Creative Chemical Solutions in the Field of Veterinary Drug Residues Analysis Dr. Joe O. Boison, Senior Research Scientist, Centre for Veterinary Drug Residues (CVDR), Canadian Food Inspection Agency (CFIA), 116 Veterinary Road, Saskatoon, SK S7N 2R3 Abstract: Antibiotics are used at sub-therapeutic levels frequently in modern agricultural practice on a herd basis as additives to feed and water to promote weight gain, improve feed conversion efficiency and to prevent disease. At therapeutic dosage levels, they are used to treat individual animals for specific disease conditions. Antibiotics used in food producing animals must be safe and effective in the animals, and the edible products derived from these treated food animals must be safe for human consumption. However, such usages may lead to problems with residues in the food-producing animal and to environmental contamination. The inspection of agricultural products including food-producing animals for unacceptable levels of residues is one of the most important duties of a public health agency or regulatory authority. To support this inspection, a combination of in-plant (slaughter house) and laboratory tests for antibiotics are employed. It is from this testing perspective that this presentation will focus. The presentation will use examples from our Saskatoon laboratory to demonstrate how chemistry has been used to provide creative global solutions to some otherwise very difficult challenges in the analysis of trace levels (ng/g or part per billion) of antibiotic drug residues in milk, muscle, kidney, liver and fat from traditional and non-traditional livestock to support regulatory decisions and protect consumer health and safety.