ASPET Cardiovascular Division
EB2013 Events and Meetings in Boston
ASPET Office = Hancock Room of the Westin
Saturday, April 20 2013
ASPET Business Meeting
6:00 – 7:30 PM
Convention Center, Rm 107AB
ASPET Opening and Awards Reception
Boston Convention Center, SW Lobby
7:30 PM – 9:30 PM
Sunday April 21, 2013
CVD Executive Committee Meeting
12:30 – 2:30 PM
Westin, Webster room
SYMPOSIUM
Orthostatic intolerance: Insights into pharmacologic, physiologic and gender issues
Boston Convention Center, Room 106
9:30 AM – Noon
Sponsored by the Divisions for Cardiovascular Pharmacology & Integrative Systems,
Translational and Clinical Pharmacology
Chairs: Julian Stewart, New York Med. Col. and Amy Arnold, Vanderbilt Univ. Sch. of Med.
Vasovagal syncope: putative triggers and pharmacological and physiological approaches to
management
Roger Hainsworth, Univ. of Leeds
Neural and non-neural control of orthostatic intolerance: implications for sex
Qi Fu, Texas Healthy Presbyterian Hosp. Dallas
differences
Identifying sympathetic nervous system abnormalities in orthostatic intolerance
Elisabeth Lambert, Human Neurotransmitter Lab.
Ehlers Danlos Syndrome, joint hypermobility and orthostatic intolerance
Peter Rowe, Johns Hopkins Children's Ctr.
Hypo-osmolality pressor stimulus is linked to transient receptor potential vanilloid 4 (TRPV4) in
the portal region
Junior Speaker: Tu Mai, Vanderbilt Univ.
Loss of muscle sympathetic nerve activity and blood pressure phase synchronization in
postural vasovagal syncope
Junior Speaker: Christopher E. Schwartz, New York Med. Col.
SYMPOSIUM
Novel functions for cyclic nucleotide phosphodiesterases and their implications for
pharmacological intervention
Boston Convention Center, Room 107AB
9:30 AM – Noon
Sponsored by the Divisions for Molecular Pharmacology; Cardiovascular Pharmacology;
Integrative Systems, Translational and Clinical Pharmacology; and Neuropharmacology
Chair: Marco Conti, UCSF
Domain structure and interactions in cyclic nucleotide phosphodiesterases: An atomic view of
PDE regulation
Jayvardhan Pandit, Pfizer Global R&D, Groton Labs.
Novel insights into the mechanism of action of beta-adrenergic antagonists: Modulation of
PDE4-beta-adrenergic receptor complexes
Wito Richter, UCSF
Phosphodiesterases and cyclic nucleotide compartments in the regulation of cardiac function
Rodolphe Fischmeister, Univ. de Paris-Sud XI, France
PDE inhibitors and the treatment of airway inflammation
Clive Page, King’s College, London
Post translation regulation of PDE10 and the implication in their physiological role in the CNS
and in drug discovery
Nicholas Brandon, AstraZeneca, Cambridge
SYMPOSIUM
Emerging technologies for delivering neurotherapeutics across the blood-brain barrier
Boston Convention Center, Room 109A
9:30 AM – Noon
Sponsored by the Divisions for Integrative Systems, Translational and Clinical Pharmacology;
Cardiovascular Pharmacology; Drug Discovery and Development; and Neuropharmacology
Chairs: Nisha Nanaware-Kharade, Univ. of Arkansas for Med. Sci. and Eric C. Peterson, Univ.
of Arkansas for Med. Sci.
Anatomy and physiology of the blood brain barrier (BBB) with special emphasis on transport
of biologicals across the BBB and insights into the development of in vitro BBB model
Eric Shusta, Univ. of Wisconsin-Madison
Principles for targeting tight junction proteins and functions
Maria Balda, Univ. Col. London, Inst. of Ophthalmology
Intranasal drugs, biopharmaceuticals and stem cells bypass the blood-brain barrier to treat
Alzheimer’s, Parkinson’s, stroke, brain tumors, PTSD, TBI and other CNS disorders
Willam H. Frey, Regions Hosp.
Gene delivery across the blood brain barrier for treating neurological disorders
Brian Kaspar, Nationwide Children's Hosp.
SYMPOSIUM
Innate immunity and cardiovascular disease: Unfolding the therapeutic potential of tolllike receptors
Boston Convention Center, Room 108
3:00 PM – 5:30 PM
Sponsored by the Divisions for Cardiovascular Pharmacology & Integrative Systems,
Translational and Clinical Pharmacology
Chairs: R. Clinton Webb, Georgia Hlth. Sci. Univ. and Styliana Goulopoulou, Georgia Hlth. Sci.
Univ.
Danger, tissue injury and immunity
Polly Matzinger, NIAID, NIH
Toll-like receptors in gestational hypertension
Brett Mitchell, Texas A&M Hlth. Sci. Ctr.
Innate immune mechanisms in viral myocarditis
Jesus Vallejo, Baylor Col. of Med.
Toll-like receptors: Therapeutic targets in cardiovascular disease?
Claudia Monaco, Imperial Col. London
The influence of methadone on toll-like receptor 4 and human mu opioid receptor expression
Junior Speaker: Summer Dodson, Oklahoma State Univ.
Chronic Toll-like receptor 9 activation mediates heightened vascular contractility via
attenuated NOS activity in isolated aortic segments
Junior Speaker: Cameron McCarthy, Georgia Hlth. Scie. Univ.
Testosterone induces activation of the extrinsic apoptotic pathway in VSMC by mechanisms
involving ROS generation
Junior Speaker: Rheure Lopes, Univ. of Sao Paulo
SYMPOSIUM
Therapeutic approaches for erectile dysfunction (ED) and benign prostatic hyperplasia
(BPH): Present & future
Boston Convention Center, Room 109A
3:00 PM – 5:30 PM
Sponsored by the British Pharmacological Society; and the ASPET Divisions for Cardiovascular
Pharmacology; Drug Discovery and Development; and Integrative Systems, Translational and
Clinical Pharmacology
Chair: Selim Cellek, Cranfield Univ., Bedfordshire
Pathophysiological link between ED and BPH
Selim Cellek, Cranfield Univ., Bedfordshire
Soluble guanylate cyclase activators for ED
Peter Sandner, Bayer HealthCare AG, Wuppertal
PDE5 inhibitors for treatment of BPH
Arthur Burnett, Johns Hopkins Hosp.
Novel therapeutic approaches to ED and BPH
Michael O’Leary, Harvard Med. Sch.
Use of PDE5 inhibitors in indications other than ED and BPH
Ian Eardley, Leeds Royal Infirmary
Student/Postdoc Best Abstract Competition
Westin Boston Waterfront, Grand Ballroom AB
6:30 PM – 8:30 PM
Monday April 22, 2013
SYMPOSIUM
Local Ca2+ signals in the endothelium: Key regulators of vascular function and
dysfunction
Boston Convention Center, Room 109A
3:00 PM – 5:30 PM
Sponsored by the Division for Cardiovascular Pharmacology
Chairs: Mark T. Nelson, Univ. of Vermont and Sean Marrelli, Baylor Col. of Med.
Conducted vasodilation in resistance arteries: Ca2+ signaling between endothelial cells
Steven S. Segal, Univ. of Missouri
TRPA1-induced endothelial calcium signals and vasodilation
Scott Early, Colorado State Univ.
Differential regulation of SK and IK channels during endothelium dependent
hyperpolarization
Kim A. Dora, Univ. of Oxford
Elementary TRPV4 Ca2+ signals regulate endothelium dependent vasodilation
Swapnil K. Sonkusare, Univ. of Vermont
Endothelial Ca2+ wavelets and myoendothelial feedback
Donald G. Welsh, Univ. of Calgary
Alteration of endothelial CaMKII in AngII-induced hypertensive mice
Junior Speaker: Chimene Charbel, Montreal Heart Inst.
Tuesday April 23, 2013
•CVD Trainee Showcase
2:30 – 4:30 PM
Convention Center, Rm 107AB
Sestrin2 is cardioprotective against ischemia/reperfusion injury by promoting LKB1-mediated
AMPK activation
Alexander Morrison-Nozik, Univ. at Buffalo (SUNY)
Pregnane X receptor mediates dyslipidemia Induced by the HIV protease inhibitor
amprenavir in mice
Robert Helsley, Univ. of Kentucky
Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: Enrichment at the
intercalated disk
Miyoun Hong, New York Univ. Sch. of Med.
Genetic deletion of the TRPC3 channel blunts the development of angiotensin II-induced
hypertension in mice
Asif Pathan, Univ. of Arkansas for Med. Sciences
Angiotensin II receptor blockade, but not ACE inhibition, reduces nocturnal hypertesion and
natriuresis in autonomic failure patients with low renin activity
Amy Arnold, Vanderbilt Univ.
Aged eNOS-/- mice display increased APP expression, microglial activation, and impaired
spatial memory
Susan Austin, Mayo Clinic
•CVD Benedict R. Lucchesi Distinguished Award Lecture in Cardiac Pharmacology
Boston Convention Center, Room 107AB
4:30 PM – 5:30 PM
Andre Terzic, Mayo Clinic
Regenerative cardiac pharmacology: The next frontier
Introduction: Nancy Rusch, Univ. of Arkansas for Med. Sci.
•CVD Business Meeting
5:45 – 6:45 PM
Convention Center Rm 107AB
•CVD Mixer
6:00 – 8:00 PM
Westin, Grand Ballroom D
Wednesday, April 24, 2013
SYMPOSIUM
Apolipoprotein E: A protein at the intersection of vascular and neurodegenerative
disease biology
Boston Convention Center, Room 106
9:30 AM – Noon
Sponsored by the Divisions for Neuropharmacology & Cardiovascular Pharmacology
Chairs: Cheryl Wellington, Univ. of British Columbia and Michael Wood, AstraZeneca
Pharmaceuticals
Molecular basis for differential effects of apolipoprotein E isoforms on lipoprotein metabolism
Michael C. Phillips, Univ. of Pennsylvania Sch. of Med.
Vascular contributions to the pathogenesis of Alzheimer’s disease
Richard Mayeux, Columbia Univ. Med. Ctr.
ApoE isoform-specific ApoE/Aß complex levels: potential mechanism(s) for AD risk, novel
AD biomarker and therapeutic target
Mary Jo LaDu, Univ. of Illinois at Chicago
From concussion to dementia: A key role for apolipoprotein E in the central nervous system
Cheryl Wellington, Univ. of British Columbia
Roundtable Discussion
Michael Wood, AstraZeneca Pharmaceuticals
SYMPOSIUM
New roles for signaling by G protein beta/gamma subunits
Boston Convention Center, Room 107C
9:30 AM – Noon
Sponsored by the Divisions for Molecular Pharmacology; Cardiovascular Pharmacology; and
Neuropharmacology
Chair: Alan Smrcka, Univ. of Rochester Sch. of Med.
Pharmacological targeting of Gbg subunits: Mechanisms and outcomes
Alan Smrcka, Univ. of Rochester Sch. of Med.
Translocation of Gbetagamma subunits to subcellular compartments
N. Gautam, Washington Univ. Sch. of Med.
Distinct roles for individual G bg isoforms in neurological signaling circuits
Janet Robishaw, Weis Ctr. for Res.
Scaffolding of Gbg by WD40 repeat proteins
Songhai Chen, Univ. of Iowa
G protein betagamma subunits in regulating trafficking and assembly of signaling complexes
Terry Hébert, McGill Univ.
SYMPOSIUM
Sleep apnea: A sleeping giant in disease pathologies
Boston Convention Center, Room 107B
3:00 PM – 5:30 PM
Sponsored by the Divisions for Integrative Systems, Translational and Clinical Pharmacology;
Behavioral Pharmacology; Cardiovascular Pharmacology; and Neuropharmacology
Chairs: Issy Laher, Univ. of British Columbia and Najib Ayas, Univ. of British Columbia
Sleep apnea for non-experts
Najib Ayas, Univ. of British Columbia
Animal models of sleep apnea
Vsevolod Polotsky, Johns Hopkins Univ.
Sleep apnea as a risk factor for cardiovascular diseases
T. Douglas Bradley, Univ. of Toronto/Mount Sinai Hosp.
Sleep apnea and type 2 diabetes
Esra Tasali, Univ. of Chicago Med. Ctr.
Biomarkers in sleep apnea
Atul Malhotra, Brigham and Women's Hosp. and Harvard Med. Sch.
ASPET Closing Reception
Boston Convention Center, Ballroom Foyer
6:00 PM – 8:00 PM