Clinical Expert Series Diabetic Ketoacidosis in Pregnancy Baha M. Sibai, MD, and Oscar A. Viteri, MD Obstet Gynecol 2014;123(1) Continuing Medical Education credit is provided through joint sponsorship with The American College of Obstetricians and Gynecologists. ACCME Accreditation The American College of Obstetricians and Gynecologists (the College) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. AMA PRA Category 1 Credit(s)™ The American College of Obstetricians and Gynecologists designates this enduring material for a maximum of 2 AMA PRA Category 1 Credits.™ Physicians should claim only the credit commensurate with the extent of their participation in the activity. College Cognate Credit(s) The American College of Obstetricians and Gynecologists designates this enduring material for a maximum of 2 Category 1 College Cognate Credits. The College has a reciprocity agreement with the AMA that allows AMA PRA Category 1 Credits™ to be equivalent to College Cognate Credits. Disclosure Statement Current guidelines state that continuing medical education (CME) providers must ensure that CME activities are free from the control of any commercial interest. All authors, reviewers, and contributors have disclosed to the College all relevant financial relationships with any commercial interests. The authors, reviewers, and contributors declare that neither they nor any business associate nor any member of their immediate families has financial interest or other relationships with any manufacturer of products or any providers of services discussed in this program. Any conflicts have been resolved through group and outside review of all content. Submission Before submitting this form, please print a completed copy as confirmation of your program participation. College Fellows: To obtain credits, complete and return this form by e-mail (obgyn@greenjournal.org) or fax (202-479-0830). Your score, and a copy of the answer key, will be e-mailed to you after receipt of a completed quiz. Credit will be recorded for those participants answering 80–100% of questions correctly. Online transcripts will be updated twice monthly. College Fellows may check their transcripts online at http://www.acog.org. Please direct questions to the Obstetrics & Gynecology Editorial Office, 202-314-2317 (phone) or obgyn@greenjournal.org (e-mail). Non–College Fellows: To obtain credits, submit the printout of the completed quiz to your accrediting institution. The printout of the completed quiz is documentation for your continuing medical education credits. Continuing medical education credit for “Diabetic Ketoacidosis in Pregnancy” will be available through January 2017. 1. Ketoacidosis during pregnancy differs from that seen in nonpregnant patients by virtue of it being: Slower in progression of symptoms Found at lower glucose levels Associated with lower morbidity rates Associated with renal failure Treatable as an outpatient CME Quiz for the Clinical Expert Series Obstet Gynecol 2014;123(1) Credit available through January 2017 Page 1 of 3 2. Potential precipitating factors for ketoacidosis during pregnancy include: Insulin overdose Steroid administration for fetal lung maturation Minimal or any alcohol consumption Multiparity Use of oral hypoglycemic agents 3. Initial correction of hyperglycemia during an acute episode of diabetic ketoacidosis in pregnancy is best achieved with: Intravenous NPH insulin Intravenous Lantus insulin Intravenous regular insulin Subcutaneous regular insulin Oral metformin 4. The pregnancy-related hormone most closely associated with reduced cellular sensitivity to insulin is: Human chorionic gonadotropin (HCG) Human placental lactogen (HPL) Progesterone Insulin-like growth factor Human growth hormone (HGH) 5. During maternal diabetic ketoacidosis, fetal arrhythmias are thought to occur because of: Decreased oxygen release from the red blood cells Hypokalemia Respiratory alkalosis Fetal hypervolemia Hypophosphatemia 6. The administration of corticosteroids for fetal lung maturation will result in acute elevations in serum glucose that can last up to: 6 hours 12 hours 24 hours 3 days 5 days CME Quiz for the Clinical Expert Series Obstet Gynecol 2014;123(1) Credit available through January 2017 Page 2 of 3 7. The most important factor in correctly diagnosing diabetic ketoacidosis in pregnancy is: Frequent blood glucose measurements A high level of suspicion Level of maternal hemoglobin A1c Presence of urinary ketone bodies Urine osmolality 8. Initial fluid replacement for a pregnant patient with diabetic ketoacidosis should be approximately: 1 mL/kg of body weight 10 mL/kg of body weight 100 mL/kg of body weight 1 L/kg of body weight 2 L/kg of body weight 9. During the fluid resuscitation of a pregnant diabetic patient with ketoacidosis, it is appropriate to use intravenous solutions containing 5% glucose after the patient’s serum glucose is below: 50 mg/dL 100 mg/dL 150 mg/dL 250 mg/dL 350 mg/dL 10. Most complications from diabetic ketoacidosis in pregnancy result from: Prematurity Inadequate fluid management Insulin overuse Maternal age Hypophosphatemia College ID Number: Name: Address: City/State/Zip: E-mail Address: Actual time spent completing this activity (you may record up to 2 hours): CME Quiz for the Clinical Expert Series Obstet Gynecol 2014;123(1) Credit available through January 2017 Page 3 of 3