Instrumental Analytical Chemistry Liquid Chromatography Portfolio VENDORS 1. 2. 3. 4. 5. 6. 7. 8. Hamilton company Bio-Rad Fisher Scientific Hitachi High Technologies America, Inc. Agilent Technologies Buck Scientific Cecil Instruments Ltd Dionex Corporation RESEARCH ARTICLES Quiñones-Torrelo, C., Sagrado, S.,Villanueva-Camañas, R. M., Medina-Hernández, M. J. Development of Predictive Retention−Activity Relationship Models of Tricyclic Antidepressants by Micellar Liquid Chromatography. Journal of Medicinal Chemistry. 1999. 42(16), pp. 3154-3162. This research presented in this article presents the use of a particular type of liquid chromatography known as Micellar Liquid Chromatography (MLC). MLC has been used to emulate in vitro the partitioning procedure of biomembranes in this experiment. A particular type of mobile phrase, micelluar solutions of BRil35, in the reverse- Instrumental Analytical Chemistry Liquid Chromatography Portfolio phrase LC, has been deemed very essential and helpful to predict the biological activities of anesthetics, barbiturates, catecholamines, and benzodiazepines. Yang, Cindy L. H., Chik, Stanley C. C., and et al. Identification of the Bioactive Constituent and Its Mechanisms of Action in Mediating the Anti-Inflammatory Effects of Black Cohosh and Related Cimicifuga species on Human Primary Blood Macrophages. Journal of Medicinal Chemistry. 2009 52 (21), pp. 6707-6715. This article present research of biologically active compounds derived from Cimicifuga species of an herbal substance. One of the instruments used to biologically purify the compound mixture was high-pressure liquid chromatography and the extraction was completed by using partitioning extraction. This process of using both partitioning extraction and HPLC helped researchers purify and isolate the rhizome extracts of Cimicifuga racemosa. Yanguas-Casás, Nieto-Sampedro, Manuel, Romero-Ramírez, Lorenzo, and Fernández-Mayoralas, Alfonso. Synthesis of Antimitotic Thioglycosides: In Vitro and in Vivo Evaluation of Their Anticancer Activity. Journal of Medicinal Chemistry. 2011. 54 (19), pp. 6949-6955. This article displays research done in synthesis of biological compounds oleylN-acetyl-α- and β-D-glucosaminides and their thioglycosyl analogues. These compounds showed to be anti-mitotic on rat glimoa and human lung carcinoma. The cell extracts were analyzed using a liquid chromatography with a mass spectrometry detector. Th LC-MS showed that the glycosides induced changes to the glycosphingolipid metabolism. Thus, in vitro experiments with the thioglycosyl analogues showed to decrease the amount of tumor being induced. COMMON USES FOR LIQUID CHROMATOGRAPHY Liquid Chromatography is used for separation of compounds that have more of the attributes or characteristics of a liquid substance. Different instrumentation related to liquid chromatography, such as HPLC are used to help quantify the concentration of a substance, while other various LC instruments are used to characterize and indentify liquid-like compounds.