Program Director/Principal Investigator (Last, First, Middle):
Meyskens, Frank L.
5P30CA062203-17
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Gulsen, Gultekin
Associate Professor of Radiological Sciences,
Physics, and Biomedical Engineering
eRA COMMONS USER NAME
gultekingulsen
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Bogazici University, Istanbul, Turkey
Bogazici University, Istanbul, Turkey
Bogazici University, Istanbul, Turkey
Bogazici University, Istanbul, Turkey
University of California-Irvine
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
B.S.
M.S.
Ph.D.
Postdoc
Postdoc
06/93
06/95
06/99
06/99-06/00
06/00-06/01
Physics
Physics
Physics
Fiber Optic Sensors
Medical Imaging
A. Personal Statement
I have been working on in vivo optical imaging techniques for more than a decade. My main research area
is multi-modality imaging, particularly integrating Diffuse Optical Tomography with anatomic imaging
modalities such as MRI and X-ray CT. For example, my team has been developing a gantry-based
combined X-ray CT and Fluorescence Tomography system for animal imaging. This hybrid system is
currently operational and is capable of in vivo imaging. This system is unique in that both x-ray CT and
optical imaging systems are on the same gantry rotating around the animal and capable of revealing crosssectional background absorption map and anatomic images to obtain quantitatively correct fluorophore
concentration maps. Another hybrid system that is being developed in my lab is a combined MRI-Diffuse
Optical Tomography (MR-DOT) scanner for small animal and human breast cancer imaging in absorbance
& fluorescence mode. Meanwhile, I have been serving as the director for the IVFOI shared resource for
several years. I have been providing consultation regarding projects related to various imaging modalities
such as MRI, Optical, Nuclear Medicine and X-ray CT. I will continue helping investigators design their
particular imaging studies, prepare materials to support their grant applications, and help them design
imaging protocols, as well as help develop data analysis methods.
B. Positions and Honors.
Positions and Employment
1998-1999
2001-2005
2005-2009
200520092002-2009
2009-
Biomedical Physicist, American Hospital, Istanbul, Turkey
Assistant Researcher, UC-Irvine
Assistant Professor, UC-Irvine
Director, Division of Optical Imaging, Department of Radiology, UC-Irvine
Associate Professor, UC-Irvine
Co-Director, Onco-Imaging Resource, Chao Family Comprehensive Cancer Center, UC-Irvine
Director, Onco-Imaging Resource, Chao Family Comprehensive Cancer Center, UC-Irvine
Other Experience and Professional Memberships
200520012001200220072004-
NTROI, Network for Transitional Research for Optical Imaging
OSA, Optical Society of America
SPIE, the International Society of Optical Engineering
IEEE, Institute for Electronics Engineers
Committee member and chair for Multi-modality Imaging Conference - SPIE Photonics West
Ad hoc Reviewer for NIH and DOD Army BCRP/PCRP program
PHS 398/2590 (Rev. 06/09)
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Program Director/Principal Investigator (Last, First, Middle):
Meyskens, Frank L.
C. Selected peer-reviewed publications (in chronological order).
Most relevant to the current application
1. Gulsen, G., Yu, H., Wang, J., Bevilacqua, F., Durkin, A., Cuccia, D., Merritt, S., Tromberg, B.J. and
Nalcioglu, O. (2002). Congruent MRI and NIR spectroscopy for functional and structural imaging of tumors.
J. Tech. Cancer Research & Treatment, 1-6:497-505. PMID 12625777.
2. Gulsen, G., Birgul, O., Unlu, M. B., Shafiiha, R. and Nalcioglu, O. (2006). Combined diffuse optical
tomography (DOT) and MRI system for cancer imaging in small animals. J. Tech. Cancer Research &
Treatment, 5(4), pp. 351-363. PMID 16866566.
3. Lin, Y., Gao, H., Nalcioglu, O. and Gulsen, G. (2007). Fluorescence diffuse optical tomography with
functional and anatomical a priori information: feasibility study. Phys. Med. Biol., 52: 5569-5585. PMID
17804882.
4. Lin, Y., Barber, W., Iwanczyk, J., Roeck, W., Nalcioglu, O. and Gulsen, G. (2010). Quantitative
fluorescence tomography using a combined tri-modality FT/DOT/XCT system. Optics Express, 18, (8),
7835-7850. PMID 20588625. PMCID 2898749.
5. Lin, Y., Ghijsen, M., Nalcioglu, O. and Gulsen, G. (2011). Photo-multiplier tube based hybrid MRI and
fluorescence tomography system for small animal imaging. Phys in Med. Bio., 56: 4731-4747 (2011). PMID
21753235.
Additional recent publications of importance to the field (in chronological order)
1. Gulsen, G., Birgul, O., Xiong, B. and Nalcioglu O. (2006). Design and Implementation of a Multi-Frequency
Diffuse Optical Tomography (MF-DOT) System. Journal of Biomed. Optics, 11(1), p. 014020-1:10. PMID
16526897.
2. Unlu, B., Lin, Y., Birgul, O., Nalcioglu, O. and G. Gulsen. (2008). Simultaneous in vivo dynamic magnetic
resonance-diffuse optical tomography for small animal imaging. Journal of Biomedical Optics Letters,
13(6): 060501. PMID 19123642. PMCID 2943837.
3. Chung, S., Cerussi, A., Klifa, C., Baek, H., Birgul, O., Gulsen, G., Merritt, S., Hsiang, D., and Tromberg, B.
(2008). In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy.
Phys. Med. Biol, 53 6713-6727. PMID 18997265. PMCID 2586905.
4. Lin, Y., Yan, K., Nalcioglu, O. and Gulsen, G. (2009). Quantitative fluorescence tomography with functional
and structural a priori information. Applied Optics, 48 (7) 1328-1336. PMID 19252634. PMCID 2737514.
5. Unlu, B., Lin, Y. and Gulsen, G. (2009). Dynamic contrast enhanced diffuse optical tomography (DCEDOT): experimental validation with a dynamic phantom. Phys in Med. Bio., 54 (21), 6739–6755. PMID
19841515
6. Thayer, D., Unlu, B., Lin, Y., Yan, K. Nalcioglu, O. and G. Gulsen. (2010). Dual-Contrast Dynamic MRIDOT for Small Animal Imaging. Tech. Cancer Research & Treatment, 9(1) 61-69. PMID 20082531.
7. Gao, H., Lin, Y., Gulsen, G. and Zhao, H. (2010). Fully linear reconstruction method for fluorescence yield
and lifetime through inverse complex-source formulation. Optics Letters, 35(11), 899-1901. PMID
20517455.
8. Lin, Y., Nalcioglu, O., and Gulsen, G. (2010). Quantitative fluorescence tomography using a tri-modality
system: in vivo validation. JBO Letters, 15, 040503. PMID 20799770
9. 26. MT Ghijsen, Y Lin, M. Hsing, O. Nalcioglu and G. Gulsen. (2011) “Optimal Analysis Method for
Dynamic Contrast Enhanced Diffuse Optical Tomography (DCE-DOT)”, Int. Jour. Bio. Imag., 2011, 426503,
13 p. PMID 21811492. PMCID 3147123.
10. Y. Lin, D. Thayer, O. Nalcioglu and G. Gulsen. (2011) “MR-guided Near Infrared Characterization of
Breast Tumors Using Indocynine Green in a Rat Model” , JBO Letters, in press,
D. Research Support
Ongoing Research Support
5P30CA062203-16 Meyskens (PI)
02/01/09-01/31/14
NIH/NCI
University of California Irvine Cancer Center Support Grant Infrastructure and Research award to support
cancer research at UC Irvine and beyond.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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Program Director/Principal Investigator (Last, First, Middle):
Meyskens, Frank L.
Role: Shared Resource Director of In-Vivo Functional Onco-Imaging
KG101442 (Fellow: Lin, Y, PI: Gulsen, G,)
09/01/10-09/09/13
NIH/NIBIB
Role: PI-Mentor
A Combined MRI-Dynamic Contrast Enhanced Fluorescence Tomography System for Breast Cancer Imaging.
This is a training grant for Dr. Yuting Lin. who is a postdoctoral researcher in our group. This project will
develop a dynamic fluorescence tomography system that is compatible to MRI for human breast cancer
imaging.
R01 EB008716
Gulsen (PI)
08/01/08-7/31/12
NIH/NIBIB
Role: PI
Tomographic Molecular Imaging for Breast Cancer
This project will develop first-of-its-kind combined MR-Fluorescence Tomography animal imaging system that
can provide accurate concentration and lifetime information of a targeted fluorescence agent in vivo.
R21UCLA50812
Gulsen (subaward-PI)
07/15/11-06/30/13
NIH
Role: PI
Fluorescence Tomography in Small Animal Imaging Using an Ultra-fast RTE Solver (Prime Award# 1 R21
EB013387-01A1, PI Hao Gao)
This project aims to develop a graphics processing unit (GPU) based fast reconstruction algorithm using
Radiative Transfer Equation (RTE).
R21/33 CA120175
Gulsen (PI)
07/01/07-06/30/12
NIH/NCI
Role: PI
Development of a Multi-Modality System for Onco-Imaging
This project will develop a hybrid Near Infrared (NIR) and MRI dynamic imaging system with dual function
NIR/MR contrast agents to detect and characterize tumors with a higher sensitivity and specificity than current
imaging protocols.
1R01CA142989-01 Tromberg (PI)
01/01/10-12/31/14
NIH/NIBIB
Role: PI
Developing DOSI Technology for Monitoring Response To Breast Cancer Chemotherapy
This grant will support the development of optical imaging technology that can be used to improve patient
outcome by maximizing therapeutic response, minimizing unnecessary toxicity, and optimize clinical decision
making.
Completed Research Support
R21 CA121568
Su (PI)
07/01/07 - 06/30/09
NIH/NCI
Role: Co-PI
Combined MRI and Optical Imaging to Improved Breast Cancer Diagnosis
This project will investigate the performance of a combined MRI and DOT (Diffuse Optical Tomography)
system for improving diagnostic specificity of breast cancer with a small-scale clinical study.
R44 EB007873
07/01/07 - 06/30/09
NIH/NIBIB SBIR I
Role: Co-Inv
A Novel in Vivo Cell Tracking System Based on Combined XCT and FT
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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Program Director/Principal Investigator (Last, First, Middle):
Meyskens, Frank L.
The major goal is to develop a combined fluorescence tomography and CT system for cell tracking in animals.
In this project we are partners with a company (DxRay)
R21/33 CA101139
Nalcioglu (PI)
04/01/05-03/31/09
NIH Natl Cancer Inst
Role: Co-investigator
Combined MR-Diffuse Optics for Functional Imaging
The aim is to construct an MR-compatible optical spectroscopic tomography animal system for improved
spatial localization of optical measurements and accurate optical-MRI co-registration.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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