RESEARCH IN DIAGNOSTICS FOR TUBERCULOSIS: FUNDAMENTALS, BEST PRACTICES,
AND PRIORITIES
29 November to 1 December 2015
UCT Lung Institute, Cape Town http://www.lunginstitute.co.za/
Course schedule
1
Day 1, 29 November 2015 (Sunday)
8.30-9.30
Registration
9.30-9.45
Welcome, introductions, and goals
Morning chairs: Keertan Dheda and Grant Theron
THE BIG PICTURE: SETTING THE SCENE
9:45-10:15
Lecture
A new era: progress and challenges in TB diagnostics
10.15-10.45
Lecture
The END TB strategy: where do diagnostics fit in?
10.45-11.15
Refreshments
METHODS
11.15-11.45
Lecture
The diagnostic pathway
11.45-12.15
Lecture
Study designs for diagnostic research
12.15-12.30
Questions and answers
12.30-13.30
Lunch (buffet lunch provided)
Afternoon chair: Karen Steingart
HOT TOPICS AND LESSONS FOM THE FIELD
13.30-14.00
Lecture
Feasibility, accuracy, and clinical effect of point-of-care
Xpert MTB/RIF testing for tuberculosis in primary-care
settings in Africa: a multicentre, randomised, controlled trial
14.00-14.30
Lecture
The XTEND study: a cluster-randomised trial embedded in
South African roll-out of Xpert MTB/RIF
14.30-15.00
Lecture
The impact of point-of-care urine lipoarabinomannan testing
for tuberculosis on mortality: a multi-country RCT
15.00-15.30
Refreshments
PANEL DISCUSSION
15.30-16.30
Panel discussion
When do we need randomized trials for TB diagnostics?
Xpert has revolutionized TB diagnosis and control. Do you
agree or disagree and why?
Where in the clinical pathway should Xpert be placed along
with other tests, such as urine LAM?
What have we learned about diagnostic research from the
rollout of Xpert and its impact on patient/public health?
17.00-18.00
Social reception
Lobby, University Of Cape Town Lung Institute
Keertan Dheda and Karen Steingart
Keertan Dheda
Khairunisa Suleiman
Ruth McNerney
Andre Kengne
All
Facilitator: Grant Theron
Grant Theron
Gavin Churchyard
Jonny Peter
All
Panelists: Grant Theron, Gavin
Churchyard, and Jonny Peter
Facilitator: Karen Steingart
2
Day 2, 30 November 2015 (Monday)
9.00-9.15
Summing up/questions
Lessons from day 1
Morning chair: Grant Theron
THE BIG PICTURE: LESSONS FROM OTHER FIELDS
9.15-9.45
Lecture
Diagnostic approaches in cardiology
Grant Theron
9.45-10.15
Lecture
Childhood pneumonia in the Drakenstein study
Mark Nicol
10.15-10.35
10.35-11.00
METHODS
11.00-11.30
Lecture
Refreshments
IVD Regulatory landscape and HTA
Ruth McNerney
Lecture
Understanding operational research
Anthony Harries
11.30-12.00
Lecture
The consensus clinical case definitions for childhood TB
Stephen Graham
12.00-12.30
Discussion
Involving stakeholders (e.g. TB programmes, communities, end
users, patients) in diagnostic research
All
Facilitator: Ruth McNerney
12.30-13.15
Lunch (buffet lunch provided)
Afternoon chairs: Molebogeng Rangaka and Stephen Graham
HOT TOPICS AND LESSONS FROM THE FIELD
13.15-13.45
Lecture
Research on diagnosing TB in children
13.45-14.15
Lecture
Operational research in action
PANEL DISCUSSION
14.15-15.00
Panel discussion
National TB programmes should not be doing their own
operational research. Do you agree or disagree and why?
How do we overcome the challenges in diagnostic research for
childhood TB?
Scientific rigor versus pragmatism in TB diagnostic studies, how
do we get the right balance?
15.00-15.30
Refreshments
15.30-16.00
Lecture
Systematic reviews: what they are and why they are needed
16.00-16.30
Lecture
GRADE approach for developing recommendations for TB
diagnostics
16.30-17.00
Lecture
WHO policy recommendations: the three most important lessons
I have learned
Bongani Mayosi
Heather Zar
Jacob Creswell
All
Panelists: Heather Zar, Anthony
Harries, and Jacob Creswell
Facilitators: Molebogeng
Rangaka and Stephen Graham
Taryn Young
Karen Steingart
Chris Gilpin
3
Day 3, 1 December 2015 (Tuesday)
9.00-9.15
Summing up/questions
Morning chair: Karen Steingart
THE BIG PICTURE: THE WAY FORWARD
9.15-9.45
Lecture
9.45-10.15
Lecture
10.15-10.45
Refreshments
METHODS
10.45-11.15
Lecture
11.15-11.45
Lecture
11.45-12.30
Debate
Lessons from day 2
Karen Steingart
TB diagnostic research agenda, perspective from FIND
Diagnosis of HIV-associated TB
Claudia Denkinger
Stephen Lawn
Impact and cost-effectiveness: the contribution of modelling
Added value of a new test
Active case finding (ACF) refers to a strategy of actively
searching for TB in a defined population, including community
screening programmes. Is ACF the answer?
David Dowdy
Molebogeng Rangaka
Pro: Liz Corbett
Con: David Dowdy
Moderator: Karen Steingart
12.30-13.30
Lunch (buffet lunch provided)
Afternoon chair: Ruth McNerney
HOT TOPICS AND LESSONS FROM THE FIELD
13.30-14.00
Lecture
Fast followers and the NAAT pipeline
14.00-14.30
Lecture
Whole genome sequencing for the detection of DR-TB
14.30-15.00
Lecture
PET/CT for LTBI
15.00 -15.05
Small groups
Allocate small groups
15.05-15.30
Refreshments
15.30-15.50
The future agenda, small group Priorities in TB diagnostic research
discussion
15.50-16.10
Reporting back to the full
Priorities top ten
group
16.10-16.30
Course evaluation and distribution of certificates
16.30-16:45
Closing remarks
Adjourn
David Boyle
Megan Murray
Cliff Barry
Facilitator: Ruth McNerney
All
All
Facilitator: Ruth McNerney
Karen Steingart
Keertan Dheda
4