Johns Hopkins Department of Psychiatry and Behavioral Sciences
ANNUAL RESEARCH POTPOURRI
May 29, 2014
Oral Presentations 3-5 PM | Meyer 1-191
Poster Presentation and Reception 5-6:30 PM | Meyer 8th Floor Library
3:00 DISC1 serine-713 phosphorylation dependent neurodevelopmental switch:
impact upon anatomy and cognition in major mental disorders.
NJ Gamo, A Sawa and K Ishizaku.
3:15 Posterior cingulated cortex N-acetyl-aspartate concentrations in bipolar
disorder and schizophrenia: a 7 tesla proton magnetic resonance
spectroscopy study.
PB Mahon, PG Unschuld, H Eldredge, A Brandt, G Churchill, A Wijtenburg, PB
Barker, CA Ross and RL Margolis.
3:30 Chronic variable stress results in cognitive impairments and Alzheimer’s
disease-related gene expression changes among wild type mice.
ZA Cordner and KL Tamashiro
3:45 Pilot study of the 5-HT2A agonist psilocybin in the treatment of tobacco
addiction.
MW Johnson, A Garcia-Romeu, MP Cosimano and RR Griffiths.
4:00
RNA toxicity and aberrant expATXN2-RBP interactions – a novel paradigm
in the pathogenesis and therapy of Spinocerebral ataxia type 2 (SCA2)
PP LI, X. Sun, S. Zhu, H. Tsoi, QT Zhang, LO Marque, CA Ross, RL Margolis,
M Disney, SM Pulst, HYE Chan and DD Rudnicki.
4:15 Oxytocin receptor epigenetic variation and postpartum depression.
M Kimmel, j Payne and Z Kaminsky.
4:30 The schizophrenia and autism spectrum disorder gen TCF4 regulates
neuronal migration and intrinsic excitability in the developing neocortex.
MD Rannals, SC Paige, AE Jaffe, M Campbell, JH Shin, R Tao, A Briley, TM
Hyde, J Kleinman, DR Weinberger and BJ Maher.
4:45 Defining molecular mediators of lithium action in patients with bipolar
disorder.
Y Chung, S Nrayan, A Sawa, E Nwulia and K Ishizuka.
Johns Hopkins Department of Psychiatry and Behavioral Sciences
ANNUAL RESEARCH POTPOURRI
May 29, 2014
Poster Presentations 5-6:30 PM | Meyer Library
1. GAT1 Expression in Human Brain: Alternate Transcripts, Expression in
Development, and Potential Relationships to Brain Function and Schizophrenia.
MI Mighdoll, H Mitchell, G Ursini, J H Shin, A Jaffe, R Tao, DR Weinberger, JE
Kleinman, TM Hyde.
2.
The Use of Mood 24/7 in the Treatment of Major Depressive Episodes in
Outpatient Setting. AM Riehm, S Woods, KA Rahn, AI Kaplin.
3. Longitudinal evaluation using the recently developed Defense Automated
Neurobehavioral Assessment (DANA) tool of the cognitive impact of
electroconvulsive therapy (ECT) in the treatment of depressive disorder. S Woods,
K Rahn, A Riehm, A Kaplin.
4. White matter abnormalities in Hdh250Q mutant huntingtin knock-in mice. J Jin, A
Langseth, M Tao, Q Peng, SH Kang, M Jiang, Z Guo, JC Troncoso, CA Ross, D
Bergles, W Duan.
5. Rescue of CAG expansion-dependent cell toxicity in HD iPS cells using smallmolecule TrkB agonists. SS Akimov, B Bears, N Arbez, T Ratovitski, M Jiang, VB
Mattis, CN Svendsen, LM Thompson, K Ye, W Duan, CA Ross.
6. Forebrain Specific Ankyrin G knockout Mouse displays mania like behavior,
rescued by anti-psychiatric drugs and shows deficit in GABAergic synapse
formation and ion channel activity. S Zhu, J Kim, B Wollums, X Wang, V Bennett, M
Pletnikov, S Brown, CA Ross.
7. Construct Validity of the ADHD Rating Scale-IV in HIV-Exposed Ugandan
Children. MD Burkey, SM Murray, R Opoka, M Boivin, J Bass.
8. A natural product as a tool to explore novel therapeutic targets for the treatment
of stress-associated behaviors. K Ito, A Saito, MD Ballinger, A Kamiya.
9. Adolescent cannabis exposure interacts with a genetic risk factor for major
mental disorders: effects on emotional learning circuits in adulthood. MD
Ballinger, A Saito, B Abazyan, Y Taniguchi, CH Huang, K Ito, DF Wong, M Pletnikov, A
Kamiya.
10. S-Nitrosylation of NDEL1 mediates activity-dependent dendritic development in
the prefrontal cortex. A Saito, Y Taniguchi, SH Kim, B Selvakumar, MD Ballinger, J
Sabra, M Jallow, P Yan, K Ito, S Hirotsune, A Wynshaw-Boris, SH Snyder, A Sawa, A
Kamiya.
11. A translational study of deep brain stimulation for autistic self-injurious
behavior. AD Chang, I Reti.
12. Relationship between frequent family relocation and risk of depression and
substance use among children in the National Survey on Drug Use and Health. R
Susukida.
13. The neural basis of familial obesity risk: fMRI responses to food words in lean
adolescents with obese/overweight mothers. S Carnell, L Benson, V K-Y Chang, Z
Wang, A Geliebter, BS Peterson.
14. Prenatal stress and a passive coping-style together increase vulnerability for
activity based anorexia. GJ Boersma, NC Liang, L Moody, S Aryal, TH Moran, KL
Tamashiro.
15. The Effects of Voluntary Exercise on Binge Behavior and its Consequences. JD
Alberts, TH Moran.
16. Short-term exposure to a calorically dense diet alters peripheral gustatory nerve,
but not unconditioned lick responses to sucrose. Y Treesukosol, C Inui-Yamamoto,
T Yamamoto, TH Moran.
17. Behavioral Response to Monetary Reward Predicts Lower Pain Sensitivity. L
Samawi, PH Finan, MW Johnson, JA Haythornthwaite, MT Smith.
18. Assessment of Pain Sensitivity in Individuals Diagnosed with Prader-Willi
Syndrome. GW Rooker, BA Iwata, EM Camp.
19. Sleep duration moderates the group difference in laboratory pain sensitivity
between TMJD patients and healthy controls. M Robinson, C Campbell, J
Haythornthwaite, LF Buenaver.
20. Evaluating the Relationship Between Sleep and Challenging Behavior in Children
with Disabilities. J Zarcone, M Scheithauer.
21. Sleep duration moderates the relationship between chronic knee osteoarthritis
and laboratory pain sensitivity. MO Redding, CM Campbell, LF Buenaver, ML
Robinson, LJ Swedberg, SC Bounds, LM McCauley, AB Bockhorst, RR Edwards, MT
Smith.
22. Prenatal high-fat diet during gestation affects expression of nutrient transporters
in rat placenta. L. Song, GJ Boersma, ZA Cordner, AA Moghadam, JQ Yan, TH
Moran, KL Tamashiro.
23. Maternal high–fat diet results in cognitive impairment and hippocampal changes
in rat offspring. ZA Cordner, T Summers, GJ Boersma, L Song, TH Moran, KL
Tamashiro
24. Mutant DISC1 produces smaller Purkinje cells and impairs recognition memory
and social behavior in adult mice. AV Shevelkin, B. Abazyan, GL Rudow, CA Ross,
JC Troncoso, MV Pletnikov.
25. expHTT RNA neurotoxicity and aberrant interaction with RBPs involved in splicing.
X Sun, P Li, L Marque, M Bañez-Coronel, E Waldron-Roby, CA Ross, LPW Ranum, RL
Margolis, DD Rudnicki.
26. Delineating Subtypes of Self-Injurious Behavior Maintained by Automatic
Reinforcement. LP Hagopian, GW Rooker, JR Zarcone.
27. The beneficial effects of a Sirt1 activator SRTAY02 in N171-82Q Huntington’s
disease mouse model. M Jiang, J Zheng, Q Peng, Z Hou, J Zhang, S Mori, JL Ellis,
GP Vlasuk, R Fries, V Suri, W Duan.
28. D-Serine deficiency during neonatal development in Pick1 knockout mice results
in NMDA receptor-mediated adult behavioral and physiological abnormalities. T
Cash-Padgett, J Nomura, F Huppe-Gourgues, E Lewis, M Pletnikov, P O’Donnell, A
Sawa, H Jaaro-Peled.
29. Glutathione: An antioxidant reservoir of synaptic glutamate. M Koga, A Kamiya, C
Higgs, P Talalay, SH Snyder, A Sawa, T Sedlak.
30. A Thousand Words Worth A Picture – A Quantitative Word Cloud For Expressing
Biomedical Data. J Matelsky, M Koga, T Sedlak.
31. A novel chromosomal deletion and duplication in a patient with schizophrenia. D
Batista, K McEvoy, T Sedlak.
32. Neuropsychiatric Symptoms (NPS) as Predictors of Progression to Severe
Alzheimer’s Dementia and Death: The Cache County Study. ME Peters, S
Schwartz, DD Han, PV Rabins, JT Tschanz, CG Lyketsos, The Cache County
Investigators.
33. High Resolution FMR1 Genetic and Epigenetic Molecular Assessments in a Well
Characterized Cohort of Full Mutation and Premutation Fragile X Patients. GJ
Latham, R Hinton, M Johnston, R Findling, S Filipovic‐Sadic, A. Hadd, D Budimirovic.
34. An animal model for assessing CNS deficits in neurobehavioral function. CM
Davis, RD Hienz.
35. Differences in extinction of cue-maintained conditioned responses associated
with self-administration: alcohol versus a non-alcoholic reinforcer. AF Holtyn, BJ
Kaminski, GS Wand, EM Weerts.