Genetics - 7th Grade Essential Vocabulary Words: allele, Chromosome Theory of Inheritance, chromosome, DNA, dominant, gene, genotype, heterozygous, homozygous, nucleus, phenotype, Punnett Square, recessive, traits Content Information: Inside every cell, the smallest unit of life, there is genetic material called Deoxyribonucleic Acid or DNA. This DNA is a network of nitrogen bases, phosphates, and sugars arranged in double helix pattern that looks like a spiral ladder. DNA creates instructions for all of the cell functions and is found in the nucleus of eukaryotic cells. DNA is the genetic code that is known as the blueprint or recipe for making structures. DNA is found in chromosomes. Chromosomes are strands of DNA that contain genes. Genes are what organisms inherit from parents. According to the Chromosome Theory of Inheritance, genes are passed from parents to offspring on chromosomes. The genes on chromosomes have control for different traits. For example a gene may control eye color. All genes come in pairs. Different forms of genes are known as alleles. For example, when considering eye color in human beings, the color is the gene. The specific color of brown eyes, blue eyes, and green eyes is the allele. The genes on chromosomes control different traits. For example, a gene may control eye color. All genes come in pairs. Dominant allele – a trait that always shows up when the allele is present – Symbol – Capital letter (T) Recessive allele – a trait that is covered up or masked when a dominant allele is present – Symbol – lower case letter (t) For example, brown eyes (B) are dominant over blue (b), and appear more often. B represents the dominant trait brown; b represents the recessive trait of blue. The child could have B from one parent and B from the other = child with brown eyes GENOTYPE: BB PHENOTYPE: Brown Eyes The child could have B from one parent and b from the other = child with brown eyes. GENOTYPE: Bb PHENOTYPE: Brown Eyes The child could have b from one parent and b from the other = child with blue eyes GENOTYPE: bb PHENOTYPE: Blue Eyes Any time the dominant gene appears, the offspring will have the dominant trait. Genotype Phenotype BB or Bb Brown Eyes bb Blue Eyes Humans have 46 chromosomes in each body cell or 23 pairs. The sex chromosomes are on the 23rd pair. This combination of alleles determines the sex of the offspring, XX for female and XY for male. All of the other pairs of chromosomes are called autosomes. Some traits are carried down from parent to offspring on the X or Y chromosomes. For example, colorblindness is a trait controlled by a recessive allele on the X chromosome. Since males only have one X in their genotype, more males have colorblindness than females. If the recessive trait for colorblindness is present in the X allele, the trait will be present. Pea Plants have 14 chromosomes in each cell or 7pairs. We are made of thousands of genes (over 60,000 in humans). Each parent contributes half of each chromosome pair to their offspring. Usually there is one pair of sex chromosomes. Offspring receive one member of each pair from their mother, the other member of each pair from their father. Humans: 23 chromosomes from mother 23 chromosomes from father (XX) (XY) Pea Plants: 7 chromosomes from mother (XX) 7 chromosomes from father (XY) Genotype is the combination of alleles and phenotype is the physical trait that shows up as a result of the allele combination or genotype. There are three possible genotypes or combination of alleles. When there are two of the same allele, the genotype is considered homozygous or purebred. For example, BB and bb are homozygous or purebred genotypes. When two different alleles make up a genotype, the pair is considered heterozygous or hybrid. For example, Bb is a heterozygous or hybrid genotype. Gregor Mendel Gregor Mendel was a monk that experimented with cross pollinating pea plants. In his findings, he discovered a pattern in genetic probability. He cross pollinated a tall homozygous/purebred pea plants with short homozygous/purebred pea plants. The pea plants that resulted in the cross pollination were all tall (F1 Generation). These tall pea plants self-pollinated. The result of the self-pollination (F2 Generation) was that 75% of the pea plants were tall and 25% of the pea plants were short. Because of this finding, the short trait was proven to be a recessive trait. The illustration below provides an illustration of Mendel’s experiment. Image courtesy of http://library.thinkquest.org/17109/tutorial.htm Gregor Mendel Experimented with several traits in pea plants shape of the seed: round or wrinkled. color of the pea: yellow or green. color of the seed: gray or white. form of the ripe pod: inflated or constricted between peas. color of the unripe pod: green or yellow. position of the flower: terminal or axial. length of the stem: tall or short Mendel’s genetic probability can be expressed using a Punnett Square developed by English geneticist Reginald Punnett in the early 20th century. T= tall/dominant t= short/recessive Parents: Tt and Tt Genotypes TT Tt Tt tt Phenotypes Tall Tall Tall short T t T t TT Tt Tt tt Results: 3 out 4 or 75% of the dominant trait or tall trait is shown. 1 out 4 or 25% of the recessive trait or short trait is shown. A common misconception about dominant and recessive traits is that dominant traits show up in organisms more so than recessive traits. Ideally, since 2 out of 3 genotypes produce a phenotype that shows the dominant trait, this thinking makes sense but is not the case. Some students may see this 2 to 3 ratio and use it to support their hypothesis. It is important that you highlight factors that affect an organism’s percentage of dominant to recessive traits. These factors include the frequency of the various alleles in the gene pool and the probability (not certainty) of traits being passed on. A certain population of organisms may reproduce in an environment where a recessive trait is more suited to that environment over the dominant trait for survival. In this instance, the recessive trait becomes more prevalent in that population of organisms and is more likely to occur. In the genoworm lab, your results for each pair and total class results may show more recessive traits or may show more dominant traits. These results can occur in the Human Genetics Population Study as well. A common conclusion you may draw with your students is that the dominant trait will not always show up more in a population based on the factors mentioned. GENETICS REVIEW BACKGROUND INFORMATION Inside every cell, the smallest unit of life, there is genetic material called deoxyribonucleic acid or ________. This DNA is a network of nitrogen bases, phosphates, and sugars arranged in double helix pattern. This looks like a spiral ladder. DNA creates instructions for all of the cell functions and is found in the ___________ of eukaryotic cells. DNA is the genetic code that is known as the blueprint or recipe for making structures. DNA is found in chromosomes. Chromosomes are strands of DNA that contain genes. __________ are what organisms inherit from parents. According to the _________________________________, genes are passed from parents to offspring on chromosomes. The genes on chromosomes control different traits. For example, a gene may control eye color. All genes come in pairs. There are different forms of genes for a certain trait. Different forms of genes are known as __________. For example, when considering eye color in human beings, the color is the gene. The specific color of brown eyes, blue eyes, and green eyes is the allele. The genes on chromosomes have control for different traits. For example a gene may control for eye color. All genes come in pairs. Human Genetics Population Study Have you ever wondered why some people have blue eyes while others have brown eyes? Why do some people have a widow’s peak, while others do not display this hairy trait? The answer is in our genes. Genes have different forms called alleles that determine which traits we will inherit from our parents. The combination of alleles will determine what an organism looks like. The physical characteristic an organism displays is known as the organism’s phenotype. The combination of the alleles and the actual genetic make-up of the organism is known as the organism’s genotype. A dominant allele is one that always shows up in the organism. A recessive allele is an allele that is masked or hidden when a dominant allele is present. Meiosis Definition Function Type of Reproduction Occurs in Genetically Crossing Over Pairing of Homologous Number of Divisions Number of Haploid Daughter Cells Creates Chromosome Number Mitosis A type of cellular reproduction in which the number of chromosomes are reduced by half through the separation of homologous chromosomes, producing two haploid cells. A process of asexual reproduction in which the cell divides in two producing a replica, with an equal number of chromosomes in each resulting diploid cell. Sexual Reproduction Cellular reproduction & general growth & repair of the body Asexual Sexual Humans, animals, plants, fungi Different Yes, mixing of chromosomes can occur Yes All organisms identical No, crossing over cannot occur 2 4 1 2 Sex cells only- female egg cells or male sperm cells Reduced by half Makes everything other than sex cells Remains the same No Website Links: Dominant VS Recessive http://www.thetech.org/genetics/ask.php?id=188 http://www.blinn.edu/socialscience/ldthomas/feldman/handouts/0203hand.htm Gregor Mendel http://anthro.palomar.edu/mendel/mendel_1.htm http://anthro.palomar.edu/mendel/glossary.htm#genetics http://library.thinkquest.org/17109/tutorial.htm Punnett Square Practice http://biology.clc.uc.edu/courses/bio105/geneprob.htm http://www2.edc.org/weblabs/Punnett/punnettsquares.html http://www.hobart.k12.in.us/jkousen/Biology/psquare.htm http://ethemes.missouri.edu/themes/1015 Dragon Lab http://www2.edc.org/weblabs/DragonMeiosis/DragonMeiosisMenu.html Genetics Web Labs http://www2.edc.org/weblabs/WebLabDirectory1.html Genetics Games http://nature.ca/genome/04/041/041_e.cfm DNA: The Double Helix http://nobelprize.org/educational/medicine/dna_double_helix/ DNA Detective http://www.tryscience.org/experiments/experiments_dna_online.html Blood Typing Game http://nobelprize.org/educational/medicine/landsteiner/readmore.html CSI Experience http://forensics.rice.edu/ Interactive DNA http://www.pbs.org/wgbh/nova/sheppard/analyze.html