Delgado Protocol, Inc. WorldWide EstroBlock EVIDENCE SUMMARY ROSEMARY For added safety and efficacy, we are making reference to the NHPD monograph for Oral Rosemary Monograph: Rosemary Date: 2008-01-23 Proper name: Rosmarinus officinalis L. (Lamiaceae) Common name: Rosemary Source material: Leaf Uses: Traditionally used in Herbal Medicine to help ease (gastric) headaches Traditionally used in Herbal Medicine to help relieve flatulent dyspepsia (carminative) Preparation: dry, powder, decoction & infusion + non-standardized Extracts Dose(s): 0.6 -12 grams/d, dried leaf Duration of use: No statement is required Cautions: Consult a health care practitioner prior to use if symptoms persist Consult a health care practitioner if symptoms worsen Contraindication(s) Do not use if you are pregnant or breastfeeding Known Adverse Reaction(s): No statement is required Based on the ‘information box’ under Safety Evidence Section 2.5 of ‘Pathway for Licensing Natural Health Products Making Modern Health Claims’, the following question/statement suggests that ingredients used as foods provide safety of that ingredient. Each of the ingredients in EstroBlock has demonstrated safe food use. Did you know that demonstrated food use of a medicinal ingredient can support the safety of that ingredient? The accumulated evidence supports that rosemary is one of the important antioxidants which are commonly used in different nation’s folk medicine. Rosmarinic acid is well absorbed from gastrointestinal tract and from the skin. It increases the production of prostaglandin E2 and reduces the production of leukotriene B4 in human polymorphonuclear leucocytes, and inhibits the complement system. It is concluded that rosemary and its constituents especially caffeic acid derivatives such as rosmarinic acid have a therapeutic potential in treatment or prevention of bronchial asthma, spasmogenic disorders, peptic ulcer, inflammatory diseases, hepatotoxicity, atherosclerosis, ischaemic heart disease, cataract, cancer and poor sperm motility. Scientific data No scientific data is provided for Rosemary as the NHPD has generated a monograph with pre-cleared published data. Delgado Protocol Inc. Delgado Protocol, Inc. Traditional references Botanical Safety Handbook American Herbal Products Associations CRC Press 1997 Michael McGuffin, Christopher Hobbs, Roy Upton and Alicia Goldberg Sesame seed Pgs. 99, 98, 192, 193, 196 . Class 1: herbs that can be safely consumed when used appropriately Handbook of Medicinal Herbs Second Edition CRC Press 1929, pg. 630-632 James Duke and Peggy Ann Duke C.E. Hobbs Botanical Hand-Book pgs. 235, 236, 240, 234, 260 Crude Vegetable Drugs, Etc., in Common Use: Their Properties, Productions and Uses, in an Abbreviated Form In Three Parts Printed by Chas. C. Roberts 21 Brattle Street Boston, 1876 Materia Medica of India and their Therapeutics pgs. 495 Rustomjee Naserwanjee Khory and Nanabhai Navrosji Katrak Bombay India: Printed by the Caxton Works 1903 Rosmarinus officinalis Delgado Protocol Inc.