Blending Theory – People believed that offspring were a blending of the two parent’s genetic material. Gregor Mendel (1865) – An Austrian Monk disproved this theory by performing experiments on pea plants. He found that when you mixed a pure breeding tall plant with a pure breeding short plant, all the offspring were tall plants. Then when he crossbred the first generation, he found that he got tall plants and short plants in a 3:1 ratio. Mendel suggested that the traits were contained in gene pairs called Alleles. In breeding, each parent would contribute 1 allele. Usually, there was a dominant allele for one trait and a recessive allele for the alternative trait. Codominance – Mendel also noticed that in some species of flowers, the alleles shared their dominance, rather than one dominating the other. Vocabulary Allele: One alternative of a pair or group of genes (TT or Tt) Dominant: An allele producing the same phenotypic effect whether inherited heterozygously or homozygously; an allele that "masks" a recessive allele. Gene: A unit of genetic information that occupies a specific position on a chromosome and comes in multiple versions called alleles. Genotype: The genetic constitution of an organism. Heterozygous: Having a genotype with two different and distinct alleles for the same trait. Homozygous: Having a genotype with two of the same alleles for a trait. Phenotype: The physical or observable characteristics of an organism. Recessive: An allele producing no phenotypic effect when inherited heterozygously and only affecting the phenotype when inherited homozygously; an allele "masked" by a dominant allele. Problem #1 The ability to roll the tongue is dominant over the inability to do so in humans. 1. If two heterozygous tongue-rollers have children, what genotypes could their children have? 2. If a non-tongue-roller has children with a homozygous tongue-roller, what will their children's genotypes be? Problem #1: Basic Monohybrid Cross The ability to roll the tongue is dominant over the inability to do so in humans. (A) If two heterozygous tongue-rollers have children, what genotypes could their children have? Using T=tongue-rolling and t=non-tongue-rolling, the genotypes and ratios are - 1 TT : 2 Tt : 1 tt. See Punnett square below. T t T TT Tongue-roller Tt Tongue-roller t Tt tt Tongue-roller Non-tongue-roller (B) If a non-tongue-roller has children with a homozygous tongue-roller, what will their children's genotypes be? All the children will be tongue-rollers. See Punnett square below. T T t Tt Tt Tongue-roller Tongue-roller t Tt Tt Tongue-roller Tongue-roller Problem #2 In an alien species, eye colors can be black, white, or gray. A white-eyed mother and a black-eyed father have all gray-eyed children. 1. What genetic pattern is most likely demonstrated here? 2. A gray-eyed couple has two babies: one white-eyed and one black-eyed. Does this confirm or deny your answer to part A? If necessary, revise your hypothesis. 3. A gray-eyed alien and her black-eyed husband want a white-eyed baby. Is this possible? Problem #2 In an alien species, eye colors can be black, white, or gray. A white-eyed mother and a black-eyed father have all gray-eyed children. (A) What genetic pattern is most likely demonstrated here? The genetic pattern most likely demonstrated in this example is that of codominance, or incomplete dominance. (B) A gray-eyed couple has two babies: one white-eyed and one black-eyed. Does this confirm or deny your answer to part A? If necessary, revise your hypothesis. This new evidence confirms the hypothesis of incomplete dominance. See Punnett square below (W=black eyes, w=white eyes). W w W WW Ww Black eyes Gray eyes w Ww ww Gray eyes White eyes (C) A gray-eyed alien and her black-eyed husband want a white-eyed baby. Is this possible? This is not possible. See Punnett square below (W=black eyes, w=white eyes). W w W WW Ww Black eyes Gray eyes W WW Ww Black eyes Gray eyes Problem #3 A mother has blood type A and genotype AO. A father has blood type B and genotype BO. What blood types are possible for the offspring? Problem #3 A mother has blood type A and genotype AO. A father has blood type B and genotype BO. What blood types are possible for the offspring? The genotypes AO (type A blood), BO, (type B blood), AB (type AB blood), and OO (type O blood) are all possible. See Punnett square below. A O B AB BO Type AB Type B O AO OO Type A Type O Problem #4 Pattern baldness is sex-linked, but cannot be expressed normally in females. 1. If a carrier female marries a pattern-bald man, what are the possible genotypes of their children? 2. If female is homozygous for pattern baldness (but does not express the trait due to hormones), and she marries a normal man, what percentage of her sons will be pattern-bald? Problem #4 Pattern baldness is sex-linked, but cannot be expressed normally in females. (A) If a carrier female marries a pattern-bald man, what are the possible genotypes of their children? Using XB as bald and X as normal, the genotypes possible are: XBXB, XXB, XBY, XY. XB XB Y X XBXB XXB Affected female Carrier female (not expressed) XBY Affected male XY Normal male (B) If female is homozygous for pattern baldness (but does not express the trait due to hormones), and she marries a normal man, what percentage of her sons will be patternbald? Using XB as bald and X as normal, the genotypes possible are: XBX, XXB, XBY, XBY. Therefore her sons will all be pattern-bald. XB XB X XBX XBX Carrier female Carrier female Y XBY XBY Affected male Affected male