Synthesis, electrochemistry, imaging and analytical systems for the diagnosis
UTCBS CNRS 8258 – INSERM 1022
Chimie ParisTech, 11 rue Pierre et Marie Curie, F-75231 Paris cedex 05 (France)
Dr Fethi BEDIOUI, Directeur de Recherche CNRS
Phone : 33 (0)144 27 64 89 ; Fax : 33 (0)144 27 64 96 ; fethi.bedioui@chimie-paristech.fr
Main fields of expertise
Development and use in automated synthesis of recyclable supported catalysts for the Huisgen reaction and
synthesis of libraries of molecules with or without solvent. Study of reactivity and bis-triazole regioselective
synthesis.
Identification of ligands for proteins by screening on small molecules chip
Preparation of targeted imaging agents. Development of molecular magnetic resonance imaging MRI methods
and functional imaging methods for the characterization and therapeutic follow-up of cancer in preclinics.
Electrochemical sensors for biological system: Multi sensor arrayed platform for screening biological markers.
Molecular materials for electroanalysis and electrocatalysis. Microelectrochemical patterning of surfaces using
scanning electrochemical microscopy. Label-free electrochemical detection of microRNAs
Development of miniaturized total analysis systems for applications ranging from environmental monitoring to
in-vitro medical diagnostics Characterization of new selective objects : Aptamers, peptide nanotubes Design of
original biocompatible nano-objects and quantitative characterization of their non-covalent interactions for use as
selective operators in electrokinetic separation methods, diagnostics, imaging and therapy
Significant recent publications :
Doan BT et al. Colon tumor growth and antivascular treatment in mice: complementary assessment with MR elastography and
diffusion-weighted MR imaging. Radiology 2012, 264 : 436-444
Doan BT et al. X-ray photolysis to release ligands from caged reagents by an intramolecular antenna sensitive to magnetic
resonance imaging. Angew Chem Int Ed Engl 2011, 50:9708-9711.
d'Orlye, F , Varenne A et al. Aptamer-conjugated nanoparticles: Preservation of targeting functionality demonstrated by
microchip electrophoresis in frontal mode Analytical Biochemistry Volume: 435 Issue: 2 Pages: 150-152
d'Orlye, F ; Varenne A et al. Red blood cells decorated with functionalized core-shell magnetic nanoparticles: elucidation of the
adsorption mechanism . Chemical Communications Volume: 49 Issue: 47 Pages: 5393-5395
Griveau S, Bedioui F et al. On-chip multi-electrochemical sensor array platform for simultaneous screening of nitric oxide and
peroxynitrite Lab on a Chip 2011, 11:1342-1350.
Griveau S, Bedioui F et al. In vivo electrochemical detection of nitric oxide in tumor-bearing mice.
Analytical Chemistry 2007, 79:1030-1033.
C. Girard et al. "Chemoselective Preparation of Disymmetric Bistriazoles from Bisalkynes"; Tetrahedron Letters 2011: 52, 658660.
Beauvineau C, Girard C et al. “Automated Synthesis of a 96-Product Sized Library of Triazole Derivatives using a Solid Phase
Supported Copper Catalyst”; Molecules 2010, 15, 3087-3120.