SAFETY DATA SHEET
N-butyl acetate, Grade A
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SECTION 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/
UNDERTAKING
1.1
1.1.1
Product identifier
Commercial Product Name
N-butyl acetate, Grade A
1.1.2
Product code
CAS-No.: 123-86-4
EINECS-No.: 204-658-1
Common name(s), synonym(s) of the substance: 1-butyl acetate, 1-butyl ethanoate, Acetic acid n-butyl ester
1.2
Relevant identified uses of the substance or mixture and uses advised against
1.2.1
Recommended use
1.3
1.3.3
Industrial: manufacture, distribution; formulation & (re)packaging; use in coatings and cleaning agents; use in
laboratories.
Professional: use in coatings and cleaning agents, use in laboratories.
Details of the supplier of the safety data sheet
Identification of the manufacturer
"Dmitrievsky chemical plant – Production", LLC
1, Proizvodstvennaya street
155800 Kineshma, Ivanovo region
Russia
Telephone: (49331) 5-72-89, (495) 988-68-42
Email: http://www.dhz.ru
1.4
1.4.1
Emergency telephone number
Telephone number, name and address
Poison centres, Europe: http://www.who.int/pcs/poisons/centre/directory/euro/en/
See SECTION 16.6 for the list of telephone numbers of poison centers in the European Economic Area.
SECTION 2. HAZARDS IDENTIFICATION
2.1
In accordance with Directive 67/548/EEC and Regulation 1272/2008 this substance is classified as hazardous.
The substance is a flammable liquid (H226). Exposure to vapours may cause drowsiness or dizziness (H336).
Frequent contact can lead to skin dryness of cracking of the skin (EUH066).
Classification of the substance or mixture
67/548/EEC (DSD)
R10
R66
R67
1272/2008 (CLP)
Flam. Liq. 3, H226
STOT SE 3, H336
SAFETY DATA SHEET
N-butyl acetate, Grade A
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EUH066
2.2
Label elements
1272/2008 (CLP)
GHS07 - GHS02
Signal word
Warning
Hazard Statements
H226
Flammable liquid and vapour.
H336
May cause drowsiness or dizziness.
EUH066
Repeated exposure may cause skin dryness or cracking.
Precautionary Statements
P210
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233
Keep container tightly closed.
P235
Keep cool.
P261
Avoid breathing dust/fume/gas/mist/vapours/spray.
P280
Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin
P304+P340
P312
2.3
with water/shower.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
Call a POISON CENTER or doctor/physician if you feel unwell.
Other hazards
Vapour is heavier than air and can travel considerable distance to a source ignition and flashback. Vapours may
form explosive mixture with air. Components of the product may be absorbed into the body by inhalation.
Seveso substance: Main Seveso Category 6. Flammable
The substance does not fulfil the PBT criteria (not PBT) nor the vPvB criteria (not vPvB), see section 12 for
further information.
SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1
Substances
N-butyl acetate is a mono-constituent substance of organic origin.
CAS/EC and EINECS
Chemical name of the
Concentration Classification
Reg.number
substance
123-86-4
204-658-1
n-butyl acetate
> 99 %
DSD: R10; R66; R67
CLP: Flam. Liq. 3, H226; STOT
SE 3, H336
SECTION 4. FIRST AID MEASURES
4.1
Description of first aid measures
4.1.2
Inhalation
Remove contaminated, soaked clothing immediately and dispose of safely. First aider needs to protect himself.
4.1.3
4.1.4
4.1.5
Keep at rest. Move to fresh air. When symptoms persist or in all cases of doubt seek medical advice.
Skin contact
Wash off immediately with soap and plenty of water. When symptoms persist or in all cases of doubt seek
medical advice.
Eye contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses.
Immediate medical attention is required.
Ingestion
Call a physician immediately. Do not induce vomiting without medical advice.
SAFETY DATA SHEET
N-butyl acetate, Grade A
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4.2
Most important symptoms and effects, both acute and delayed
Exposure to vapours may cause drowsiness or dizziness. Frequent contact can lead to skin dryness of cracking
of the skin.
4.3
Cough, nausea, vomiting, headache, unconsciousness, shortness of breath, dizziness, narcosis.
Special hazard: Lung oedema, central nervous system effects, Prolonged skin contact may defat the skin and
produce dermatitis.
Indication of immediate medical attention and special treatment needed
Notes to physician: Treat symptomatically.
SECTION 5. FIREFIGHTING MEASURES
The substance is classified as a flammable liquid cat. 3 (H226). Exposure to vapours may cause drowsiness
or dizziness (H336).
5.1
5.1.1
5.1.2
5.2
5.3
5.4
Vapour is heavier than air and can travel considerable distance to a source of ignition and flashback. Vapours
may form explosive mixtures with air.
Extinguishing media
Suitable extinguishing media
Foam, dry chemical, carbon dioxide (CO2), water spray.
Extinguishing media which must not be used for safety reasons
Do not use a solid water stream as it may scatter and spread fire.
Special hazards arising from the substance or mixture
Under conditions giving incomplete combustion, hazardous gases produced may consist of:
- carbon monoxide (CO)
- carbon dioxide (CO2)
Combustion gases of organic materials must in principle be graded as inhalation poisons.
Vapour is heavier than air and can travel considerable distance to a source of ignition and flashback.
Vapours may form explosive mixtures with air.
Advice for firefighters
Fire fighter protection should include a self-contained breathing apparatus (NIOSH-approved or EN 133) and full
fire-fighting turn out gear.
Specific methods
Cool containers / tanks with water spray. Dike and collect water used to fight fire. Water run-off can cause
environmental damage. Keep people away from and upwind of fire.
SECTION 6. ACCIDENTAL RELEASE MEASURES
6.1
6.2
6.3
Personal precautions, protective equipment and emergency procedures
Avoid contact with skin and eyes. Avoid breathing vapors or mists. Keep people away from and upwind of
spill/leak. Ensure adequate ventilation, especially in confined areas. Keep away from heat and sources of
ignition.
For emergency responders: Personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage. Do not discharge product into the aquatic environment without pretreatment
(biological treatment plant). See Section 8: Environmental exposure controls.
Methods and materials for containment and cleaning up
Methods for containment
Stop the flow of material, if possible without risk. Dike spilled material, where this is possible.
Methods for cleaning up
Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. If liquid has been spilt in
large quantities clean up promptly by scoop or vacuum. Dispose of in accordance with local regulations. Take
necessary action to avoid static electricity discharge (which might cause ignition of organic vapours).
SAFETY DATA SHEET
N-butyl acetate, Grade A
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6.4
Reference to other sections
For personal protection see section 8.
SECTION 7. HANDLING AND STORAGE
7.1
Precautions for safe handling
General industrial hygiene practice. Ensure that eyewash stations and safety showers are close to the
workstation location. When using, do not eat, drink or smoke. Take off all contaminated clothing immediately.
7.2
7.3
Avoid contact with skin, eyes and clothing. Do not breathe vapours or spray mist. Wash hands before breaks
and immediately after handling the product. Provide sufficient air exchange and/or exhaust in work rooms. Keep
away from sources of ignition - No smoking. Take necessary action to avoid static electricity discharge (which
might cause ignition of organic vapours). In case of fire, emergency cooling with water spray should be
available. Ground and bond containers when transferring material. Vapour is heavier than air and can travel
considerable distance to a source of ignition and flashback. Vapours may form explosive mixture with air.
Conditions for safe storage, including any incompatibilities
Keep containers tightly closed in a cool, well-ventilated place. Handle and open container with care.
Suitable storage material : stainless steel, mild steel, aluminium
Unsuitable storage material : copper, attacks some forms of plastic and rubber
Specific end use(s)
The quantitative exposure assessment for the substance n-Butyl Acetate was performed using the Chesar tool
(version 1.1.2). Only the inhalative exposure route is taken into account (DNELs for dermal route have not been
derived). The methodology and all input parameters are described in the Exposure Scenarios (ES) available in
the Annexes to this Safety Data Sheet. The following uses are covered by the exposure scenarios:
Industrial:
ES1 Manufacture of Butyl acetate;
ES2 Distribution of Butyl acetate;
ES3 Formulation;
ES4 Use in coatings;
ES7 Use in cleaning agents;
ES10 Use in laboratories.
Professional:
ES5 Use in coatings;
ES8 Use in cleaning agents;
ES11 Use in laboratories.
See further the information provided in the Annexes to this SDS. The technical conditions and measures at
process level as well as for controlling dispersion from source towards the workers and environment are also
summarized in sections 7 and 8 of this SDS.
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1
Control parameters
8.1.1
Threshold limits
123-86-4
n-butyl acetate
8.1.2
Other information on limit values
8.1.3
no other information available
Limit values in other countries
150 ppm (8 h)
720 mg/m3 (8 h)
200 ppm (15 min)
960 mg/m3 (15 min)
SAFETY DATA SHEET
N-butyl acetate, Grade A
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Germany MAK: 100 ppm, 480 mg/m3 (8h), 960 mg/m3 (short-term); Peak limitation category: I(2); Pregnancy
risk group: C; (DFG 2003).
NIOSH REL: TWA 150 ppm (710 mg/m3); STEL 200 ppm (950 mg/m3)
8.1.4
OSHA PEL: TWA 150 ppm (710 mg/m3); STEL 200 ppm (950 mg/m3)
DNELs
Based on available data, the classification criteria are not met for acute toxicity, nor for skin or respiratory
irritation. The DNELs for dermal acute exposure (systemic and local) and the DNEL for dermal long-term
exposure (systemic and local) are not derived, because no relevant hazards leading to classification have been
identified. The German MAK commission determined a scientific OEL for n-butyl acetate of 100 ppm (480
mg/m3), 8 hours of exposure. Regarding the occupational situation, the critical toxic effect of exposure to nbutyl acetate is considered the irritative effect on the eyes and the mucosa of the upper respiratory tract. The
MAK value is based on available human data that indicates that the aforementioned effects do not appear at
concentrations of 100 ppm or below. In addition, there are no systemic toxic effects expected, even on
reproduction and development, if the MAK value will be adhered to. Therefore the German MAK values were
adopted for acute and long-term (systemic and local) inhalation limit values.
Workers
Acute exposure - Systemic
inhalation: 960 mg/m3 (derived based on MAK short-term limit)
Acute exposure - Local
inhalation: 960 mg/m3 (derived based on MAK short-term limit)
8.1.5
Long-term exposure - Systemic
inhalation: 480 mg/m3 (derived based on MAK long-term limit)
Long-term exposure - Local
inhalation: 480 mg/m3 (derived based on MAK long-term limit)
PNECs
The PNEC values for the water compartment are derived based on the lowest short-term toxicity test results for
freshwater fish ( Pimephales promelas) with LC50 (96h) value of 18 mg/l.
The following assessment factors (AF) are used:
PNEC aqua (freshwater): 0.18 mg/l (AF=100)
PNEC aqua (marine water): 0.018 mg/l (AF=1000)
PNEC aqua (intermittent releases): 0.36 mg/l (AF=50)
PNEC sediment: No data for sediment organisms are available. However, the PNEC sediment can also be
calculated according to the equilibrium partitioning method and the PNEC aqua. This calculated PNEC was
converted to dry weight (conversion factor: 4.6).
PNEC sediment (freshwater): 0.981 mg/kg sediment dw (calculated to be 0.213 mg/kg ww; Koc = 18.5; PNEC
aqua (freshwater) = 0.18 mg/L).
PNEC sediment (marine water): 0.0981 mg/kg sediment dw (calculated to be 0.0213 mg/kg ww; Koc = 18.5;
PNEC aqua (marine water) = 0.018 mg/L).
PNEC soil: direct and indirect exposure of the soil compartment is unlikely. However, the PNEC soil can also be
calculated according to the equilibrium partitioning method and the PNEC aqua. This PNEC was converted to dry
weight (conversion factor: 1.13).
PNEC soil: 0.0903 mg/kg soil dw (calculated to be 0.0799 mg/kg ww (Henry's Law constant = 28.5 Pa; Koc =
18.5; PNEC aqua (freshwater) = 0.18 mg/L).
The PNEC value for sewage treatment plant (STP) is derived based on the growth inhibiting effect of n-butyl
acetate on the ciliate ( Tetrahymena pyriformis) with EC50/LC50/40h value of 356 mg/L. The following
assessment factor (AF) was applied:
PNEC STP: 35.6 mg/L (AF=10)
SAFETY DATA SHEET
N-butyl acetate, Grade A
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8.2
8.2.1
8.2.2
8.2.2.1
8.2.2.2
Exposure controls
Appropriate engineering controls
General or dilution ventilation is frequently insufficient as the sole means of controlling employee exposure.
Local ventilation is usually preferred. Explosion-proof equipment (for example fans, switches, and grounded
ducts) should be used in mechanical ventilation systems.
Individual protection measures
Respiratory protection
Respirator with A filter. Full mask with above mentioned filter according to producers using requirements or
self-contained breathing apparatus. Equipment should conform to respiratory protection standards EN 136 or EN
140 and EN 143.
Hand protection
Wear protective gloves. Recommendations are listed below. Other protective material may be used, depending
on the situation, if adequate degradation and permeation data is available. If other chemicals are used in
conjunction with this chemical, material selection should be based on protection for all chemicals present.
Suitable material: butyl-rubber
Evaluation according to protective glove standard EN 374: level 3
Glove thickness approx 0.3 mm
Break through time approx 60 min
8.2.2.3
8.2.2.4
8.2.3
Suitable material: polyvinylchloride / nitrile rubber
Evaluation according to protective glove standard EN 374: level 2
Glove thickness approx 0.9 mm
Break through time approx 30 min
Eye/face protection
Tightly fitting safety goggles. In addition to goggles, wear a face shield if there is a reasonable chance for
splash to the face. Equipment should conform to eye&face protection standard EN 166.
Skin protection
Impervious clothing. Wear face-shield and protective suit for abnormal processing problems.
Environmental exposure controls
If possible use in closed systems. If leakage cannot be prevented, the substance needs to be sucked off at the
emersion point, if possible without danger. Observe the exposure limits, clean exhaust air if needed. If recycling
is not practicable, dispose of in compliance with local regulations. Inform the responsible authorities in case of
leakage into the atmosphere, or of entry into waterways, soil or drains.
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
9.1
9.1.1
Important Health Safety and Environmental Information
Appearance
9.1.9
Clear, colorless liquid.
Odour
Odour threshold
pH
Melting point/freezing point
Initial boiling point and boiling range
Flash point
Evaporation rate
Flammability (solid, gas)
9.1.10
9.1.10.1
Explosive properties
Lower explosion limit
9.1.2
9.1.3
9.1.4
9.1.5
9.1.6
9.1.7
9.1.8
no data available
no data available
no data available
< -90°C (at 1013 hPa) (no test method specified)
126 °C (at 1013 hPa) (no test method specified)
27 °C (at 1013 hPa), EU test method A.9: closed-cup
no data available
Flammable liquid Cat. 3 (based on flash point). No chemical
groups associated with pyrophoric properties or flammability
on contact with water.
1.2 vol% (no test method specified)
SAFETY DATA SHEET
N-butyl acetate, Grade A
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9.1.10.2
Upper explosion limit
9.1.11
Vapour pressure
9.1.12
Vapour density
9.1.13
Relative density
9.1.14
9.1.14.1
Solubility(ies)
Water solubility
9.1.14.2
9.1.15
9.1.16
9.1.17
9.1.18
9.1.19
9.1.20
9.2
7.6 vol% (no test method specified)
15 hPa at 20 °C (no test method specified)
no data available
0.8812 g/cm³ (at 20°C) (no test method specified)
5.3 g/L (at 20 °C) OECD Guideline 105 and EU test method
A.6: flask method
Fat solubility (solvent - oil to be specified) no data available
Partition coefficient: n-octanol/water
Log Kow = 2.3 (at 25 °C) OECD Guideline 117 and EU test
method A.8: HPLC
Auto-ignition temperature
415 °C (at 1013 hPa), EU test method A.15
Decomposition temperature
not applicable (see boiling point)
Viscosity
0.83 mm²/s (static; at 20°C) OECD Guideline 114
Explosive properties
non explosive (no chemical groups associated with explosive
properties present in the molecule). Vapours may form
explosive mixture with air.
Oxidising properties
not applicable (substance is flammable)
Other information
Surface tension of aqueous solution: 61.3 mN/m (at 20°C and 1000 mg/L) OECD Guideline 115 and EU test
method A.5: ring method.
SECTION 10. STABILITY AND REACTIVITY
10.1
10.2
10.3
10.4
10.5
10.6
Reactivity
Stable under recommended storage conditions.
Chemical stability
no data available
Possibility of hazardous reactions
Vapours may form explosive mixture with air.
Conditions to avoid
Avoid contact with heat, sparks, open flame, and static discharge. Avoid any source of ignition.
Incompatible materials
Strong acids and strong bases, strong oxidizing agents.
Hazardous decomposition products
No decomposition if stored and applied as directed.
SECTION 11. TOXICOLOGICAL INFORMATION
11.1
11.1.1
11.1.2
Information on toxicological effects
Exposure to vapours may cause drowsiness or dizziness (STOT SE 3 - H336). Due to the defatting solvent
character of n-butyl acetate it is assumed that frequent contact can lead to skin dryness of cracking of the skin
(Additional hazard statement: EUH066).
Acute toxicity
Based on available data, the classification criteria are not met. LD50/oral/rat:
10760 mg/kg bw (method similar to OECD Guideline 423) LD50/dermal/rabbit:
14000 mg/kg bw (method similar to OECD Guideline 402)
Data on acute toxicity of n-butyl acetate after inhalation exposure are inconsistent. No definite LC50 value can be
stated.
Irritation and corrosion
SAFETY DATA SHEET
N-butyl acetate, Grade A
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Based on available data, the classification criteria are not met.
Skin irritation (rabbits): not irritating (OECD Guideline 404)
Eye irritation (rabbits): not irritating (OECD Guideline 405)
Respiratory irritation (human): not irritating (no guideline followed, Iregren et al. (1993))
Investigations with human volunteers indicate, that weak irritation of the eyes and respiratory tract occurs after
short term inhalation exposure to concentrations of about 200 ppm.
11.1.3
11.1.4
11.1.5
11.1.6
11.1.7
11.1.8
Due to the defatting solvent character of n-butyl acetate it is assumed that frequent contact can lead to skin
dryness of cracking of the skin (Additional hazard statement: EUH066 - Repeated exposure may cause skin
dryness or cracking).
Sensitisation
Based on available data, the classification criteria are not met.
Animal experiments (Gad et al., 1986; mouse, guinea pig) and investigations with humans (Gad et al., 1986;
Roed-Petersen, 1980; Anon., 1989) revealed that n-butyl acetate is not sensitising to skin.
Subacute, subchronic and prolonged toxicity
Repeated dose toxicity: Based on available data, the classification criteria are not met. NOAEC
(inhalation/rat): 2400 mg/m³ (subchronic), test method EPA OTS 798.2450
Mutagenicity: Based on available data, the classification criteria are not met. Used test methods in vitro:
similar to OECD Guideline 471, OECD Guideline 476; in vivo: OECD Guideline 474, EU Method B.12, EPA OTS
798.5395. Test substance: n-butyl acetate and butan-1-ol (metabolite of n-butyl acetate)
Reproductive toxicity: Based on available data, the classification criteria are not met:
- - Effects on fertility: NOAEC (inhalation/rat): 9640 mg/m³, test methods OECD Guideline 416, EPA OPPTS
870.3800
- - Developmental toxicity: LOAEC (inhalation/rabbit): 7230 mg/m³, test method similar to OECD Guideline
414
Carcinogen: Based on available data, the classification criteria are not met.
STOT-single exposure
Classified as STOT SE 3 - H336 - May cause drowsiness or dizziness. Route: inhalation.
N-Butyl acetate induced neurotoxicity (mainly sedatory effects) in rats exposed to 1500 ppm (7.2 mg/L) test item
for a single 6 hour period or subchronically. Effects occurred only transiently during exposure, no effects were
detectable shortly after stop of exposure. No neurotoxicity could be detected in rats exposed subchronically to
500 ppm (2.4 mg/L) n-butyl acetate, whereas transient sedation was seen at 1500 ppm and above.
NOAEC (inhalation/rats): 2410 mg/m³, test methods EPA OTS 798.6050, EPA OTS 798.6200, EPA OTS
798.6500, 40 CFR Part 798.2450.
STOT-repeated exposure
Based on available data, the classification criteria are not met.
Aspiration hazard
Based on available data, the classification criteria are not met.
Other information on acute toxicity
no data available
SECTION 12. ECOLOGICAL INFORMATION
12.1
12.1.1
Toxicity
Aquatic toxicity
SAFETY DATA SHEET
N-butyl acetate, Grade A
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Based on available data, the classification criteria are not met (Acute toxicity is >10 mg/L, the substance is
readily biodegradable and does not bioaccumulate significantly (experimentally determined log Kow <= 4).
Moreover, the chronic toxicity is > 1 mg/L).
Short-term aquatic toxicity:
LC50/96h/freshwater fish ( Pimephales promelas) = 18 mg/l (similar to OECD Guideline 203).
EC50/48h/freshwater invertebrates ( Daphnia Sp.) = 44 mg/l (similar to OECD Guideline 202).
NOEC/72h/freshwater algae ( Desmodesmus subspicatus) = 200 mg/l (Method according to Umweltbundesamt
(German Federal Environment Agency) proposal/draft, version February 1984).
12.1.2
12.2
12.2.1
12.2.2
Long-term aquatic toxicity:
NOEC/21d/freshwater invertebrates ( Daphnia Magna) = 23 mg/l (OECD Guideline 211). Test substance:
isobutyl acetate
Toxicity to other organisms
Aquatic micro-organisms:
EC50/LC50/40h for ciliate ( Tetrahymena pyriformis): 356 mg/L (TETRATOX assay; Schultz, 2006)
NOEC/28d for domestic activated sewage sludge : >10 mg/L (OECD Guideline 301 D, Waggy et al., 1994)
Terrestrial plants:
EC50/14d for lettuce ( Lactuca sativa) : > 1000 mg/kg soil dry weight (similar to OECD Guideline 208)
Persistence and degradability
Biodegradation
n-Butyl acetate is readily biodegradable according to OECD criteria in the Closed Bottle test (OECD Guideline 301
D: 83 % in 28 d, 10-d window met; Waggy et al., 1994).
Chemical degradation
n-Butyl acetate will hydrolyze slowly in contact with water. The hydrolytic half-life was estimated by calculation
(HYDROWIN v2.00) to be 78 d at pH 8 and 2 years at pH 7 (ECT, 2009).
The substance will also degrade in contact with air by reaction with OH-radicals. The overall OH rate constant
was determined to be 4.9 -12 cm3/molecule*sec. The half-life was calculated to be 3.3 days (24 -h d; 0.5 E+06
OH/cm3). These values were determined experimentally (Kwok & Atkinson, 1994; cited in AOP v1.92).
12.3
Bioaccumulative potential
12.4
The substance has a low potential for bioaccumulation.
The log Kow of 2.3 for n-butyl acetate indicates a low potential for bioaccumulation. In addition, the substance is
readily biodegradable. Based on a measured log Pow of 2.3, the bioconcentration factor (BCF) of n-butyl acetate
was estimated to be 15 by using the BCFBAF program (v3.00). This estimate refers to the uncharged molecule.
According to the BCF, n-butyl acetate has a low potential for bioaccumulation in aquatic organisms.
Mobility in soil
The substance is readily biodegradable and has a low potential for adsorption due to a low octanol-water
partition coefficient (log Kow=2.3) and estimated adsorption coefficient (log Koc < 3). The determined Henry's
Law constant indicated that low volatilisation is expected. Therefore, adsorption to soil is not expected and the
substance may be mobile in soil. It is also not expected that the substance will contaminate ground waters since
it is readily biodegradable in water.
The adsorption coefficient (log Koc) was estimated by calculation (KOCWIN v2.00) to be less than 3 (MCI
method: 1.3; Kow method: 1.8).
Koc: 18.54 - 69.84; log Koc: 1.268 - 1.844
The Henry's Law constant (HLC) of n-butyl acetate was experimental determined to be 28.5 Pa*m³/mol
(Kieckbusch and King, 1976, as cited in ECT, 2009). The calculated value lies slightly above this value
(HENRYWIN v3.20 41.6 Pa*m³/mol at 25 °C).
SAFETY DATA SHEET
N-butyl acetate, Grade A
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12.5
12.6
Results of PBT and vPvB assessment
The substance is not persistent (not P) and not very persistent (not vP) in the environment. The substance is not
bioaccumulative (not B) and not very bioaccumulative (not vB). The substance is not toxic (not T). Taking into
account all available data on biotic and abiotic degradation, bioaccumulation and toxicity it can be stated that the
substance does not fulfil the PBT criteria (not PBT) nor the vPvB criteria (not vPvB).
Other adverse effects
No other adverse effects identified for this substance.
SECTION 13. DISPOSAL CONSIDERATIONS
13.1
The choice of the appropriate disposal method depends on the product composition by the time of disposal as
well as the local statutes and possibilities for disposal. Waste codes in accordance with the list of European
Waste Catalogue (EWC) should be assigned by the user prior to final disposal. Dispose of product residue in
accordance with the instructions of the person responsible for waste disposal. Refer to local and national waste
management regulations and dispose of in accordance with selected waste classification.
Waste treatment methods
Dispose of in accordance with waste classification. The primary waste management option for unused
substance and contaminated packaging is hazardous waste incineration. Refer to local or national waste
management regulations.
Waste from residues / unused products
Contaminated packaging should be emptied as far as possible and after appropriate cleansing may be taken for
reuse. Disposal as hazardous waste.
SECTION 14. TRANSPORT INFORMATION
1123
Butyl acetates
Class 3; Classification code F1
III
14.1
UN number
14.2
UN proper shipping name
14.3
Transport hazard class(es)
14.4
Packing group
14.5
Environmental hazards
14.6
Special precautions for users
14.7
IMDG Marine trasport
EmS number: F-E; S-D
Not a marine pollutant.
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
IBC-Code
Product name Butyl acetate
Ship type 3
Pollution category Y
Not classified as hazardous to the environment. See Section 8 for environmental exposure controls.
SECTION 15. REGULATORY INFORMATION
15.1
15.2
Safety, health and environmental regulations/legislation specific for the substance or mixture
n-Butyl Acetate is classified in Main Seveso Category 6. Flammable according to Annex I of Council Directive
96/82/EC of 9 December 1996 on the control of major-accident hazards involving dangerous substances (OJ L
10, 14.1.1997, p. 13).
Chemical safety assessment
In accordance with REACH Article 14, a Chemical Safety Assessment has been carried out for this substance.
SAFETY DATA SHEET
N-butyl acetate, Grade A
Page 11 / 12
"Dmitrievsky chemical plant – Production", LLC
Date 11/04/2011
Previous date: 03/03/2011
SECTION 16. OTHER INFORMATION
16.1
16.2
16.3
16.4
16.5
Additions, Deletions, Revisions
Version 3.0, The Lead Registrant has adapted the DNEL values to the German MAK values. Consequently the
Chemical Safety Report was updated, and Exposure Assessment and Risk Characterisation was corrected. All
sections of this SDS are aligned with the updated REACH Chemical Safety Report.
This safety data sheet is drawn up to comply with the requirements of Regulation (EC) No. 1907/2006 (REACH),
as amended by Annex I to Commission Regulation (EU) No 453/2010 of 20 May 2010.
Key or legend to abbreviations and acronyms
-AF - Assessment factor
-BCF - Bioconcentration factor
-CAS - Registry Numbers assigned by the "Chemical Abstracts Service"
-CLP - Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on
classification, labelling and packaging of substances and mixtures, amending and repealing Directives
67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
-DNEL - Derived no-effect level
-DSD - Council Directive 67/548/EEC (Dangerous Substances Directive)
-dw - dry weight
-EC50 - Concentration of the substance that causes 50 % reduction of a certain effect on test organisms
-EINECS - Registry number in the European Inventory of Existing Commercial Chemical Substances
-EPA OPPTS - Environmental Protection Agency, Office for Prevention, Pesticides & Toxic Substances (USA)
-EPA OTS - Environmental Protection Agency, Office for Toxic Substances (USA)
-ES - Exposure scenario
-EU - European Union
-Koc - Soil adsorption coefficient
-LC50 -Lethal concentration of the substance that causes 50 % mortality of the test population
-LOAEC - Lowest observed adverse effect concentration
-MAK - Maximale Arbeitsplatzkonzentrationen (Germany): maximum concentration of a chemical substance in
the workplace, expressed as daily 8-hour time-weighed average values and apply to healthy adults.
-NIOSH - NAtional Institute for Occupational Safety and Health (USA)
-NOAEC - No observed adverse effect concentration
-NOAEL- No observed adverse effect level
-NOEC - No observed effect concentration
-OECD - Organisation for Economic Co-operation and Development
-OEL - Occupational exposure limit
-OSHA - Occupational Safety and Health Administration (USA)
-PBT/vPvB - Persistent, bioaccumulative and toxic/ very persistent and very bioaccumulative
-PEL - Permissible exposure limit
-PNEC - Predicted no-effect concentration
-REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006
concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals
-REL - Recommended exposure limit
-STEL - Short term exposure limit
-STP - Sewage treatment plant
-TWA - Time weighted average
Key literature references and sources for data
REACH Chemical Safety Report Part B for n-butyl acetate.
All referenced studies within this safety data sheet can be found from the original Chemical Safety Report.
Classification procedure
This substance has a harmonized classification according to Annex VI to Regulation (EC) No 1272/2008 (CLP).
List of relevant R phrases, hazard statements, safety phrases and/or precautionary statements
R10
Flammable.
R66
Repeated exposure may cause skin dryness or cracking.
R67
Vapours may cause drowsiness and dizziness.
SAFETY DATA SHEET
N-butyl acetate, Grade A
Page 12 / 12
"Dmitrievsky chemical plant – Production", LLC
Date 11/04/2011
Previous date: 03/03/2011
16.6
Emergency telephone number
Europe-wide emergency number: 112
16.7
Contact a poison control centre. List of Telephone Numbers :
AUSTRIA (Vienna Wien) +43 1 406 43 43; BELGIUM (Brussels Bruxelles) +32 70 245 245; BULGARIA (Sofia) +
359 2 9154 409; CZECH REPUBLIC (Prague Praha) +420 224 919 293; DENMARK (Copenhagen) 82 12 12 12;
ESTONIA (Tallinn) 112; FINLAND (Helsinki) +358 9 471 977; FRANCE (Paris) +33 1 40 0548 48; GERMANY
(Berlin) +49 30 19240; GREECE (Athens Athinai) +30 10 779 3777; HUNGARY (Budapest) 06 80 20 11 99;
ICELAND (Reykjavik) +354 525 111, +354 543 2222; IRELAND (Dublin) +353 1 8379964; ITALY (Rome) +39
06 305 4343; LATVIA (Riga) +371 704 2468; LITHUANIA (Vilnius) +370 5 236 20 52 or +370 687 53378;
MALTA (Valletta) 2425 0000; NETHERLANDS (Bilthoven) +31 30 274 88 88; NORWAY (Oslo) 22 591300;
POLAND (Gdansk) +48 58301 65 16 or +48 58 349 2831; PORTUGAL (Lisbon Lisboa) 808 250 143; ROMANIA
(Bucharest) +40 21 3183606 SLOVAKIA (Bratislava) +421 2 54 77 4166; SLOVENIA (Ljubljana) + 386 41 650
500; SPAIN (Barcelona) +34 93 227 98 33 or +34 93 227 54 00 bleep 190; SWEDEN (Stockholm) 112 or +46 8
33 12 31 (mon-fri 9.00-17.00); UNITED KINGDOM (London) 112 or 0845 4647 (NHS Direct).
Recommended restrictions
DISCLAIMER OF LIABILITY: The information in this SDS was obtained from recent Chemical Safety Report of
this substance from REACH registration 2010. However, the information is provided without any warranty,
express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of
the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not
assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way
connected with the handling, storage, use or disposal of the product. This SDS was prepared and is to be used
only for this product. If the product is used as a component in another product, this SDS information may not be
applicable.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 1 of 51
ES 1 - Manufacture of Butyl Acetate
Manufacture of Butyl Acetate
Environment:
ERC 1
Worker
Use in closed process, no likelihood of exposure
PROC 1
Use in closed, continuous process with occasional controlled exposure
PROC 2
Use in closed batch process (synthesis or formulation)
PROC 3
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 4
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at non-dedicated facilities
PROC 8a
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at dedicated facilities
PROC 8b
Use as laboratory reagent
PROC 15
Operational conditions and risk management measures
Control of environmental exposure: Manufacture of Butyl Acetate
Product characteristics
Amounts used
Daily use at a site
<= 400 tonnes/day
Annual use at a site
<= 1.2E5 tonnes/year
Percentage of tonnage used at regional scale
= 100 %
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 3.456E6 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2.88E4 m3/d
Application of the STP sludge on agricultural soil
No
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 2 of 51
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed process, no likelihood of
exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure"
[PROC 2]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed, continuous process with
occasional controlled exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
Technical conditions and measures at process level (source) to prevent release
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 3 of 51
Level of containment
L
Use in closed batch process (synthesis or
formulation)
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for
exposure arises" [PROC 4]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in batch and other process (synthesis)
where opportunity for exposure arises
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at non-dedicated facilities" [PROC 8a]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 4 of 51
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities" [PROC 8b]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use as laboratory reagent" [PROC 15]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 5 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
PROC
(inhalation +
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 1
0.048
NA
NA
1E-4
1E-4
PROC 2
48.4
NA
NA
0.101
0.101
PROC 3
121
NA
NA
0.252
0.252
PROC 4
96.8
NA
NA
0.202
0.202
PROC 8a 242
NA
NA
0.504
0.504
PROC 8b 242
NA
NA
0.504
0.504
PROC 15 48.4
NA
NA
0.101
0.101
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
The values for the parameters river flow and effluent discharge rate have been refined to reflect a realistic
dilution rate (river). Furthermore it is taken into account that the sludge from STP is not discharged to soil. The
RCR values for marine compartments are not considered as relevant for the manufacturing scenario as the
production site is located in a sufficient distance from sea (*).
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
0.048
mg/l
0.267
0.981
mg/kgdwt
0.963
mg/kgdwt
0.982
0.018
mg/l
0.058
mg/l
3.2 (*)
0.0981
mg/kgdwt
1.15
mg/kgdwt
11.72 (*)
35.6
mg/l
5.75
mg/l
0.162
0.0903
mg/kgdwt
0.07
mg/kgdwt
0.78
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 6 of 51
ES 2 – Distribution of Butyl Acetate
Distribution of Butyl Acetate
Environment:
ERC 1
Worker
Use in closed process, no likelihood of exposure
PROC 1
Use in closed, continuous process with occasional controlled exposure
PROC 2
Use in closed batch process (synthesis or formulation)
PROC 3
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 4
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at non-dedicated facilities
PROC 8a
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at dedicated facilities
PROC 8b
Transfer of substance or preparation into small containers (dedicated filling line,
including weighing)
PROC 9
Use as laboratory reagent
PROC 15
Operational conditions and risk management measures
Control of environmental exposure: Distribution of Butyl Acetate
Product characteristics
Amounts used
Daily use at a site
<= 400 tonnes/day
Annual use at a site
<= 1.2E5 tonnes/year
Percentage of tonnage used at regional scale
= 100 %
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Amounts used
Frequency and duration of use/exposure
No
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 7 of 51
Duration of activity
L
>4 hours
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed process, no likelihood of
exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure"
[PROC 2]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed, continuous process with
occasional controlled exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 8 of 51
Place of use
L
Indoors
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed batch process (synthesis or
formulation)
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for
exposure arises" [PROC 4]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in batch and other process (synthesis)
where opportunity for exposure arises
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at non-dedicated facilities" [PROC 8a]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
Technical conditions and measures at process level (source) to prevent release
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 9 of 51
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities" [PROC 8b]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation into small containers (dedicated
filling line, including weighing) " [PROC 9]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
Additional good practice advice beyond the REACH CSA
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 10 of 51
Control of workers exposure for "Use as laboratory reagent" [PROC 15]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 11 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
(inhalation +
PROC
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 1
0.048
NA
NA
1E-4
1E-4
PROC 2
48.4
NA
NA
0.101
0.101
PROC 3
121
NA
NA
0.252
0.252
PROC 4
96.8
NA
NA
0.202
0.202
PROC 8a 242
NA
NA
0.504
0.504
PROC 8b 242
NA
NA
0.504
0.504
PROC 15 48.4
NA
NA
0.101
0.101
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
0.022
mg/l
0.124
0.981
mg/kgdwt
0.447
mg/kgdwt
0.456
0.018
mg/l
0.002
mg/l
0.123
0.0981
mg/kgdwt
0.044
mg/kgdwt
0.454
35.6
mg/l
0.218
mg/l
0.006
0.0903
mg/kgdwt
0.083
mg/kgdwt
0.915
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 12 of 51
ES 3 - Formulation
Formulation
Market sector:
Environment:
ERC 2
Worker
Use in closed process, no likelihood of exposure
PROC 1
Use in closed, continuous process with occasional controlled exposure
PROC 2
Use in closed batch process (synthesis or formulation)
PROC 3
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 4
Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/or significant contact)
PROC 5
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at non-dedicated facilities
PROC 8a
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at dedicated facilities
PROC 8b
Transfer of substance or preparation into small containers (dedicated filling line,
including weighing)
PROC 9
Production of preparations or articles by tabletting, compression, extrusion,
pelletisation
PROC 14
Use as laboratory reagent
PROC 15
Operational conditions and risk management measures
Control of environmental exposure: Formulation
Product characteristics
Amounts used
Daily use at a site
<= 13.33 tonnes/day
Annual use at a site
<= 4E3 tonnes/year
Percentage of tonnage used at regional scale
= 100 %
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]
Inhal*)
Derm*)
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 13 of 51
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed process, no likelihood of
exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure"
[PROC 2]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed, continuous process with
occasional controlled exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
SAFETY DATA SHEET
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n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 14 of 51
Amounts used
Frequency and duration of use/exposure
Duration of activity
>4 hours
L
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed batch process (synthesis or
formulation)
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for
exposure arises" [PROC 4]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in batch and other process (synthesis)
where opportunity for exposure arises
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Mixing or blending in batch processes for formulation of preparations
and articles (multistage and/or significant contact) " [PROC 5]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Amounts used
Frequency and duration of use/exposure
No
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 15 of 51
Duration of activity
L
>4 hours
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at non-dedicated facilities" [PROC 8a]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities" [PROC 8b]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
L
SAFETY DATA SHEET
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n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 16 of 51
Local Exhaust Ventilation
L
No
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation into small containers (dedicated
filling line, including weighing) " [PROC 9]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Production of preparations or articles by tabletting, compression,
extrusion, pelletisation" [PROC 14]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
Additional good practice advice beyond the REACH CSA
L
SAFETY DATA SHEET
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n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 17 of 51
Control of workers exposure for "Use as laboratory reagent" [PROC 15]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 18 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
(inhalation +
PROC
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 1
0.048
NA
NA
1E-4
1E-4
PROC 2
48.4
NA
NA
0.101
0.101
PROC 3
121
NA
NA
0.252
0.252
PROC 4
96.8
NA
NA
0.202
0.202
PROC 5
242
NA
NA
0.504
0.504
PROC 8a 242
NA
NA
0.504
0.504
PROC 8b 242
NA
NA
0.504
0.504
PROC 9
242
NA
NA
0.504
0.504
PROC 14 242
NA
NA
0.504
0.504
PROC 15 48.4
NA
NA
0.101
0.101
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
0.015
mg/l
0.083
0.981
mg/kgdwt
0.301
mg/kgdwt
0.307
0.018
mg/l
0.002
mg/l
0.083
0.0981
mg/kgdwt
0.03
mg/kgdwt
0.306
35.6
mg/l
0.145
mg/l
0.004
0.0903
mg/kgdwt
0.065
mg/kgdwt
0.724
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 19 of 51
ES 4 - Use in coatings (industrial)
use in coatings (industrial)
Market sector:
PC 9a - Coatings and Paints, Thinners, paint removers
Sector of use:
SU 7 - Printing and reproduction of recorded media
Environment:
ERC 4
Worker
Use in closed process, no likelihood of exposure
PROC 1
Use in closed, continuous process with occasional controlled exposure
PROC 2
Use in closed batch process (synthesis or formulation)
PROC 3
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 4
Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/or significant contact)
PROC 5
Industrial spraying
PROC 7
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at non-dedicated facilities
PROC 8a
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at dedicated facilities
PROC 8b
Roller application or brushing
PROC 10
Treatment of articles by dipping and pouring
PROC 13
Use as laboratory reagent
PROC 15
Operational conditions and risk management measures
Control of environmental exposure: use in coatings
Product characteristics
Amounts used
Daily use at a site
<= 16.66 tonnes/day
Annual use at a site
<= 5E3 tonnes/year
Percentage of tonnage used at regional scale
= 100 %
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
SAFETY DATA SHEET
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n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 20 of 51
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed process, no likelihood of
exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure"
[PROC 2]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed, continuous process with
occasional controlled exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]
Inhal*)
Derm*)
SAFETY DATA SHEET
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Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 21 of 51
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed batch process (synthesis or
formulation)
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for
exposure arises" [PROC 4]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in batch and other process (synthesis)
where opportunity for exposure arises
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Mixing or blending in batch processes for formulation of preparations
and articles (multistage and/or significant contact) " [PROC 5]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
SAFETY DATA SHEET
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Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 22 of 51
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Industrial spraying" [PROC 7]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
Yes
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at non-dedicated facilities" [PROC 8a]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
SAFETY DATA SHEET
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n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 23 of 51
Place of use
L
Indoors
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities" [PROC 8b]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Roller application or brushing" [PROC 10]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
L
SAFETY DATA SHEET
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n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 24 of 51
Respiratory protection
L
Respiratory protection is not used
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Treatment of articles by dipping and pouring" [PROC 13]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use as laboratory reagent" [PROC 15]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 25 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
PROC
(inhalation +
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 1
0.048
NA
NA
1E-4
1E-4
PROC 2
48.4
NA
NA
0.101
0.101
PROC 3
121
NA
NA
0.252
0.252
PROC 4
96.8
NA
NA
0.202
0.202
PROC 5
242
NA
NA
0.504
0.504
PROC 7
60.5
NA
NA
0.126
0.126
PROC 8a 242
NA
NA
0.504
0.504
PROC 8b 242
NA
NA
0.504
0.504
PROC 10 242
NA
NA
0.504
0.504
PROC 13 242
NA
NA
0.504
0.504
PROC 15 48.4
NA
NA
0.101
0.101
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
0.019
mg/l
0.103
0.981
mg/kgdwt
0.374
mg/kgdwt
0.381
0.018
mg/l
0.002
mg/l
0.103
0.0981
mg/kgdwt
0.037
mg/kgdwt
0.379
35.6
mg/l
0.181
mg/l
0.005
0.0903
mg/kgdwt
0.073
mg/kgdwt
0.811
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 26 of 51
ES 5- Use in coatings (professional)
Use in coatings (professional)
Market sector:
PC 9a - Coatings and Paints, Thinners, paint removers
Environment:
ERC 8a
Worker
Use in closed process, no likelihood of exposure
PROC 1
Use in closed, continuous process with occasional controlled exposure
PROC 2
Use in closed batch process (synthesis or formulation)
PROC 3
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 4
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at non-dedicated facilities
PROC 8a
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at dedicated facilities
PROC 8b
Roller application or brushing
PROC 10
Non industrial spraying
PROC 11
Treatment of articles by dipping and pouring
PROC 13
Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/or significant contact)
PROC 5
Use as laboratory reagent
PROC 15
Hand-mixing with intimate contact and only PPE available
PROC 19
Operational conditions and risk management measures
Control of environmental exposure: use in coatings (professional)
Product characteristics
Amounts used
Daily wide dispersive use
= 5.5E-4 tonnes/day
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]
Inhal*)
Derm*)
Loc Sys Loc Sys
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 27 of 51
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed process, no likelihood of
exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure"
[PROC 2]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed, continuous process with
occasional controlled exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Amounts used
No
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 28 of 51
Frequency and duration of use/exposure
Duration of activity
>4 hours
L
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed batch process (synthesis or
formulation)
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for
exposure arises" [PROC 4]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in batch and other process (synthesis)
where opportunity for exposure arises
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at non-dedicated facilities" [PROC 8a]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
Amounts used
Frequency and duration of use/exposure
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 29 of 51
Duration of activity
L
>4 hours
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities" [PROC 8b]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Roller application or brushing" [PROC 10]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
Technical conditions and measures at process level (source) to prevent release
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 30 of 51
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Non industrial spraying" [PROC 11]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection capable offering a
90% reduction in inhaled concentrations of
the substance
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Treatment of articles by dipping and pouring" [PROC 13]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 31 of 51
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Mixing or blending in batch processes for formulation of preparations
and articles (multistage and/or significant contact) " [PROC 5]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use as laboratory reagent" [PROC 15]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Hand-mixing with intimate contact and only PPE available" [PROC
19]
Inhal*)
Derm*)
Loc Sys Loc Sys
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 32 of 51
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 33 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
(inhalation +
PROC
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 1
0.048
NA
NA
1E-4
1E-4
PROC 2
96.8
NA
NA
0.202
0.202
PROC 3
121
NA
NA
0.252
0.252
PROC 4
242
NA
NA
0.504
0.504
PROC 5
290.4
NA
NA
0.605
0.605
PROC 8a 290.4
NA
NA
0.605
0.605
PROC 8b 242
NA
NA
0.504
0.504
PROC 10 290.4
NA
NA
0.605
0.605
PROC 11 242
NA
NA
0.504
0.504
PROC 13 290.4
NA
NA
0.605
0.605
PROC 15 48.4
NA
NA
0.101
0.101
PROC 19 290.4
NA
NA
0.605
0.605
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
5.37E-4
mg/l
0.003
0.981
mg/kgdwt
0. 011
mg/kgdwt
0.011
0.018
mg/l
4.68E-5
mg/l
0.003
0.0981
mg/kgdwt
9.38E-4
mg/kgdwt
0.01
35.6
mg/l
3E-4
mg/l
8.427E-6
0.0903
mg/kgdwt
1.25E-4
mg/kgdwt
0.002
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 34 of 51
ES 7 -Use in cleaning agents (industrial)
Use in cleaning agents (industrial)
Market sector:
PC 35 - Washing and Cleaning Products (including solvent based products)
Sector of use:
SU 8 - Manufacture of bulk, large scale chemicals (including petroleum products)
Environment:
ERC 4
Worker
Use in closed process, no likelihood of exposure
PROC 1
Use in closed, continuous process with occasional controlled exposure
PROC 2
Use in closed batch process (synthesis or formulation)
PROC 3
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 4
Industrial spraying
PROC 7
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at non-dedicated facilities
PROC 8a
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at dedicated facilities
PROC 8b
Roller application or brushing
PROC 10
Treatment of articles by dipping and pouring
PROC 13
Operational conditions and risk management measures
Control of environmental exposure: use in cleaning agents
Product characteristics
Amounts used
Daily use at a site
<= 5 tonnes/day
Annual use at a site
<= 100 tonnes/year
Percentage of tonnage used at regional scale
= 100 %
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]
Inhal*)
Derm*)
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 35 of 51
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed process, no likelihood of
exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure"
[PROC 2]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed, continuous process with
occasional controlled exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
SAFETY DATA SHEET
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n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 36 of 51
Amounts used
Frequency and duration of use/exposure
Duration of activity
>4 hours
L
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed batch process (synthesis or
formulation)
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for
exposure arises" [PROC 4]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in batch and other process (synthesis)
where opportunity for exposure arises
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Industrial spraying" [PROC 7]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 37 of 51
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
Yes
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at non-dedicated facilities" [PROC 8a]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities" [PROC 8b]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 38 of 51
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Roller application or brushing" [PROC 10]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Treatment of articles by dipping and pouring" [PROC 13]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 39 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
(inhalation +
PROC
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 1
0.048
NA
NA
1E-4
1E-4
PROC 2
48.4
NA
NA
0.101
0.101
PROC 3
121
NA
NA
0.252
0.252
PROC 4
96.8
NA
NA
0.202
0.202
PROC 7
60.5
NA
NA
0.126
0.126
PROC 8a 242
NA
NA
0.504
0.504
PROC 8b 242
NA
NA
0.504
0.504
PROC 10 242
NA
NA
0.605
0.605
PROC 13 242
NA
NA
0.605
0.605
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
0.003
mg/l
0.018
0.981
mg/kgdwt
0. 065
mg/kgdwt
0.066
0.018
mg/l
3.16E-4
mg/l
0.018
0.0981
mg/kgdwt
0.006
mg/kgdwt
0.065
35.6
mg/l
0.027
mg/l
7.64E-4
0.0903
mg/kgdwt
0.014
mg/kgdwt
0.151
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 40 of 51
ES 8 - Use in cleaning agents (professional)
Use in cleaning agents (professional)
Market sector:
PC 35 - Washing and Cleaning Products (including solvent based products)
Environment:
ERC 8a
Worker
Use in closed process, no likelihood of exposure
PROC 1
Use in closed, continuous process with occasional controlled exposure
PROC 2
Use in closed batch process (synthesis or formulation)
PROC 3
Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 4
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at non-dedicated facilities
PROC 8a
Transfer of substance or preparation (charging/discharging) from/to vessels/large
containers at dedicated facilities
PROC 8b
Roller application or brushing
PROC 10
Non industrial spraying
PROC 11
Treatment of articles by dipping and pouring
PROC 13
Operational conditions and risk management measures
Control of environmental exposure: use in cleaning agents (professional)
Product characteristics
Amounts used
Daily wide dispersive use
= 2.7E-4 tonnes/day
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed process, no likelihood of exposure" [PROC 1]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Amounts used
No
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 41 of 51
Frequency and duration of use/exposure
Duration of activity
>4 hours
L
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed process, no likelihood of
exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed, continuous process with occasional controlled exposure"
[PROC 2]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed, continuous process with
occasional controlled exposure
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in closed batch process (synthesis or formulation) " [PROC 3]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 42 of 51
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in closed batch process (synthesis or
formulation)
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use in batch and other process (synthesis) where opportunity for
exposure arises" [PROC 4]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Level of containment
Use in batch and other process (synthesis)
where opportunity for exposure arises
L
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at non-dedicated facilities" [PROC 8a]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 43 of 51
Place of use
L
Indoors
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Transfer of substance or preparation (charging/discharging) from/to
vessels/large containers at dedicated facilities" [PROC 8b]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Roller application or brushing" [PROC 10]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
Organisational measures to prevent /limit releases, dispersion and exposure
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 44 of 51
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Non industrial spraying" [PROC 11]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection capable offering a
90% reduction in inhaled concentrations of
the substance
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Treatment of articles by dipping and pouring" [PROC 13]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 45 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
(inhalation +
PROC
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 1
0.048
NA
NA
1E-4
1E-4
PROC 2
96.8
NA
NA
0.202
0.202
PROC 3
121
NA
NA
0.252
0.252
PROC 4
242
NA
NA
0.504
0.504
PROC 8a 290.4
NA
NA
0.605
0.605
PROC 8b 242
NA
NA
0.504
0.504
PROC 10 290.4
NA
NA
0.605
0.605
PROC 11 242
NA
NA
0.504
0.504
PROC 13 290.4
NA
NA
0.605
0.605
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
5.07E-4
mg/l
0.003
0.981
mg/kgdwt
0.01
mg/kgdwt
0.01
0.018
mg/l
4.38E-5
mg/l
0.002
0.0981
mg/kgdwt
8.78E-4
mg/kgdwt
0.009
35.6
mg/l
1.47E-8
mg/l
4.129E-10
0.0903
mg/kgdwt
3.39E-5
mg/kgdwt
3.754E-4
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 46 of 51
ES 10 - Use in laboratories (ind)
Use in laboratories (ind)
Market sector:
PC 21 - Laboratory Chemicals
Sector of use:
SU 9 - Manufacture of fine chemicals
Environment:
ERC 4
Worker
Roller application or brushing
PROC 10
Use as laboratory reagent
PROC 15
Operational conditions and risk management measures
Control of environmental exposure: use in laboratories (ind)
Product characteristics
Amounts used
Daily use at a site
<= 0.05 tonnes/day
Annual use at a site
<= 1 tonnes/year
Percentage of tonnage used at regional scale
= 100 %
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Roller application or brushing" [PROC 10]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 47 of 51
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use as laboratory reagent" [PROC 15]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 48 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
(inhalation +
PROC
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 10 242
NA
NA
0.504
0.504
PROC 15 48.4
NA
NA
0.101
0.101
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
0.006
mg/l
0.033
0.981
mg/kgdwt
0.119
mg/kgdwt
0.121
0.018
mg/l
5.88E-4
mg/l
0.033
0.0981
mg/kgdwt
0.012
mg/kgdwt
0.12
35.6
mg/l
0.054
mg/l
0.002
0.0903
mg/kgdwt
0.02
mg/kgdwt
0.225
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 49 of 51
ES 11 - Use in laboratories (prof)
Use in laboratories (prof)
Market sector:
PC 21 - Laboratory Chemicals
Environment:
ERC 8a
Worker
Roller application or brushing
PROC 10
Use as laboratory reagent
PROC 15
Operational conditions and risk management measures
Control of environmental exposure: use in laboratories (prof)
Product characteristics
Amounts used
Daily wide dispersive use
= 1.37E-7 tonnes/day
Frequency and duration of use
Environment factors not influenced by risk management
Receiving surface water flow rate
>= 1.8E4 m3/d
Other given operational conditions affecting environmental exposure
Technical conditions and measures at process level (source) to prevent release
Technical onsite conditions and measures to reduce or limit discharges, air emissions and releases to soil
Organizational measures to prevent/limit release from site
Conditions and measures related to municipal sewage treatment plant
Municipal STP
Yes [Water: 89.1%]
Discharge rate of STP
>= 2E3 m3/d
Application of the STP sludge on agricultural soil
Yes
Conditions and measures related to external treatment of waste for disposal
Conditions and measures related to external recovery of waste
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Roller application or brushing" [PROC 10]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
Yes
L
Concentration of substance in product
5 – 25%
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 50 of 51
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
Control of workers exposure for "Use as laboratory reagent" [PROC 15]
Inhal*)
Derm*)
Loc Sys Loc Sys
Product characteristics
Substance in preparation
No
L
>4 hours
L
Amounts used
Frequency and duration of use/exposure
Duration of activity
Human factors not influenced by risk management
Other given operational conditions affecting workers exposure
Place of use
Indoors
L
Technical conditions and measures at process level (source) to prevent release
Technical conditions and measures to control dispersion from source towards the worker
Local Exhaust Ventilation
No
L
Organisational measures to prevent /limit releases, dispersion and exposure
Conditions and measures related to personal protection, hygiene and health evaluation
Respiratory protection
Respiratory protection is not used
L
Additional good practice advice beyond the REACH CSA
*) The route of exposure (Inhalation, Dermal) and type of effect (Local, Systemic and Acute or Long term) for which
the determinant has been used for exposure estimation are reported.
SAFETY DATA SHEET
"Dmitrievsky chemical plant – Production", LLC
n-Butyl acetate
Annex to extended safety data sheet (eSDS)
Date: 11/04/2011
Previous date: 03/03/2010
Page 51 of 51
Workers – Quantitative Exposure Assessment (TRA workers) and Risk Characterisation.
Derived DNEL covers both systemic and local effects. Exposure assessment for dermal exposures is not
required (DNEL was not derived as no respective hazard was observed).
According to ECHA Guidance on Information Requirements and Chemical Safety Assessment, R.14
(Occupational Exposure Assessment), shift average estimates obtained by ECETOC TRA can be considered to
represent conservative 90th percentiles of the distribution of exposure concentrations. According to the
Guidance document, potential peak exposure concentrations at the workplace (representing 95th percentiles of
the peak exposure concentrations) can be extrapolated from these shift average concentrations by an additional
factor of 2. No information is available from the use and practical experience with the substance, which would
require a higher factor.
Based on this extrapolation peak exposures may exceed ECETOC TRA estimated shift averages by a factor of
2, whereas the DNEL for short-term exposure is twice the long-term DNEL. Hence, it can be concluded that for
all workplace situations, where safe use could be demonstrated based on exposure estimates from ECETOC
TRA, that also potential peak exposures would not give rise to increased risks.
DNEL dermal =
DNEL inhalation long-term systemic =
RCR TOTAL
Not derived
480 mg/m 3 (100 ppm)
(inhalation +
PROC
Estimated
Estimated
dermal)
RCR
RCR
3
exposure (mg/m )
exposure
PROC 10 290.4
NA
NA
0.605
0.605
PROC 15 48.4
NA
NA
0.101
0.101
Environment – Quantitative Exposure Assessment (EUSES 2.1) and Risk Characterisation
Environment type
Water: Fresh Water
(Pelagic)
Water: Fresh Water
(Sediment)
Water: Marine Water
(Pelagic)
Water: Marine Water
(Sediment)
Water: Sewage
Treatment Plant
(Effluent)
Soil: Agricultural Soil
PNEC
PEC/Local
RCR
0.18
mg/l
5.07E-4
mg/l
0.003
0.981
mg/kgdwt
0.01
mg/kgdwt
0.01
0.018
mg/l
4.38E-5
mg/l
0.002
0.0981
mg/kgdwt
8.79E-4
mg/kgdwt
0.009
35.6
mg/l
3.73E-6
mg/l
1.048E-7
0.0903
mg/kgdwt
3.53E-5
mg/kgdwt
3.909E-4