Synthesis, electrochemistry, imaging and analytical systems for the diagnosis
UTCBS CNRS 8258 – INSERM 1022
Chimie ParisTech, 11 rue Pierre et Marie Curie, F-75231 Paris cedex 05 (France)
Dr Fethi BEDIOUI, Directeur de Recherche CNRS
Phone : 33 (0)144 27 64 89 ; Fax : 33 (0)144 27 64 96 ; fethi.bedioui@chimie-paristech.fr
Main fields of expertise
Development and use in automated synthesis of recyclable supported catalysts for the Huisgen reaction and
synthesis of libraries of molecules with or without solvent. Study of reactivity and bis-triazole regioselective
synthesis.
Identification of ligands for proteins by screening on small molecules chip
Preparation of targeted imaging agents. Development of molecular magnetic resonance imaging MRI methods
and functional imaging methods for the characterization and therapeutic follow-up of cancer in preclinics.
Electrochemical sensors for biological system: Multi sensor arrayed platform for screening biological markers.
Molecular materials for electroanalysis and electrocatalysis. Microelectrochemical patterning of surfaces using
scanning electrochemical microscopy. Label-free electrochemical detection of microRNAs
Development of miniaturized total analysis systems for applications ranging from environmental monitoring to
in-vitro medical diagnostics Characterization of new selective objects : Aptamers, peptide nanotubes Design of
original biocompatible nano-objects and quantitative characterization of their non-covalent interactions for use as
selective operators in electrokinetic separation methods, diagnostics, imaging and therapy
Significant recent publications :
Doan BT et al. Colon tumor growth and antivascular treatment in mice: complementary assessment with MR elastography and
diffusion-weighted MR imaging. Radiology 2012, 264 : 436-444
Doan BT et al. X-ray photolysis to release ligands from caged reagents by an intramolecular antenna sensitive to magnetic
resonance imaging. Angew Chem Int Ed Engl 2011, 50:9708-9711.
d'Orlye, F , Varenne A et al. Aptamer-conjugated nanoparticles: Preservation of targeting functionality demonstrated by
microchip electrophoresis in frontal mode Analytical Biochemistry Volume: 435 Issue: 2 Pages: 150-152
d'Orlye, F ; Varenne A et al. Red blood cells decorated with functionalized core-shell magnetic nanoparticles: elucidation of the
adsorption mechanism . Chemical Communications Volume: 49 Issue: 47 Pages: 5393-5395
Griveau S, Bedioui F et al. On-chip multi-electrochemical sensor array platform for simultaneous screening of nitric oxide and
peroxynitrite Lab on a Chip 2011, 11:1342-1350.
Griveau S, Bedioui F et al. In vivo electrochemical detection of nitric oxide in tumor-bearing mice.
Analytical Chemistry 2007, 79:1030-1033.
C. Girard et al. "Chemoselective Preparation of Disymmetric Bistriazoles from Bisalkynes"; Tetrahedron Letters 2011: 52, 658660.
Beauvineau C, Girard C et al. “Automated Synthesis of a 96-Product Sized Library of Triazole Derivatives using a Solid Phase
Supported Copper Catalyst”; Molecules 2010, 15, 3087-3120.
0
