PHILIPPINE CHILDREN’S MEDICAL CENTER Quezon Avenue, Quezon City CASE MANAGEMENT APPROACH TO PATIENTS WITH SCROTAL ENLARGEMENT March 23, 2015 Presentor: Regine P. Dominguez, MD Reactor: Dexter S. Aison M.D. Moderator: Eve G. Fernandez M.D. CASE 1 Residents in charge: Karen Icel Bautista M.D.- insert middle initial Fellows in charge: Roselda Mirasol M.D.- insert middle initial Patient is JD, a two year old male from Sampaloc, Manila who was seen for the first time at our institution last February 25, 2015. Chief Complaint: Scrotal enlargement, left Informant: Mother Reliability: Good reliability History of Present Illness: Two years prior to consultation, when the patient was on the 3rd day of life, mother noted patient’s left scrotum to be larger compared to the right. There was no associated vomiting, constipation or diarrhea. Consult was done with a private pediatrician. Assessment was hydrocele and was advised observation. Since then, the left scrotal mass would increase in size especially when crying and straining. Size would spontaneously decrease without manipulation. There was no associated fever, skin changes, abdominal pain or fever noted. Few hours prior to consultation, scrotal mass was palpated when patient started to cry. However, there was no spontaneous reduction of the mass size prompting consult at our institution. Review of Systems: - kulang No weight loss. No rashes. No cough and colds. No difficulty of breathing. No oliguria. Maternal and Birth History Patient was born to a thirty two year old G3P3 (3003) mother with no history of alcohol and tobacco use during pregnancy. Prenatal check-ups were done starting at three months age of gestation at a local clinic with a midwife. During the sixth month of gestation, mother had cough and colds for three days, which spontaneously resolved without medication. At the seventh month of gestation, mother was referred to a secondary hospital for delivery. During consult, blood pressure was noted to be elevated. Unrecalled antihypertensive medications were given and mother claimed that blood pressure then was controlled Patient was born full term via Caesarian section secondary to a nonreassuring fetal heart rate pattern. Patient had good cry and activity. No cyanosis, no jaundice and no difficulty of breathing were noted. There was no cord coil or meconium stained amniotic fluid. Patient had bowel movement and urine output on the first day of life. Birth weight was 4 kilograms. Patient was discharged on the third hospital day. Newborn screening was done. No hearing screening was done. Nutritional History Patient was breastfed until the age of one year and six months. Complimentary feeding was started at six months. Currently patient has four to five meals per day consisting of 1 cup of rice mixed with soup and minced vegetable or meat. Immunization history Patient received one dose of BCG, three doses of DPT, three doses of OPV, three doses of Hepatitis B, one dose of Measles at a local health center with no untoward reactions. No MMR and no Hib vaccines were given Growth and Developmental History Gross motor: Rolled over at the 6 months Crawled at 10 months Walked independently at 16 months. Ran at 2 years old Fine motor: Feeds self with crackers at 10 months Language: Mama and papa at 10 months, Walks well at 18 months Social: Social smile at 3 months, Laughs out loud at 5 months Family History (+) Hypertension – maternal (-) Diabetes mellitus (-) Bronchial asthma (-) Cancer 33 year old bookeeper 34 year old housewife Personal and Social History Patient lives with five household members in a single level house, well lit and well ventilated. Water source is mineral water. Garbage collection was done regularly. No exposure to second hand smoke. No nearby factories noted. Past Medical History No previous hospitalization. No allergies No history of measles or varicella Physical Examination Awake, alert, not in cardiorespiratory distress, Vital signs BP 90/60, HR 100 bpm, RR 24 cpm Temp Weight: 13. 6 (z>0 ), Height 93 cm (z >0) No jaundice, no rashes Anicteric sclera, pink palpebral conjunctiva, No tragal tenderness, non-hyperemic external auditory canal, intact tympanic membrane Moist buccal mucosa, nonhyperemic posterior pharyngeal wall No cervical lymphadenopathies Symmetric chest expansion, no retractions, no lagging, clear breath sounds Adynamic precordium, normal rate, regular rhythm, PMI at 4th left intercostal space, midclavicular line, no heaves, thrills, lifts and murmurs Globular abdomen, no visible veins, normoactive bowel sounds, no tenderness, no masses, no organomegaly (+) Left scrotal mass extending from inguinal area, nontender, (+) transillumination test Full pulses, capillary refill time less than 2 seconds, warm extremities Assessment: Inguinal Hernia, left, reducible Course at the OPD Patient was referred to Surgery and assessment was inguinal hernia, left, reducible. Patient was scheduled for herniorrhaphy and is currently awaiting schedule. CASE 2: Fellow in charge: Marjorie Grace P. Apigo M.D. Urology fellow in charge: Dr Hao/ Dr. Flores – full name MD sa dulo Patient is DT, a 2 year old male from Quezon City who came in last February 23, 2015 for the first time at our institution Chief complaint: scrotal enlargement, right Informant Reliability History of Present Illness: Six months prior to consultantion, mother noted that the patient’s right scrotum was larger than the patient’s left scrotum. Both right and left scrotum noted to have gradually increased in size measuring. There was no associated pain, fever, constipation, vomiting or increase in size when patient strains or cries. Persistence of the mass lead to consult with a private surgeon and was advised surgery. Review of Systems No weight loss, No rashes. No jaundice No cough. No difficulty of breathing Birth and Maternal History Patient was born to a thirty seven year old G4P3 (4013) with regular prenatal checkup at Mary Chiles Hospital starting at three months age of gestation. Mother denied alcohol and tobacco use and claims compliance to multivitamins and ferrous sulfate. Patient’s mother is a known case of hypothyroidism and was on Levothyroxine during pregnancy. Normal ultrasound, urinalysis and CBC were noted during pregnancy. No history of hypertension, asthma and diabetes were noted. Patient was born full term via normal spontaneous delivery at a private hospital delivered by an obstetrician. Patient had good cry and activity at birth. There was no cord coil and no meconium stained amniotic fluid. Bowel movement and urine output noted within the first day of life. Newborn screening done with normal results. Nutritional History Patient was never breastfed and was on milk formula since birth (Bonna) Complimentary feeding started at 6 months with mashed vegetables. Immunization History: Patient received one dose of BCG, three doses of DPT, three doses of OPV, three doses of Hepatitis B and one dose of Measles at a local health center with no untoward reactions Growth and Developmental History Gross motor: Sits with support at 8 months Walked independently at 13 months. Ran at 2 years old Fine motor: Currently can hold spoon Language: Currently can say 20-30 words. Social: Social smile at 2 months, Laughs out loud at 4 months Family History 40 year old businessman 41 year old employee (-) Hypertension (+) Diabetes mellitus -maternal (-) Bronchial asthma (-) Cancer (+) Thyroid disease – maternal Personal and Social history Patient lives with five household members in a two level house with good ventilation and lighting. No exposure to second hand smoke. No pets at home. Garbage collection was done once a week. Past Medical History No previous hospitalization No known allergies to food and medication No history of varicella or measles Physical Examination Awake, alert not in cardio respiratory distress BP 90/60, CR 110 bpm, RR 19 cpm, Temperature 36.7 Weight 12.6 kg (z<-2 ), Height 87 (z >0) Pink palpebral conjunctiva, Anicteric sclera No tragal tenderness, external auditory canal nonhyperemic, tympanic membrane intact Nasal septum midline, turbinates not congested Moist buccal mucosa, nonhyperemic posterior pharyngeal wall No cervical lymphadenopathies Symmetric chest expansion, no retractions, no lagging, clear breath sounds Adynamic precordium, apex beat at 5th ICS MCL normal rate and regular rhythm, no murmur Soft globular abdomen, normoactive bowel sounds, no tenderness, liver and spleen not enlarged, no palpated masses (+) transillumination test No inguinal bulging, bilateral scrotum enlarged 4x4 cm, soft with no tenderness Assessment: Hydrocoele, right Course at OPD Patient was seen at the General OPD and was referred to Urosurgery. CBC, urinalysis were requested for preoperative clearance. Patient was scheduled for herniotomy. CASE 3: Resident in charge: Dr. Raisa Linsy Yu Fellows in charge: Dr. Hao/ Dr. Flores Patient is AC 1 year old and 5 month old male from Bulacan who came in for consult for the first time at our institution Chief complaint: right scrotal enlargement Informant Reliability History of Present Illness Three months prior to consult, mother noted patient’s right scrotum to be larger than patient’s left scrotum. No associated hyperemia. No change in size noted upon crying or defecation. No urinary and bowel symptoms noted. Two weeks prior to consultation, mother noted increase in the size of the mass at the right scrotal sac measuring. No other associated symptoms noted. No fever, pallor and urinary symptoms noted. Increase in the size of the mass lead to consult at our institution. Review of Systems No weight loss, No rashes. No cough. No jaundice No difficulty of breathing Birth and Maternal History Patient was born to an eighteen year old G1P1 (1001), nonsmoker, non-alcoholic beverage drinker. The mother had regular prenatal check-up starting at three months at a Local Health Center. She took multivitamins and ferrous sulfate and denies history hypertension, diabetes and asthma. There was also no history of upper respiratory infection and urinary tract infection. Patient was born full term via normal spontaneous delivery at a lying-in clinic delivered by a midwife. No meconium stained amniotic fluid. No cord coil. Birth weight was 3 kg. Newborn screening was normal. Nutritional history Patient was breastfed until three months of life. Milk formula started thereafter. Complimentary feeding started at six months. Currently, is a picky eater with 4 meals per day. Meals consisted of ½ cup of rice and 1 piece of hotdog or 2 matchbox sizes of minced meat or fish. Immunization history Patient received one dose of BCG, three doses of DPT, three doses of OPV, three doses of Hepatitis B and three doses of Hib, 1 dose of Measles and 1 dose of MMR at a local health center with no untoward reactions. Family History 22 laborer 19 housewife (-) Hypertension (-) Diabetes mellitus (-) Bronchial asthma (-) Cancer Growth and Developmental History Gross motor – Crawled at 6 months, Stands alone at 10 months, walks alone at 15 months, runs at 17 months Fine Motor – holds a bottle at 10 months Language – Babbles at 8 months, two word phrases at 12 months Social- social smile at 2 months, Laughs out at 5 months Personal and Social History Patient lives with extended family maternal side in a single level house, fairly lit and ventilated. Water source is store bought mineral water. Garbage collection was done twice a week. No pets at home. No exposure to second hand smoke. Past Medical History No previous hospitalization No known allergies to food and medication Physical Examination Awake, comfortable, not in cardiorespiratory distress BP: HR 102 bpm, RR 24 cpm Temp 38 Weight: 8.2 kg (z -2 ) ; Height: 74 cm (z < -3 ) Warm skin, no rashes Anicteric sclera, pink palpebral conjunctiva No tragal tenderness, external auditory canal, tympanic membrane intact Nasal septum midline, turbinates not congested Moist buccal mucosa, nonhyperemic posterior pharyngeal wall No cervical lymphadenopathies Symmetric chest expansion, no retractions, no lagging, clear breath sounds Adynamic precordium, apex beat at 5th ICS MCL, no heaves, lifts, thrills, no murmur Flat abdomen, normoactive bowel sounds, no mass, no hepatosplenomegaly, soft, nontender, no guarding Right scrotum enlarged, 6 x 4 cm, nontender, hard, noncompressible; Left scrotum 2x2 soft, No inguinal bulging. (+) transillumination test No inguinal lymph nodes Assessment: Scrotal mass, probably yolk sac tumor, right Course at the OPD Patient was seen at the OPD and was advised scrotal ultrasound which revealed enlarged right testes measuring 3.9x2.7x3.4 cm suggestive of abscess and necrosis. Once seen at the surgery OPD, patient was referred to Urology service. At the Urology OPD, the following tumor markers were requested. Beta HCG: less than 0.100, LDH was normal at 863.0 and Alpha feto protein was elevated at 15,041. Assessment was a yolk sac tumor, right. Patient was admitted and scheduled for radical orchiectomy.