Date of Preparation: December 30, 2015
Joan C. Han, MD
CURRICULUM VITAE
EDUCATION:
Harvard College (9/1991-6/1995), AB, Magna cum Laude in Biochemical Sciences, 1995
Harvard Medical School (9/1995-6/1999), MD, 1999
Boston Combined Residency Program in Pediatrics at Boston Children’s Hospital and Boston
Medical Center, Boston, MA (Internship 7/1999-6/2000, Residency 7/2000-6/2002)
Clinical Research Fellowship, Division of Endocrinology, Nemours Children’s Clinic,
Jacksonville, FL (7/2003-6/2004)
Pediatric Endocrinology Fellowship, National Institutes of Health, Bethesda, MD (7/20046/2007)
HONORS/AWARDS:
2014 Mentor of Kristina Decker (graduate student), Winner of Prader-Willi SyndromeAssociation (USA) Travel Award for Trainees and Junior Faculty
2014 Mentor of Daniela Reyes-Capo (medical student), Winner of Outstanding Poster Award,
NIH Postbac Poster Day: Endocrine and Metabolic Characterization of Alström Syndrome
2012 Mentor of Alyson Hanish (graduate student), Winner of Endocrine Society Presidential
Poster Competition: Pineal Hypoplasia and Decreased Melatonin Secretion in Patients with
PAX6 Haploinsufficiency due to WAGR Syndrome or PAX6 Mutations
2012 Endocrine Society Travel Award (for early career investigators and junior faculty)
2011 NIH Clinical Center Bench-to-Bedside Award (Principal Investigator): Amitriptyline for
the Treatment of BDNF Haploinsufficiency
2010 NIH Merit Award: In recognition of outstanding contributions to clinical patient care and
research on growth, metabolism, obesity, and rare genetic diseases associated with
disordered energy homeostasis
2010 Rare Diseases Clinical Research Network Travel Award for the 2nd Conference on Clinical
Research for Rare Diseases
2010 The 5th International Congress of the Growth Hormone Research Society and the InsulinLike Growth Factor Society Travel Grant Award
2010 Foundation for Prader-Willi Research Grant (Co-Investigator): The Relationship between
Serum Brain-Derived Neurotrophic Factor (BDNF) Levels, BDNF Haplotypes and
Neurocognitive Performance in Children with Prader-Willi Syndrome (PWS)
2010 NICHD Intramural Bench-to-Bedside Award (Principal Investigator): The Role of BDNF
in Autism Spectrum Disorder and Cognitive Function
Joan C. Han, MD
2010 Prader-Willi Syndrome Association (USA) Best Idea Grant for Hyperphagia Research
(Principal Investigator): Brain-Derived Neurotrophic Factor in Prader-Willi Syndrome and
MC4R Function-Altering Mutations
2009 NIH Clinical Center Bench-to-Bedside Award (Co-Investigator): FTO and Eating in
Absence of Hunger
2009 Nominee, Rare Disease Day Research Hall of Fame, National Organization for Rare
Disorders
2008 Mentor of Kavitha Anandalingam (high school student), Intel Science Talent Search SemiFinalist: Associations between FTO genotype and eating behavior phenotype in children
2008 NIH Fellows Award for Research Excellence
2007 NIH Fellows Award for Research Excellence
2007 Ethan Sims Obesity Society Young Investigator Award
2007 NIH Clinical Center Bench-to-Bedside Award (Principal Investigator): WAGR
Syndrome-Clinical Characterization and Correlation with Genotype
2007 Genentech Clinical Fellows Travel Grant to Endocrine Society Meeting
2007 Pediatric Academic Societies Young Investigator Travel Award
2007 Lawson Wilkins Pediatric Endocrine Society Travel Grant Award
2006 Endocrine Society Travel Grant Award
2006 Lawson Wilkins Pediatric Endocrine Society Travel Grant Award
2005 Lawson Wilkins Pediatric Endocrine Society Travel Grant Award
2004 Genentech Clinical Fellows Travel Grant to Endocrine Society Meeting
1994 Phi Beta Kappa
1994 John Harvard Scholarship
1994 Elizabeth Cary Agassiz Scholarship
1993 John Harvard Scholarship
1993 Elizabeth Cary Agassiz Scholarship
1992 John Harvard Scholarship
1992 Elizabeth Cary Agassiz Scholarship
1992 Detur Book Prize
1991 National Science Scholar
UNIFORMED SERVICE:
Commissioned Officer in the United States Public Health Service (9/20/2004-12/19/2010),
attained rank of O-5 (Commander) prior to honorable release from active duty
BOARD CERTIFICATION:
General Pediatrics (10/15/2002-Current)
Pediatric Endocrinology (11/19/2007-Current)
American Board of Obesity Medicine (12/31/2013-Current)
LICENSURE:
Medical Doctor, Tennessee, MD0000050763, issued 10/30/2013, active
Medical Doctor, Florida, ME84327, issued 2/23/2002, retired
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Joan C. Han, MD
SOCIETY MEMBERSHIPS:
Since 2012
Since 2007
Since 2006
Since 2005
Since 2004
Since 1999
Since 1996
Since 1995
Society for Pediatric Research
American Society of Human Genetics
Obesity Society
Pediatric Endocrine Society
Endocrine Society
American Academy of Pediatrics
American Medical Association
Massachusetts Medical Society
UNIVERSITY/INSTITUTE APPOINTMENTS:
Associate Professor, University of Tennessee Health Science Center, Memphis (7/2014-Current)
Director, Pediatric Obesity Program, UT/Le Bonheur Children’s Hospital, Memphis (1/2014Current)
Clinical Associate Professor, University of Tennessee Health Science Center, Memphis (1-6/2014)
Assistant Clinical Investigator, National Institutes of Health, Bethesda, MD (7/2009-6/2014)
Senior Clinical Fellow, National Institutes of Health, Bethesda, MD (7/2007-6/2009)
Assistant Professor of Pediatrics, University of Florida, Jacksonville, FL (7/2002-6/2003)
HOSPITAL CLINICAL APPOINTMENTS:
Le Bonheur Children’s Hospital, Memphis, TN: Attending Physician, 8/2014-Current, active
National Institutes of Health Clinical Research Center, Bethesda, MD: Attending Physician,
7/2004-7/2014, inactive
Shands Jacksonville Medical Center, Jacksonville, FL: Attending Physician, 7/2002-6/2003,
inactive
TEACHING EXPERIENCE:
Lecturer, National Institute of Child Health and Human Development Post-baccalaureate Fellow
Course: Becoming an Effective Scientist (1 hour/year, 2006-2012)
Attending Physician, National Institutes of Health Pediatric Endocrinology Fellowship Program (5
hours/week teaching/supervising fellows and residents, 2007-2014)
Attending Physician, University of Tennessee Health Science Center (4 hours/week
teaching/supervising fellows and residents, 2014-Current)
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Joan C. Han, MD
INVITED LECTURES:
Digestive Disease Week, American Gastroenterological Association, San Diego, CA, May 2016:
Impact of Genetics on Pathogenesis and Response to Treatment in Pediatric Obesity
13th International Neurotrophin Conference, Monterey, CA, April 2016: Neurotrophins and
Disease
6th Annual Sanford Rare Disease Symposium, Sanford Research, Sioux Falls, SD, February 2016:
Rare Genetic Obesity Disorders: Insights for Energy Balance in the General Population
14th Annual Symposium on Pediatric Diabetes and Endocrinology, Icahn School of Medicine at
Mount Sinai, New York, NY, November 2015: Genetics of Obesity
nd
2 Annual UTHSC Pediatric Obstructive Sleep Apnea Symposium, Memphis, TN, April 2015:
Pediatric Obesity and Obstructive Sleep Apnea
UTHSC Neuroscience Symposium on the Neurobiology of Appetite, Memphis TN, April 2015:
Brain-Derived Neurotrophic Factor and Obesity
West Tennessee Psychiatric Association Meeting, Memphis TN, March 2015:
Pediatric Obesity and Psychotropic Medications
th
11 Annual Mid-South Conference on the Complex Newborn, Memphis, TN, January 2015:
Measuring Body Composition of Babies
UTHSC Medical Student Pediatric Interest Group, Memphis, TN, December 2015:
Pediatric Obesity
University of Tennessee Family Medicine Residency Program Conference at Jackson-Madison
County General Hospital, Jackson, TN, October 2014: Pediatric Obesity
Pediatric Grand Rounds, Le Bonheur Children’s Hospital, Memphis, TN, September 2014:
Pediatric Obesity
16th International Congress of Endocrinology & The Endocrine Society’s 96th Annual Meeting &
Expo, Chicago, IL, June 2014: Brain Derived Neurotrophic Factor (BDNF) in Rare and
Common Forms of Pediatric Obesity at the Symposium on Pediatric Obesity: New
Peptides and Pathways
UTHSC Endocrinology Grand Rounds, Memphis, TN, March 2014:
Brain-Derived Neurotrophic Factor in Obesity and Neurocognitive Function
NICHD Exchange: Healthy Lifestyles Symposium, Bethesda, MD, February 2014:
Prevention and Treatment of Obesity
Aniridia Foundation International and University of Virginia Scientific Symposium,
Charlottesville, VA, August 2013: Hormones and Metabolism in PAX6 Haploinsufficiency
Department of Neuroscience Research Meeting, Mayo Clinic, Jacksonville, FL, January 2013:
Brain-Derived Neurotrophic Factor in Obesity and Neurocognitive Function
Division of Endocrinology, Diabetes, and Nutrition Grand Rounds, University of Maryland
School of Medicine, Baltimore, MD, July 2012: Brain-Derived Neurotrophic Factor and
Obesity
International WAGR Syndrome Association Meeting, Gaithersburg, MD, July 2012: PhenotypeGenotype Correlation in WAGR Syndrome
Eighth Annual NICHD Fellows Retreat, National Zoo Conference Center, Washington DC, May
2012: Brain-Derived Neurotrophic Factor in Obesity and Neurocognitive Function
Rare Syndromic Body Fat Disorders Workshop, NIDDK and Office of Rare Diseases Research,
NIH, Bethesda, MD, February 2012: Brain-Derived Neurotrophic Factor in WAGR
Syndrome and Non-Syndromic Obesity
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Joan C. Han, MD
Toward a Clinical Definition of Leptin Resistance Workshop, NIDDK, Bethesda, MD, February
2011: Does hyperleptinemia serve as an indicator of leptin resistance in humans with leptin
signaling defects?
Rare Disease Day at NIH, Bethesda, MD, February 2011: WAGR Syndrome: Clinical
Characterization and Correlation with Genotype
Research Conference for the Obesity and Diabetes Clinical Research Section, NIDDK, Phoenix,
AZ, January 2011: Brain-Derived Neurotrophic Factor and Human Energy Homeostasis
The Obesity Society Annual Scientific Meeting, San Diego, CA, October 2010: Brain-Derived
Neurotrophic Factor and Obesity in the WAGR Syndrome
Foundation for Prader-Willi Research Annual Meeting, Bethesda, MD, September 2010: BrainDerived Neurotrophic Factor and Prader-Willi Syndrome
International WAGR Syndrome Association Meeting, Gaithersburg, MD, July 2010: Autism and
Cognitive Function in WAGR Syndrome
Obesity in Children with Developmental and/or Physical Disabilities Workshop, NICHD,
Bethesda, MD, July 2010: Overview of Childhood Obesity
Alström Syndrome International Conference, Helen, GA, June 2010: Hyperphagia and Food
Management Issues
Uniformed Services University Research Symposium, Bethesda, MD, May 2010: Association
between Variants in the FTO Gene and Loss of Control over Eating
International WAGR Syndrome Association Meeting, Gaithersburg, July 2009: Impaired Pain
Perception and Short Stature in WAGR Syndrome
International Conference on Hyperphagia, Prader-Willi Syndrome Association (USA), Baltimore,
MD, June 2009: Hyperphagia and Obesity in WAGR Syndrome
International WAGR Syndrome Association Meeting, Vienna, VA, July 2007: BDNF and Obesity
in WAGR Syndrome
International WAGR Syndrome Association Meeting, Yardley, PA, July 2006: NIH WAGR
Syndrome Research Study
COMMITTEES:
Service to Institution:
2012-2014
NICHD Representative, NIH Clinical Center Pediatric Care Committee
2010-2014
NIH Clinical Research Information System Quality Review Committee
2005-2006
NICHD Clinical Fellows Representative, NIH Fellows Committee
2005-2006
Member, NIH Fellows Career Development Committee
Medical Advisory Board:
2012-Current International WAGR Syndrome Association
Conference Organization:
Member, Organizing Committee, 2nd International Conference on Hyperphagia, Pennington
Biomedical Research Center, Baton Rouge LA, October 17-21, 2012
PROFESSIONAL ACTIVITIES:
Associate Editor for Journal
Since 2015
Pediatric Associate Editor for the International Journal of Obesity
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Joan C. Han, MD
Review Editor for Journal
Since 2015
Frontiers in Endocrinology - Structural and Molecular Endocrinology
Ad Hoc Reviewer for Journals:
Since 2014
Annals of Clinical Biochemistry
Since 2012
Gene
Since 2012
Pediatric Diabetes
Since 2011
British Journal of Nutrition
Since 2010
American Journal of Medical Genetics: Part A
Since 2010
American Journal of Physiology - Regulatory, Integrative and Comparative
Physiology
Since 2010
European Journal of Human Genetics
Since 2010
International Journal of Obesity
Since 2009
Journal of Clinical Endocrinology and Metabolism
Since 2008
Journal of Pediatrics
Since 2008
Pediatrics
Reviewer for Abstracts:
Since 2014
Endocrine Society
Since 2014
Digestive Disease Week
Since 2011
Pediatric Academic Societies
Reviewer for Grant Proposals:
Since 2013
Foundation for Prader-Willi Research
Since 2012
Great Ormond Street Hospital Children's Charity
Since 2011
Pediatric Endocrine Society
Since 2010
Action Medical Research, UK
Symposium Chair
Chair, Symposium on Preventing and Reversing Obesity in Minority Children at the 98th Annual
Meeting of the Endocrine Society, Boston, MA, April 2016
Chair, University of Tennessee Health Science Center James H. Horner, MD Distinguished
Visiting Professorship, Obesity Prevention and Treatment Symposium, Memphis, TN
September 2015
Chair, Obesity Symposium-New Insights on Epidemiology, Investigational Models, and
Therapeutic Targets, 26th Annual NIH Research Festival, Bethesda, MD, October 2012
GRADUATE STUDENT AND JUNIOR FACULTY MENTORING:
Graduate Student Mentor:
Alyson Hanish, PhD, University of Iowa and National Institute of Nursing Research
Graduate Partnership Program (8/2011-1/2015), Sleep-Related Phenotypes:
Adolescence and PAX6 Haploinsuffiency; currently Postdoctoral Research
Associate at the University of Nebraska Medical Center
Postdoctoral Fellow Mentor:
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Joan C. Han, MD
Liam McAllan, PhD (from Teagasc Food Research Center & University College Cork,
Ireland), Postdoctoral Fellow, Department of Pediatrics, University of Tennessee
Health Science Center, 4/2015 to present
Graduate Student Thesis Committee Member:
Innocence Harvey, PhD candidate, Department of Physiology, University of Tennessee
Health Science Center, 9/2014 to present
Junior Faculty Research Mentoring Committee Member:
Rebecca Krukowski, PhD, Assistant Professor, Department of Preventive Medicine,
University of Tennessee Health Science Center, 2/2015 to present
RESEARCH SUPPORT:
Memphis Research Consortium
$1,000,000
7/1/14-6/30/17
PI: J Han
“Genetic, Behavioral, and Environmental Determinants of Metabolic Health”
Childhood Brain Tumor Foundation
$35,000
10/1/12-9/30/14
Co-PIs: P Wolters and K Warren; Co-Investigator: J Han
"A Randomized Controlled Trial Evaluating a Physical Activity Intervention to Improve
Cognitive Late Effects in Children with Brain Tumors Treated with Cranial Radiation"
NIH Bench-to-Bedside Research Award
$270,000
10/1/10-9/30/12
Co-PIs: J Han, B Martin, S Maudsley
“Amitriptyline for the Treatment of BDNF Haploinsufficiency”
Prader-Willi Syndrome Association USA
$50,000
7/1/10-6/30/12
Co-PIs: J Han and J Yanovski
“Brain-Derived Neurotrophic Factor in Prader-Willi Syndrome and MC4R FunctionAltering Mutations”
Foundation for Prader-Willi Research Grant
$50,000
6/1/10-5/31/12
PI: A Haqq; Co-Investigator: J Han
“The Relationship between Serum Brain-Derived Neurotrophic Factor (BDNF) Levels,
BDNF Haplotypes and Neurocognitive Performance in Children with Prader-Willi
Syndrome (PWS)”
NICHD Bench-to-Bedside Research Award
$100,000
10/1/09-9/30/11
Co-PIs: J Han and K. Martinowich
“The Role of BDNF in Autism Spectrum Disorder and Cognitive Function”
NIH Bench-to-Bedside Research Award
$270,000
10/1/08-9/30/10
Co-PIs: J Yanovski and M Tanofsky-Kraff; Co-Investigator: J Han
“FTO and Eating in Absence of Hunger”
NIH Bench-to-Bedside Research Award
$200,000
10/1/06-9/30/08
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Joan C. Han, MD
Co-PIs: J Han, B Lu
“WAGR Syndrome: Clinical Characterization and Correlation with Genotype”
BOOK CHAPTERS:
1) Han JC, Yanovski JA. Chapter 21: Intensive Therapies for the Treatment of Pediatric
Obesity. In Jelalian E, Steele RG, eds. Handbook of Child and Adolescent Obesity. New
York, NY: Springer Science + Business Media, LLC (2008).
2) Han JC. Rare Syndromes and Common Variants of the Brain-Derived Neurotrophic Factor
Gene in Human Obesity. In Tao YX, ed. Progress in Molecular Biology and Translational
Science, Volume 140: Genetics of Monogenic and Syndromic Obesity. New York, NY:
Elsevier B.V. (2016).
PEER-REVIEWED JOURNAL ARTICLES:
1) Chu TC, Ogidigben M, Han JC, Potter DE. Allicin-induced hypotension in rabbit eyes. J
Ocul Pharmacol 1993;9(3):201-9. PMID: 8228529
2) Han J, Lawson L, Chu TC, Potter D, Han G, Han P. Modification of catalytic properties of
chicken liver fructose 1,6-bisphosphatase by allicin. Biochem Mol Biol Int 1993;31(6):100715. PMID: 8193584
3) Han JC, Han GY. A procedure for quantitative determination of tris(2carboxyethyl)phosphine, an odorless reducing agent more stable and effective than
dithiothreitol. Anal Biochem 1994;220(1):5-10. PMID: 7978256
4) Han J, Lawson L, Han G, Han P. A spectrophotometric method for quantitative
determination of allicin and total garlic thiosulfinates. Anal Biochem 1995;225(1):157-60.
PMID: 7778769
5) Chu TC, Burch JL, de Paula Brotto MA, Creazzo TL, Han J, Han GY, Potter, DE. Elevation
of intracellular Ca2+ concentration in rabbit nonpigmented ciliary epithelial cells by allicin.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1996;115(1):89-94. PMID:
8983172
6) Han J, Payne V, Yen S, Han G, Han P. Use of tris(2-carboxyethyl)phosphine for quantitation
of iodine and iodate. Anal Biochem 1996;242(1):150-2. PMID: 8923979
7) Han J, Yen S, Han G, Han P. Quantitation of hydrogen peroxide using tris(2carboxyethyl)phosphine. Anal Biochem 1996;234(1):107-9. PMID: 8742092
8) Han J, Chu T-C, Han G, Browne J, Brown I, Han P. Spectrophotometric assay for
hypochlorite/hypochlorous acid using tris(2-carboxyethyl)phosphine. Microchemical Journal
1998;58(2):218-24. http://dx.doi.org/10.1006/mchj.1997.1542
9) Han J, Clark C, Han G, Chu TC, Han P. Preparation of 2-nitro-5-thiobenzoic acid using
immobilized Tris(2-carboxyethyl)phosphine. Anal Biochem 1999;268(2):404-7. PMID:
10075833
10) Han J, Story T, Han G. A Spectrophotometric Method for Quantitative Determination of
Bromine Using Tris(2-carboxyethyl)phosphine. Journal of Chemical Education
1999;76(7):976-7. http://pubs.acs.org/doi/pdfplus/10.1021/ed076p976
11) Han JC, Balagopal P, Sweeten S, Darmaun D, Mauras N. Evidence for Hypermetabolism in
Boys with Constitutional Delay of Growth and Maturation. J Clin Endocrinol Metab
2006;91(6):2081-6. PMID: 16551727
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Joan C. Han, MD
12) Gray J, Yeo GS, Cox JJ, Keogh JM, Morton J, Adlam AR, Yanovski JA, El Gharbawy A,
Han JC, Tung YC, Hodges JR, Raymond FL, O’ Rahilly S, Farooqi IS. Hyperphagia, severe
obesity, impaired cognitive function and hyperactivity associated with functional loss of one
copy of the BDNF gene. Diabetes 2006;55(12):3366-71. PMCID: PMC2413291
13) Fleisch AF, Agarwal N, Roberts MD, Han JC, Theim KR, Vexler A, Troendle J, Yanovski
SZ, Yanovski JA. Influence of Serum Leptin on Weight and Body Fat Growth in Children at
High Risk for Adult Obesity. J Clin Endocrinol Metab 2007;92(3):948-54. PMCID:
PMC1862865
14) Drinkard B, Roberts MD, Ranzenhofer LM, Han JC, Yanoff LB, Merke DP, Savastano DM,
Brady S, Yanovski JA.Oxygen-Uptake Efficiency Slope as a Determinant of Fitness in
Overweight Adolescents. Med Sci Sports Exerc 2007;39(10):1811-6. PMCID: PMC2266873
15) Olney RC, Prickett TC, Yandle TG, Espiner EA, Han JC, Mauras N. Amino-Terminal
Propeptide of C-Type Natriuretic Peptide (NTproCNP) and Linear Growth in Children:
Effects of Puberty, Testosterone and Growth Hormone. J Clin Endocrinol Metab
2007;92(11):4294-8. PMID: 17684048
16) Han JC, Rutledge MS, Kozlosky M, Salaita CG, Gustafson JK, Keil MF, Fleisch AF,
Roberts MD, Ning C, Yanovski JA. Insulin Resistance, Hyperinsulinemia, and Energy Intake
in Overweight Children. J Pediatr 2008;152(5):612-7. PMCID: PMC2276579
17) Han JC, Liu QR, Jones M, Levinn RL, Menzie CM, Jefferson-George KS, Adler-Wailes DC,
Sanford EL, Lacbawan FL, Uhl GR, Rennert OM, Yanovski JA. Brain-Derived Neurotrophic
Factor and Obesity in the WAGR Syndrome. N Engl J Med 2008;359(9):918-27. PMCID:
PMC2553704
18) Xu S, Han JC, Morales A, Menzie CM, Williams K, Fan YS. Characterization of 11p12-14
deletion in WAGR syndrome by array CGH for identifying genes contributing to mental
retardation and autism. Cytogenet and Genome Res 2008;122(2):181-7; erratum in: Cytogenet
Genome Res. 2009;124(1):112. PMID: 19096215
19) Roberts MD, Drinkard B, Ranzenhofer LM, Salaita CG, Sebring NG, Brady SM, Pinchbeck
C, Hoehl J, Yanoff LB, Savastano DM, Han JC, Yanovski JA. Prediction of maximal oxygen
uptake by bioelectrical impedance analysis in overweight adolescents. J Sports Med Phys
Fitness. 2009;49(3):240-5. PMCID: PMC3027125
20) Savastano DM, Tanofsky-Kraff M, Han JC, Ning C, Sorg RA, Roza CA, Wolkoff LE,
Anandalingam K, Jefferson-George KS, Figueroa RE, Sanford EL, Brady S, Kozlosky,
Schoeller DA, Yanovski JA. Energy Intake and Energy Expenditure among Children with
Polymorphisms of the Melanocortin-3 Receptor. Am J Clin Nutr 2009;90(4):912-20.
PMCID: PMC2744620
21) Solomon BD, Pineda-Alvarez DE, Balog JZ, Hadley D, Gropman AL, Nandagopal R, Han
JC, Hahn JS, Blain D, Brooks B, Muenke M. Compound heterozygosity for mutations in
PAX6 in a patient with complex brain anomaly, neonatal diabetes mellitus, and
microophthalmia. Am J Med Genet A. 2009 Nov;149A(11):2543-6. PMCID: PMC2783496
22) Tanofsky-Kraff M*, Han JC*, Anandalingam K, Shomaker LB, Columbo KM, Wolkoff LE,
Kozlosky M, Elliott C, Ranzenhofer LM, Roza CA, Yanovski SZ, Yanovski JA. The FTO
Gene rs9939609 Obesity Risk Allele and Loss of Control over Eating. Am J Clin Nutr
2009;90:1483–8. (*these authors contributed equally) PMCID: PMC2777464
23) Gustafson JK, Yanoff LB, Easter BD, Brady SM, Keil MF, Roberts MD, Sebring NG, Han
JC, Yanovski SZ, Hubbard VS, Yanovski JA. The stability of metabolic syndrome in children
and adolescents. J Clin Endocrinol Metab 2009;94:4828-34. PMCID: PMC2795665
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Joan C. Han, MD
24) Van den Berg L, Delemarre-van de Waal H, Han JC, Ylstra B, Eijk P, Nesterova M, Heutink
P, Stratakis CA. Investigation of a Patient with a Partial Trisomy 16q including the Fat mass
and Obesity Associated gene (FTO): Fine Mapping and FTO Gene Expression Study. Am J
Med Genet A 2010;152A(3):630-7. PMCID: PMC3031344
25) Han JC, Lawlor DA, Kimm SY. Childhood Obesity. Lancet 2010; 375: 1737–48. PMCID:
PMC3073855
26) Han JC, Muehlbauer MJ, Cui HN, Newgard CB, Haqq AM. Lower Brain-Derived
Neurotrophic Factor (BDNF) in Patients with Prader-Willi Syndrome (PWS) Compared to
Obese and Lean Control Subjects. J Clin Endocrinol Metab 2010;95(7):3532-6. PMCID:
PMC2928902
27) Shomaker LB, Tanofsky-Kraff M, Young-Hyman D, Han JC, Yanoff LB, Brady SM,
Yanovski SZ, Yanovski JA. Psychological Symptoms and Insulin Sensitivity in Adolescents.
Pediatr Diabetes 2010;11:417-23. PMCID: PMC2942090
28) Han JC, Damaso L, Welch S, Balagopal P, Hossain J, Mauras N. Effects of Growth Hormone
and Nutritional Therapy in Boys with Constitutional Growth Delay: A Randomized
Controlled Trial. J Pediatr 2011;158:427-32. PMID: 20961566
29) Feuillan PP*, Ng D†, Han JC†, Sapp JC, Wetsch K, Spaulding E, Zheng YC, Caruso RC,
Brooks B, Johnston JJ, Yanovski JA, Biesecker LG. Leptin Resistance in Patients with
Bardet-Biedl Syndrome. J Clin Endocrinol Metab 2011; 96(3):E528-35 (*submitted
posthumously in her honor; †these authors contributed equally). PMCID: PMC2928902
30) Olney RC, Permuy JW, Prickett TC, Han JC, Espiner EA. Amino-terminal propeptide of Ctype natriuretic peptide (NTproCNP) predicts height velocity in healthy children. Clin
Endocrinol (Oxf) 2012;77(3):416-22). PMCID:PMC3466812
31) Drgonova J, Jacobsson JA, Han JC, Yanovski JA, Fredriksson R, Marcus C, Schiöth HB,
Uhl GR. Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesityrelated phenotypes. PLoS One 2013; 8(9):e68245. PMCID: PMC3762852.
32) Sherafat-Kazemzadeh R, Ivey L, Kahn SR, Sapp JC, Hicks MD, Kim RC, Krause AJ,
Shomaker LB, Biesecker LG, Han JC, Yanovski JA. Hyperphagia among patients with
Bardet-Biedl syndrome. Pediatr Obes 2013; 8(5):E64-7. PMID: 23776152
33) Stofanko M, Han JC, Sarah H. Elsea SH, Pena HB, Gonçalves-Dornelas H, Pena SDJ. Rapid
and inexpensive screening of genomic copy number variations using a novel quantitative
fluorescent PCR method. Disease Markers 2013; 35(6):589-94. PMCID: PMC3830787.
34) Han JC, Thurm A, Williams CG, Joseph LA, Zein WM, Brooks BP, Butman JA, Brady SM,
Fuhr SR, Hicks MD, Huey AE, Hanish AE, Danley KM, Raygada MJ, Rennert OM,
Martinowich K, Sharp SJ, Tsao JW, Swedo SE. Association of brain-derived neurotrophic
factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive
functioning in WAGR/11p13 deletion syndrome. Cortex 2013; 49(10):2700-10. PMCID:
PMC3762943
35) Gill R, Cheung YH, Shen Y, Lanzano P, Mirza NM, Ten S, Maclaren NK, Motaghedi R, Han
JC, Yanovski JA, Leibel RL, Chung WK. Whole-exome sequencing identifies novel LEPR
mutations in individuals with severe early onset obesity. Obesity 2014; 22(2):576-84.
PMCID: PMC3791145
36) Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll
DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC,
Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M,
Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: Current
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Joan C. Han, MD
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Concepts and Future Directions - Proceedings of the 2nd International Conference on
Hyperphagia. Obesity 2014; 22:S1-S17. PMID: 24574081.
Hohenadel MG, Thearle MS, Grice BA, Huang H, Dai MH, Tao YX, Hunter LA, Palaguachi
GI, Mou Z, Kim RC, Tsang MM, Haack K, Voruganti VS, Cole SA, Butte NF, Comuzzie
AG, Muller YL, Baier LJ, Krakoff J, Knowler WC, Yanovski JA, Han JC. Brain-Derived
Neurotrophic Factor in Human Subjects with Function-Altering Melanocortin-4 Receptor
Variants. Int J Obes (Lond) 2014; 38(8):1068-74. PMCID: PMC4033711.
Hellings JA, Reed G, Cain SE, Zhou X, Barth FX, Aman MG, Palaguachi GI, Mikhnev D,
Teng R, Andridge R, Logan M, Butler MG, Han JC. Loxapine Add-on for Adolescents and
Adults with Autism Spectrum Disorders and Irritability. Journal of Child and Adolescent
Psychopharmacology 2015; 25(2):150-9. PMCID: PMC4442591
Adler-Wailes DC, Alberobello AT, Ma X, Hugendubler L, Stern EA, Mou Z, Han JC, Kim
PW, Sumner AE, Yanovski JA, Mueller E. Analysis of Variants and Mutations in the Human
Winged Helix FOXA3 Gene and Associations with Metabolic Traits. Int J Obes (Lond) 2015;
39(6):888-92. PMCID: PMC4462767
Hutchison M, Pei J, Leung WZW, Mackenzie M, Hicks MD, Thurm AE, Han JC, Haqq AM.
Parental Ratings of Children and Adolescents with Prader-Willi Syndrome on the Behavior
Rating Inventory of Executive Function (BRIEF). Journal of Mental Health Research in
Intellectual Disabilities 2015; 8(2):55-71. DOI:10.1080/19315864.2015.1017893
Hanish AE, Butman JA, Thomas F, Yao J, Han JC. Pineal Hypoplasia, Reduced Melatonin,
and Sleep Disturbance in Patients with PAX6 Haploinsufficiency. Journal of Sleep Research
2015 Oct 6. doi: 10.1111/jsr.12345 [Epub ahead of print]. PMID: 26439359
Mou Z, Hyde TM, Lipska BK, Martinowich K, Wei P, Ong C, Hunter LA, Palaguachi GI,
Morgun E, Teng R, Lai C, Condarco TA, Demidowich AP, Krause AJ, Marshall LJ, Haack K,
Voruganti VS, Cole SA, Butte NF, Comuzzie AG, Nalls MA, Zonderman AB, Singleton AB,
Evans MK, Martin B, Maudsley S, Tsao JW, Kleinman JE, Yanovski JA, Han JC. Human
Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus.
Cell Reports 2015; 13(6):1073-80. PMID: 26526993
ABSTRACTS:
Selected for Oral Platform Presentation at National/International Meetings:
1) Han, JC, Balagopal P, Sweeten S, Darmaun D, Mauras N. Differences in Body Composition
and Total Energy Expenditure in Boys with Constitutional Delay of Growth and Maturation
vs. Healthy Controls: A Metabolic Study. European Society for Paediatric
Endocrinology/Lawson Wilkins Pediatric Endocrine Society 7th Joint Meeting in Lyon,
France, September 21-24, 2005. Hormone Research 2005;64(S1):302.
2) Han JC, Mirch MC, Schollnberger M, Tanofsky-Kraff M, Theim KR, Fleisch AF, Roberts
MD, Ning C, Yanovski JA. Insulin Resistance and Hyperinsulinemia are Associated with
Greater Energy Intake in Overweight Children. Pediatric Academic Societies’ Annual
Meeting, San Francisco, CA, April 29-May 2, 2006. E-PAS2006:59:3845.5.
3) Han JC, Devaney JM, Taylor E, Theim KR, Mirch MC, Fleisch A, Ranzenhofer LE,
Tanofsky-Kraff M, Roberts MD, Ning C, Tosi LL, Hoffman EP, Yanovski JA. AKT1
+G205T Locus Genotype is Associated with Differences in Bone Mineral Density and Insulin
Sensitivity in Children. Endocrine Society’s 88th Annual Meeting in Boston, MA, June 23-27,
2006.
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4) Han JC, Mirch MC, Schollnberger M, Tanofsky-Kraff M, Theim KR, Fleisch A, Roberts
MD, Ning C, Yanovski JA. Energy Intake, Insulin Secretion, and Insulin Resistance in
Overweight Children. NAASO, The Obesity Society’s Annual Scientific Meeting in Boston,
MA, October 20-24, 2006.
5) Han JC, Menzie CM, Adler-Wailes DC, Sanford EL, Jones MP, Lacbawan FL, Yanovski JA.
Association of BDNF Haploinsufficiency with Overweight in Children with WAGR
Syndrome. Pediatric Academic Societies’ Annual Meeting, Toronto, Canada, May 5-8, 2007.
E-PAS2007:617515.1.
6) Han JC, Menzie, CM, Adler-Wailes DC, Sanford EL, Lacbawan FL, Rennert OM, Yanovski
JA. BDNF Haploinsufficiency and Early-Onset Overweight in WAGR Syndrome. Endocrine
Society’s 89th Annual Meeting, Toronto, Canada, June 2-5, 2007.
7) Han JC, Menzie CM, Adler-Wailes DC, Sanford EL, Jones M, Lacbawan FL, Rennert OM,
Yanovski JA. Brain-Derived Neurotrophic Factor (BDNF) in Human Energy Balance:
WAGR Syndrome as a Model of BDNF Haploinsufficiency. NAASO: The Obesity Society
Annual Scientific Meeting in New Orleans, LA, October 20-24, 2007. Obesity
2007;15(9):A27.
8) Xu S (oral presenter), Han J, Morales A, Menzie C, Williams K, Fan Y. Searching for genes
contributing to autism in WAGR syndrome by oligo array CGH. American Society of Human
Genetics 27th Annual Meeting in San Diego, CA, October 23-27, 2007.
9) Han J, Damaso L, Welch S, Sweeten S, Balagopal P, Mauras N. Effects of GH and Nutritional
Therapy in Boys with Constitutional Growth Delay: A Randomized Controlled Trial.
European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society
8th Joint Meeting, New York, NY, September 9-12, 2009.
10) Han JC, Tanofsky-Kraff M, Anandalingam K, Shomaker L, Columbo K, Wolkoff L,
Kozlosky M, Elliott C, Ranzenhofer R, Roza C, Yanovski SZ,Yanovski JA. Association
between Variants in the FTO Gene and Loss of Control over Eating. Obesity Society’s 27th
Annual Scientific Meeting, Washington, DC, October 24-28, 2009.
11) Han JC, Muehlbauer M, Cui HN, Newgard CB, Haqq AM. Lower Serum Brain-Derived
Neurotrophic Factor (BDNF) in Patients with Prader-Willi Syndrome (PWS) Compared with
Obese Controls. Pediatric Academic Societies’ Annual Meeting, Vancouver, British
Columbia, Canada, May 1-4, 2010.
12) Han JC, Damaso L, Welch S, Sweeten S, Balagopal P, Hossain J, Killen K, Mauras N.
Randomized Controlled Trial on the Effects of Growth Hormone Therapy and Nutritional
Supplementation in Boys with Constitutional Growth Delay. Fifth International Congress of
the GRS-IGF Society in New York City, NY, October 3-7, 2010.
13) Ong CJ, Han JC (oral presenter), Hyde TM, Lipska BK, Mou ZY, Tsao JW, Kleinman JE,
Yanovski JA. Associations of Single Nucleotide Polymorphisms (SNPs) in Brain-Derived
Neurotrophic Factor (BDNF) with BDNF Expression in Human Ventromedial Hypothalamus
(VMH) and with Body Mass Index. Obesity Society Annual Scientific Meeting in San Diego,
CA, October 8-12, 2010.
14) Hunter LA, Han JC (oral presenter), Chung SY, Mou Z, Brady SM, Tanofsky-Kraff M,
McDuffie JR, Hubbard VS, Yanovski JA. Association between FTO rs9939609 Genotype and
Response to Orlistat in Obese African American and Caucasian Adolescents. Obesity Society
Annual Scientific Meeting in San Antonio, TX, September 20-24, 2012.
15) Hicks MD, Brady SM, Kim RC, Haqq AM, Yanovski JA, Han JC (oral presenter). BrainDerived Neurotrophic Factor in Prader-Willi Syndrome. 2nd International Conference on
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Hyperphagia and PWSA (USA) Scientific Day Conference, Pennington Biomedical Research
Center, Louisiana State University, Baton Rouge LA, October 17-21, 2012
Han JC, Hohenadel MG, Thearle MS, Hunter LA, Palaguachi GI, Kim RC, Tsang MM,
Butte NF, Krakoff JA, Knowler WC, Yanovski JA. Brain-Derived Neurotrophic Factor
(BDNF) in Human Subjects with Function-Altering Melanocortin-4 Receptor (MC4R)
Mutations. 2nd International Conference on Hyperphagia and PWSA (USA) Scientific Day
Conference, Pennington Biomedical Research Center, Louisiana State University, Baton
Rouge LA, October 17-21, 2012.
Sherafat-Kazemzadeh R (oral presenter), Ivey L, Kahn SR, Sapp JC, Hicks MD, Kim RC,
Biesecker LG, Han JC, Yanovski JA. Hyperphagia in patients with Bardet Biedl syndrome.
2nd International Conference on Hyperphagia and PWSA (USA) Scientific Day Conference,
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge LA,
October 17-21, 2012.
Marshall JD (oral presenter), Han JC, Naggert JK, Yildirimli D, Bryant J, Fischer R, Zein W,
Daryanani K, Turkbey B, Turkbey E, Liu CY, Choyke P, Heller T, Rosing D, Brofferio A,
Sachdev V, Olivieri L, Bridges N, Myles J, Bernstein S, Olivier K, Shamburek R, Huizing M,
Gahl WA, Gunay-Aygun M. NIH Study “Clinical and Molecular Investigations into
Ciliopathies”: Findings on Alström Syndrome. American Society of Human Genetics in
Boston, MA, October 22-26, 2013.
Hutchison M (oral presenter), Pei J, Mackenzie ML, Hicks MD, Thurm A, Han JC, Haqq
AM. Executive function abilities of children with PWS on the BRIEF. Prader-Willi Syndrome
Association (USA) 27th Scientific Day Conference in Orlando, FL, November 7, 2013.
Völgyi E (oral presenter), Nguyen TG, Palmer FB, Murphy LE, Graff CJ, Whitaker TM,
Richey PA, Thurston IB, Han JC, Tylavsky FA. Nutritional Status and Cognitive
Development during the First Four Years of Life. North American Society for Pediatric
Exercise Medicine Biennial Conference, University of Minnesota, Minneapolis, MN, August
20-23, 2014.
Earley BJ, Cinar R, Harvey-White J, Reyes-Capo DP, Haqq AM, Wevrick R, Han JC, Tam J
(oral presenter). Targeting the Endocannabinoid/CB1 Receptor System for the Treatment of
Obesity in Prader-Willi Syndrome. Obesity Society Annual Meeting, Boston, MA, November
2-7, 2014.
Gray EW (oral presenter), Parvathareddy R, Mack RT, Pulusani SR, Morrison JB, Volgyi E,
Han JC. Association of Self-Reported Physical Activity and Television Watching with
Obesity in US Teenagers. Pediatric Academic Societies Annual Meeting, San Diego, CA,
April 25-28, 2015.
Völgyi E (oral presenter), Smith WA, Parvathareddy RR, Tune BN, Mack RT, Gray EW, Sen
F, Nagisetty N, Han JC. Association between Anthropometrics, Body Composition and
Motor Proficiency in Pediatric Patients with Severe Obesity in an Urban Hospital Clinic.
Pediatric Work Physiology Meeting XXIX in Utrecht, Netherlands, September 9-13, 2015.
Hanish AE (oral presenter) and Han JC. PROMIS Sleep Disturbance and Sleep-related
Impairment in Adolescents: Examining Psychometrics Using a Subjective Legacy Measure
and Objective Actigraphy Data Adolescent Health Research Symposium at the Midwest
Nursing Research Society Annual Conference in Milwaukee, Wisconsin, March 17-20, 2016.
Selected for Poster Presentation at National/International Meetings:
1) Theim K, Tanofsky-Kraff M,Yanovski S, Bernstein S, Bassett A, Roberts M, Han J, Ning C,
Yanovski J. Validation of the Emotional Eating Scale Adapted for Use in Children &
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Adolescents (EES-A). Pediatric Academic Societies’ Annual Meeting, San Francisco, CA,
April 29-May 2, 2006. E-PAS2006:59:5430.6.
Fleisch A, Agarwal N, Theim K, Roberts M, Han J, Ning C, Yanovski S, Yanovski S. Leptin
and Sleep Duration as Predictors of Weight Gain During Childhood. Pediatric Academic
Societies’ Annual Meeting, San Francisco, CA, April 29-May 2, 2006. EPAS2006:59:3845.9.
Roberts MD, Drinkard B, Ranzenhofer L, Norman AC, Merke D, Han JC, Ning C, Fleisch
AF, Menzie C, Yanovski JA. Oxygen Uptake Efficiency Slope (OUES) in overweight and
non-overweight adolescents. NAASO, The Obesity Society’s Annual Scientific Meeting in
Boston, MA, October 20-24, 2006.
Fleisch AF, Agarwal N, Roberts MD, Han JC, Theim KR, Ranzenhofer LM, Menzie CM,
Vexler A, Troendle J, Yanovski JA. A longitudinal study of serum leptin as a predictor of
weight and body fat gain in children at high risk for adult obesity. NAASO, The Obesity
Society’s Annual Scientific Meeting in Boston, MA, October 20-24, 2006.
Olney RC, Prickett TCR, Yandle TG, Espner EA, Han JC, Mauras N. Amino-terminal
Propeptide of C-type Natriuretic Peptide (NT-proCNP) Correlates with Growth Velocity in
Children: Effects of Puberty and Growth Hormone. Endocrine Society’s 89th Annual Meeting,
Toronto, Canada, June 2-5, 2007.
Rutledge MS, Kozlosky M, Han JC, Roberts MD, Brady SM, Keil MF, Salaita CG,
Savastano DM, Yanovski JA. Association of Serum Androgen Concentrations with Ability to
Adjust for Prior Energy Intake during Buffet Meals in Overweight Children. Endocrine
Society’s 89th Annual Meeting, Toronto, Canada, June 2-5, 2007.
Gustafson JK, Roberts MD, Han JC, Yanoff LB, Brady SM, Keil MF, Hubbard VS,
Yanovski JA. Development of Abnormalities of Glucose Metabolism in Normal-Weight and
Overweight Youth. Endocrine Society’s 89th Annual Meeting, Toronto, Canada, June 2-5,
2007.
Han JC, Menzie CM, Levinn RL, Adler-Wailes DC, Sanford EL, Jones M, Lacbawan FL,
Rennert OM, Yanovski JA. Association of BDNF Haploinsufficiency with Childhood
Overweight in WAGR Syndrome. Conference on Clinical Research for Rare Diseases,
Bethesda, MD, September 5, 2007
Roberts MD, Drinkard B, Ranzenhofer LM, Salaita CG, Sebring NG, Brady SM, Hoehl J,
Yanoff LB, Savastano DM, Han JC, Yanovski JA. Bioelectrical Impedance AnalysisDerived Impedance Index as a Predictor of Fitness in Overweight Adolescents. NAASO: The
Obesity Society Annual Scientific Meeting in New Orleans, LA, October 20-24, 2007.
Obesity 2007;15(9):A129.
Brady SM, Fleisch AF, Gustafson JK, Roberts MD, Han JC, Vexler A, Troendle J, Yanovski
JA. Limited Influence of Diurnal Variation in Serum Leptin on Weight and Fat Growth in
Children at High Risk for Adult Obesity. NAASO: The Obesity Society Annual Scientific
Meeting in New Orleans, LA, October 20-24, 2007. Obesity 2007;15(9):A145-146.
Gustafson JK, Easter BD, Keil MF, Brady SM, Han JC, Roberts MD, Yanoff LB, Yanovski
SZ, Yanovski JA. Instability of the Diagnosis of Metabolic Syndrome in Children. NAASO:
The Obesity Society Annual Scientific Meeting in New Orleans, LA, October 20-24, 2007.
Obesity 2007;15(9):A172.
Savastano DM, Tanofsky-Kraff M, Schvey NA, Gustafson JK, Han JC, Figueroa R, Sanford
EL, Kozlosky M, Yanovski JA. Energy Intake of Children with C17A + G241A
Homozygous Missense Mutations of the Melanocortin-3-Receptor (MC3R). NAASO: The
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Obesity Society Annual Scientific Meeting in New Orleans, LA, October 20-24, 2007.
Obesity 2007;15(9):A2.
Han JC, Menzie CM, Sanford EL, Adler-Wailes DC, Raygada MJ, Jones M, Lacbawan FL,
Rennert OM, Yanovski JA. Association of BDNF haploinsufficiency with childhood
overweight in WAGR Syndrome. American Society of Human Genetics 27th Annual
Meeting in San Diego, CA, October 23-27, 2007.
Levinn RL, Tsao JW, Adler-Wailes DC, Wijesinghe CA, Jefferson-George KS, Rennert OM,
Yanovski JA, Han JC. BDNF Haploinsufficiency in Patients with WAGR Syndrome is
Associated with Decreased Behavioral Responses to Pain. Pediatric Academic Societies’
Annual Meeting, Honolulu, HI, May 2-6, 2008.
Levinn RL, Han JC, Wijesinghe CA, Gustafson JK, Checchi JM, Adler-Wailes DC,
Jefferson-George KS, Rennert OM, Yanovski JA. Childhood stature in WAGR syndrome.
Endocrine Society’s 90th Annual Meeting, San Francisco, CA, June 15-18, 2008.
Shomaker LB, Tanofsky-Kraff M, Young-Hyman D, Gustafson JA, Schvey N, Han JC,
Yanoff LB, Brady SM, Foster M, Yanovski SZ, Yanovski JA. Psychological symptoms and
insulin sensitivity in adolescence. Obesity Society Annual Scientific Meeting, Phoenix, AZ,
October 3-7, 2008.
Han JC, Wei P, Hyde TM, Lipska BK, Wang L, Liu QR, Danley KM, Tsao JW, Uhl GR,
Kleinman JE, Yanovsk JA. Association between Human Hypothalamic Expression of BrainDerived Neurotrophic Factor (BDNF) and Body Mass Index (BMI). Keystone Symposium on
Obesity: Novel Aspects of the Regulation of Body Weight in Banff, Alberta, Canada, January
20-25, 2009.
Anandalingam K, Han JC, Tanofsky-Kraff M, Shomaker L, Wolkoff L, Columbo K,
Yanovski SZ, Sebring NG, Kozlosky M, Yanovski JA. Associations between FTO genotype
and reported eating in the absence of hunger (EAH) and loss of control (LOC) eating in
children. Endocrine Society’s 91st Annual Meeting, Washington, DC, June 10-13, 2009.
Han JC, Wei P, Hyde TM, Lipska BK, Wang L, Liu QR, Danley KM, Ong CJ, Tsao JW, Uhl
GR, Kleinman JE, Yanovski JA. Body Mass Index (BMI) and Human Hypothalamic BrainDerived Neurotrophic Factor (BDNF) Expression. Endocrine Society’s 91st Annual Meeting,
Washington, DC, June 10-13, 2009.
Golden Williams C, Thurm A, Danley K, Tune M, Joseph L, Pekar M, Swedo S, Han J.
WAGR Syndrome and Autism Spectrum Disorder. Society for the Study of Behavioural
Phenotypes 12th International Research Symposium, Corpus Christ College, Cambridge,
England, October 14-15, 2009.
Domingo DL, Tomona N, Danley KM, Tune MK, Han JC. WAGR Syndrome: Oral and
Craniofacial Characteristics. American Society of Human Genetics 59th Annual Meeting,
Honolulu, HI, October 20-24, 2009.
Wen X, Spitzer A, Liu Y, Adler-Wailes D, Danley K, Han JC, Aguilera G, Yanovski JA.
Determination of the transcriptional start sites of the Mus musculus MC3R by 5’ RLM-RACE.
Obesity Society’s 27th Annual Scientific Meeting, Washington, DC, October 24-28, 2009.
Han JC, Hyde TM, Lipska BK, Wang L, Liu QR, Ong CJ, Tsao JW, Uhl GR, Kleinman JE,
Yanovski JA. Human Body Mass Index and Region-Specific Differences in Hypothalamic
Expression of Brain-Derived Neurotrophic Factor (BDNF). Obesity Society’s 27th Annual
Scientific Meeting, Washington, DC, October 24-28, 2009.
Danley KM, Henderson WA, Ibrahim T, Hadigan CM, Han JC. Acute Pancreatitis after
Propofol Administration in a Child with WAGR Syndrome. North American Society for
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Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, National Harbor, MD,
November 12-14, 2009.
Han JC, Feuillan PP, Ng D, Sapp JC, Zheng YC, Yanovski JA, Biesecker LG. Differences in
Metabolic Parameters of Patients with Bardet-Biedl Syndrome Compared with BMI-Z
Matched Controls. Endocrine Society’s 92nd Annual Meeting in San Diego, CA, June 19-22,
2010.
Fuhr SR, Golden Williams C, Thurm A, Lee MD, Swedo SE, Han JC. Brain-Derived
Neurotrophic Factor in WAGR Syndrome and Autism Symptoms. Society for Developmental
and Behavioral Pediatrics Annual Meeting in Boston, MA, September 11-14, 2010.
Han JC, Feuillan PP, Ng D, Sapp JC, Zheng YC, Yanovski JA, Biesecker LG. Leptin
Resistance in Patients with Bardet-Biedl Syndrome. 2nd Conference on Clinical Research for
Rare Diseases, Bethesda, MD, September 21, 2010.
Fuhr SR, Golden Williams C, Thurm A, Lee MD, Swedo SE, Han JC. Brain-Derived
Neurotrophic Factor in WAGR Syndrome and Autism Symptoms. 2nd Conference on Clinical
Research for Rare Diseases, Bethesda, MD, September 21, 2010.
Sorouri M*, Mou ZY*, Spitzer A, Han JC, Ali AH, Crocker MK, Yanoff LB, Stern EA,
Shomaker LB, Tanofsky-Kraff M, Yanovski JA (*SM/ZY contributed equally). Association
of polymorphisms in HRH3, a presynaptic receptor that autoregulates release of histamine,
with BMI, body fat, and insulin sensitivity in children and adults. Obesity Society Annual
Scientific Meeting in San Diego, CA, October 8-12, 2010.
Han JC, Feuillan PP, Ng D, Sapp JC, Zheng YC, Yanovski JA, Biesecker LG. Comparison
of Metabolic Parameters in Patients with Bardet-Biedl Syndrome and BMI-Z Matched
Controls. Obesity Society Annual Scientific Meeting in San Diego, CA, October 8-12, 2010.
Fuhr SR, Golden Williams C, Thurm A, Brady SM, Lee MD, Zheng YC, Swedo SE, Han JC.
The association of brain-derived neurotrophic factor haploinsufficiency and autism symptoms
in WAGR syndrome. American Society of Human Genetics 60th Annual Meeting,
Washington, DC, November 2-6, 2010.
Zein WM, Butman JA, Lehky TJ, Sharp SJ, Levy TL, Hanowell JC, Tsao JW, Bowles KE,
Brooks BP, Han JC. Duane Syndrome in WAGR Patients with CGH-defined Deletions of
11p and Neuroradiologic Absence of the Abducens Nerve. Association for Research in
Vision and Ophthalmology Annual Meeting in Fort Lauderdale, FL, May 1-5, 2011.
Huey AE, Marshall JD, Maffei P, Tsang MM, Wolde MG, Fuhr SR, Stern EA, Brady SM,
Tsao JW, Milan G, Naggert J, Yanovski JA, Han JC. Higher Leptin Concentrations
Suggestive of Leptin Resistance in Patients with Alström Syndrome as Compared to BMI-Z
Matched Controls. Endocrine Society Annual Scientific Meeting in Boston, MA, June 4-7,
2011.
Mou Z, Morgun E, Hyde TM, Lipska BK, Ong C, Marshall LJ, Ali AH, Stern EA, Tsao JW,
Kleinman JE, Yanovski JA, Han JC. The Brain-Derived Neurotrophic Factor (BDNF) SNP
rs12291186 Minor C Allele is Positively Associated with BMI, Negatively Associated with
BDNF Expression in Human Ventromedial Hypothalamus (VMH), and Alters Yin-Yang 1
(YY1) Transcription Factor Binding. Endocrine Society Annual Scientific Meeting in Boston,
MA, June 4-7, 2011.
Butman JA, Zein WM, Fuhr SR, Huey AE, Crossman JR, Tsang MM, Bowles KE, Sharp SJ,
Tsao JW, Brooks BP, Han JC. Agenesis of the Olfactory (CN I) and Abducens (CN VI)
Nerves in WAGR Syndrome. American Society of Neuroradiology 49th Annual Meeting in
Seattle WA, June 4-9, 2011.
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36) McEntee JE, Butman JA, Pham DL, Fuhr SR, Huey AE, Sharp SJ, Tsao JW, Han JC.
Morphologic alterations in brain structure in patients with WAGR/11p deletion syndrome.
Organization for Human Brain Mapping’s 17th Annual Meeting, Quebec City, Canada, June
26-30, 2011.
37) Shomaker, LB, Tanofsky-Kraff M, Han JC, Zocca J, Mou Z, Courville AB, Conway E,
Yanovski SZ, Yanovski JA. FTO Genotype is Associated with Observed Eating in the
Absence of Hunger in the Laboratory and with Parent-Reported Eating in the Absence of
Hunger. Obesity Society’s 29th Annual Scientific Meeting in Orlando, FL, October 1-5, 2011.
38) Mou Z, Morgun E, Hyde TM, Lipska BK, Ong C, Marshall LJ, Ali AH, Stern EA, Tsao JW,
Kleinman JE, Yanovski JA, Han JC. The Minor C Allele of Brain-Derived Neurotrophic
Factor (BDNF) rs12291186 is Associated with Higher BMI, Lower BDNF Expression in
Human Ventromedial Hypothalamus (VMH), and Altered Yin-Yang 1 (YY1) Transcription
Factor Binding. Obesity Society’s 29th Annual Scientific Meeting in Orlando, FL, October 15, 2011.
39) Huey AE, Marshall JD, Maffei P, Tsang MM, Wolde MG, Fuhr SR, Stern EA, Brady SM,
Tsao JW, Milan G, Naggert J, Yanovski JA, Han JC. Higher Leptin Concentrations in
Patients with Alström Syndrome as Compared to BMI-Z Matched Controls are Suggestive of
Ciliopathy-Associated Leptin Resistance. Obesity Society’s 29th Annual Scientific Meeting
in Orlando, FL, October 1-5, 2011.
40) Hanish AE, Butman JA, Huey AE, Lee MD, Yin E, Hunter LA, Hicks MD, Singh T, Tsang M,
Han JC. Pineal Hypoplasia and Decreased Melatonin Secretion in Patients with PAX6
Haploinsufficiency due to WAGR Syndrome or PAX6 Mutations. 94th Annual Meeting of the
Endocrine Society in Houston, TX, June 23-26, 2012. Note: Winner in the Endocrine Society
Presidential Poster Competition.
41) Thurm A, Joseph L, Swedo SE, Golden Williams C, Black D, Butler K, Brady SM, Conley
SK, Han JC, Porter FD. Measuring Autism Symptoms and Diagnosis in Select Rare Genetic
Diseases. 3rd Conference on Clinical Research for Rare Diseases in Rockville, MD, October
2, 2012.
42) Hicks MD, Marshall JD, Maffei, P, Hanish AE, Hunter LA, Brady SM, Sedaka NM, Sherafat
Kazemzadeh R, Tsao JW, Milan G, Naggert J, Yanovski JA, Han JC. Hyperphagia, leptin,
and brain-derived neurotrophic factor in subjects with Alström syndrome and BMI-Z matched
controls. American Society of Human Genetics Annual Meeting in San Francisco, CA,
November 6-10, 2012.
43) Kokx M, Zalewski CK, King KA, Brady SM, Hanish AE, Hicks MD, Huey AE, Fuhr SR,
Danley KM, Brewer CC, Han JC. Auditory Function in WAGR Syndrome and Isolated
Aniridia. 40th Annual Scientific and Technology Conference of the American Auditory
Society in Scottsdale, AZ on March 7-9, 2013.
44) Sherafat-Kazemzadeh R, Ivey L, Kahn SR, Sapp JC, Hicks MD, Kim RC, Krause AJ,
Biesecker LG, Han JC, Yanovski JA. Hyperphagia in patients with Bardet Biedl syndrome.
Pediatric Academic Societies Annual Meeting, Water E. Washington Convention Center,
Washington DC, May 4-7, 2013
45) Kim RC, Smith ACM, Introne WJ, Ramnitz MS, Hicks MD, Palaguachi GI, Hanish AE, Han
JC. Higher Serum Brain-Derived Neurotrophic Factor Concentrations in Children and
Adolescents with Smith-Magenis Syndrome Compared to BMI-Matched Control Subjects.
Pediatric Academic Societies Annual Meeting, Water E. Washington Convention Center,
Washington DC, May 4-7, 2013
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46) Hellings JA, Palaguachi GI, Reed G, Barth F, Cain SE, Butler MG, Zhou X, Aman MG, Han
JC. LAASDAI: Loxapine Add-On for Adolescents and Adults with Autism Spectrum
Disorders, Aggression and Irritability. 53rd NCDEU: Annual Meeting Sponsored by the
American Society of Clinical Psychopharmacology in Hollywood, FL on May 28-31, 2013.
47) Palaguachi GI, Jimenez D, Mikhnev D, Gavrilova O, Tessarollo L, Lu B, Martinowich K,
Han JC. The Role of Specific Brain-Derived Neurotrophic Factor (BDNF) Promoters in
Obesity. Endocrine Society’s 95th Annual Meeting & Expo Conference, San Francisco, CA,
June 15-18, 2013.
48) Gunay-Aygun M, Cullinane A, Vilboux T, Yildirimli D, Bryant J, Zein W, Brooks B,
Marshall J, Han J, Fischer R, Daryanani K, Turkbey B, Choyke P, Heller T, Huizing M,
Doherty D, Gahl WA.NIH Study “Clinical and Molecular Investigations into Human
Ciliopathies" (www.clinicaltrials.gov, trial NCT00068224). Federation of American Societies
for Experimental Biology - Biology of Cilia and Flagella Scientific Research Conference in
Niagara Falls, NY on June 23-28, 2013
49) Stofanko M, Han JC, Elsea SH, Gonçalves-Dornelas H, Pena HB, Pena SDJ. Rapid
screening of chromosomal microdeletions and microduplications using MQF-PCR. The 59th
Brazilian Congress of Genetics, September 16-19, 2013.
50) Mou Z, Palaguachi GI, Jimenez D, Mikhnev D, Gavrilova O, Tessarollo L, Lu B,
Martinowich K, Han JC. Disruption of Promoter I but not Promoters IV or VI of BrainDerived Neurotrophic Factor (BDNF) is Associated with Obesity. The 31st Annual Scientific
Meeting of the Obesity Society in Atlanta, GA, November 11-16, 2013.
51) Khincha PP, Gadalla SM, Katki HA, Giri N, Wong J, Spellman S, Yanovski J, Han J, De Vivo
I, Alter BP, Savage SA. Evaluating the Utility of Telomere Length Measurement by QPCR as
a Diagnostic Test for Dyskeratosis Congenita. American Society of Hematology, New
Orleans, LA, December 7-10, 2013.
52) Hanish AE, Butman JA, Caplan Y, Tsang M, Thomas F, Yao J, Han JC. PAX6
Haploinsufficiency: Pineal Hypoplasia, Reduced Melatonin, & Sleep Disturbance. SLEEP
(28th Annual Meeting of the Associated Professional Sleep Societies) in Minneapolis, MN,
May 31-June 4th, 2014.
53) Lalonde F, Raznahan A, Butman J, Kim R, Reyes-Capo D, Sharp S, Tsao J, Giedd J, Han J.
Developmental Cortical Grey Matter Differences Between WAGR, PAX6 Patients, and
Healthy Controls. Organization for Human Brain Mapping Annual Meeting in Hamburg,
Germany, June 8-12, 2014.
54) Reyes-Capo DP, Marshall JD, Naggert JK, Bryant JC, Hicks MD, Kattapuram MM, Heller H,
Liu CY, Turkbey EB, Myles JG, Bernstein SB, Reynolds JC, Shamburek RD, Gahl WA,
Gunay-Aygun M, Han JC. Endocrine and Metabolic Characterization of Alström Syndrome.
International Congress of Endocrinology and Endocrine Society Joint Meeting in Chicago, IL,
June 21-24, 2014.
55) Han JC, Kim RC, Lai C, Brady SM, Hanish AE, Palaguachi GI, Singh T, Racine N, Shriver
T, Schoeller DA, Yanovski JA. Brain-Derived Neurotrophic Factor (BDNF) in the Regulation
of Human Energy Homeostasis: Body Composition and Energy Expenditure (EE) in Human
BDNF Haploinsufficiency (BDNF +/-). Obesity Society Annual Meeting, Boston, MA,
November 2-7, 2014.
56) Lee JA, Volgyi E, Nagisetty N, Han JC. Use of Electronic Medical Records to Determine the
Prevalence of Obesity and Diagnosis of Obesity in Children Evaluated at an Urban Children's
Hospital. Pediatric Academic Societies Annual Meeting, San Diego, CA, April 25-28, 2015.
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Joan C. Han, MD
57) Volgyi E, Nguyen TG, Han JC, Tylavsky FA. Changes in Dietary Patterns from 2nd
trimester to 4 weeks postpartum: The Conditions Affecting Neurocognitive Development and
Learning in Early Childhood (CANDLE) Study. Pediatric Academic Societies Annual
Meeting, San Diego, CA, April 25-28, 2015.
58) Smith WA, Völgyi E, Tune BN, Parvathareddy RR, Mack RT, Gray EW, Sen F, Nagisetty N,
Viangteeravat T, Han JC. Associations of physical activity, television watching, and physical
fitness in children with severe obesity. Pediatric Work Physiology Meeting XXIX in Utrecht,
Netherlands, September 9-13, 2015.
59) Lalonde FM, Raznahan A, Butman JA, Han JC. PAX6 haploinsufficiency association with
reduced amygdala volumes. Society for Neuroscience 2015 Annual Meeting in Chicago, IL,
October 17-21, 2015.
60) Armbruster-Lee J, Völgyi E, Jones TL, Sen F, Nagisetty, N, Viangteeravat T, Han JC. Does
obesity status affect length of hospital stay for asthma or appendicitis? The American Society
for Metabolic & Bariatric Surgery (ASMBS) and the Obesity Society (TOS) Annual Meetings
at Obesity Week in Los Angeles, CA, November 2-7, 2015.
61) Banks GG, Thurston IB, Berlin KS, Decker KM, Parvathareddy RR, Mack RT, Han JC.
Predicting Psychological Symptoms Using Parental Perception of Well-Being in TreatmentSeeking Children and Adolescents with Obesity. The American Society for Metabolic &
Bariatric Surgery (ASMBS) and the Obesity Society (TOS) Annual Meetings at Obesity
Week in Los Angeles, CA, November 2-7, 2015.
62) Decker KM, Thurston IB, Banks GG, Parvathareddy RR, Han JC. Mental Health Predictors
of Maladaptive Eating Behaviors among Black Children and Adolescents with Obesity. The
American Society for Metabolic & Bariatric Surgery (ASMBS) and the Obesity Society (TOS)
Annual Meetings at Obesity Week in Los Angeles, CA, November 2-7, 2015.
63) Edwards P, Parvathareddy RR, Smith WA, Mack RT, Gray EW, Delos-Santos N, Han JC.
Association of Obesity Severity, Waist Circumference, and Percent Body Fat with Systolic
and Diastolic Blood Pressures in Children and Adolescents. The American Society for
Metabolic & Bariatric Surgery (ASMBS) and the Obesity Society (TOS) Annual Meetings at
Obesity Week in Los Angeles, CA, November 2-7, 2015.
64) Gray EW, Parvathareddy RR, Taralli GH, Mack RT, Saravia TN, Smith WA, Eshun JK, Han
JC. Associations of Obesity Classification, Metabolic Syndrome, and Alanine
Aminotransferase in Children and Adolescents. The American Society for Metabolic &
Bariatric Surgery (ASMBS) and the Obesity Society (TOS) Annual Meetings at Obesity
Week in Los Angeles, CA, November 2-7, 2015.
65) Mack RT, Parvathareddy RR, Gray EW, Saravia TN, Han JC. Association of Hemoglobin
A1c and Fasting Glucose in Children Seeking Treatment in a Weight Management Clinic.
The American Society for Metabolic & Bariatric Surgery (ASMBS) and the Obesity Society
(TOS) Annual Meetings at Obesity Week in Los Angeles, CA, November 2-7, 2015.
66) Mantilla C, Decker KM, Jacobo AM, Parvathareddy RR, Thurston IB, Mack RT, Smith WA,
Völgyi E, Han JC. Associations among Parental Perception of Child Weight Status, Body
Composition, and Physical Activity Participation in Pediatric Patients with Obesity. The
American Society for Metabolic & Bariatric Surgery (ASMBS) and the Obesity Society (TOS)
Annual Meetings at Obesity Week in Los Angeles, CA, November 2-7, 2015.
67) Smith WA, Vӧlgyi E, Tune BN, Parvathareddy RR, Gray EW, Mack RT, Han JC. Physical
Performance Limitations in Children with Obesity. The American Society for Metabolic &
Bariatric Surgery (ASMBS) and the Obesity Society (TOS) Annual Meetings at Obesity
Week in Los Angeles, CA, November 2-7, 2015.
19
Joan C. Han, MD
68) Taralli GH, Parvathareddy RR, Dourisseau D, Wolfe MK, Edwards PT, Mack RT, Han JC.
Dietary Practices of Children in a Weight Management Clinic. The American Society for
Metabolic & Bariatric Surgery (ASMBS) and the Obesity Society (TOS) Annual Meetings at
Obesity Week in Los Angeles, CA, November 2-7, 2015.
69) Völgyi E, Smith WA, Parvathareddy RR, Tune BN, Mack RT, Gray EW, Sen F, Nagisetty N,
Ajayi O, Han JC. Motor Proficiency in Pediatric Patients with Obesity in a Multidisciplinary
Weight Management Clinic. The American Society for Metabolic & Bariatric Surgery
(ASMBS) and the Obesity Society (TOS) Annual Meetings at Obesity Week in Los Angeles,
CA, November 2-7, 2015.
70) Decker KM, Thurston IB, Rybak, TM, Burton ET, Han JC. The Association between Weight
Misperception and Mental Health among Black and White Youth in a Pediatric Obesity Clinic.
Society of Pediatric Psychology Annual Conference in Atlanta, GA, April 14-16, 2016.
71) Rybak TM, Thurston IB, Decker KM, Burton ET, Han JC. Caregivers’ Readiness to Change
Lifestyle Habits in Relation to Perception of Child’s Weight and Psychosocial Difficulties at a
Tertiary Pediatric Obesity Clinic. Society of Pediatric Psychology Annual Conference in
Atlanta, GA, April 14-16, 2016.
UTHSC Clinical Research Protocols:
Principal Investigator:
15-04043-XP: Leptin Pathway Defects in Obesity
15-04011-XP: NICHD Data and Sample Tracking Protocol 14-CH-N095: Samples from Human
Patients Enrolled in 12-CH-0051 (Brain-Derived Neurotrophic Factor in Obesity
and Neurocognitive Function) and 08-CH-0213 (WAGR Syndrome and Other
11p Contiguous Gene Deletions: Clinical Characterization and Correlation with
Genotype)
15-03845-XM: Healthy Lifestyle Clinic Chart Review
15-03636-FB: Genetic, Behavioral, and Environmental Determinants of Metabolic Health
Associate Investigator:
15-03716-XP: Insulin Superheroes Club
14-03604-XP: Memphis Community Assessment: The role of cognition, mental health, physical
fitness, and metabolic functioning on health behaviors in youth
14-03571-XP: Effect of obesity on lung function and serum inflammatory markers in children
with and without asthma; and also the correlation of these conditions and
subjective assessment of sleep: Cross-sectional study of lung function including
eNO in children with obesity and asthma
14-03604-XP: The role of cognition, mental health, physical fitness, and metabolic functioning
on health behaviors in youth
14-03586-XP: An Observational Study (Registry) Assessing Treatment Outcomes and Safety for
Children and Adults Who Are Prescribed Norditropin® (Human Growth
Hormone): The ANSWER Registry
14-03317-FB: Obesity, exercise and sensorimotor development in children
14-03338-XM: Body Mass Index of Pediatric Patients
11-01435-FB: Brain function and percent body fat in 4 year olds (closed/completed study)
NIH Clinical Research Protocols:
20
Joan C. Han, MD
Associate Investigator/Active Studies:
01-HG-0109: Natural History Study of the Clinical and Molecular Manifestations of SmithMagenis Syndrome
00-CH-0180: Endocrine Studies in Health and Disease
03-HG-0264: Clinical and Molecular Investigations into Ciliopathies
Associate Investigator/Data Analysis Only:
14-CH-N095: NICHD Data and Sample-Tracking Protocol
12-CH-0051: Brain-Derived Neurotrophic Factor in Obesity and Neurocognitive Function
08-CH-0213: WAGR Syndrome and Other 11p Contiguous Gene Deletions: Clinical
Characterization and Correlation with Genotype
08-CH-0085: Eating Behavior in Adolescents
07-CH-0126: Pilot Study of the Metabolic Effects of Betahistine Hydrochloride in Overweight
Women
06-M-0102: Clinical and Immunological Investigations of Subtypes of Autism
06-CH-0038: Body Heat Content and Dissipation in Obese and Normal Weight Adults
Completed:
05-CH-0077: Nutrients and Hormones: Effects in Boys with Disordered Growth-Pilot Study
21