G, Goossens H; ESAC Project Group.Collaborators (56)(A.Antoniadou included) European Surveillance of Antimicrobial Consumption (ESAC): outpatient penicillin use in Europe (1997-2009). J Antimicrob Chemother. 2011;66 Suppl 6:13-23. Versporten A, Coenen S, Adriaenssens N, Muller A, Minalu G, Faes C, Vankerckhoven V, Aerts M, Hens N, Molenberghs G, Goossens H; ESAC Project Group. Collaborators (56)(A.Antoniadou included). European Surveillance of Antimicrobial Consumption (ESAC): outpatient cephalosporin use in Europe (1997-2009). J Antimicrob Chemother. 2011;66 Suppl 6:25-35 10 83. Adriaenssens N, Coenen S, Versporten A, Muller A, Minalu G, Faes C, Vankerckhoven V, Aerts M, Hens N, Molenberghs G, Goossens H; ESAC Project Group. Collaborators (56)(A.Antoniadou included). European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe (1997-2009). J Antimicrob Chemother. 2011 ;66 Suppl 6:3-12 84. Adriaenssens N, Coenen S, Versporten A, Muller A, Minalu G, Faes C, Vankerckhoven V, Aerts M, Hens N, Molenberghs G, Goossens H; ESAC Project Group. . Collaborators (56)(A.Antoniadou included). European Surveillance of Antimicrobial Consumption (ESAC): outpatient macrolide, lincosamide and streptogramin (MLS) use in Europe (1997-2009). J Antimicrob Chemother. 2011;66 Suppl 6:37-45 85. Adriaenssens N, Coenen S, Versporten A, Muller A, Minalu G, Faes C, Vankerckhoven V, Aerts M, Hens N, Molenberghs G, Goossens H; ESAC Project Group. . Collaborators (56)(A.Antoniadou included). European Surveillance of Antimicrobial Consumption (ESAC): outpatient quinolone use in Europe (1997-2009). J Antimicrob Chemother 2011;66 Suppl 6:47-56 86. Adriaenssens N, Coenen S, Versporten A, Muller A, Minalu G, Faes C, Vankerckhoven V, Aerts M, Hens N, Molenberghs G, Goossens H; ESAC Project Group. . Collaborators (56)(A.Antoniadou included). European Surveillance of Antimicrobial Consumption (ESAC): outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009). J Antimicrob Chemother. 2011;66 Suppl 6:57-70 87. Adriaenssens N, Coenen S, Versporten A, Muller A, Vankerckhoven V, Goossens H; ESAC Project Group. Collaborators (56)(A.Antoniadou included). European Surveillance of Antimicrobial Consumption (ESAC): quality appraisal of antibiotic use in Europe. J Antimicrob Chemother. 2011;66 Suppl 6:71-77 88. Zarb P, Amadeo B, Muller A, Drapier N, Vankerckhoven V, Davey P, Goossens H; ESAC-3 Hospital Care Subproject Group. Collaborators (34) (A.Antoniadou included) Antimicrobial prescribing in hospitalized adults stratified by age: data from the ESAC point-prevalence surveys. Drugs Aging. 2012;29:53-62 89. Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. Collaborators (130)(A.Antoniadou included) CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. . PLoS Med. 2012;9:e1001194 90. HIV-CAUSAL Collaboration.(1290 collaborators including A.Antoniadou). Impact of antiretroviral therapy on tuberculosis incidence among HIV-positive patients in high-income countries. Clin Infect Dis. 2012;54:1364-72 91. HIV-CAUSAL Collaboration.(1290 collaborators including A.Antoniadou). The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study. AIDS. 2012;26:1691-705 92. Zarb P, Amadeo B, Muller A, Drapier N, Vankerckhoven V, Davey P, Goossens H; ESAC-3 hospital care subproject group.(Collaborators 34 including A.Antoniadou) Antifungal therapy in European hospitals: data from the ESAC point-prevalence surveys 2008 and 2009. Clin Microbiol Infect. 2012;18:E389-95 93. Theys K, Deforche K, Vercauteren J, Libin P, van de Vijver DA, Albert J, Asjö B, Balotta C, Bruckova M, Camacho RJ, Clotet B, Coughlan S, Grossman Z,Hamouda O, Horban A, Korn K, Kostrikis LG, Kücherer C, Nielsen C, Paraskevis D, Poljak M, Puchhammer-Stockl E, Riva 11 C, Ruiz L, Liitsola K, Schmit JC,Schuurman R, Sönnerborg A, Stanekova D, Stanojevic M, Struck D, Van Laethem K, Wensing AM, Boucher CA, Vandamme AM; SPREAD-programme. (Collaborators 231 including A.Antoniadou). Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients. Retrovirology. 2012;9:81. doi: 10.1186/1742-4690-9-8 94. Zetterberg E, Neuhaus J, Baker JV, Somboonwit C, Llibre JM, Palfreeman A, Chini M, Lundgren JD; INSIGHT SMART Study Group.(Collaborators 319 including A. Antoniadou). Platelet count kinetics following interruption of antiretroviral treatment. AIDS 2013; 27:59-68 95. Huang X, Lodi S, Fox Z, Li W, Phillips A, Porter K, Lutsar I, Kelleher A, Li N, Xu X, Wu H, Johnson AM; Beijing PRIMO cohort study; CASCADE Collaboration in EuroCoord. (Collaborators 157 including A.Antoniadou). Rate of CD4 decline and HIV-RNA change following HIV seroconversion in men who have sex with men: a comparison between the Beijing PRIMO and CASCADE cohorts. J Acquir Immune Defic Syndr. 2013; 62:441-446 96. Bjerk SM, Baker JV, Emery S, Neuhaus J, Angus B, Gordin FM, Pett SL, Stephan C, Kunisaki KM; INSIGHT SMART Study Group.(Collaborators 751 including A.Antoniadou). Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study. PLoS One. 2013;8(2):e56249 97. Davey RT Jr, Lynfield R, Dwyer DE, Losso MH, Cozzi-Lepri A, Wentworth D, Lane HC, Dewar R, Rupert A, Metcalf JA, Pett SL, Uyeki TM, Bruguera JM, AngusB,Cummins N, Lundgren J, Neaton JD; INSIGHT FLU 002 & 003 Study Groups.(Collaborators 228, including A.Antoniadou). The association between serum biomarkers and disease outcome in influenza A(H1N1)pdm09 virus infection: results of two international observational cohort studies. PLoS One. 2013;8(2):e57121 98. Frentz D, Wensing AM, Albert J, Paraskevis D, Abecasis AB, Hamouda O, Jørgensen LB, Kücherer C, Struck D, Schmit JC, Åsjö B, Balotta C, Beshkov D,Camacho RJ, Clotet B, Coughlan S, De Wit S, Griskevicius A, Grossman Z, Horban A, Kolupajeva T, Korn K, Kostrikis LG, Liitsola K, Linka M, Nielsen C, Otelea D,Paredes R, Poljak M, Puchhammer-Stöckl E, Sönnerborg A, Stanekova D, Stanojevic M, Vandamme AM, Boucher CA, Van de Vijver DA; SPREAD Programme.(Collaborators 237, including A.Antoniadou). Limited cross-border infections in patients newly diagnosed with HIV in Europe. Retrovirology. 2013;10:36 99. Saira K, Lin X, DePasse JV, Halpin R, Twaddle A, Stockwell T, Angus B, Cozzi-Lepri A, Delfino M, Dugan V, Dwyer DE, Freiberg M, Horban A, Losso M, Lynfield R, Wentworth DN, Holmes EC, Davey R, Wentworth DE, Ghedin E; INSIGHT FLU002 Study Group; INSIGHT FLU003 Study Group.(Collaborators 227, including A.Antoniadou). Sequence analysis of in vivo defective interfering-like RNA of influenza A H1N1 pandemic virus. J Virol. 2013 Jul;87(14):8064-74 100. Lodi S, Fisher M, Phillips A, De Luca A, Ghosn J, Malyuta R, Zangerle R, Moreno S, Vanhems P, Boufassa F, Guiguet M, Porter K; CASCADE Collaboration in EuroCoord.Collaborators (74) Kelleher T, Cooper D, Grey P, Finlayson R, Bloch M, Kelleher T, Ramacciotti T, Gelgor L, Cooper D, Smith D, Zangerle R, Gill J, Lutsar I, Chêne G, Dabis F, Thiebaut R, Masquelier B, Costagliola D, Guiguet M, Vanhems P, Chaix ML, Ghosn J, Meyer L, Boufassa F, Hamouda O, Kücherer C, Bartmeyer B, Antoniadou A, Chrysos G, Daikos GL, Touloumi G, Pantazis N, Katsarou O, Rezza G, Dorrucci M, d'Arminio Monforte A, De Luca A, Prins M, Geskus R, van der Helm J, Schuitemaker H, Sannes M, Brubakk O, Bakken Kran AM, Rosinska M, Muga R, Tor J, Garcia de Olalla P,Cayla J, del Amo J, Moreno S, Monge S, Del Amo J, del Romero J, Pérez-Hoyos S, Bucher 12 HC, Rickenbach M, Francioli P, Malyuta R, Murphy G,Sabin C, Porter K, Johnson A, Phillips A, Babiker A, Pillay D, Morrison C, Salata R, Mugerwa R, Chipato T, Amornkul PN, Gilmour J, Kamali A,Karita E. Symptomatic illness and low CD4 cell count at HIV seroconversion as markers of severe primary HIV infection. PLoS One. 2013;8(11):e78642. (Impact factor 3.73 Αναφορές:SCOPUS 0, ISI 0) 101. Borges AH, O'Connor JL, Phillips AN, Baker JV, Vjecha MJ, Losso MH, Klinker H, Lopardo G, Williams I, Lundgren JD; INSIGHT SMART Study Group; ESPRIT Study Group; SILCAAT Scientific Committee.(Collaborators 1350 including A.Antoniadou) Factors associated with Ddimer levels in HIV-infected individuals PLoS One. 2014 Mar 13;9(3):e90978. doi: 10.1371/journal.pone.0090978. eCollection 2014 13