Figure 1. Questions on the pre/posttest asking students about a type of cancer that affects
females. The first number after each answer indicates the percentage of students who
selected that answer on the pretest and the second number indicates the percentage of
students who selected the answer on the posttest (pretest/posttest).
Pre/posttest question 1 (This questions targets LO1): The DOK1 gene has been
implicated in early onset ovarian cancer. This is a pedigree of a family showing the
incidence of ovarian cancer with a particular DOK1- allele.
DOK1+/ DOK1- females that have this DOK1- allele have a high chance of developing
early onset ovarian cancer.
Males cannot get ovarian cancer.
Male I-1 and Female I-4 are DOK1+/ DOK1+
There are no DOK1-/ DOK1- individuals in this family.
Which mode of inheritance is most consistent with the information above?
A. Autosomal dominant 49/76
B. Autosomal recessive 5/13
C. X-linked dominant 14/3
D. X-linked recessive 8/5
E. Y-linked 0/0
F. More than one of the above is possible 24/3
Answer: A
Pre/posttest question 2 (This questions targets LO2): II-3 has a daughter with Greg.
Greg does not have any family history of ovarian cancer. What is the chance their
daughter will develop early onset ovarian cancer if the disease is fully penetrant?
A. 0% 3/5
B. 25% 8/8
C. 50% 81/81
D. 66.7% 0/0
E. 100% 8/6
Answer: C