Relevant tools and models for translation of advanced drug delivery
systems
SFNano Workshop 2014, 2 – 4 October 2014, Porto, Portugal
Time
Proposed topics
Day 1
Registration
I. Introductory presentations
Speakers
9:00 –
9:45
9:45 –
10:30
10:30 –
11:00
11:00 –
11:45
11:45 –
12:30
Pharmacokinetics and pharmacodynamic
concepts
Computational approaches for
prediction/simulation of drug delivery
Coffee break
Tobias Paehler, Sanofi, Germany
In vitro/in vivo correlation in drug delivery
12:30 –
13:15
13:15 –
14:30
Electroporation : characterization, tools, and
constraints for in vivo delivery
Lunch break and Networking
Jean-Michel Cardot, (Laboratoire Biopharmacie, Univ
Clermont 1, Clermont-Ferrand)
Marie-Pierre Rols (Institute of pharmacology and
structural biology, Toulouse, France) (A confirmer par
Marie-Pierre)
Damijan Miklavcic (Univ Ljubljana, Ljubljana,
Slovenia)
Principles of Electroporation for drug delivery
Tarek Mounir, Univ Nancy, France
I. Oral route
14:30 –
Current scenario, barriers, and challenges
15:15
15:15 –
Computational models
16:00
16:00 –
Coffee break
16:30
16:30 –
In vitro models for assessment of oral drug
17:15
absorption
Short oral communications
17 :15 – PLGA particles as a vector for oral insulin
17 :30
delivery: in vitro and in vivo validation of
biofunctionality
17 :30 – Chitosan nanocapsules for peptide delivery
17 :45
17 :45 – A neurofilament-derived peptide targets
18 :00
neural stem cells
18 :00 – Improving the ability of S4(13)-PV cell18 :15
penetrating peptide to mediate siRNA delivery
through peptide acylation
Clive Wilson, Univ Strathclyde, UK
Michael B. Bolger, Simulations Plus, California, USA
Per Artursson
El Hadji Mouhamadou Bamba Diop, University of
Strasbourg, France
Belén L. Bouzo et al., University of Santiago de
Compostela, Spain
Joel Eyer, University of Angers, France
Catarina M. Morais et al., University of Coimbra,
Portugal
Day 2
II. Parenteral route
1. Intravenous (models/tools for drug delivery to cancer and to brain)
9:00 –
Physiological barriers to drug delivery by i.v.
Jean Marie Devoisselle, Univ Montpellier, France
9:45
route, clinical relevance, and challenges)
9:45 –
In vitro and in vivo models for drug delivery
Khaled Greish, Univ Otago, New Zealand
10:30
to cancer
10:30 –
Coffee break
11:00
11:00 –
Electroporation in Preclinic :
Gregor Sersa ((Institute of Oncology Ljubljana, Zaloška
11:45
11:45 –
12:30
12 :30 –
13:15
13:15 –
14:30
Electrochemotherapy (ECT) for cutaneous
cancers
Targeting the Blood-brain-Barrier to improve
drug delivery to the brain of low molecular
drugs
Targeting the Blood-brain-Barrier to improve
drug delivery to the brain of macromolecules
Lunch break and networking
2. Alternative routes: Pulmonary & Nasal, Cutaneous
14:30 –
Drug delivery through pulmonary route:
15:15
Physiology, barriers, and the associated
challenges
15:15 –
In vitro and in vivo models for drug delivery
16:00
to lung
16:00 –
Coffee Break
16:30
Short oral communications
16:30 –
Biodistribution, tumor targeting and
16 :45
melanoma anticancer properties of innovative
pegylated siRNA lipid nanocapsules
16:45 –
Platform KINE C3 : relevant technological
17 :00
methods to assess brain bioavailability of new
therapeutic compounds.
17:00 –
Organized and differentiated 3D model
17 :15
mimicking the human pulmonary alveolar
epithelium: an alternative model for drug
discovery, toxicology and radiobiology
17:15 –
Pegalation of the metal organic framework,
17 :30
MIL89 improves stability and
confers an inhibitory effect on iNOS activity
in macrophages
17:30 –
Development and optimization of pegylated
17 :45
lipoplexes for vaginal application
17:45 –
Intrapulmonary delivery of gadolinum-based
18 :00
nanoparticles: a theranostic approach for lung
imaging and radiosensitization
cesta 2, SI - 1000 Ljubljana, Slovenia)
Xavier Descleves, Univ Paris Descartes
Didier Betbeder, Lille, France
Rita Vanbever (Univ Louvain, Belgium)
Carsten Ehrhardt, Univ Dublin, Ireland
Pauline Resnier et al., University of Angers, France
Thibaud Thiollier et al., Cynbiose SAS, France
Romain Grall et al., CEA, Fontenay-aux-Roses, France
Nura A Mohamed et al., Imperial college, United
Kingdom
Anna Lechanteur et al., University of Liege, Liege,
Belgium
Sandrine Dufort et al. INSERM-UJF U823, Grenoble,
France
Day 3
9:00 –
9:45
Drug delivery by cutaneous route: Physiology,
barriers, associated challenges, and in vitro/in
vivo models
DNA electroporation for local delivery of
therapeutic proteins and vaccines
Coffee break
B. Delgado-Charro, Bath, United Kingdom
Current clinical experience on electroporation
based treatments, and future prospects
Julie Gehl (Herlev Hospital/Herlev Ringvej 75/ 2730
Herlev/Copenhagen, Denmark)
11:45 –
12:30
Nanomedicine revolution: the path through
regulatory science into personalized medicine
Rogerio Gaspar, Portugal
12:30
Lunch & End of the Workshop
9:45–
10:30
10:30 –
11:00
11:00 –
11:45
Gaelle Vandermeulen (Louvain Drug Research Institute,
Univ Catholique de Louvain, Brussels, Belgium)